JP2019530439A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019530439A5 JP2019530439A5 JP2019511910A JP2019511910A JP2019530439A5 JP 2019530439 A5 JP2019530439 A5 JP 2019530439A5 JP 2019511910 A JP2019511910 A JP 2019511910A JP 2019511910 A JP2019511910 A JP 2019511910A JP 2019530439 A5 JP2019530439 A5 JP 2019530439A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- population
- platelet
- insulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 60
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 32
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 17
- 102000004877 Insulin Human genes 0.000 claims 16
- 108090001061 Insulin Proteins 0.000 claims 16
- 229940125396 insulin Drugs 0.000 claims 16
- 238000000034 method Methods 0.000 claims 13
- 238000000338 in vitro Methods 0.000 claims 8
- 108091023040 Transcription factor Proteins 0.000 claims 6
- 102000040945 Transcription factor Human genes 0.000 claims 6
- 239000000090 biomarker Substances 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 5
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims 5
- 101001033280 Homo sapiens Cytokine receptor common subunit beta Proteins 0.000 claims 5
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims 5
- 102000055647 human CSF2RB Human genes 0.000 claims 5
- 201000001421 hyperglycemia Diseases 0.000 claims 5
- 230000008672 reprogramming Effects 0.000 claims 5
- 210000004700 fetal blood Anatomy 0.000 claims 4
- 239000011886 peripheral blood Substances 0.000 claims 4
- 210000005259 peripheral blood Anatomy 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 102100021177 ATP-sensitive inward rectifier potassium channel 11 Human genes 0.000 claims 3
- 102100036465 Autoimmune regulator Human genes 0.000 claims 3
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 3
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 3
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 claims 3
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 claims 3
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 3
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 3
- 101100402341 Caenorhabditis elegans mpk-1 gene Proteins 0.000 claims 3
- 102100031351 Galectin-9 Human genes 0.000 claims 3
- 101710121810 Galectin-9 Proteins 0.000 claims 3
- 102100028096 Homeobox protein Nkx-6.2 Human genes 0.000 claims 3
- 101000614701 Homo sapiens ATP-sensitive inward rectifier potassium channel 11 Proteins 0.000 claims 3
- 101000928549 Homo sapiens Autoimmune regulator Proteins 0.000 claims 3
- 101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 claims 3
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 3
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 claims 3
- 101000578258 Homo sapiens Homeobox protein Nkx-6.2 Proteins 0.000 claims 3
- 101000971533 Homo sapiens Killer cell lectin-like receptor subfamily G member 1 Proteins 0.000 claims 3
- 101001094700 Homo sapiens POU domain, class 5, transcription factor 1 Proteins 0.000 claims 3
- 101000713275 Homo sapiens Solute carrier family 22 member 3 Proteins 0.000 claims 3
- 101000979205 Homo sapiens Transcription factor MafA Proteins 0.000 claims 3
- 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 claims 3
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 claims 3
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 3
- OGQSCIYDJSNCMY-UHFFFAOYSA-H iron(3+);methyl-dioxido-oxo-$l^{5}-arsane Chemical compound [Fe+3].[Fe+3].C[As]([O-])([O-])=O.C[As]([O-])([O-])=O.C[As]([O-])([O-])=O OGQSCIYDJSNCMY-UHFFFAOYSA-H 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 102100037853 C-C chemokine receptor type 4 Human genes 0.000 claims 2
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 2
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims 2
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims 2
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 claims 2
- 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 claims 2
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims 2
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 claims 2
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims 2
- 102100034221 Growth-regulated alpha protein Human genes 0.000 claims 2
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims 2
- 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 claims 2
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 claims 2
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims 2
- 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 claims 2
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 2
- 108010018951 Interleukin-8B Receptors Proteins 0.000 claims 2
- 102100033467 L-selectin Human genes 0.000 claims 2
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims 2
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000001808 exosome Anatomy 0.000 claims 2
- 239000012997 ficoll-paque Substances 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 210000003593 megakaryocyte Anatomy 0.000 claims 2
- 239000011859 microparticle Substances 0.000 claims 2
- 210000003967 CLP Anatomy 0.000 claims 1
- 102000009618 Transforming Growth Factors Human genes 0.000 claims 1
- 108010009583 Transforming Growth Factors Proteins 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 230000003345 hyperglycaemic effect Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000011287 therapeutic dose Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662380913P | 2016-08-29 | 2016-08-29 | |
| US62/380,913 | 2016-08-29 | ||
| PCT/US2017/048945 WO2018044809A1 (en) | 2016-08-29 | 2017-08-28 | Compositions and methods for reprogramming adult cells through the stemness of a platelet rich fraction of blood containing platelet-like cells in humans |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019530439A JP2019530439A (ja) | 2019-10-24 |
| JP2019530439A5 true JP2019530439A5 (https=) | 2020-09-24 |
| JP7219211B2 JP7219211B2 (ja) | 2023-02-07 |
Family
ID=61309448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511910A Active JP7219211B2 (ja) | 2016-08-29 | 2017-08-28 | ヒトにおける血小板様細胞を含有する血液の血小板に富む画分の幹細胞性により成体細胞を再プログラミングするための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11066648B2 (https=) |
| EP (1) | EP3503909A4 (https=) |
| JP (1) | JP7219211B2 (https=) |
| KR (1) | KR20190039822A (https=) |
| CN (1) | CN109843317A (https=) |
| AU (2) | AU2017321314A1 (https=) |
| CA (1) | CA3033539A1 (https=) |
| WO (1) | WO2018044809A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2788472T (lt) | 2011-12-06 | 2019-04-10 | Astellas Institute For Regenerative Medicine | Kryptingos diferenciacijos būdas, skirtas ragenos endotelio ląstelių gamybai |
| US11360097B2 (en) * | 2015-11-12 | 2022-06-14 | Edward J Goetzl | Platelet biomarkers and diagnostic methods for vascular diseases |
| JP2021509812A (ja) | 2018-01-05 | 2021-04-08 | プレートレット バイオジェネシス， インコーポレイテッド | 巨核球を産生するための組成物および方法 |
| CN108642005B (zh) * | 2018-05-22 | 2021-07-27 | 广州迪澳医疗科技有限公司 | 一种含连接剂的淋巴细胞分离液 |
| AU2019291955A1 (en) | 2018-06-29 | 2021-02-18 | Platelet Biogenesis, Inc. | Compositions for drug delivery and methods of use thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020142769A1 (en) * | 2019-01-04 | 2020-07-09 | Kenneth Allen Pettine | Isolation and use of autogenous platelet derived exosomes |
| KR102234394B1 (ko) * | 2019-03-08 | 2021-03-31 | 신지섭 | 타가면역세포배양방법, 그 방법으로 얻어진 면역세포배양액 및 이를 포함하는 면역세포치료제 |
| US12590310B2 (en) | 2020-04-22 | 2026-03-31 | Direct Biologics, Llc | Methods and compositions for treating inflammatory conditions associated with infectious disease |
| WO2024097131A1 (en) * | 2022-11-04 | 2024-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Rebalancing the immune system through depletion of myeloid-biased hematopoietic stem cells |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040136973A1 (en) * | 2002-11-07 | 2004-07-15 | Eliezer Huberman | Human stem cell materials and methods |
| WO2004098646A1 (en) * | 2003-05-12 | 2004-11-18 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| US20050260158A1 (en) * | 2003-11-07 | 2005-11-24 | Eliezer Huberman | Human stem cell materials and methods |
| US9388382B2 (en) * | 2005-10-05 | 2016-07-12 | The Board Of Trustees Of The University Of Illinois | Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells |
| WO2008048671A1 (en) * | 2006-10-18 | 2008-04-24 | University Of Illinois | Embryonic-like stem cells derived from adult human peripheral blood and methods of use |
| WO2009072003A2 (en) * | 2007-12-07 | 2009-06-11 | Miltenyi Biotec Gmbh | Sample processing system and methods |
| AU2012279995C1 (en) | 2011-07-06 | 2019-10-24 | Cell Therapy Limited | Progenitor cells of mesodermal lineage |
| US20140356893A1 (en) | 2013-06-04 | 2014-12-04 | Allan Mishra | Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation |
-
2017
- 2017-08-28 KR KR1020197008712A patent/KR20190039822A/ko not_active Ceased
- 2017-08-28 AU AU2017321314A patent/AU2017321314A1/en not_active Abandoned
- 2017-08-28 JP JP2019511910A patent/JP7219211B2/ja active Active
- 2017-08-28 CN CN201780066764.2A patent/CN109843317A/zh active Pending
- 2017-08-28 US US15/688,498 patent/US11066648B2/en active Active
- 2017-08-28 CA CA3033539A patent/CA3033539A1/en active Pending
- 2017-08-28 EP EP17847317.9A patent/EP3503909A4/en not_active Withdrawn
- 2017-08-28 WO PCT/US2017/048945 patent/WO2018044809A1/en not_active Ceased
-
2022
- 2022-12-16 AU AU2022287675A patent/AU2022287675B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019530439A5 (https=) | ||
| JP2019530438A5 (https=) | ||
| JP7440027B2 (ja) | 多能性幹細胞から免疫細胞療法用ｔ細胞を誘導する方法 | |
| JP7304844B2 (ja) | 免疫調節特性が増加した細胞ならびにその使用および製造のための方法 | |
| Consentius et al. | Immunogenicity of allogeneic mesenchymal stromal cells: what has been seen in vitro and in vivo? | |
| Zhou et al. | Engineering induced pluripotent stem cells for cancer immunotherapy | |
| Knorr et al. | Clinical-scale derivation of natural killer cells from human pluripotent stem cells for cancer therapy | |
| Gregori et al. | Engineered T regulatory type 1 cells for clinical application | |
| Kariminekoo et al. | Implications of mesenchymal stem cells in regenerative medicine | |
| Cany et al. | Combined IL-15 and IL-12 drives the generation of CD34+-derived natural killer cells with superior maturation and alloreactivity potential following adoptive transfer | |
| Hall et al. | Distinct regulatory CD4+ T cell subsets; differences between naïve and antigen specific T regulatory cells | |
| EP3476934A1 (en) | Method for producing cd4/cd8 double-positive t cells | |
| CN103517982B (zh) | 源自多能干细胞的褐色脂肪细胞、源自多能干细胞的细胞凝聚物，其制造方法以及细胞疗法、内科疗法 | |
| Jones et al. | Peripherally induced tolerance depends on peripheral regulatory T cells that require Hopx to inhibit intrinsic IL-2 expression | |
| Kim et al. | Human iPS cell–derived hematopoietic progenitor cells induce T-cell anergy in in vitro–generated alloreactive CD8+ T cells | |
| Banovic et al. | Graft-versus-host disease prevents the maturation of plasmacytoid dendritic cells | |
| JP2019530439A (ja) | ヒトにおける血小板様細胞を含有する血液の血小板に富む画分の幹細胞性により成体細胞を再プログラミングするための組成物および方法 | |
| Tynecka et al. | Old friends with unexploited perspectives: current advances in mesenchymal stem cell-based therapies in asthma | |
| Zhang et al. | Enhancing and stabilization of cord blood regulatory T-cell suppressive function by human mesenchymal stem cell (MSC)-derived exosomes | |
| Lei et al. | Pluripotent stem cell-based immunotherapy: advances in translational research, cell differentiation, and gene modifications | |
| WO2016010153A1 (ja) | 免疫細胞療法用ｔ細胞の誘導方法 | |
| Tabayoyong et al. | HOXB4-Transduced Embryonic Stem Cell-Derived Lin− c-kit+ and Lin− Sca-1+ Hematopoietic Progenitors Express H60 and Are Targeted by NK Cells | |
| Beksac et al. | Modalities to improve cord blood engraftment | |
| US20210254007A1 (en) | Platelet-derived mitochondria treatment and method of generating multipotent cells | |
| EP2221364A1 (en) | Compositions for treating an allergic or asthmatic condition |