JP2019530438A5 - - Google Patents
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- JP2019530438A5 JP2019530438A5 JP2019511844A JP2019511844A JP2019530438A5 JP 2019530438 A5 JP2019530438 A5 JP 2019530438A5 JP 2019511844 A JP2019511844 A JP 2019511844A JP 2019511844 A JP2019511844 A JP 2019511844A JP 2019530438 A5 JP2019530438 A5 JP 2019530438A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- platelet
- cell
- islet
- population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 65
- 210000004153 islets of langerhan Anatomy 0.000 claims 28
- 238000000034 method Methods 0.000 claims 11
- 210000003470 mitochondria Anatomy 0.000 claims 9
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 8
- 102100037853 C-C chemokine receptor type 4 Human genes 0.000 claims 8
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims 8
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims 8
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 claims 8
- 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 claims 8
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims 8
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 claims 8
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims 8
- 102100034221 Growth-regulated alpha protein Human genes 0.000 claims 8
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims 8
- 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 claims 8
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 claims 8
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims 8
- 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 claims 8
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 8
- 108010018951 Interleukin-8B Receptors Proteins 0.000 claims 8
- 102100033467 L-selectin Human genes 0.000 claims 8
- 102100036465 Autoimmune regulator Human genes 0.000 claims 7
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 7
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 7
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 claims 7
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 claims 7
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 7
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 7
- 101100402341 Caenorhabditis elegans mpk-1 gene Proteins 0.000 claims 7
- 102100031351 Galectin-9 Human genes 0.000 claims 7
- 101710121810 Galectin-9 Proteins 0.000 claims 7
- 102100028096 Homeobox protein Nkx-6.2 Human genes 0.000 claims 7
- 101000928549 Homo sapiens Autoimmune regulator Proteins 0.000 claims 7
- 101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 claims 7
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 7
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 claims 7
- 101000578258 Homo sapiens Homeobox protein Nkx-6.2 Proteins 0.000 claims 7
- 101000971533 Homo sapiens Killer cell lectin-like receptor subfamily G member 1 Proteins 0.000 claims 7
- 101000979205 Homo sapiens Transcription factor MafA Proteins 0.000 claims 7
- 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 claims 7
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims 7
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims 7
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 7
- 238000000338 in vitro Methods 0.000 claims 7
- OGQSCIYDJSNCMY-UHFFFAOYSA-H iron(3+);methyl-dioxido-oxo-$l^{5}-arsane Chemical compound [Fe+3].[Fe+3].C[As]([O-])([O-])=O.C[As]([O-])([O-])=O.C[As]([O-])([O-])=O OGQSCIYDJSNCMY-UHFFFAOYSA-H 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 claims 6
- 108010075254 C-Peptide Proteins 0.000 claims 6
- 101001094700 Homo sapiens POU domain, class 5, transcription factor 1 Proteins 0.000 claims 6
- 101000713275 Homo sapiens Solute carrier family 22 member 3 Proteins 0.000 claims 6
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 claims 6
- 230000003833 cell viability Effects 0.000 claims 6
- 102100021177 ATP-sensitive inward rectifier potassium channel 11 Human genes 0.000 claims 5
- 101000614701 Homo sapiens ATP-sensitive inward rectifier potassium channel 11 Proteins 0.000 claims 5
- 210000004700 fetal blood Anatomy 0.000 claims 5
- 210000005259 peripheral blood Anatomy 0.000 claims 5
- 239000011886 peripheral blood Substances 0.000 claims 5
- 210000000130 stem cell Anatomy 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 210000001808 exosome Anatomy 0.000 claims 3
- 239000008187 granular material Substances 0.000 claims 3
- 201000001421 hyperglycemia Diseases 0.000 claims 3
- 239000011859 microparticle Substances 0.000 claims 3
- 230000008672 reprogramming Effects 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 210000003593 megakaryocyte Anatomy 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 210000003967 CLP Anatomy 0.000 claims 1
- 101150086694 SLC22A3 gene Proteins 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- -1 and Proteins 0.000 claims 1
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012997 ficoll-paque Substances 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662380913P | 2016-08-29 | 2016-08-29 | |
| US62/380,913 | 2016-08-29 | ||
| US201762520241P | 2017-06-15 | 2017-06-15 | |
| US62/520,241 | 2017-06-15 | ||
| PCT/US2017/048907 WO2018044795A1 (en) | 2016-08-29 | 2017-08-28 | Compositions and methods for programming adult cells with platelet rich fraction of blood containing platelet-like cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019530438A JP2019530438A (ja) | 2019-10-24 |
| JP2019530438A5 true JP2019530438A5 (https=) | 2020-10-01 |
| JP7177041B2 JP7177041B2 (ja) | 2022-11-22 |
Family
ID=61241132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511844A Active JP7177041B2 (ja) | 2016-08-29 | 2017-08-28 | 血小板様細胞を含有する血液の血小板に富む画分を用いて成体細胞をプログラミングするための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10729730B2 (https=) |
| EP (1) | EP3504320A4 (https=) |
| JP (1) | JP7177041B2 (https=) |
| KR (1) | KR102396303B1 (https=) |
| CN (1) | CN110023488A (https=) |
| AU (1) | AU2017321300B2 (https=) |
| CA (1) | CA3033750A1 (https=) |
| IL (1) | IL264815B2 (https=) |
| WO (1) | WO2018044795A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2788472T (lt) | 2011-12-06 | 2019-04-10 | Astellas Institute For Regenerative Medicine | Kryptingos diferenciacijos būdas, skirtas ragenos endotelio ląstelių gamybai |
| JP2021509812A (ja) | 2018-01-05 | 2021-04-08 | プレートレット バイオジェネシス， インコーポレイテッド | 巨核球を産生するための組成物および方法 |
| JP2021526556A (ja) | 2018-05-30 | 2021-10-07 | ダイレクト バイオロジクス エルエルシー | 成長因子および細胞外小胞を凍結または粉状にした、間葉系幹細胞（ｍｓｃ）の調製物を含む助剤、ならびにその使用方法 |
| AU2019291955A1 (en) | 2018-06-29 | 2021-02-18 | Platelet Biogenesis, Inc. | Compositions for drug delivery and methods of use thereof |
| AU2019305092A1 (en) | 2018-07-19 | 2021-03-11 | Platelet Biogenesis, Inc. | Stacked recirculating bioreactor |
| CN108888636A (zh) * | 2018-08-14 | 2018-11-27 | 东营凤起生物科技发展有限公司 | 一种治疗糖尿病和动脉粥样硬化的方法 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| EP3863650A4 (en) * | 2018-10-10 | 2022-09-14 | North Carolina State University | PRESENTATION BLISTERS OF PD-L1 TO REVERSE NEW ONSET OF TYPE 1 DIABETES |
| WO2020142769A1 (en) * | 2019-01-04 | 2020-07-09 | Kenneth Allen Pettine | Isolation and use of autogenous platelet derived exosomes |
| AU2020265737A1 (en) * | 2019-05-01 | 2021-12-02 | Immunebridge Inc. | Methods of making oligopotent and unipotent precursors |
| AU2020277774A1 (en) * | 2019-05-22 | 2021-12-09 | Thankstem S.R.L. | Method for expanding adult stem cells from whole blood |
| EP4103694A4 (en) * | 2020-02-14 | 2024-03-20 | Hackensack Meridian Health, Inc. | TREATMENT MITOCHONDRIA FROM THROMBOCYTES AND METHOD FOR GENERATING MULTIPOTENT CELLS |
| US12590310B2 (en) | 2020-04-22 | 2026-03-31 | Direct Biologics, Llc | Methods and compositions for treating inflammatory conditions associated with infectious disease |
| CA3178268A1 (en) | 2020-05-11 | 2021-11-18 | Jonathan Thon | Compositions and methods related to megakaryocyte-derived extracellular vesicles |
| CN115917316B (zh) * | 2020-06-12 | 2025-10-24 | 新加坡科技研究局 | 嗜中性粒细胞祖细胞及相关方法和用途 |
| CN112156111B (zh) * | 2020-08-31 | 2022-10-18 | 中南大学湘雅三医院 | 脐血血小板线粒体在制备治疗自身免疫疾病药物中的应用 |
| JP2024518770A (ja) | 2021-04-26 | 2024-05-02 | ストーム バイオ インコーポレイテッド | ファンコニ貧血のための巨核球由来細胞外小胞に関する組成物及び方法 |
| JPWO2023079655A1 (https=) * | 2021-11-04 | 2023-05-11 | ||
| CN114990164B (zh) * | 2022-06-16 | 2023-12-05 | 北京大学 | 中介体复合物亚基抑制剂及其应用 |
| WO2024086955A1 (es) * | 2022-10-26 | 2024-05-02 | Cells For Cells S.A. | Efecto inmunosupresor sobre linfocitos t cd4+ de una composición enriquecida en mitocondrias circulantes |
| WO2025017354A1 (en) * | 2023-07-14 | 2025-01-23 | Id Medical Group Australia Pty Ltd | Isolated autological double-derived cell population enriched with mesenchymal stem cells (mscs) and methods for obtaining and using the same |
| CN116836920B (zh) * | 2023-08-21 | 2024-05-24 | 广东横琴粤澳深度合作区齐美国际干细胞医院有限公司 | 一种无血清培养基及其制备间充质干细胞的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004098646A1 (en) | 2003-05-12 | 2004-11-18 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| WO2008048671A1 (en) * | 2006-10-18 | 2008-04-24 | University Of Illinois | Embryonic-like stem cells derived from adult human peripheral blood and methods of use |
| WO2008022651A1 (en) * | 2006-08-21 | 2008-02-28 | Antoine Turzi | Process and device for the preparation of platelet rich plasma for extemporaneous use and combination thereof with skin and bone cells |
| GB201004072D0 (en) | 2010-03-11 | 2010-04-28 | Turzi Antoine | Process, tube and device for the preparation of wound healant composition |
| AU2012279995C1 (en) * | 2011-07-06 | 2019-10-24 | Cell Therapy Limited | Progenitor cells of mesodermal lineage |
| US20140356893A1 (en) | 2013-06-04 | 2014-12-04 | Allan Mishra | Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation |
-
2017
- 2017-08-28 JP JP2019511844A patent/JP7177041B2/ja active Active
- 2017-08-28 AU AU2017321300A patent/AU2017321300B2/en active Active
- 2017-08-28 CN CN201780066883.8A patent/CN110023488A/zh active Pending
- 2017-08-28 EP EP17847310.4A patent/EP3504320A4/en not_active Withdrawn
- 2017-08-28 WO PCT/US2017/048907 patent/WO2018044795A1/en not_active Ceased
- 2017-08-28 CA CA3033750A patent/CA3033750A1/en active Pending
- 2017-08-28 KR KR1020197008892A patent/KR102396303B1/ko active Active
- 2017-08-28 US US15/688,464 patent/US10729730B2/en active Active
- 2017-08-28 IL IL264815A patent/IL264815B2/en unknown
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