JP2019529581A5 - - Google Patents
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- JP2019529581A5 JP2019529581A5 JP2019540308A JP2019540308A JP2019529581A5 JP 2019529581 A5 JP2019529581 A5 JP 2019529581A5 JP 2019540308 A JP2019540308 A JP 2019540308A JP 2019540308 A JP2019540308 A JP 2019540308A JP 2019529581 A5 JP2019529581 A5 JP 2019529581A5
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- JP
- Japan
- Prior art keywords
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- missense mutation
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- Prior art date
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662406859P | 2016-10-11 | 2016-10-11 | |
| US62/406,859 | 2016-10-11 | ||
| US201762457759P | 2017-02-10 | 2017-02-10 | |
| US62/457,759 | 2017-02-10 | ||
| US201762502299P | 2017-05-05 | 2017-05-05 | |
| US62/502,299 | 2017-05-05 | ||
| PCT/US2017/055970 WO2018093484A1 (en) | 2016-10-11 | 2017-10-10 | Lasofoxifene treatment of er+ breast cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021022514A Division JP7247241B2 (ja) | 2016-10-11 | 2021-02-16 | Ｅｒ＋乳がんのラソフォキシフェン処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019529581A JP2019529581A (ja) | 2019-10-17 |
| JP2019529581A5 true JP2019529581A5 (enExample) | 2020-11-19 |
| JP6892151B2 JP6892151B2 (ja) | 2021-06-23 |
Family
ID=60186386
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019540308A Active JP6892151B2 (ja) | 2016-10-11 | 2017-10-10 | Ｅｒ＋乳がんのラソフォキシフェン処置 |
| JP2021022514A Active JP7247241B2 (ja) | 2016-10-11 | 2021-02-16 | Ｅｒ＋乳がんのラソフォキシフェン処置 |
| JP2023003699A Active JP7418052B2 (ja) | 2016-10-11 | 2023-01-13 | Ｅｒ＋乳がんのラソフォキシフェン処置 |
| JP2023219161A Active JP7774896B2 (ja) | 2016-10-11 | 2023-12-26 | Ｅｒ＋乳がんのラソフォキシフェン処置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021022514A Active JP7247241B2 (ja) | 2016-10-11 | 2021-02-16 | Ｅｒ＋乳がんのラソフォキシフェン処置 |
| JP2023003699A Active JP7418052B2 (ja) | 2016-10-11 | 2023-01-13 | Ｅｒ＋乳がんのラソフォキシフェン処置 |
| JP2023219161A Active JP7774896B2 (ja) | 2016-10-11 | 2023-12-26 | Ｅｒ＋乳がんのラソフォキシフェン処置 |
Country Status (20)
| Country | Link |
|---|---|
| US (8) | US20180098963A1 (enExample) |
| EP (2) | EP4035662A1 (enExample) |
| JP (4) | JP6892151B2 (enExample) |
| KR (5) | KR102462433B1 (enExample) |
| CN (3) | CN110099680B (enExample) |
| AU (3) | AU2017360365B2 (enExample) |
| BR (1) | BR112019007254A2 (enExample) |
| CA (1) | CA3040266A1 (enExample) |
| DK (1) | DK3525774T3 (enExample) |
| ES (1) | ES2909576T3 (enExample) |
| IL (2) | IL284875B (enExample) |
| MX (2) | MX387856B (enExample) |
| NZ (1) | NZ752443A (enExample) |
| PL (1) | PL3525774T3 (enExample) |
| PT (1) | PT3525774T (enExample) |
| RU (1) | RU2019114079A (enExample) |
| SG (2) | SG10201913951YA (enExample) |
| TW (4) | TWI896001B (enExample) |
| WO (2) | WO2018071440A1 (enExample) |
| ZA (1) | ZA201902454B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816437B (zh) | 2016-03-29 | 2018-08-03 | 深圳市药欣生物科技有限公司 | 一种帕布昔利布的药物制剂及其制备方法 |
| ES2909576T3 (es) | 2016-10-11 | 2022-05-09 | Univ Duke | Tratamiento con lasofoxifeno del cáncer de mama ER+ |
| US11497730B2 (en) | 2018-04-10 | 2022-11-15 | Duke University | Lasofoxifene treatment of breast cancer |
| CN114306245A (zh) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | 无定形固体分散体的药物组合物及其制备方法 |
| GB202116903D0 (en) * | 2021-11-18 | 2022-01-05 | Sermonix Pharmaceuticals Inc | Lasofoxifene treatment of aromatase-resistant er+ cancer |
| JP2025517483A (ja) * | 2022-05-25 | 2025-06-05 | サーモニックス ファーマシューティカルズ， インコーポレイテッド | Ｃｄｋ４／６阻害剤で進行したｅｒ＋乳がんのラソフォキシフェン併用処置 |
| WO2025075631A1 (en) | 2023-10-06 | 2025-04-10 | Sermonix Pharmaceuticals, Inc. | Lasofoxifene treatment of endocrine therapy resistant er+ cancer |
| MX2023013107A (es) * | 2023-11-06 | 2025-06-02 | Centro De Investig Y De Estudios Avanzados Del I P N | Composiciones sinergicas de loratadina-raloxifeno-sorafenib para el tratamiento de cancer hepatico. |
| WO2025122504A1 (en) * | 2023-12-04 | 2025-06-12 | Foundation Medicine, Inc. | Esr1 mutations, esr1 co-occurring mutations, and uses thereof |
| WO2025165887A1 (en) * | 2024-01-30 | 2025-08-07 | Sermonix Pharmaceuticals, Inc. | Lasofoxifene treatment of er+ cancers with constitutively active esr1 mutations |
| CN119842900A (zh) * | 2025-01-17 | 2025-04-18 | 厦门飞朔生物技术有限公司 | 一种可用于乳腺癌内分泌耐药治疗指导的人esr1基因突变检测试剂盒 |
Family Cites Families (52)
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| US6060503A (en) | 1991-12-02 | 2000-05-09 | Endorecherche, Inc. | Benzopyran-containing compounds and method for their use |
| US5552412A (en) | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| UA51676C2 (uk) | 1995-11-02 | 2002-12-16 | Пфайзер Інк. | (-)цис-6(s)-феніл-5(r)[4-(2-піролідин-1-ілетокси)феніл]-5,6,7,8-тетрагідронафталін-2-ол d-тартрат, спосіб його одержання, спосіб лікування захворювань, що піддаються лікуванню агоністами естрогену, та фармацевтична композиція |
| IL120266A (en) | 1996-02-28 | 2005-05-17 | Pfizer | Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions |
| HN1996000101A (es) | 1996-02-28 | 1997-06-26 | Inc Pfizer | Terapia combinada para la osteoporosis |
| US20040044080A1 (en) | 1997-10-28 | 2004-03-04 | Place Virgil A. | Treatment of dyspareunia with topically administered nitroglycerin formulations |
| WO1999065498A1 (en) | 1998-06-19 | 1999-12-23 | Senju Pharmaceutical Co., Ltd. | Agents for relieving side effects of adrenal cortex hormone |
| YU26700A (sh) | 1999-05-24 | 2002-06-19 | Pfizer Products Inc. | Postupak za cis-1-(2-(4-(6-metoksi-2-fenil-1,2,3,4- tetrahidronaftalen-1-il)fenoksi)etil)pirolidin |
| EP1086692A3 (en) | 1999-07-28 | 2003-07-09 | Pfizer Products Inc. | Estrogen agonists and antagonists for multiple indications |
| US6436977B1 (en) | 1999-09-29 | 2002-08-20 | Pfizer Inc. | Dosing regimens for lasofoxifene |
| CO5271697A1 (es) | 2000-01-12 | 2003-04-30 | Pfizer Prod Inc | Composiciones y procedimientos para el tratamiento de afecciones que responden a un aumento de testosterona |
| BR0108107A (pt) | 2000-01-28 | 2003-03-11 | Endorech Inc | Moduladores seletivos dos receptores de estrogênio em combinação com estrogênios; kits e composições farmacêuticas para praticar tal combinação; bem como a administração da referida combinação |
| DE10039199A1 (de) | 2000-08-10 | 2002-02-21 | Schering Ag | Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen |
| JP2004507465A (ja) | 2000-08-11 | 2004-03-11 | ワイス | エストロゲン受容体陽性癌腫の治療方法 |
| WO2002056903A2 (en) | 2001-01-17 | 2002-07-25 | Praecis Pharmaceuticals Inc. | Methods for treating hormone associated conditions using a combination of lhrh antagonists and specific estrogen receptor modulators |
| AU781168B2 (en) | 2001-01-26 | 2005-05-12 | Pfizer Products Inc. | Method of treating certain cancers using an estrogen agonist/antagonist |
| RU2278861C2 (ru) | 2002-03-28 | 2006-06-27 | Пфайзер Продактс Инк. | Очищенный лазофоксифен и способ очистки рацемического лазофоксифена рекристаллизацией |
| PA8576201A1 (es) | 2002-07-10 | 2004-05-26 | Pfizer Prod Inc | Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco |
| US8835413B2 (en) | 2004-10-20 | 2014-09-16 | Endorecherche, Inc. | Sex steroid precursors alone or in combination with a selective estrogen receptor modulator and/or with estrogens and/or a type 5 cGMP phosphodiesterase inhibitor for the prevention and treatment of vaginal dryness and sexual dysfunction in postmenopausal women |
| US20090012052A1 (en) | 2006-11-09 | 2009-01-08 | Ore Pharmaceuticals Inc. | Method for treating er+ breast cancer |
| US20110015134A1 (en) | 2007-04-16 | 2011-01-20 | Retsky Michael W | Method of treatment for early stage cancer |
| CZ2007373A3 (cs) | 2007-05-29 | 2008-12-10 | Zentiva, A. S | Zpusob prípravy lasofoxifenu |
| CA2725390C (en) | 2008-04-08 | 2014-09-23 | Syndax Pharmaceuticals, Inc. | Use of a hdac inhibitor and a her-2 inhibitor in the treatment of breast cancer |
| WO2009137543A2 (en) * | 2008-05-06 | 2009-11-12 | Ore Pharmaceuticals Inc. | Methods for breast cancer screening and treatment |
| CN102405047B (zh) | 2009-01-30 | 2014-07-09 | 葛兰素史密斯克莱有限责任公司 | 结晶型的n-{(1s)-2-氨基-1-[(3-氟苯基)甲基]乙基}-5-氯-4-(4-氯-1-甲基-1h-吡唑-5-基)-2-噻吩甲酰胺盐酸盐 |
| EP2239570A1 (en) * | 2009-04-10 | 2010-10-13 | PamGene B.V. | Method for determining the estrogen receptor status of breast cancer |
| MX373926B (es) * | 2009-05-27 | 2020-07-10 | Ptc Therapeutics Inc | Metodos para tratar cancer y estados no neoplasicos. |
| US20130253035A1 (en) | 2010-08-16 | 2013-09-26 | Duke University | Camkk-beta as a target for treating cancer |
| US20120052508A1 (en) * | 2010-08-27 | 2012-03-01 | Rutgers, The State University Of New Jersey | Genetic markers and diagnostic methods for resistance of breast cancer to hormonal therapies |
| US20140134170A1 (en) | 2011-03-11 | 2014-05-15 | Merrimack Pharmaceuticals, Inc. | Use of inhibitors of egfr-family receptors in the treatment of hormone refractory breast cancers |
| AU2012255920A1 (en) | 2011-05-18 | 2013-11-07 | Merck Sharp & Dohme Corp. | Therapeutic anti-IGF1R combinations |
| WO2013056178A2 (en) * | 2011-10-14 | 2013-04-18 | Foundation Medicine, Inc. | Novel estrogen receptor mutations and uses thereof |
| EP2791128A4 (en) | 2011-12-16 | 2015-04-22 | Olema Pharmaceuticals Inc | NOVEL BENZOPYRAN COMPOUNDS, COMPOSITIONS AND USES THEREOF |
| US20160038506A1 (en) | 2012-02-14 | 2016-02-11 | Repros Therapeutics Inc. | Selective Estrogen Receptor Modulators With Short Half-Lives and Uses Thereof |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| US9204286B1 (en) | 2013-03-15 | 2015-12-01 | Sprint Communications Company L.P. | System and method of branding and labeling a mobile device |
| SG11201607339VA (en) * | 2014-03-13 | 2016-10-28 | Hoffmann La Roche | Methods and compositions for modulating estrogen receptor mutants |
| WO2015136016A2 (en) | 2014-03-13 | 2015-09-17 | F. Hoffmann-La Roche Ag | Therapeutic combinations with estrogen receptor modulators |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| ES3055185T3 (en) | 2014-03-28 | 2026-02-10 | Univ Duke | Treatment of an estrogen receptor positive breast cancer using a selective estrogen receptor modulator |
| CN113101292B (zh) | 2014-05-08 | 2023-07-11 | 上海市生物医药技术研究院 | 双炔失碳酯组合物和疾病治疗方法 |
| KR20170078811A (ko) | 2014-11-07 | 2017-07-07 | 리폭센 테크놀로지즈 리미티드 | 원발성 호르몬 저항성 자궁내막암 및 유방암 치료 방법 |
| AU2016247674A1 (en) | 2015-04-14 | 2017-10-19 | Atossa Genetics Inc. | Compositions and methods of treatment of breast disorders and estrogen-related disorders |
| KR20250152679A (ko) * | 2015-04-29 | 2025-10-23 | 래디어스 파마슈티컬스, 인코포레이티드 | 암을 치료하는 방법 |
| WO2018071437A1 (en) | 2016-10-11 | 2018-04-19 | Sermonix Pharmaceuticals, Llc | Lasofoxifene treatment of vva and osteoporosis in survivors of breast cancer and other malignancies |
| ES2909576T3 (es) | 2016-10-11 | 2022-05-09 | Univ Duke | Tratamiento con lasofoxifeno del cáncer de mama ER+ |
| CN115737637A (zh) | 2017-01-10 | 2023-03-07 | 王巍 | 拉索昔芬调节膜结合雌激素信号的应用及治疗癌症的方法 |
| US11497730B2 (en) | 2018-04-10 | 2022-11-15 | Duke University | Lasofoxifene treatment of breast cancer |
| JP7571006B2 (ja) * | 2018-08-17 | 2024-10-22 | ジェネンテック， インコーポレイテッド | 乳がんの処置のための診断的および治療的方法 |
| EP4412649A4 (en) | 2021-10-05 | 2025-11-05 | Univ Duke | Compositions containing small molecule tumor immunity regulators and their methods of use |
| GB202116903D0 (en) | 2021-11-18 | 2022-01-05 | Sermonix Pharmaceuticals Inc | Lasofoxifene treatment of aromatase-resistant er+ cancer |
| JP2025517483A (ja) | 2022-05-25 | 2025-06-05 | サーモニックス ファーマシューティカルズ， インコーポレイテッド | Ｃｄｋ４／６阻害剤で進行したｅｒ＋乳がんのラソフォキシフェン併用処置 |
-
2017
- 2017-10-10 ES ES17791239T patent/ES2909576T3/es active Active
- 2017-10-10 RU RU2019114079A patent/RU2019114079A/ru unknown
- 2017-10-10 KR KR1020217023829A patent/KR102462433B1/ko active Active
- 2017-10-10 DK DK17791239.1T patent/DK3525774T3/da active
- 2017-10-10 US US15/729,320 patent/US20180098963A1/en not_active Abandoned
- 2017-10-10 NZ NZ752443A patent/NZ752443A/en unknown
- 2017-10-10 KR KR1020247000452A patent/KR20240007720A/ko active Pending
- 2017-10-10 JP JP2019540308A patent/JP6892151B2/ja active Active
- 2017-10-10 KR KR1020197013405A patent/KR102285453B1/ko active Active
- 2017-10-10 SG SG10201913951YA patent/SG10201913951YA/en unknown
- 2017-10-10 WO PCT/US2017/055974 patent/WO2018071440A1/en not_active Ceased
- 2017-10-10 IL IL284875A patent/IL284875B/en unknown
- 2017-10-10 KR KR1020237008605A patent/KR102531354B1/ko active Active
- 2017-10-10 CN CN201780073528.3A patent/CN110099680B/zh active Active
- 2017-10-10 MX MX2019004184A patent/MX387856B/es unknown
- 2017-10-10 SG SG11201903236SA patent/SG11201903236SA/en unknown
- 2017-10-10 AU AU2017360365A patent/AU2017360365B2/en active Active
- 2017-10-10 CN CN202110143863.4A patent/CN112933082A/zh active Pending
- 2017-10-10 PT PT177912391T patent/PT3525774T/pt unknown
- 2017-10-10 PL PL17791239T patent/PL3525774T3/pl unknown
- 2017-10-10 EP EP21215433.0A patent/EP4035662A1/en active Pending
- 2017-10-10 WO PCT/US2017/055970 patent/WO2018093484A1/en not_active Ceased
- 2017-10-10 BR BR112019007254-3A patent/BR112019007254A2/pt not_active Application Discontinuation
- 2017-10-10 US US16/341,033 patent/US20190231718A1/en not_active Abandoned
- 2017-10-10 EP EP17791239.1A patent/EP3525774B1/en active Active
- 2017-10-10 CA CA3040266A patent/CA3040266A1/en active Pending
- 2017-10-10 CN CN202011320148.5A patent/CN112353796A/zh active Pending
- 2017-10-10 KR KR1020227037620A patent/KR102623130B1/ko active Active
- 2017-10-11 TW TW113106582A patent/TWI896001B/zh active
- 2017-10-11 TW TW106134805A patent/TWI729227B/zh active
- 2017-10-11 TW TW110124571A patent/TWI790672B/zh active
- 2017-10-11 TW TW111149243A patent/TWI836808B/zh active
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2018
- 2018-03-28 US US15/939,218 patent/US10258604B2/en active Active
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2019
- 2019-02-01 US US16/265,109 patent/US10905659B2/en active Active
- 2019-04-10 MX MX2021013911A patent/MX2021013911A/es unknown
- 2019-04-10 IL IL265938A patent/IL265938B/en unknown
- 2019-04-17 ZA ZA2019/02454A patent/ZA201902454B/en unknown
-
2020
- 2020-10-16 US US17/073,253 patent/US20210361596A1/en not_active Abandoned
-
2021
- 2021-02-16 JP JP2021022514A patent/JP7247241B2/ja active Active
-
2022
- 2022-10-09 AU AU2022246480A patent/AU2022246480B2/en active Active
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2023
- 2023-01-13 JP JP2023003699A patent/JP7418052B2/ja active Active
- 2023-03-30 US US18/193,207 patent/US11980597B2/en active Active
- 2023-12-26 JP JP2023219161A patent/JP7774896B2/ja active Active
-
2024
- 2024-04-08 US US18/629,894 patent/US20250064757A1/en active Pending
- 2024-07-04 US US18/764,274 patent/US12414924B2/en active Active
-
2025
- 2025-01-16 AU AU2025200327A patent/AU2025200327B2/en active Active
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