JP2019528797A5 - - Google Patents
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- JP2019528797A5 JP2019528797A5 JP2019539732A JP2019539732A JP2019528797A5 JP 2019528797 A5 JP2019528797 A5 JP 2019528797A5 JP 2019539732 A JP2019539732 A JP 2019539732A JP 2019539732 A JP2019539732 A JP 2019539732A JP 2019528797 A5 JP2019528797 A5 JP 2019528797A5
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- 210000004027 cell Anatomy 0.000 claims 37
- 150000007523 nucleic acids Chemical group 0.000 claims 22
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 21
- 108090000623 proteins and genes Proteins 0.000 claims 19
- -1 egl6 Proteins 0.000 claims 18
- 230000002538 fungal effect Effects 0.000 claims 17
- 108091033319 polynucleotide Proteins 0.000 claims 15
- 102000040430 polynucleotide Human genes 0.000 claims 15
- 239000002157 polynucleotide Substances 0.000 claims 15
- 102000004169 proteins and genes Human genes 0.000 claims 15
- 101100378100 Mus musculus Ace3 gene Proteins 0.000 claims 10
- 230000001939 inductive effect Effects 0.000 claims 9
- 239000000758 substrate Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 6
- 108010059892 Cellulase Proteins 0.000 claims 5
- 102000035195 Peptidases Human genes 0.000 claims 5
- 108091005804 Peptidases Proteins 0.000 claims 5
- 102100026189 Beta-galactosidase Human genes 0.000 claims 4
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims 4
- 102100022624 Glucoamylase Human genes 0.000 claims 4
- 241000499912 Trichoderma reesei Species 0.000 claims 4
- 108090000637 alpha-Amylases Proteins 0.000 claims 4
- 102000004139 alpha-Amylases Human genes 0.000 claims 4
- 108010030291 alpha-Galactosidase Proteins 0.000 claims 4
- 102000005840 alpha-Galactosidase Human genes 0.000 claims 4
- 229940024171 alpha-amylase Drugs 0.000 claims 4
- 108010005774 beta-Galactosidase Proteins 0.000 claims 4
- 229940106157 cellulase Drugs 0.000 claims 4
- 235000019833 protease Nutrition 0.000 claims 4
- 239000004382 Amylase Substances 0.000 claims 3
- 108010065511 Amylases Proteins 0.000 claims 3
- 102000013142 Amylases Human genes 0.000 claims 3
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 3
- 101100272090 Hypocrea jecorina axe1 gene Proteins 0.000 claims 3
- 235000019418 amylase Nutrition 0.000 claims 3
- 230000010261 cell growth Effects 0.000 claims 3
- 230000012010 growth Effects 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 230000014616 translation Effects 0.000 claims 3
- 108010011619 6-Phytase Proteins 0.000 claims 2
- 108091005508 Acid proteases Proteins 0.000 claims 2
- 102000004400 Aminopeptidases Human genes 0.000 claims 2
- 108090000915 Aminopeptidases Proteins 0.000 claims 2
- 108010005694 Aspartate 4-decarboxylase Proteins 0.000 claims 2
- 108090000145 Bacillolysin Proteins 0.000 claims 2
- 101100499346 Caenorhabditis elegans dld-1 gene Proteins 0.000 claims 2
- 102000005367 Carboxypeptidases Human genes 0.000 claims 2
- 108010006303 Carboxypeptidases Proteins 0.000 claims 2
- 108010031396 Catechol oxidase Proteins 0.000 claims 2
- 102000030523 Catechol oxidase Human genes 0.000 claims 2
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 2
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 2
- 108010001682 Dextranase Proteins 0.000 claims 2
- 101100278473 Drosophila melanogaster PolZ1 gene Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 108010036781 Fumarate Hydratase Proteins 0.000 claims 2
- 102100036160 Fumarate hydratase, mitochondrial Human genes 0.000 claims 2
- 108010015776 Glucose oxidase Proteins 0.000 claims 2
- 239000004366 Glucose oxidase Substances 0.000 claims 2
- 108010062875 Hydroxysteroid Dehydrogenases Proteins 0.000 claims 2
- 102000011145 Hydroxysteroid Dehydrogenases Human genes 0.000 claims 2
- 101100398376 Hypocrea jecorina pki1 gene Proteins 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- 108010059881 Lactase Proteins 0.000 claims 2
- 102000003960 Ligases Human genes 0.000 claims 2
- 108090000364 Ligases Proteins 0.000 claims 2
- 108090001060 Lipase Proteins 0.000 claims 2
- 102000004882 Lipase Human genes 0.000 claims 2
- 239000004367 Lipase Substances 0.000 claims 2
- 108090000856 Lyases Proteins 0.000 claims 2
- 102000004317 Lyases Human genes 0.000 claims 2
- 102100024295 Maltase-glucoamylase Human genes 0.000 claims 2
- 108010054377 Mannosidases Proteins 0.000 claims 2
- 102000001696 Mannosidases Human genes 0.000 claims 2
- 101100216047 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) gla-1 gene Proteins 0.000 claims 2
- 108091005507 Neutral proteases Proteins 0.000 claims 2
- 102000035092 Neutral proteases Human genes 0.000 claims 2
- 108010073038 Penicillin Amidase Proteins 0.000 claims 2
- 108090000284 Pepsin A Proteins 0.000 claims 2
- 102000057297 Pepsin A Human genes 0.000 claims 2
- 102000003992 Peroxidases Human genes 0.000 claims 2
- 108010059820 Polygalacturonase Proteins 0.000 claims 2
- 108090000783 Renin Proteins 0.000 claims 2
- 102100028255 Renin Human genes 0.000 claims 2
- 108010083644 Ribonucleases Proteins 0.000 claims 2
- 102000006382 Ribonucleases Human genes 0.000 claims 2
- 108060008539 Transglutaminase Proteins 0.000 claims 2
- 241000223259 Trichoderma Species 0.000 claims 2
- 102000004142 Trypsin Human genes 0.000 claims 2
- 108090000631 Trypsin Proteins 0.000 claims 2
- 108010028144 alpha-Glucosidases Proteins 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 229940009098 aspartate Drugs 0.000 claims 2
- 108010019077 beta-Amylase Proteins 0.000 claims 2
- 108010051210 beta-Fructofuranosidase Proteins 0.000 claims 2
- 108010005400 cutinase Proteins 0.000 claims 2
- YERABYSOHUZTPQ-UHFFFAOYSA-P endo-1,4-beta-Xylanase Chemical compound C=1C=CC=CC=1C[N+](CC)(CC)CCCNC(C(C=1)=O)=CC(=O)C=1NCCC[N+](CC)(CC)CC1=CC=CC=C1 YERABYSOHUZTPQ-UHFFFAOYSA-P 0.000 claims 2
- 229940088598 enzyme Drugs 0.000 claims 2
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 claims 2
- 108010093305 exopolygalacturonase Proteins 0.000 claims 2
- 229940116332 glucose oxidase Drugs 0.000 claims 2
- 235000019420 glucose oxidase Nutrition 0.000 claims 2
- 108010002430 hemicellulase Proteins 0.000 claims 2
- 239000001573 invertase Substances 0.000 claims 2
- 235000011073 invertase Nutrition 0.000 claims 2
- 229940116108 lactase Drugs 0.000 claims 2
- 230000002646 lignocellulolytic effect Effects 0.000 claims 2
- 235000019421 lipase Nutrition 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- HNJJXZKZRAWDPF-UHFFFAOYSA-N methapyrilene Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CS1 HNJJXZKZRAWDPF-UHFFFAOYSA-N 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 229940111202 pepsin Drugs 0.000 claims 2
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 2
- 229940085127 phytase Drugs 0.000 claims 2
- 229940108461 rennet Drugs 0.000 claims 2
- 108010058314 rennet Proteins 0.000 claims 2
- 102000055501 telomere Human genes 0.000 claims 2
- 108091035539 telomere Proteins 0.000 claims 2
- 210000003411 telomere Anatomy 0.000 claims 2
- 102000003601 transglutaminase Human genes 0.000 claims 2
- 239000012588 trypsin Substances 0.000 claims 2
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 claims 1
- 101150073246 AGL1 gene Proteins 0.000 claims 1
- 101150063865 AGL3 gene Proteins 0.000 claims 1
- 108091005658 Basic proteases Proteins 0.000 claims 1
- 101100489917 Caenorhabditis elegans abf-1 gene Proteins 0.000 claims 1
- 101100489922 Caenorhabditis elegans abf-2 gene Proteins 0.000 claims 1
- 101100026178 Caenorhabditis elegans egl-3 gene Proteins 0.000 claims 1
- 108010053835 Catalase Proteins 0.000 claims 1
- 102000016938 Catalase Human genes 0.000 claims 1
- 108030002440 Catalase peroxidases Proteins 0.000 claims 1
- 108010022172 Chitinases Proteins 0.000 claims 1
- 102000012286 Chitinases Human genes 0.000 claims 1
- 108010035722 Chloride peroxidase Proteins 0.000 claims 1
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 claims 1
- 108090000371 Esterases Proteins 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 108700007698 Genetic Terminator Regions Proteins 0.000 claims 1
- 101100218354 Geobacillus stearothermophilus axe2 gene Proteins 0.000 claims 1
- 108010056771 Glucosidases Proteins 0.000 claims 1
- 102000004366 Glucosidases Human genes 0.000 claims 1
- 102000009127 Glutaminase Human genes 0.000 claims 1
- 108010073324 Glutaminase Proteins 0.000 claims 1
- 101100378577 Hypocrea jecorina agl2 gene Proteins 0.000 claims 1
- 101100506040 Hypocrea jecorina cel61a gene Proteins 0.000 claims 1
- 101100506045 Hypocrea jecorina egl5 gene Proteins 0.000 claims 1
- 102000004195 Isomerases Human genes 0.000 claims 1
- 108090000769 Isomerases Proteins 0.000 claims 1
- 108010014251 Muramidase Proteins 0.000 claims 1
- 102000016943 Muramidase Human genes 0.000 claims 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 1
- 101100283946 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) gtr-1 gene Proteins 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 108010064785 Phospholipases Proteins 0.000 claims 1
- 102000015439 Phospholipases Human genes 0.000 claims 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 claims 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 101100071627 Schizosaccharomyces pombe (strain 972 / ATCC 24843) swo1 gene Proteins 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 101150099793 XYN3 gene Proteins 0.000 claims 1
- 101150075580 Xyn1 gene Proteins 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 108010047754 beta-Glucosidase Proteins 0.000 claims 1
- 102000006995 beta-Glucosidase Human genes 0.000 claims 1
- 101150100570 bglA gene Proteins 0.000 claims 1
- 101150052795 cbh-1 gene Proteins 0.000 claims 1
- 101150114858 cbh2 gene Proteins 0.000 claims 1
- 101150089280 cip2 gene Proteins 0.000 claims 1
- 101150066032 egl-1 gene Proteins 0.000 claims 1
- 101150003727 egl2 gene Proteins 0.000 claims 1
- 229940059442 hemicellulase Drugs 0.000 claims 1
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 1
- 229960000274 lysozyme Drugs 0.000 claims 1
- 239000004325 lysozyme Substances 0.000 claims 1
- 235000010335 lysozyme Nutrition 0.000 claims 1
- 101150026430 manA gene Proteins 0.000 claims 1
- 235000019419 proteases Nutrition 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023084937A JP7605902B2 (ja) | 2016-10-04 | 2023-05-23 | 誘導基質の非存在下における糸状菌細胞内でのタンパク質の産生 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662403787P | 2016-10-04 | 2016-10-04 | |
| US62/403,787 | 2016-10-04 | ||
| PCT/US2017/054983 WO2018067599A1 (en) | 2016-10-04 | 2017-10-03 | Protein production in filamentous fungal cells in the absence of inducing substrates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023084937A Division JP7605902B2 (ja) | 2016-10-04 | 2023-05-23 | 誘導基質の非存在下における糸状菌細胞内でのタンパク質の産生 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528797A JP2019528797A (ja) | 2019-10-17 |
| JP2019528797A5 true JP2019528797A5 (enExample) | 2020-11-12 |
| JP7285780B2 JP7285780B2 (ja) | 2023-06-02 |
Family
ID=60245185
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539732A Active JP7285780B2 (ja) | 2016-10-04 | 2017-10-03 | 誘導基質の非存在下における糸状菌細胞内でのタンパク質の産生 |
| JP2023084937A Active JP7605902B2 (ja) | 2016-10-04 | 2023-05-23 | 誘導基質の非存在下における糸状菌細胞内でのタンパク質の産生 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023084937A Active JP7605902B2 (ja) | 2016-10-04 | 2023-05-23 | 誘導基質の非存在下における糸状菌細胞内でのタンパク質の産生 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10876103B2 (enExample) |
| EP (1) | EP3523415A1 (enExample) |
| JP (2) | JP7285780B2 (enExample) |
| KR (1) | KR102593668B1 (enExample) |
| CN (1) | CN109790510B (enExample) |
| WO (1) | WO2018067599A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110760537A (zh) * | 2018-07-27 | 2020-02-07 | 中国农业科学院饲料研究所 | 用于快速筛选重组菌株的重组表达载体及应用 |
| US20220025423A1 (en) * | 2018-11-28 | 2022-01-27 | Novozymes A/S | Modified Filamentous Fungal Host Cells |
| US12534500B2 (en) | 2019-07-16 | 2026-01-27 | Centro Nacional De Pesquisa Em Energia E Materiais | Modified Trichoderma fungal strain for the production of an enzyme cocktail |
| EP4055177B1 (en) * | 2019-11-08 | 2024-07-31 | Danisco US Inc. | Fungal strains comprising enhanced protein productivity phenotypes and methods thereof |
| US12606837B2 (en) | 2019-11-18 | 2026-04-21 | Kao Corporation | Mutant filamentous fungus, and method for producing protein using same |
| CN113106114B (zh) * | 2020-01-13 | 2024-04-12 | 中国科学院分子植物科学卓越创新中心 | 调控里氏木霉蛋白表达效率的因子、调控方法及应用 |
| JP7799621B2 (ja) * | 2020-04-22 | 2026-01-15 | ダニスコ・ユーエス・インク | 糸状菌細胞におけるタンパク質産生の増強のための組成物及び方法 |
| JP7827410B2 (ja) * | 2021-04-09 | 2026-03-10 | 花王株式会社 | 改変糸状菌、及びそれを用いたタンパク質の製造方法 |
| CN116813728B (zh) * | 2023-07-07 | 2024-08-09 | 山东大学 | 一种真菌木质纤维素降解酶合成调控蛋白突变体及其应用 |
| CN118389304A (zh) * | 2023-12-28 | 2024-07-26 | 福州道福生物科技有限公司 | 一种生产索马甜ⅰ蛋白的重组里氏木霉菌株及其构建方法与应用 |
| WO2025165968A1 (en) | 2024-01-31 | 2025-08-07 | Danisco Us Inc. | Conditional regulation of protein function in filamentous fungal cells |
| CN121202977B (zh) * | 2025-10-28 | 2026-05-01 | 华东理工大学 | 里氏木霉转录激活因子ace3突变体、编码基因及其应用 |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ217373A (en) | 1985-08-29 | 1990-10-26 | Genencor Inc | Production of heterologous peptide in filamentous fungi, vectors and dna |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| WO1992006221A1 (en) | 1990-10-05 | 1992-04-16 | Genencor International, Inc. | Methods for treating cotton-containing fabrics with cellulase |
| EP0551386B1 (en) | 1990-10-05 | 2004-01-07 | Genencor International, Inc. | Methods for treating cotton-containing fabrics with cellulase |
| WO1992006183A1 (en) | 1990-10-05 | 1992-04-16 | Genencor International, Inc. | Methods for treating cotton-containing fabrics with cellulase |
| DK0562003T4 (en) | 1990-12-10 | 2015-07-13 | Danisco Us Inc | Improved saccharification of cellulose by cloning and amplification of.-Glucosidase gene from Tricodermareesei |
| US6017870A (en) | 1996-10-09 | 2000-01-25 | Genencor International, Inc. | Purified cellulase and method of producing |
| US6255115B1 (en) | 1997-04-07 | 2001-07-03 | Unilever Patent Holdings Bv | Agrobacterium mediated transformation of moulds, in particular those belonging to the genus Aspergillus |
| US6268328B1 (en) | 1998-12-18 | 2001-07-31 | Genencor International, Inc. | Variant EGIII-like cellulase compositions |
| ATE481492T1 (de) | 2000-08-04 | 2010-10-15 | Genencor Int | Mutierte trichoderma reesei egiii cellulasen, dafür kodierende dna und verfahren zu deren herstellung |
| US6982159B2 (en) | 2001-09-21 | 2006-01-03 | Genencor International, Inc. | Trichoderma β-glucosidase |
| US7049125B2 (en) | 2001-12-18 | 2006-05-23 | Genencor International, Inc. | EGVIII endoglucanase and nucleic acids encoding the same |
| US7045331B2 (en) | 2001-12-18 | 2006-05-16 | Genencor International, Inc. | EGVII endoglucanase and nucleic acids encoding the same |
| US7045332B2 (en) | 2001-12-18 | 2006-05-16 | Genencor International, Inc. | BGL4 β-glucosidase and nucleic acids encoding the same |
| US7005289B2 (en) | 2001-12-18 | 2006-02-28 | Genencor International, Inc. | BGL5 β-glucosidase and nucleic acids encoding the same |
| US7056721B2 (en) | 2001-12-18 | 2006-06-06 | Genencor International, Inc. | EGVI endoglucanase and nucleic acids encoding the same |
| US7972832B2 (en) | 2002-08-16 | 2011-07-05 | Danisco Us Inc. | Variant Hypocrea jecorina CBH1 cellulases |
| JP5366286B2 (ja) | 2002-09-10 | 2013-12-11 | ジェネンコー・インターナショナル・インク | 高濃度糖類混合物を用いた遺伝子発現の誘発 |
| US7582462B2 (en) | 2002-11-07 | 2009-09-01 | Danisco Us Inc., Genencor Division | BGL6 beta-glucosidase and nucleic acids encoding the same |
| US7407788B2 (en) | 2002-11-21 | 2008-08-05 | Danisco A/S, Genencor Division | BGL7 beta-glucosidase and nucleic acids encoding the same |
| CN1898381B (zh) | 2003-03-21 | 2013-07-17 | 金克克国际有限公司 | Cbh1同源物和cbh1纤维素酶变体 |
| WO2005001065A2 (en) | 2003-04-01 | 2005-01-06 | Genencor International, Inc. | Variant humicola grisea cbh1.1 |
| CA2915553A1 (en) | 2003-05-29 | 2005-01-06 | Genencor International, Inc. | Trichoderma genes |
| EP1735447A2 (en) | 2004-03-25 | 2006-12-27 | Genencor International, Inc. | Cellulase fusion protein and heterologous cellulase fusion construct encoding the same |
| US8097445B2 (en) | 2004-03-25 | 2012-01-17 | Danisco Us Inc. | Exo-endo cellulase fusion protein |
| CA2559827A1 (en) * | 2004-04-02 | 2005-10-13 | Dsm Ip Assets B.V. | Filamentous fungal mutants with improved homologous recombination efficiency |
| US7413887B2 (en) | 2004-05-27 | 2008-08-19 | Genecor International, Inc. | Trichoderma reesei glucoamylase and homologs thereof |
| EP1838849B1 (en) | 2004-12-30 | 2015-08-26 | Danisco US Inc. | Variant hypocrea jecorina cbh2 cellulases |
| US20070231819A1 (en) * | 2006-03-15 | 2007-10-04 | Christopher Lawrence | Targeted and non-targeted gene insertions using a linear minimal element construct |
| US8143046B2 (en) | 2007-02-07 | 2012-03-27 | Danisco Us Inc., Genencor Division | Variant Buttiauxella sp. phytases having altered properties |
| US20090253173A1 (en) * | 2008-04-08 | 2009-10-08 | Danisco Us Inc., Genencor Division | Filamentous fungi with inactivated protease genes for altered protein production |
| EP2628796A1 (en) | 2008-06-06 | 2013-08-21 | Danisco US Inc. | Compositions and methods comprising cellulase variants with reduced affinity to non-cellulosic materials |
| CN104862293A (zh) | 2009-06-03 | 2015-08-26 | 丹尼斯科美国公司 | 具有改善的表达、活性和/或稳定性的纤维素酶变体,及其用途 |
| CN102791853B (zh) | 2009-09-23 | 2015-08-12 | 丹尼斯科美国公司 | 新型糖基水解酶及其用途 |
| CA2780767A1 (en) | 2009-11-20 | 2011-05-26 | Danisco Us Inc. | Beta-glucosidase i variants with improved properties |
| CN101831452B (zh) * | 2010-04-22 | 2012-09-05 | 中国农业科学院生物技术研究所 | 通过重组瑞氏木霉以诱导型方式高效表达和生产t4溶菌酶的方法 |
| US8962295B2 (en) | 2010-06-01 | 2015-02-24 | California Institute Of Technology | Stable, functional chimeric cellobiohydrolase class I enzymes |
| CN102939382B (zh) * | 2010-06-03 | 2017-02-15 | 丹尼斯科美国公司 | 丝状真菌宿主菌株和dna构建体以及它们的使用方法 |
| FI20105632A0 (fi) * | 2010-06-04 | 2010-06-04 | Valtion Teknillinen | Menetelmä proteiinien tuottamiseksi rihmamaisilla sienillä |
| DK2630249T3 (en) * | 2010-10-20 | 2018-12-17 | Danisco Us Inc | THERMOSTABLE TRICHODERMA CELLULASE |
| AU2012229042B2 (en) | 2011-03-17 | 2017-03-02 | Danisco Us Inc. | Glycosyl hydrolase enzymes and uses thereof for biomass hydrolysis |
| BR112013023715A2 (pt) | 2011-03-17 | 2016-09-13 | Danisco Us Inc | "polipeptídeo, polinucleotídeo, vetor, célula hospedeira, e composição para uso em hidrólise de biomassa, bem como métodos para hidrolisar material de biomassa celulósica e para produzir composição de mistura de cultura ou caldo de fermentação" |
| US20140134677A1 (en) | 2011-03-17 | 2014-05-15 | Danisco Us Inc. | Method for reducing viscosity in saccharification process |
| CN102311951B (zh) * | 2011-07-13 | 2013-03-20 | 深圳大学 | 里氏木霉组成型表达盒、表达载体、重组菌株及其应用 |
| WO2013096056A1 (en) | 2011-12-21 | 2013-06-27 | Danisco Us Inc. | Improving fungal gene expression using insulator dna sequences |
| BR112014016587A2 (pt) | 2012-01-05 | 2020-10-27 | Novartis Ag | células fúngicas filamentosas deficientes de protease e métodos de uso das mesmas |
| CN104781385A (zh) | 2012-09-20 | 2015-07-15 | 丹尼斯科美国公司 | 用于对细胞培养物控释培养组分的微量滴定板 |
| MX2015005427A (es) | 2012-10-31 | 2015-08-05 | Danisco Inc | Beta-glucosidasa de magnaporthe grisea. |
| EP2914719A1 (en) | 2012-10-31 | 2015-09-09 | Danisco US Inc. | Compositions and methods of use |
| WO2014070844A1 (en) | 2012-10-31 | 2014-05-08 | Danisco Us Inc. | Beta-glucosidase from neurospora crassa |
| CN104870643A (zh) | 2012-12-12 | 2015-08-26 | 丹尼斯科美国公司 | 纤维二糖水解酶的变体 |
| EP3290515A1 (en) | 2012-12-12 | 2018-03-07 | Danisco US Inc. | Variants of cellobiohydrolases |
| EP2931886A1 (en) | 2012-12-12 | 2015-10-21 | Danisco US Inc. | Variants of cellobiohydrolases |
| BR112015013646A2 (pt) | 2012-12-12 | 2017-11-14 | Danisco Us Inc | variante isolada de uma enzima celobio-hidrolase (cbh) parental, polinucleotídeo isolado, vetor, célula hospedeira, composição detergente, aditivo alimentar, método para hidrolisar um substrato celulósico, sobrenadante de cultura celular, métodos de produção de um polipeptídeo cbh variante e sobrenadante de cultura celular |
| CN104870642A (zh) | 2012-12-12 | 2015-08-26 | 丹尼斯科美国公司 | 纤维二糖水解酶的变体 |
| WO2015004241A2 (en) * | 2013-07-10 | 2015-01-15 | Novartis Ag | Multiple proteases deficient filamentous fungal cells and methods of use thereof |
| CN105829530A (zh) | 2013-12-04 | 2016-08-03 | 丹尼斯科美国公司 | 包含β-葡萄糖苷酶多肽的组合物及其使用方法 |
| JP2017532967A (ja) | 2014-10-27 | 2017-11-09 | ダニスコ・ユーエス・インク | ベータ−グルコシダーゼに関連する組成物および方法 |
| CN107667171A (zh) | 2014-12-16 | 2018-02-06 | 丹尼斯科美国公司 | 真菌基因组修饰系统及使用方法 |
| WO2017177289A1 (en) | 2016-04-15 | 2017-10-19 | Vtt International Oy | Process for conversion of biomass into fermentable sugars with integrated enzyme |
| CN106978360B (zh) * | 2017-04-24 | 2020-08-04 | 上海交通大学 | 一株高产纤维素酶里氏木霉重组菌株及其应用 |
| CN113106114B (zh) * | 2020-01-13 | 2024-04-12 | 中国科学院分子植物科学卓越创新中心 | 调控里氏木霉蛋白表达效率的因子、调控方法及应用 |
| JP7799621B2 (ja) * | 2020-04-22 | 2026-01-15 | ダニスコ・ユーエス・インク | 糸状菌細胞におけるタンパク質産生の増強のための組成物及び方法 |
-
2017
- 2017-10-03 EP EP17794124.2A patent/EP3523415A1/en active Pending
- 2017-10-03 WO PCT/US2017/054983 patent/WO2018067599A1/en not_active Ceased
- 2017-10-03 JP JP2019539732A patent/JP7285780B2/ja active Active
- 2017-10-03 CN CN201780059992.7A patent/CN109790510B/zh active Active
- 2017-10-03 KR KR1020197010929A patent/KR102593668B1/ko active Active
- 2017-10-03 US US16/336,500 patent/US10876103B2/en active Active
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2020
- 2020-11-13 US US17/097,044 patent/US20220145278A1/en not_active Abandoned
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2023
- 2023-05-23 JP JP2023084937A patent/JP7605902B2/ja active Active
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