JP2019530739A5 - - Google Patents
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- Publication number
- JP2019530739A5 JP2019530739A5 JP2019532215A JP2019532215A JP2019530739A5 JP 2019530739 A5 JP2019530739 A5 JP 2019530739A5 JP 2019532215 A JP2019532215 A JP 2019532215A JP 2019532215 A JP2019532215 A JP 2019532215A JP 2019530739 A5 JP2019530739 A5 JP 2019530739A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- trifluoromethyl
- sulfonamide
- chloro
- sulfamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC1C=C(C)C*1 Chemical compound CC1C=C(C)C*1 0.000 description 4
- HJSRNXXEYHCMDR-UHFFFAOYSA-N CC(C#CC)N(C)C Chemical compound CC(C#CC)N(C)C HJSRNXXEYHCMDR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662380659P | 2016-08-29 | 2016-08-29 | |
| US62/380,659 | 2016-08-29 | ||
| PCT/IB2017/055162 WO2018042316A1 (en) | 2016-08-29 | 2017-08-28 | N-(pyridin-2-yl)pyridine-sulfonamide derivatives and their use in the treatment of disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019530739A JP2019530739A (ja) | 2019-10-24 |
| JP2019530739A5 true JP2019530739A5 (enExample) | 2020-08-27 |
| JP7035055B2 JP7035055B2 (ja) | 2022-03-14 |
Family
ID=59923496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019532215A Expired - Fee Related JP7035055B2 (ja) | 2016-08-29 | 2017-08-28 | Ｎ－（ピリジン－２－イル）ピリジン－スルホンアミド誘導体および疾患の処置におけるそれらの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10450273B2 (enExample) |
| EP (1) | EP3504194B1 (enExample) |
| JP (1) | JP7035055B2 (enExample) |
| KR (1) | KR20190040319A (enExample) |
| CN (1) | CN109641873B (enExample) |
| AR (1) | AR109437A1 (enExample) |
| AU (1) | AU2017319430A1 (enExample) |
| BR (1) | BR112019003883A2 (enExample) |
| CA (1) | CA3031073A1 (enExample) |
| EA (1) | EA201990609A1 (enExample) |
| ES (1) | ES2898069T3 (enExample) |
| MX (1) | MX2019002439A (enExample) |
| TW (1) | TW201811766A (enExample) |
| UY (1) | UY37379A (enExample) |
| WO (1) | WO2018042316A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201811766A (zh) * | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
| KR102825974B1 (ko) | 2016-09-13 | 2025-06-30 | 삼성디스플레이 주식회사 | 표시 장치 |
| MA53488A (fr) * | 2018-08-31 | 2021-12-08 | Xenon Pharmaceuticals Inc | Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques |
| CN113226464A (zh) * | 2018-12-18 | 2021-08-06 | 诺华股份有限公司 | N-(吡啶-2-基磺酰基)环丙烷甲酰胺衍生物及其在治疗cftr介导的疾病中的用途 |
| EP3898621A1 (en) * | 2018-12-21 | 2021-10-27 | Novartis AG | Macrocyclic compounds and their use in the treatment of disease |
| JP2022519301A (ja) * | 2019-02-06 | 2022-03-22 | ノバルティス アーゲー | Ｎ－（ピリジン－２－イル）ピリジン－スルホンアミド誘導体及び疾患の処置におけるそれらの使用 |
| TWI848092B (zh) | 2019-04-03 | 2024-07-11 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白調節劑 |
| TWI899097B (zh) | 2019-08-14 | 2025-10-01 | 美商維泰克斯製藥公司 | 製備cftr調節劑之方法 |
| TWI867024B (zh) * | 2019-08-14 | 2024-12-21 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
| US11873300B2 (en) | 2019-08-14 | 2024-01-16 | Vertex Pharmaceuticals Incorporated | Crystalline forms of CFTR modulators |
| CA3158057A1 (en) * | 2019-11-12 | 2021-05-20 | Genzyme Corporation | 5-membered heteroarylaminosulfonamides for treating conditions mediated by deficient cftr activity |
| MX2022005810A (es) * | 2019-11-12 | 2022-06-08 | Genzyme Corp | Heteroarilaminosulfonamidas de 6 miembros para tratar enfermedades y afecciones mediadas por la actividad de regulador de la conductancia transmembrana de la fibrosis quistica (cftr) deficiente. |
| WO2021113808A1 (en) | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Cftr-modulating arylamides |
| WO2021113806A1 (en) | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Arylamides and methods of use thereof |
| WO2021113809A1 (en) | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Arylamides and methods of use thereof |
| US20230050418A1 (en) * | 2019-12-13 | 2023-02-16 | Rhodia Operations | Production of benzene derivatives |
| WO2022036060A1 (en) | 2020-08-13 | 2022-02-17 | Vertex Pharmaceuticals Incorporated | Crystalline forms of cftr modulators |
| CN122537531A (zh) | 2020-08-20 | 2026-08-11 | 小利兰·斯坦福大学托管委员会 | 用于治疗以黏液分泌过多为特征的呼吸系统疾病的方法 |
| US12612416B2 (en) | 2020-10-07 | 2026-04-28 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| MX2023006770A (es) | 2020-12-10 | 2023-08-14 | Vertex Pharma | Metodos de tratamiento para fibrosis quistica. |
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| WO1996009818A1 (en) | 1994-09-27 | 1996-04-04 | Merck & Co., Inc. | Endothelin receptor antagonists for the treatment of emesis |
| US5939431A (en) * | 1996-06-20 | 1999-08-17 | Schering Corporation | Naphthyridines which affect IL-4 and G-CSF |
| JP2002514195A (ja) | 1996-12-05 | 2002-05-14 | アムジエン・インコーポレーテツド | 置換ピリミジン化合物およびそれの使用 |
| SE0102439D0 (sv) | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| WO2003087044A2 (en) | 2002-04-09 | 2003-10-23 | 7Tm Pharma A/S | Novel carboxamide compounds for use in mch receptor related disorders |
| EP1562911B1 (en) | 2002-11-01 | 2010-01-06 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of jak and other protein kinases |
| US20040204422A1 (en) | 2003-04-14 | 2004-10-14 | Abbott Gmbh & Co. Kg. | N-[(Piperazinyl)hetaryl]arylsulfonamide compounds |
| SE0301654D0 (sv) | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| US7504401B2 (en) | 2003-08-29 | 2009-03-17 | Locus Pharmaceuticals, Inc. | Anti-cancer agents and uses thereof |
| JPWO2005040135A1 (ja) | 2003-10-24 | 2007-03-08 | 小野薬品工業株式会社 | 抗ストレス薬およびその医薬用途 |
| PE20060285A1 (es) | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
| NZ550114A (en) | 2004-04-20 | 2011-02-25 | Transtech Pharma Inc | Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators |
| FR2874011B1 (fr) | 2004-08-03 | 2007-06-15 | Sanofi Synthelabo | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| DE602005020313D1 (de) | 2004-08-12 | 2010-05-12 | Amgen Inc | Bisaryl-sulfonamide |
| RU2383533C2 (ru) | 2004-10-04 | 2010-03-10 | Ф.Хоффманн-Ля Рош Аг | Алкилированные производные пиридина в качестве ингибиторов 11-бета при диабете |
| EP1666467A1 (en) | 2004-11-08 | 2006-06-07 | Evotec AG | 11Beta-HSD1 Inhibitors |
| SE0402735D0 (sv) | 2004-11-09 | 2004-11-09 | Astrazeneca Ab | Novel compounds |
| WO2006106423A2 (en) | 2005-04-07 | 2006-10-12 | Pfizer Inc. | Amino sulfonyl derivatives as inhibitors of human 11-.beta.-hydrosysteroid dehydrogenase |
| WO2007021941A2 (en) | 2005-08-16 | 2007-02-22 | Icagen, Inc. | Inhibitors of voltage-gated sodium channels |
| CN101243051A (zh) | 2005-08-25 | 2008-08-13 | 霍夫曼-拉罗奇有限公司 | p38 MAP激酶抑制剂及使用它的方法 |
| FR2896798A1 (fr) | 2006-01-27 | 2007-08-03 | Sanofi Aventis Sa | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| JP2009535386A (ja) | 2006-05-03 | 2009-10-01 | アストラゼネカ アクチボラグ | チアゾール誘導体および抗腫瘍剤としてのその使用 |
| US20080280891A1 (en) | 2006-06-27 | 2008-11-13 | Locus Pharmaceuticals, Inc. | Anti-cancer agents and uses thereof |
| US8519135B2 (en) | 2006-07-14 | 2013-08-27 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2/CCR9 |
| CN101511800B (zh) | 2006-07-14 | 2013-02-27 | 坎莫森特里克斯公司 | 三唑基苯基苯磺酰胺 |
| WO2008022286A2 (en) | 2006-08-16 | 2008-02-21 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Small molecule inhibitors of kynurenine-3-monooxygenase |
| RU2009112719A (ru) | 2006-09-08 | 2010-10-20 | Новартис АГ (CH) | Производные n-биарил(гетеро)арилсульфонамида, применимые в лечении заболеваний, опосредованных взаимодействием лимфоцитов |
| WO2008033455A2 (en) | 2006-09-13 | 2008-03-20 | The Institutes For Pharmaceutical Discovery, Llc | Biphenyl and heteroaryl phenyl derivatives as protein tyrosine phosphatases inhibitors |
| DK3567035T3 (da) | 2007-04-11 | 2022-09-05 | Canbas Co Ltd | N-substituerede 2,5-dioxo-azolin-forbindelser til anvendelse ved behandling af cancer |
| WO2008157500A1 (en) | 2007-06-17 | 2008-12-24 | Kalypsys, Inc. | Aminoquinazoline cannabinoid receptor modulators for treatment of disease |
| WO2009011850A2 (en) | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
| JP2011500823A (ja) | 2007-10-22 | 2011-01-06 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Ｐｉ３キナーゼ阻害物質としてのピリドスルホンアミド誘導体 |
| CA2714232A1 (en) | 2008-02-05 | 2009-08-13 | Pfizer Inc. | Pyridinyl amides for the treatment of cns and metabolic disorders |
| EA201001847A1 (ru) | 2008-06-11 | 2011-08-30 | Айрм Ллк | Соединения и композиции, применяемые для лечения малярии |
| US20110294853A1 (en) | 2008-09-12 | 2011-12-01 | Benjamin Pelcman | Bis Aromatic Compounds for Use in the Treatment of Inflammation |
| WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| CN102458122A (zh) * | 2009-04-20 | 2012-05-16 | 人类健康研究所 | 含有哒嗪磺胺衍生物的化合物、组合物和方法 |
| EP2253617A1 (de) | 2009-05-20 | 2010-11-24 | Bayer CropScience AG | Halogen-substituierte Verbindungen als Pestizide |
| US20130022629A1 (en) | 2010-01-04 | 2013-01-24 | Sharpe Arlene H | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof |
| CN103119036B (zh) | 2010-06-28 | 2018-05-08 | 拜耳知识产权有限责任公司 | 作为杀虫剂的杂环化合物 |
| WO2012004293A2 (de) | 2010-07-08 | 2012-01-12 | Bayer Cropscience Ag | Insektizide und fungizide wirkstoffkombinationen |
| US9656959B2 (en) | 2010-12-22 | 2017-05-23 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
| US9295676B2 (en) | 2011-03-17 | 2016-03-29 | The Trustees Of The University Of Pennsylvania | Mutation mimicking compounds that bind to the kinase domain of EGFR |
| JP6165733B2 (ja) * | 2011-09-16 | 2017-07-19 | ノバルティス アーゲー | Ｎ−置換ヘテロシクリルカルボキサミド類 |
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| US9896443B2 (en) | 2012-08-21 | 2018-02-20 | Peter Maccallum Cancer Institute | Perforin inhibiting benzenesulfonamide compounds, preparation and uses thereof |
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| EP2968285A4 (en) | 2013-03-13 | 2016-12-21 | Flatley Discovery Lab | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS |
| WO2014181287A1 (en) | 2013-05-09 | 2014-11-13 | Piramal Enterprises Limited | Heterocyclyl compounds and uses thereof |
| EP3087074A1 (en) | 2013-12-23 | 2016-11-02 | Norgine BV | Benzene sulfonamides as ccr9 inhibitors |
| AU2015229117A1 (en) * | 2014-03-13 | 2016-09-29 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
| TW202140422A (zh) | 2014-10-06 | 2021-11-01 | 美商維泰克斯製藥公司 | 囊腫纖維化症跨膜傳導調節蛋白之調節劑 |
| CN104844566B (zh) | 2014-12-12 | 2018-05-18 | 合肥中科普瑞昇生物医药科技有限公司 | 一种新型结构的激酶抑制剂 |
| US10047051B2 (en) | 2015-06-02 | 2018-08-14 | Abbvie S.Á.R.L. | Substituted pyridines and method of use |
| US9981945B2 (en) | 2015-10-07 | 2018-05-29 | NuBridge BioSciences | Pyrimidine derivatives as CFTR modulators |
| GB201602527D0 (en) * | 2016-02-12 | 2016-03-30 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| ES2946970T3 (es) | 2016-03-31 | 2023-07-28 | Vertex Pharma | Regulador de conductancia transmembrana de moduladores de fibrosis quística |
| TW201811766A (zh) * | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
-
2017
- 2017-08-25 TW TW106128873A patent/TW201811766A/zh unknown
- 2017-08-28 BR BR112019003883A patent/BR112019003883A2/pt not_active Application Discontinuation
- 2017-08-28 UY UY0001037379A patent/UY37379A/es not_active Application Discontinuation
- 2017-08-28 CA CA3031073A patent/CA3031073A1/en not_active Abandoned
- 2017-08-28 JP JP2019532215A patent/JP7035055B2/ja not_active Expired - Fee Related
- 2017-08-28 ES ES17771589T patent/ES2898069T3/es active Active
- 2017-08-28 EA EA201990609A patent/EA201990609A1/ru unknown
- 2017-08-28 CN CN201780052527.0A patent/CN109641873B/zh not_active Expired - Fee Related
- 2017-08-28 KR KR1020197008655A patent/KR20190040319A/ko not_active Ceased
- 2017-08-28 US US15/688,089 patent/US10450273B2/en active Active
- 2017-08-28 MX MX2019002439A patent/MX2019002439A/es unknown
- 2017-08-28 AU AU2017319430A patent/AU2017319430A1/en not_active Abandoned
- 2017-08-28 WO PCT/IB2017/055162 patent/WO2018042316A1/en not_active Ceased
- 2017-08-28 EP EP17771589.3A patent/EP3504194B1/en active Active
- 2017-08-29 AR ARP170102384A patent/AR109437A1/es unknown
-
2019
- 2019-09-10 US US16/566,083 patent/US11066369B2/en not_active Expired - Fee Related
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