JP2019532071A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019532071A5 JP2019532071A5 JP2019520039A JP2019520039A JP2019532071A5 JP 2019532071 A5 JP2019532071 A5 JP 2019532071A5 JP 2019520039 A JP2019520039 A JP 2019520039A JP 2019520039 A JP2019520039 A JP 2019520039A JP 2019532071 A5 JP2019532071 A5 JP 2019532071A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- hydrogen
- halo
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022113322A JP2022132464A (ja) | 2016-10-14 | 2022-07-14 | 非常に強力な糖質コルチコイドの構造およびデザインのための機構 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662408314P | 2016-10-14 | 2016-10-14 | |
| US62/408,314 | 2016-10-14 | ||
| PCT/US2017/056447 WO2018071736A1 (en) | 2016-10-14 | 2017-10-13 | Structures and mechanism for the design of highly potent glucocorticoids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022113322A Division JP2022132464A (ja) | 2016-10-14 | 2022-07-14 | 非常に強力な糖質コルチコイドの構造およびデザインのための機構 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532071A JP2019532071A (ja) | 2019-11-07 |
| JP2019532071A5 true JP2019532071A5 (https=) | 2020-11-12 |
| JP7146750B2 JP7146750B2 (ja) | 2022-10-04 |
Family
ID=61906432
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520039A Active JP7146750B2 (ja) | 2016-10-14 | 2017-10-13 | 非常に強力な糖質コルチコイドの構造およびデザインのための機構 |
| JP2022113322A Withdrawn JP2022132464A (ja) | 2016-10-14 | 2022-07-14 | 非常に強力な糖質コルチコイドの構造およびデザインのための機構 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022113322A Withdrawn JP2022132464A (ja) | 2016-10-14 | 2022-07-14 | 非常に強力な糖質コルチコイドの構造およびデザインのための機構 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10954265B2 (https=) |
| EP (1) | EP3525870B1 (https=) |
| JP (2) | JP7146750B2 (https=) |
| KR (1) | KR102497070B1 (https=) |
| CN (1) | CN110382033B (https=) |
| ES (1) | ES2945983T3 (https=) |
| MA (1) | MA46539A (https=) |
| PH (1) | PH12019500801A1 (https=) |
| RU (1) | RU2019111101A (https=) |
| SG (1) | SG11201903209TA (https=) |
| WO (1) | WO2018071736A1 (https=) |
| ZA (1) | ZA201902595B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025119398A1 (zh) * | 2023-12-08 | 2025-06-12 | 浙江柏拉阿图医药科技有限公司 | 高效力糖皮质激素多晶型及其制备方法和用途 |
| WO2025157225A1 (zh) * | 2024-01-24 | 2025-07-31 | 浙江柏拉阿图医药科技有限公司 | 一种高效力糖皮质激素化合物及其制备和用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK66202C (da) | 1945-03-03 | 1948-01-12 | Danske Securitas As | Kodekontakt til elektriske Alarmanlæg. |
| DK71662C (da) | 1946-09-05 | 1950-11-06 | Ingenioer Frank Broadbent | Tørrecentrifuge. |
| US4049813A (en) | 1976-07-15 | 1977-09-20 | Sandoz, Inc. | Substituted isoxazolo pyridinones |
| US5837698A (en) * | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
| CA2451057A1 (en) | 2001-06-14 | 2002-12-27 | Banyu Pharmaceutical Co., Ltd. | Novel isoxazolopyridone derivatives and use thereof |
| GB0119911D0 (en) | 2001-08-15 | 2001-10-10 | Novartis Ag | Organic Compounds |
| WO2005048927A2 (en) * | 2003-11-13 | 2005-06-02 | Combinatorx, Incorporated | Methods and reagents for the treatment of inflammatory disorders |
| EP1940863B1 (en) * | 2005-09-02 | 2012-09-05 | Nicox S.A. | Nitrooxy derivatives of glucocorticoids |
| CN1813768A (zh) * | 2005-11-18 | 2006-08-09 | 成都力思特制药股份有限公司 | 治疗呼吸系统疾病的药用组合物及其在制药中的应用 |
| NZ584160A (en) | 2007-10-04 | 2011-05-27 | Astrazeneca Ab | Steroidal [3,2-c] pyrazole compounds, with glucocorticoid activity |
| CN101945885A (zh) * | 2007-12-20 | 2011-01-12 | 阿斯利康(瑞典)有限公司 | 用作糖皮质激素受体激动剂的甾类衍生物 |
| CA2749585A1 (en) | 2009-01-13 | 2010-07-22 | Van Andel Research Institute | Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids |
| UY32523A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
| UY32520A (es) | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides |
| UY32525A (es) | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
| JP2012530140A (ja) * | 2009-06-16 | 2012-11-29 | メルク・シャープ・アンド・ドーム・コーポレーション | グルココルチコイド受容体アゴニストとしての新規［３，２−ｃ］ヘテロアリールステロイド、組成物およびこの使用 |
| JP2016531852A (ja) * | 2013-09-25 | 2016-10-13 | ヴァン アンデル リサーチ インスティテュート | 非常に強力なグルココルチコイド |
| TWI695831B (zh) * | 2014-09-13 | 2020-06-11 | 香港商南北兄弟藥業投資有限公司 | Ｃｒｔｈ２拮抗劑化合物及其用途 |
-
2017
- 2017-10-13 CN CN201780076320.7A patent/CN110382033B/zh active Active
- 2017-10-13 MA MA046539A patent/MA46539A/fr unknown
- 2017-10-13 RU RU2019111101A patent/RU2019111101A/ru unknown
- 2017-10-13 KR KR1020197013291A patent/KR102497070B1/ko active Active
- 2017-10-13 US US16/341,275 patent/US10954265B2/en active Active
- 2017-10-13 EP EP17860202.5A patent/EP3525870B1/en active Active
- 2017-10-13 JP JP2019520039A patent/JP7146750B2/ja active Active
- 2017-10-13 WO PCT/US2017/056447 patent/WO2018071736A1/en not_active Ceased
- 2017-10-13 SG SG11201903209TA patent/SG11201903209TA/en unknown
- 2017-10-13 ES ES17860202T patent/ES2945983T3/es active Active
-
2019
- 2019-04-12 PH PH12019500801A patent/PH12019500801A1/en unknown
- 2019-04-24 ZA ZA2019/02595A patent/ZA201902595B/en unknown
-
2022
- 2022-07-14 JP JP2022113322A patent/JP2022132464A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3704094B1 (en) | Modulators of the integrated stress pathway | |
| EP3704091B1 (en) | INTEGRATED STRESS RESPONSE PATH MODULATORS | |
| JP2017504576A5 (https=) | ||
| JP2010513494A5 (https=) | ||
| JP2018193405A5 (https=) | ||
| JP2021518338A (ja) | Ｐｄ１／ｐｄ−ｌ１相互作用／活性化の阻害剤としての二環式化合物 | |
| JPWO2019232419A5 (https=) | ||
| JP2008511601A5 (https=) | ||
| JP2010510976A5 (https=) | ||
| JP2005509003A5 (https=) | ||
| JP2012521411A5 (https=) | ||
| CA3045855A1 (en) | Nitrogenous macrocyclic compound, preparation method therefor, pharmaceutical composition and application thereof | |
| JP2012530758A5 (https=) | ||
| JP2019527724A5 (https=) | ||
| TW202317074A (zh) | 製備３－氟－５－（（（１Ｓ，２ａＲ）－１，３，３，４，４－五氟－２ａ－羥基－２，２ａ，３，４－四氫－１Ｈ－環戊二烯并［ＣＤ］茚－７－基）氧基）苄腈及其多晶型物之方法 | |
| JP2019532071A5 (https=) | ||
| Wójtowicz-Rajchel et al. | Synthesis of 5-fluorovinyl derivatives of pyrimidines via Suzuki–Miyaura coupling and their 1, 3-dipolar cycloaddition reactions with nitrones | |
| JP2020517676A5 (https=) | ||
| RU2019111101A (ru) | Структуры и механизм для дизайна высокоактивных глюкокортикоидов | |
| JP2013531021A (ja) | フェブキソスタットの結晶形ｉｉを調製するための方法 | |
| JP2018065817A5 (https=) | ||
| JP5671726B2 (ja) | フェニル置換複素環誘導体の製造方法 | |
| RU2015151042A (ru) | N-(2-фтор-2-фенэтил)карбоксамиды в качестве нематицидов и эндопаразитицидов | |
| WO2016004899A1 (en) | Process for making tetracyclic heterocycle compounds | |
| JP2021534084A5 (https=) |