JP2019532071A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019532071A5 JP2019532071A5 JP2019520039A JP2019520039A JP2019532071A5 JP 2019532071 A5 JP2019532071 A5 JP 2019532071A5 JP 2019520039 A JP2019520039 A JP 2019520039A JP 2019520039 A JP2019520039 A JP 2019520039A JP 2019532071 A5 JP2019532071 A5 JP 2019532071A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- hydrogen
- halo
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 45
- 150000001875 compounds Chemical class 0.000 claims 37
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 125000005843 halogen group Chemical group 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- -1 -OH Chemical group 0.000 claims 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 3
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 102000003676 Glucocorticoid Receptors Human genes 0.000 claims 2
- 108090000079 Glucocorticoid Receptors Proteins 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 241000282461 Canis lupus Species 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022113322A JP2022132464A (ja) | 2016-10-14 | 2022-07-14 | 非常に強力な糖質コルチコイドの構造およびデザインのための機構 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662408314P | 2016-10-14 | 2016-10-14 | |
| US62/408,314 | 2016-10-14 | ||
| PCT/US2017/056447 WO2018071736A1 (en) | 2016-10-14 | 2017-10-13 | Structures and mechanism for the design of highly potent glucocorticoids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022113322A Division JP2022132464A (ja) | 2016-10-14 | 2022-07-14 | 非常に強力な糖質コルチコイドの構造およびデザインのための機構 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532071A JP2019532071A (ja) | 2019-11-07 |
| JP2019532071A5 true JP2019532071A5 (cg-RX-API-DMAC7.html) | 2020-11-12 |
| JP7146750B2 JP7146750B2 (ja) | 2022-10-04 |
Family
ID=61906432
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520039A Active JP7146750B2 (ja) | 2016-10-14 | 2017-10-13 | 非常に強力な糖質コルチコイドの構造およびデザインのための機構 |
| JP2022113322A Withdrawn JP2022132464A (ja) | 2016-10-14 | 2022-07-14 | 非常に強力な糖質コルチコイドの構造およびデザインのための機構 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022113322A Withdrawn JP2022132464A (ja) | 2016-10-14 | 2022-07-14 | 非常に強力な糖質コルチコイドの構造およびデザインのための機構 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10954265B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3525870B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7146750B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102497070B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110382033B (cg-RX-API-DMAC7.html) |
| ES (1) | ES2945983T3 (cg-RX-API-DMAC7.html) |
| MA (1) | MA46539A (cg-RX-API-DMAC7.html) |
| PH (1) | PH12019500801A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2019111101A (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201903209TA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018071736A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201902595B (cg-RX-API-DMAC7.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025119398A1 (zh) * | 2023-12-08 | 2025-06-12 | 浙江柏拉阿图医药科技有限公司 | 高效力糖皮质激素多晶型及其制备方法和用途 |
| CN120365344A (zh) * | 2024-01-24 | 2025-07-25 | 浙江柏拉阿图医药科技有限公司 | 一种高效力糖皮质激素化合物及其制备和用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK66202C (da) | 1945-03-03 | 1948-01-12 | Danske Securitas As | Kodekontakt til elektriske Alarmanlæg. |
| DK71662C (da) | 1946-09-05 | 1950-11-06 | Ingenioer Frank Broadbent | Tørrecentrifuge. |
| US4049813A (en) | 1976-07-15 | 1977-09-20 | Sandoz, Inc. | Substituted isoxazolo pyridinones |
| US5837698A (en) * | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
| CA2451057A1 (en) | 2001-06-14 | 2002-12-27 | Banyu Pharmaceutical Co., Ltd. | Novel isoxazolopyridone derivatives and use thereof |
| GB0119911D0 (en) | 2001-08-15 | 2001-10-10 | Novartis Ag | Organic Compounds |
| JP2007511521A (ja) * | 2003-11-13 | 2007-05-10 | コンビナトアールエックス インコーポレーティッド | 炎症性障害を治療する方法および試薬 |
| JP5216589B2 (ja) * | 2005-09-02 | 2013-06-19 | ニコックス エス エイ | ステロイドのニトロオキシ誘導体 |
| CN1813768A (zh) * | 2005-11-18 | 2006-08-09 | 成都力思特制药股份有限公司 | 治疗呼吸系统疾病的药用组合物及其在制药中的应用 |
| NZ584160A (en) * | 2007-10-04 | 2011-05-27 | Astrazeneca Ab | Steroidal [3,2-c] pyrazole compounds, with glucocorticoid activity |
| CA2707618A1 (en) * | 2007-12-20 | 2009-07-02 | Astrazeneca Ab | Steroid derivatives acting as glucocorticosteroid receptor agonists |
| CA2749585A1 (en) | 2009-01-13 | 2010-07-22 | Van Andel Research Institute | Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids |
| UY32525A (es) | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
| UY32520A (es) | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides |
| UY32523A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
| WO2010147947A2 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS, COMPOSITIONS AND USES THEREOF |
| WO2015048316A1 (en) * | 2013-09-25 | 2015-04-02 | Van Andel Research Institute | Highly potent glucocorticoids |
| TWI695831B (zh) * | 2014-09-13 | 2020-06-11 | 香港商南北兄弟藥業投資有限公司 | Ｃｒｔｈ２拮抗劑化合物及其用途 |
-
2017
- 2017-10-13 MA MA046539A patent/MA46539A/fr unknown
- 2017-10-13 ES ES17860202T patent/ES2945983T3/es active Active
- 2017-10-13 EP EP17860202.5A patent/EP3525870B1/en active Active
- 2017-10-13 CN CN201780076320.7A patent/CN110382033B/zh active Active
- 2017-10-13 KR KR1020197013291A patent/KR102497070B1/ko active Active
- 2017-10-13 JP JP2019520039A patent/JP7146750B2/ja active Active
- 2017-10-13 RU RU2019111101A patent/RU2019111101A/ru unknown
- 2017-10-13 SG SG11201903209TA patent/SG11201903209TA/en unknown
- 2017-10-13 WO PCT/US2017/056447 patent/WO2018071736A1/en not_active Ceased
- 2017-10-13 US US16/341,275 patent/US10954265B2/en active Active
-
2019
- 2019-04-12 PH PH12019500801A patent/PH12019500801A1/en unknown
- 2019-04-24 ZA ZA2019/02595A patent/ZA201902595B/en unknown
-
2022
- 2022-07-14 JP JP2022113322A patent/JP2022132464A/ja not_active Withdrawn