JP7177041B2 - 血小板様細胞を含有する血液の血小板に富む画分を用いて成体細胞をプログラミングするための組成物および方法 - Google Patents
血小板様細胞を含有する血液の血小板に富む画分を用いて成体細胞をプログラミングするための組成物および方法 Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A—HUMAN NECESSITIES
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- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3616—Blood, e.g. platelet-rich plasma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/80—Undefined extracts from animals
- C12N2500/84—Undefined extracts from animals from mammals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/115—Platelets, megakaryocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
- C12N2506/115—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages
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- C12N2513/00—3D culture
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
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- Organic Chemistry (AREA)
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- Wood Science & Technology (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Urology & Nephrology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662380913P | 2016-08-29 | 2016-08-29 | |
| US62/380,913 | 2016-08-29 | ||
| US201762520241P | 2017-06-15 | 2017-06-15 | |
| US62/520,241 | 2017-06-15 | ||
| PCT/US2017/048907 WO2018044795A1 (en) | 2016-08-29 | 2017-08-28 | Compositions and methods for programming adult cells with platelet rich fraction of blood containing platelet-like cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019530438A JP2019530438A (ja) | 2019-10-24 |
| JP2019530438A5 JP2019530438A5 (https=) | 2020-10-01 |
| JP7177041B2 true JP7177041B2 (ja) | 2022-11-22 |
Family
ID=61241132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511844A Active JP7177041B2 (ja) | 2016-08-29 | 2017-08-28 | 血小板様細胞を含有する血液の血小板に富む画分を用いて成体細胞をプログラミングするための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10729730B2 (https=) |
| EP (1) | EP3504320A4 (https=) |
| JP (1) | JP7177041B2 (https=) |
| KR (1) | KR102396303B1 (https=) |
| CN (1) | CN110023488A (https=) |
| AU (1) | AU2017321300B2 (https=) |
| CA (1) | CA3033750A1 (https=) |
| IL (1) | IL264815B2 (https=) |
| WO (1) | WO2018044795A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2788472T (lt) | 2011-12-06 | 2019-04-10 | Astellas Institute For Regenerative Medicine | Kryptingos diferenciacijos būdas, skirtas ragenos endotelio ląstelių gamybai |
| JP2021509812A (ja) | 2018-01-05 | 2021-04-08 | プレートレット バイオジェネシス, インコーポレイテッド | 巨核球を産生するための組成物および方法 |
| JP2021526556A (ja) | 2018-05-30 | 2021-10-07 | ダイレクト バイオロジクス エルエルシー | 成長因子および細胞外小胞を凍結または粉状にした、間葉系幹細胞(msc)の調製物を含む助剤、ならびにその使用方法 |
| AU2019291955A1 (en) | 2018-06-29 | 2021-02-18 | Platelet Biogenesis, Inc. | Compositions for drug delivery and methods of use thereof |
| AU2019305092A1 (en) | 2018-07-19 | 2021-03-11 | Platelet Biogenesis, Inc. | Stacked recirculating bioreactor |
| CN108888636A (zh) * | 2018-08-14 | 2018-11-27 | 东营凤起生物科技发展有限公司 | 一种治疗糖尿病和动脉粥样硬化的方法 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| EP3863650A4 (en) * | 2018-10-10 | 2022-09-14 | North Carolina State University | PRESENTATION BLISTERS OF PD-L1 TO REVERSE NEW ONSET OF TYPE 1 DIABETES |
| WO2020142769A1 (en) * | 2019-01-04 | 2020-07-09 | Kenneth Allen Pettine | Isolation and use of autogenous platelet derived exosomes |
| AU2020265737A1 (en) * | 2019-05-01 | 2021-12-02 | Immunebridge Inc. | Methods of making oligopotent and unipotent precursors |
| AU2020277774A1 (en) * | 2019-05-22 | 2021-12-09 | Thankstem S.R.L. | Method for expanding adult stem cells from whole blood |
| EP4103694A4 (en) * | 2020-02-14 | 2024-03-20 | Hackensack Meridian Health, Inc. | TREATMENT MITOCHONDRIA FROM THROMBOCYTES AND METHOD FOR GENERATING MULTIPOTENT CELLS |
| US12590310B2 (en) | 2020-04-22 | 2026-03-31 | Direct Biologics, Llc | Methods and compositions for treating inflammatory conditions associated with infectious disease |
| CA3178268A1 (en) | 2020-05-11 | 2021-11-18 | Jonathan Thon | Compositions and methods related to megakaryocyte-derived extracellular vesicles |
| CN115917316B (zh) * | 2020-06-12 | 2025-10-24 | 新加坡科技研究局 | 嗜中性粒细胞祖细胞及相关方法和用途 |
| CN112156111B (zh) * | 2020-08-31 | 2022-10-18 | 中南大学湘雅三医院 | 脐血血小板线粒体在制备治疗自身免疫疾病药物中的应用 |
| JP2024518770A (ja) | 2021-04-26 | 2024-05-02 | ストーム バイオ インコーポレイテッド | ファンコニ貧血のための巨核球由来細胞外小胞に関する組成物及び方法 |
| JPWO2023079655A1 (https=) * | 2021-11-04 | 2023-05-11 | ||
| CN114990164B (zh) * | 2022-06-16 | 2023-12-05 | 北京大学 | 中介体复合物亚基抑制剂及其应用 |
| WO2024086955A1 (es) * | 2022-10-26 | 2024-05-02 | Cells For Cells S.A. | Efecto inmunosupresor sobre linfocitos t cd4+ de una composición enriquecida en mitocondrias circulantes |
| WO2025017354A1 (en) * | 2023-07-14 | 2025-01-23 | Id Medical Group Australia Pty Ltd | Isolated autological double-derived cell population enriched with mesenchymal stem cells (mscs) and methods for obtaining and using the same |
| CN116836920B (zh) * | 2023-08-21 | 2024-05-24 | 广东横琴粤澳深度合作区齐美国际干细胞医院有限公司 | 一种无血清培养基及其制备间充质干细胞的方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090317439A1 (en) | 2006-08-21 | 2009-12-24 | Antoine Turzi | Cell Preparations for Extemporaneous Use, Useful for Healing and Rejuvenation In Vivo |
| US20100129440A1 (en) | 2006-10-18 | 2010-05-27 | Yong Zhao | Embryonic-like stem cells derived from adult human peripheral blood and methods of use |
| JP2013522186A (ja) | 2010-03-11 | 2013-06-13 | アントワーヌ テュージィ | 創傷治癒剤組成物を調製するための方法、管および器具 |
| JP2014520523A (ja) | 2011-07-06 | 2014-08-25 | セル セラピー リミテッド | 中胚葉系列の前駆細胞 |
| US20140356893A1 (en) | 2013-06-04 | 2014-12-04 | Allan Mishra | Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004098646A1 (en) | 2003-05-12 | 2004-11-18 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
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2017
- 2017-08-28 JP JP2019511844A patent/JP7177041B2/ja active Active
- 2017-08-28 AU AU2017321300A patent/AU2017321300B2/en active Active
- 2017-08-28 CN CN201780066883.8A patent/CN110023488A/zh active Pending
- 2017-08-28 EP EP17847310.4A patent/EP3504320A4/en not_active Withdrawn
- 2017-08-28 WO PCT/US2017/048907 patent/WO2018044795A1/en not_active Ceased
- 2017-08-28 CA CA3033750A patent/CA3033750A1/en active Pending
- 2017-08-28 KR KR1020197008892A patent/KR102396303B1/ko active Active
- 2017-08-28 US US15/688,464 patent/US10729730B2/en active Active
- 2017-08-28 IL IL264815A patent/IL264815B2/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090317439A1 (en) | 2006-08-21 | 2009-12-24 | Antoine Turzi | Cell Preparations for Extemporaneous Use, Useful for Healing and Rejuvenation In Vivo |
| US20100129440A1 (en) | 2006-10-18 | 2010-05-27 | Yong Zhao | Embryonic-like stem cells derived from adult human peripheral blood and methods of use |
| JP2013522186A (ja) | 2010-03-11 | 2013-06-13 | アントワーヌ テュージィ | 創傷治癒剤組成物を調製するための方法、管および器具 |
| JP2014520523A (ja) | 2011-07-06 | 2014-08-25 | セル セラピー リミテッド | 中胚葉系列の前駆細胞 |
| US20140356893A1 (en) | 2013-06-04 | 2014-12-04 | Allan Mishra | Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation |
Non-Patent Citations (3)
| Title |
|---|
| BMC Medicine,2012年,10, 3,pp.1-11 |
| Cell research,2009年,19(4),429-438 |
| Gastroenterology,2005年,128(7),1774-1786 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110023488A (zh) | 2019-07-16 |
| KR102396303B1 (ko) | 2022-05-09 |
| WO2018044795A1 (en) | 2018-03-08 |
| IL264815B1 (en) | 2024-05-01 |
| IL264815B2 (en) | 2024-09-01 |
| EP3504320A4 (en) | 2020-04-15 |
| AU2017321300B2 (en) | 2022-11-17 |
| KR20190040333A (ko) | 2019-04-17 |
| US20180055891A1 (en) | 2018-03-01 |
| JP2019530438A (ja) | 2019-10-24 |
| AU2017321300A9 (en) | 2019-08-01 |
| EP3504320A1 (en) | 2019-07-03 |
| IL264815A (en) | 2019-03-31 |
| WO2018044795A9 (en) | 2019-03-07 |
| AU2017321300A1 (en) | 2019-02-28 |
| CA3033750A1 (en) | 2018-03-08 |
| US10729730B2 (en) | 2020-08-04 |
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