MA46539A - Structures et mécanisme pour la conception de glucocorticoïdes hautement puissants - Google Patents

Structures et mécanisme pour la conception de glucocorticoïdes hautement puissants

Info

Publication number
MA46539A
MA46539A MA046539A MA46539A MA46539A MA 46539 A MA46539 A MA 46539A MA 046539 A MA046539 A MA 046539A MA 46539 A MA46539 A MA 46539A MA 46539 A MA46539 A MA 46539A
Authority
MA
Morocco
Prior art keywords
glucocorticoids
structures
design
highly powerful
powerful
Prior art date
Application number
MA046539A
Other languages
English (en)
French (fr)
Inventor
Yuanzheng He
Huaqiang Eric Xu
Original Assignee
Van Andel Res Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Van Andel Res Institute filed Critical Van Andel Res Institute
Publication of MA46539A publication Critical patent/MA46539A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA046539A 2016-10-14 2017-10-13 Structures et mécanisme pour la conception de glucocorticoïdes hautement puissants MA46539A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662408314P 2016-10-14 2016-10-14

Publications (1)

Publication Number Publication Date
MA46539A true MA46539A (fr) 2019-08-21

Family

ID=61906432

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046539A MA46539A (fr) 2016-10-14 2017-10-13 Structures et mécanisme pour la conception de glucocorticoïdes hautement puissants

Country Status (12)

Country Link
US (1) US10954265B2 (cg-RX-API-DMAC7.html)
EP (1) EP3525870B1 (cg-RX-API-DMAC7.html)
JP (2) JP7146750B2 (cg-RX-API-DMAC7.html)
KR (1) KR102497070B1 (cg-RX-API-DMAC7.html)
CN (1) CN110382033B (cg-RX-API-DMAC7.html)
ES (1) ES2945983T3 (cg-RX-API-DMAC7.html)
MA (1) MA46539A (cg-RX-API-DMAC7.html)
PH (1) PH12019500801A1 (cg-RX-API-DMAC7.html)
RU (1) RU2019111101A (cg-RX-API-DMAC7.html)
SG (1) SG11201903209TA (cg-RX-API-DMAC7.html)
WO (1) WO2018071736A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201902595B (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025119398A1 (zh) * 2023-12-08 2025-06-12 浙江柏拉阿图医药科技有限公司 高效力糖皮质激素多晶型及其制备方法和用途
CN120365344A (zh) * 2024-01-24 2025-07-25 浙江柏拉阿图医药科技有限公司 一种高效力糖皮质激素化合物及其制备和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK66202C (da) 1945-03-03 1948-01-12 Danske Securitas As Kodekontakt til elektriske Alarmanlæg.
DK71662C (da) 1946-09-05 1950-11-06 Ingenioer Frank Broadbent Tørrecentrifuge.
US4049813A (en) 1976-07-15 1977-09-20 Sandoz, Inc. Substituted isoxazolo pyridinones
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
CA2451057A1 (en) 2001-06-14 2002-12-27 Banyu Pharmaceutical Co., Ltd. Novel isoxazolopyridone derivatives and use thereof
GB0119911D0 (en) 2001-08-15 2001-10-10 Novartis Ag Organic Compounds
JP2007511521A (ja) * 2003-11-13 2007-05-10 コンビナトアールエックス インコーポレーティッド 炎症性障害を治療する方法および試薬
JP5216589B2 (ja) * 2005-09-02 2013-06-19 ニコックス エス エイ ステロイドのニトロオキシ誘導体
CN1813768A (zh) * 2005-11-18 2006-08-09 成都力思特制药股份有限公司 治疗呼吸系统疾病的药用组合物及其在制药中的应用
NZ584160A (en) * 2007-10-04 2011-05-27 Astrazeneca Ab Steroidal [3,2-c] pyrazole compounds, with glucocorticoid activity
CA2707618A1 (en) * 2007-12-20 2009-07-02 Astrazeneca Ab Steroid derivatives acting as glucocorticosteroid receptor agonists
CA2749585A1 (en) 2009-01-13 2010-07-22 Van Andel Research Institute Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids
UY32525A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32520A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
WO2010147947A2 (en) 2009-06-16 2010-12-23 Schering Corporation NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS, COMPOSITIONS AND USES THEREOF
WO2015048316A1 (en) * 2013-09-25 2015-04-02 Van Andel Research Institute Highly potent glucocorticoids
TWI695831B (zh) * 2014-09-13 2020-06-11 香港商南北兄弟藥業投資有限公司 Ｃｒｔｈ２拮抗劑化合物及其用途

Also Published As

Publication number Publication date
EP3525870A1 (en) 2019-08-21
KR102497070B1 (ko) 2023-02-06
SG11201903209TA (en) 2019-05-30
US10954265B2 (en) 2021-03-23
EP3525870A4 (en) 2020-04-29
US20190263853A1 (en) 2019-08-29
JP2022132464A (ja) 2022-09-08
JP2019532071A (ja) 2019-11-07
CN110382033A (zh) 2019-10-25
WO2018071736A1 (en) 2018-04-19
WO2018071736A9 (en) 2019-05-23
RU2019111101A3 (cg-RX-API-DMAC7.html) 2020-11-27
PH12019500801A1 (en) 2019-11-11
CN110382033B (zh) 2022-04-15
EP3525870B1 (en) 2023-05-10
KR20190068577A (ko) 2019-06-18
ZA201902595B (en) 2021-04-28
JP7146750B2 (ja) 2022-10-04
RU2019111101A (ru) 2020-11-16
ES2945983T3 (es) 2023-07-11

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