NZ752443A - Lasofoxifene treatment of er+ breast cancer - Google Patents

Lasofoxifene treatment of er+ breast cancer

Info

Publication number
NZ752443A
NZ752443A NZ752443A NZ75244317A NZ752443A NZ 752443 A NZ752443 A NZ 752443A NZ 752443 A NZ752443 A NZ 752443A NZ 75244317 A NZ75244317 A NZ 75244317A NZ 752443 A NZ752443 A NZ 752443A
Authority
NZ
New Zealand
Prior art keywords
breast cancer
lasofoxifene
treatment
estrogen receptor
endocrine
Prior art date
Application number
NZ752443A
Other languages
English (en)
Inventor
Kaitlyn Andreano
Ching-Yi Chang
Donald Mcdonnell
Stephanie Gaillard
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Priority to NZ793063A priority Critical patent/NZ793063B2/en
Publication of NZ752443A publication Critical patent/NZ752443A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
NZ752443A 2016-10-11 2017-10-10 Lasofoxifene treatment of er+ breast cancer NZ752443A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ793063A NZ793063B2 (en) 2017-10-10 Lasofoxifene treatment of er+ breast cancer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662406859P 2016-10-11 2016-10-11
US201762457759P 2017-02-10 2017-02-10
US201762502299P 2017-05-05 2017-05-05
PCT/US2017/055970 WO2018093484A1 (en) 2016-10-11 2017-10-10 Lasofoxifene treatment of er+ breast cancer

Publications (1)

Publication Number Publication Date
NZ752443A true NZ752443A (en) 2022-11-25

Family

ID=60186386

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ752443A NZ752443A (en) 2016-10-11 2017-10-10 Lasofoxifene treatment of er+ breast cancer

Country Status (20)

Country Link
US (8) US20190231718A1 (enExample)
EP (2) EP3525774B1 (enExample)
JP (4) JP6892151B2 (enExample)
KR (5) KR102462433B1 (enExample)
CN (3) CN110099680B (enExample)
AU (3) AU2017360365B2 (enExample)
BR (1) BR112019007254A2 (enExample)
CA (1) CA3040266A1 (enExample)
DK (1) DK3525774T3 (enExample)
ES (1) ES2909576T3 (enExample)
IL (2) IL284875B (enExample)
MX (2) MX428703B (enExample)
NZ (1) NZ752443A (enExample)
PL (1) PL3525774T3 (enExample)
PT (1) PT3525774T (enExample)
RU (1) RU2019114079A (enExample)
SG (2) SG11201903236SA (enExample)
TW (4) TWI836808B (enExample)
WO (2) WO2018071440A1 (enExample)
ZA (1) ZA201902454B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11974983B2 (en) 2018-04-10 2024-05-07 Duke University Lasofoxifene treatment of breast cancer
US11980597B2 (en) 2016-10-11 2024-05-14 Duke University Lasofoxifene treatment of breast cancer
US12023321B2 (en) 2021-11-18 2024-07-02 Sermonix Pharmaceuticals, Inc. Lasofoxifene treatment of aromatase-resistant ER+cancer

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CN114306245A (zh) 2020-09-29 2022-04-12 深圳市药欣生物科技有限公司 无定形固体分散体的药物组合物及其制备方法
US20230381138A1 (en) * 2022-05-25 2023-11-30 Sermonix Pharmaceuticals, Inc. Lasofoxifene combination treatment of er+ breast cancer that has progressed on a cdk4/6 inhibitor
WO2025075631A1 (en) 2023-10-06 2025-04-10 Sermonix Pharmaceuticals, Inc. Lasofoxifene treatment of endocrine therapy resistant er+ cancer
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WO2026096820A1 (en) * 2024-10-30 2026-05-07 Sermonix Pharmaceuticals, Inc. Neoadjuvant treatment of er+ breast cancer with lasofoxifene
WO2026095931A1 (en) * 2024-10-30 2026-05-07 Sermonix Pharmaceuticals, Inc. Neoadjuvant treatment of er+ breast cancer with lasofoxifene
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11980597B2 (en) 2016-10-11 2024-05-14 Duke University Lasofoxifene treatment of breast cancer
US12414924B2 (en) 2016-10-11 2025-09-16 Duke University Lasofoxifene treatment of breast cancer
US11974983B2 (en) 2018-04-10 2024-05-07 Duke University Lasofoxifene treatment of breast cancer
US12023321B2 (en) 2021-11-18 2024-07-02 Sermonix Pharmaceuticals, Inc. Lasofoxifene treatment of aromatase-resistant ER+cancer
US12433866B2 (en) 2021-11-18 2025-10-07 Sermonix Pharmaceuticals, Inc. Lasofoxifene treatment of aromatase-resistant ER+ cancer

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AU2017360365A1 (en) 2019-05-02
KR20210096316A (ko) 2021-08-04
AU2017360365B2 (en) 2022-08-04
KR20190092377A (ko) 2019-08-07
TWI729227B (zh) 2021-06-01
SG10201913951YA (en) 2020-03-30
DK3525774T3 (da) 2022-03-14
IL265938A (en) 2019-05-30
AU2022246480A1 (en) 2022-12-08
IL284875A (en) 2021-08-31
ES2909576T3 (es) 2022-05-09
TWI790672B (zh) 2023-01-21
MX428703B (es) 2025-11-13
US10905659B2 (en) 2021-02-02
AU2022246480B2 (en) 2024-11-07
KR20220151017A (ko) 2022-11-11
MX2019004184A (es) 2019-09-27
MX387856B (es) 2025-03-19
EP3525774B1 (en) 2021-12-29
CA3040266A1 (en) 2018-05-24
TW202137980A (zh) 2021-10-16
TWI836808B (zh) 2024-03-21
EP3525774A1 (en) 2019-08-21
PT3525774T (pt) 2022-03-30
PL3525774T3 (pl) 2022-04-25
US11980597B2 (en) 2024-05-14
WO2018093484A1 (en) 2018-05-24
KR102285453B1 (ko) 2021-08-05
KR20240007720A (ko) 2024-01-16
US20210361596A1 (en) 2021-11-25
CN112353796A (zh) 2021-02-12
JP2021073316A (ja) 2021-05-13
TW201817422A (zh) 2018-05-16
US20190231718A1 (en) 2019-08-01
NZ793063A (en) 2025-09-26
SG11201903236SA (en) 2019-05-30
CN110099680A (zh) 2019-08-06
US20180098963A1 (en) 2018-04-12
WO2018071440A1 (en) 2018-04-19
RU2019114079A3 (enExample) 2021-07-23
US20240366534A1 (en) 2024-11-07
US20180221335A1 (en) 2018-08-09
TWI896001B (zh) 2025-09-01
BR112019007254A2 (pt) 2019-07-02
US12414924B2 (en) 2025-09-16
JP7418052B2 (ja) 2024-01-19
US10258604B2 (en) 2019-04-16
CN110099680B (zh) 2021-02-05
US20250064757A1 (en) 2025-02-27
TW202446367A (zh) 2024-12-01
AU2025200327B2 (en) 2026-02-19
JP7247241B2 (ja) 2023-03-28
IL284875B (en) 2022-07-01
CN112933082A (zh) 2021-06-11
KR102531354B1 (ko) 2023-05-11
JP2019529581A (ja) 2019-10-17
IL265938B (en) 2021-08-31
ZA201902454B (en) 2022-09-28
JP2024026527A (ja) 2024-02-28
KR20230042390A (ko) 2023-03-28
RU2019114079A (ru) 2020-11-13
AU2025200327A1 (en) 2025-02-06
TW202313005A (zh) 2023-04-01
US20190151286A1 (en) 2019-05-23
JP6892151B2 (ja) 2021-06-23
US20230233490A1 (en) 2023-07-27
EP4035662A1 (en) 2022-08-03
JP2023033415A (ja) 2023-03-10
KR102623130B1 (ko) 2024-01-10
JP7774896B2 (ja) 2025-11-25
KR102462433B1 (ko) 2022-11-03
MX2021013911A (es) 2022-01-18

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