JP2019528739A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019528739A5 JP2019528739A5 JP2019515294A JP2019515294A JP2019528739A5 JP 2019528739 A5 JP2019528739 A5 JP 2019528739A5 JP 2019515294 A JP2019515294 A JP 2019515294A JP 2019515294 A JP2019515294 A JP 2019515294A JP 2019528739 A5 JP2019528739 A5 JP 2019528739A5
- Authority
- JP
- Japan
- Prior art keywords
- aptamer
- polynucleotide
- nucleotides
- stem
- nucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 27
- 125000003729 nucleotide group Chemical group 0.000 claims 27
- 108091023037 Aptamer Proteins 0.000 claims 23
- 108091033319 polynucleotide Proteins 0.000 claims 16
- 239000002157 polynucleotide Substances 0.000 claims 16
- 102000040430 polynucleotide Human genes 0.000 claims 16
- 239000000729 antidote Substances 0.000 claims 6
- 230000004048 modification Effects 0.000 claims 6
- 238000012986 modification Methods 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000000539 dimer Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000013638 trimer Substances 0.000 claims 4
- 101150045640 VWF gene Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000003381 stabilizer Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 206010047249 Venous thrombosis Diseases 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- 101000869690 Homo sapiens Protein S100-A8 Proteins 0.000 claims 1
- 101100156611 Homo sapiens VWF gene Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102100032442 Protein S100-A8 Human genes 0.000 claims 1
- 229940075522 antidotes Drugs 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 230000035602 clotting Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022176918A JP7675990B2 (ja) | 2016-09-16 | 2022-11-04 | フォン・ビルブラント因子（ｖｗｆ）標的薬剤およびそれを用いる方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662395642P | 2016-09-16 | 2016-09-16 | |
| US62/395,642 | 2016-09-16 | ||
| PCT/US2017/052063 WO2018053427A1 (en) | 2016-09-16 | 2017-09-18 | Von willebrand factor (vwf)-targeting agents and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022176918A Division JP7675990B2 (ja) | 2016-09-16 | 2022-11-04 | フォン・ビルブラント因子（ｖｗｆ）標的薬剤およびそれを用いる方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528739A JP2019528739A (ja) | 2019-10-17 |
| JP2019528739A5 true JP2019528739A5 (enExample) | 2020-11-12 |
| JP7560821B2 JP7560821B2 (ja) | 2024-10-03 |
Family
ID=61619783
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019515294A Active JP7560821B2 (ja) | 2016-09-16 | 2017-09-18 | フォン・ビルブラント因子（ｖｗｆ）標的薬剤およびそれを用いる方法 |
| JP2022176918A Active JP7675990B2 (ja) | 2016-09-16 | 2022-11-04 | フォン・ビルブラント因子（ｖｗｆ）標的薬剤およびそれを用いる方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022176918A Active JP7675990B2 (ja) | 2016-09-16 | 2022-11-04 | フォン・ビルブラント因子（ｖｗｆ）標的薬剤およびそれを用いる方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US10889816B2 (enExample) |
| EP (1) | EP3512526A4 (enExample) |
| JP (2) | JP7560821B2 (enExample) |
| CN (1) | CN109982707A (enExample) |
| WO (1) | WO2018053427A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016176426A1 (en) | 2015-04-28 | 2016-11-03 | Duke University | Thrombus imaging aptamers and methods of using same |
| JP2021519093A (ja) * | 2018-03-27 | 2021-08-10 | ユーエムシー ユトレヒト ホールディング ビー．ブイ． | 微小血管血栓症の処置のための標的化血栓溶解 |
| JP2022044843A (ja) * | 2018-12-11 | 2022-03-18 | 日産化学株式会社 | 解毒剤 |
| EP4100121A4 (en) * | 2020-02-04 | 2024-04-10 | Band Therapeutics, LLC | REGULATION OF THE VON WILLEBRAND FACTOR (VWF) |
| CN113244381A (zh) * | 2021-06-02 | 2021-08-13 | 苏州大学 | 游离的血红蛋白及其衍生物抗血小板聚集的应用 |
| CN122270286A (zh) * | 2023-10-06 | 2026-06-23 | 俄亥俄州立创新基金会 | 适体bb-031及其使用方法 |
| CN121896238B (zh) * | 2026-03-24 | 2026-07-17 | 上海交通大学医学院附属仁济医院 | F碱基修饰的血管性血友病因子vWF靶向适配体及其应用 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770198A (en) | 1988-05-18 | 1998-06-23 | The Research Foundation Of The State Of New York | Platelet-specific chimeric 7E3 immunoglobulin |
| US6261774B1 (en) | 1990-06-11 | 2001-07-17 | Gilead Sciences, Inc. | Truncation selex method |
| US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| US5756291A (en) | 1992-08-21 | 1998-05-26 | Gilead Sciences, Inc. | Aptamers specific for biomolecules and methods of making |
| WO1994009792A1 (en) | 1992-10-23 | 1994-05-11 | University Of Massachusetts Medical Center | Small molecule inhibition of rna/ligand binding |
| US7396664B2 (en) | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
| US6780850B1 (en) | 1999-06-22 | 2004-08-24 | Triumf | Extending the lifetime of anticoagulant oligodeoxynucleotide aptamers in blood |
| GB0014136D0 (en) | 2000-06-10 | 2000-08-02 | Astrazeneca Ab | Combination therapy |
| GB0014134D0 (en) | 2000-06-10 | 2000-08-02 | Astrazeneca Ab | Combination therapy |
| US6376190B1 (en) | 2000-09-22 | 2002-04-23 | Somalogic, Inc. | Modified SELEX processes without purified protein |
| WO2002026932A2 (en) | 2000-09-26 | 2002-04-04 | Duke University | Rna aptamers and methods for identifying the same |
| PT2070939E (pt) | 2001-05-25 | 2014-06-09 | Univ Duke | Moduladores de agentes farmacológicos |
| AUPR604101A0 (en) | 2001-06-29 | 2001-07-26 | Unisearch Limited | Aptamers |
| US20070071744A1 (en) | 2002-06-07 | 2007-03-29 | Gotz Munch | Agents which bind to epitopes of glycoprotein VI |
| EP2380899A1 (en) * | 2002-09-23 | 2011-10-26 | E. I. du Pont de Nemours and Company | Isolation and use of ryanodine receptors |
| US20060193821A1 (en) | 2004-03-05 | 2006-08-31 | Diener John L | Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics |
| CN1980947B (zh) | 2004-04-22 | 2013-01-30 | 雷加多生物科学公司 | 改良的凝血因子调节物 |
| US7566701B2 (en) | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
| JP2008512098A (ja) * | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用 |
| AU2005282380A1 (en) | 2004-09-07 | 2006-03-16 | Archemix Corp. | Aptamer medicinal chemistry |
| TWI403334B (zh) | 2004-12-23 | 2013-08-01 | Merck Sharp & Dohme | 包含生物素殘基之抗血栓雙重抑制劑 |
| US7795009B2 (en) | 2005-06-15 | 2010-09-14 | Saint Louis University | Three-component biosensors for detecting macromolecules and other analytes |
| US8367627B2 (en) * | 2005-09-15 | 2013-02-05 | Duke University | Focused libraries, functional profiling, laser SELEX, and DESELEX |
| US20100076060A1 (en) | 2005-09-15 | 2010-03-25 | Duke University | Aptamers as agonists |
| JP2009538325A (ja) | 2006-05-26 | 2009-11-05 | リガド・バイオサイエンシーズ・インコーポレーテツド | Ｒｅｇ１抗凝固系の投与 |
| US20110118187A1 (en) | 2006-10-19 | 2011-05-19 | Duke University | Reversible platelet inhibition |
| US8790924B2 (en) * | 2006-10-19 | 2014-07-29 | Duke University | Reversible platelet inhibition |
| US8372427B2 (en) | 2007-03-05 | 2013-02-12 | Abbott Cardiovascular Systems Inc. | Therapeutic composition with enhanced endothelium targeting |
| CA2682580A1 (en) | 2007-03-30 | 2008-10-09 | Duke University | A method of modulating the activity of a nucleic acid molecule |
| WO2008150495A2 (en) * | 2007-06-01 | 2008-12-11 | Archemix Corp. | Vwf aptamer formulations and methods for use |
| JP5896742B2 (ja) | 2008-08-22 | 2016-03-30 | バクスター・ヘルスケヤー・ソシエテ・アノニムＢａｘｔｅｒ Ｈｅａｌｔｈｃａｒｅ ＳＡ | 出血性障害を処置するための方法 |
| JP2012528597A (ja) | 2009-06-03 | 2012-11-15 | レガド・バイオサイエンシズ・インク | 血小板グリコプロテインｖｉの核酸調節因子 |
| KR20220038506A (ko) | 2009-06-10 | 2022-03-28 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| IN2012DN02345A (enExample) | 2009-09-16 | 2015-08-21 | Univ Duke | |
| US9061043B2 (en) | 2010-10-13 | 2015-06-23 | Duke University | Aptamers to glycoprotein VI |
| WO2012149024A2 (en) * | 2011-04-28 | 2012-11-01 | Mayo Foundation For Medical Education And Research | Dna aptamers for promoting remyelination |
| WO2012151575A2 (en) | 2011-05-05 | 2012-11-08 | Duke University | A method of controlling coagulation |
| WO2013043902A1 (en) | 2011-09-21 | 2013-03-28 | Nplex Laboratory Inc. | Targeted nanoparticles joined to reporter molecules through multiple mechanisms |
| AU2013340414B2 (en) * | 2012-10-23 | 2019-05-02 | Caris Science, Inc. | Aptamers and uses thereof |
| WO2014169049A1 (en) * | 2013-04-09 | 2014-10-16 | Duke University | 2' fluoro-modified rnas as immunostimulators |
| WO2014193800A2 (en) * | 2013-05-28 | 2014-12-04 | The Johns Hopkins University | Aptamers for the treatment of sickle cell disease |
| WO2016019270A1 (en) * | 2014-07-31 | 2016-02-04 | Academia Sinica | An antagonistic pd-1 aptamer and its applications in cancer therapy related applications |
| WO2016176426A1 (en) | 2015-04-28 | 2016-11-03 | Duke University | Thrombus imaging aptamers and methods of using same |
-
2017
- 2017-09-18 EP EP17851722.3A patent/EP3512526A4/en active Pending
- 2017-09-18 WO PCT/US2017/052063 patent/WO2018053427A1/en not_active Ceased
- 2017-09-18 JP JP2019515294A patent/JP7560821B2/ja active Active
- 2017-09-18 US US16/334,307 patent/US10889816B2/en active Active
- 2017-09-18 CN CN201780069446.1A patent/CN109982707A/zh active Pending
-
2021
- 2021-01-11 US US17/146,147 patent/US11965160B2/en active Active
-
2022
- 2022-11-04 JP JP2022176918A patent/JP7675990B2/ja active Active
-
2024
- 2024-03-29 US US18/622,413 patent/US20240318178A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Beauté et al. | Photo-triggered polymer nanomedicines: From molecular mechanisms to therapeutic applications | |
| Mehanny et al. | Exploring the use of nanocarrier systems to deliver the magical molecule; curcumin and its derivatives | |
| JP2018522563A5 (enExample) | ||
| JP2018503668A5 (enExample) | ||
| Ibraheem et al. | Administration strategies for proteins and peptides | |
| JP2017534638A5 (enExample) | ||
| CY1121910T1 (el) | Φαρμακευτικο παρασκευασμα που περιεχει παραγωγο διυδροκιναζολινης με αντιϊικη δραση | |
| MX2017012506A (es) | Composicion farmaceutica para la prevencion y tratamiento de enfermedades del ojo que contiene, como ingrediente activo, una proteina de fusion en la cual el peptido que penetra el tejido y la preparacion del factor de crecimiento endotelial antivascular se fusionan. | |
| JP2014530253A5 (enExample) | ||
| JP7675990B2 (ja) | フォン・ビルブラント因子（ｖｗｆ）標的薬剤およびそれを用いる方法 | |
| JP2017532965A5 (enExample) | ||
| JP2016518442A5 (enExample) | ||
| JP2017503014A5 (enExample) | ||
| JP2017537985A5 (enExample) | ||
| JP2016521712A5 (enExample) | ||
| JP2013136622A5 (enExample) | ||
| JP2015514115A5 (enExample) | ||
| JP2015502389A5 (enExample) | ||
| JP2014526881A5 (enExample) | ||
| RU2017114673A (ru) | Слитый белок, наночастица, состоящая из множества мономеров указанного слитого белка, и их применение | |
| JP2018524306A5 (enExample) | ||
| JP2019508175A5 (enExample) | ||
| JP2015517484A5 (enExample) | ||
| HRP20201683T1 (hr) | Imunogeni pripravak namijenjen upotrebi u terapiji | |
| JP2018517767A5 (enExample) |