JP2016518442A5 - - Google Patents
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- Publication number
- JP2016518442A5 JP2016518442A5 JP2016513482A JP2016513482A JP2016518442A5 JP 2016518442 A5 JP2016518442 A5 JP 2016518442A5 JP 2016513482 A JP2016513482 A JP 2016513482A JP 2016513482 A JP2016513482 A JP 2016513482A JP 2016518442 A5 JP2016518442 A5 JP 2016518442A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- mucopolysaccharide
- chitosan
- botulinum neurotoxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 20
- 108030001720 Bontoxilysin Proteins 0.000 claims 8
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 6
- 231100001103 botulinum neurotoxin Toxicity 0.000 claims 6
- 229920001661 Chitosan Polymers 0.000 claims 5
- 229940053031 botulinum toxin Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 108010057266 Type A Botulinum Toxins Proteins 0.000 claims 1
- GRTOGORTSDXSFK-XJTZBENFSA-N ajmalicine Chemical compound C1=CC=C2C(CCN3C[C@@H]4[C@H](C)OC=C([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 GRTOGORTSDXSFK-XJTZBENFSA-N 0.000 claims 1
- 230000003288 anthiarrhythmic effect Effects 0.000 claims 1
- 239000003416 antiarrhythmic agent Substances 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 208000037849 arterial hypertension Diseases 0.000 claims 1
- 229940094657 botulinum toxin type a Drugs 0.000 claims 1
- 230000006196 deacetylation Effects 0.000 claims 1
- 238000003381 deacetylation reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000007972 injectable composition Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 229960000899 nadroparin Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2013122509 | 2013-05-15 | ||
| RU2013122509/15A RU2535115C1 (ru) | 2013-05-15 | 2013-05-15 | Фармацевтический состав, содержащий нейротоксин ботулина |
| PCT/IB2014/061417 WO2014184746A1 (en) | 2013-05-15 | 2014-05-14 | Pharmaceutical composition comprising a botulinum neurotoxin and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518442A JP2016518442A (ja) | 2016-06-23 |
| JP2016518442A5 true JP2016518442A5 (enExample) | 2017-04-27 |
| JP6440691B2 JP6440691B2 (ja) | 2018-12-19 |
Family
ID=50841919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513482A Expired - Fee Related JP6440691B2 (ja) | 2013-05-15 | 2014-05-14 | ボツリヌス神経毒を含む医薬組成物およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10258673B2 (enExample) |
| EP (2) | EP2996674B1 (enExample) |
| JP (1) | JP6440691B2 (enExample) |
| CN (1) | CN105209014B (enExample) |
| CA (1) | CA2911046C (enExample) |
| DK (1) | DK2996674T3 (enExample) |
| ES (1) | ES2829614T3 (enExample) |
| HK (1) | HK1217173A1 (enExample) |
| RU (1) | RU2535115C1 (enExample) |
| WO (1) | WO2014184746A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3760186A1 (en) * | 2014-04-30 | 2021-01-06 | Allergan, Inc. | Formulations of biologics for intravesical instillation |
| ES2821731T3 (es) * | 2014-07-31 | 2021-04-27 | Allergan Inc | Formulaciones de productos biológicos para instilación intravesical |
| RU2577296C1 (ru) * | 2014-12-24 | 2016-03-10 | Евгения Николаевна Анисимова | Способ выбора эффективного и безопасного местного обезболивания у пациентов с артериальной гипертензией на амбулаторном стоматологическом приеме |
| RU2651044C2 (ru) * | 2016-08-22 | 2018-04-18 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ им. ак. Е.Н. Мешалкина" Минздрава России) | Способ лечения желудочковых нарушений ритма сердца (варианты) |
| RU2762607C2 (ru) | 2016-09-13 | 2021-12-21 | Аллерган, Инк. | Стабилизированные небелковые композиции клостридиального токсина |
| JP2020525416A (ja) * | 2017-06-29 | 2020-08-27 | アドヴァイテ エルエルシー． | 眼表面障害の治療及び診断 |
| AU2019284621B2 (en) * | 2018-06-13 | 2025-02-27 | Dermata Therapeutics, Inc. | Compositions for the treatment of skin conditions |
| WO2020056204A1 (en) * | 2018-09-13 | 2020-03-19 | Allergan, Inc. | Methods for treatment of masseter muscle hypertrophy |
| US10967052B1 (en) | 2019-10-18 | 2021-04-06 | Penland Foundation | Treatment of dyslexia using botulinum toxin |
| CA3227431A1 (en) | 2019-10-18 | 2021-04-22 | Penland Foundation | Use of a botulinum toxin for treating autism and/or tolerance to narcotics |
| US10960061B1 (en) | 2019-10-18 | 2021-03-30 | Penland Foundation | Treatment of amyotrophic lateral sclerosis using botulinum toxin |
| US10973873B1 (en) | 2019-10-18 | 2021-04-13 | Penland Foundation | Treatment of asthma using botulinum toxin |
| US10960060B1 (en) * | 2019-10-18 | 2021-03-30 | Penland Foundation | Treatment of cardiac arrhythmia using botulinum toxin |
| US11241479B2 (en) | 2019-10-18 | 2022-02-08 | Penland Foundation | Treatment methods using botulinum toxins |
| US11090371B1 (en) | 2019-10-18 | 2021-08-17 | Penland Foundation | Treatment of cirrhosis using botulinum toxin |
| US10987411B1 (en) | 2019-10-18 | 2021-04-27 | Penland Foundation | Treatment of chronic obstructive pulmonary disease using botulinum toxin |
| US11738071B2 (en) | 2021-07-12 | 2023-08-29 | Penland Foundation | Treatment of acute and chronic kidney disease |
| WO2023287728A1 (en) | 2021-07-12 | 2023-01-19 | Penland Foundation | Treatment of diabetes and chronic pancreatitis using botulinum toxin |
| WO2024102345A1 (en) * | 2022-11-07 | 2024-05-16 | Allergan, Inc. | Prevention of post-operative atrial fibrillation with a botulinum toxin |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2884358A (en) | 1957-04-22 | 1959-04-28 | Southern California Gland Co | Process for preparing crude heparin |
| JPH06192296A (ja) | 1992-10-28 | 1994-07-12 | Chiba Pref Gov | 治療用医薬品としての結晶ａ型ボツリヌス毒素の製造法。 |
| US6967088B1 (en) | 1995-03-16 | 2005-11-22 | Allergan, Inc. | Soluble recombinant botulinum toxin proteins |
| US20120238504A1 (en) * | 1998-09-11 | 2012-09-20 | Solstice Neurosciences, Llc | Stable Formulations of Botulinum Toxin in Hydrogels |
| TW574036B (en) | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
| US6977080B1 (en) * | 1999-08-10 | 2005-12-20 | Allergan, Inc. | Intrapericardial botulinum toxin treatment for bradycardia |
| JP2003009897A (ja) | 2001-07-03 | 2003-01-14 | Keiji Oguma | ボツリヌス毒素の分離・精製法 |
| US20040058313A1 (en) | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
| US7691394B2 (en) | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
| US7148041B2 (en) | 2003-09-25 | 2006-12-12 | Allergan, Inc. | Animal product free media and processes for obtaining a botulinum toxin |
| US8073538B2 (en) * | 2003-11-13 | 2011-12-06 | Cardio Polymers, Inc. | Treatment of cardiac arrhythmia by modification of neuronal signaling through fat pads of the heart |
| US20050119704A1 (en) * | 2003-11-13 | 2005-06-02 | Peters Nicholas S. | Control of cardiac arrhythmias by modification of neuronal conduction within fat pads of the heart |
| US20060228404A1 (en) * | 2004-03-04 | 2006-10-12 | Anderson Daniel G | Compositions and methods for treatment of hypertrophic tissues |
| JP2005306746A (ja) * | 2004-04-19 | 2005-11-04 | Jiyugaoka Clinic | 顔面用シワ治療剤 |
| GB2416122A (en) | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| US20060073208A1 (en) * | 2004-10-01 | 2006-04-06 | Allergan, Inc. | Cosmetic neurotoxin compositions and methods |
| GB2419817A (en) * | 2004-10-29 | 2006-05-10 | Ipsen Ltd | Treatment of cardiac fibrillation disorders |
| WO2007019554A2 (en) * | 2005-08-08 | 2007-02-15 | Momenta Pharmaceuticals, Inc. | Polysaccharides for delivery of active agents |
| CA2652295A1 (en) | 2006-05-15 | 2007-11-22 | Symphony Medical, Inc. | Post-operative control of cardiac arrhythmia by modification of neuronal signaling through fat pads of the heart |
| AR061669A1 (es) | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
| EP2155167A2 (en) * | 2007-06-04 | 2010-02-24 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
| US9044477B2 (en) * | 2007-12-12 | 2015-06-02 | Allergan, Inc. | Botulinum toxin formulation |
| JP4999008B2 (ja) | 2008-07-15 | 2012-08-15 | 楽天株式会社 | 情報送信装置、情報送信方法、情報送信処理プログラム及び情報送信システム |
| LT2379104T (lt) | 2008-12-31 | 2018-04-10 | Revance Therapeutics, Inc. | Injekcinės botulino toksino vaisto formos |
| EP3760186A1 (en) * | 2014-04-30 | 2021-01-06 | Allergan, Inc. | Formulations of biologics for intravesical instillation |
-
2013
- 2013-05-15 RU RU2013122509/15A patent/RU2535115C1/ru active
-
2014
- 2014-05-14 EP EP14727073.0A patent/EP2996674B1/en active Active
- 2014-05-14 EP EP20190163.4A patent/EP3750525A1/en not_active Withdrawn
- 2014-05-14 US US14/888,511 patent/US10258673B2/en not_active Expired - Fee Related
- 2014-05-14 WO PCT/IB2014/061417 patent/WO2014184746A1/en not_active Ceased
- 2014-05-14 CA CA2911046A patent/CA2911046C/en not_active Expired - Fee Related
- 2014-05-14 DK DK14727073.0T patent/DK2996674T3/da active
- 2014-05-14 CN CN201480027168.XA patent/CN105209014B/zh not_active Expired - Fee Related
- 2014-05-14 HK HK16105183.8A patent/HK1217173A1/zh unknown
- 2014-05-14 ES ES14727073T patent/ES2829614T3/es active Active
- 2014-05-14 JP JP2016513482A patent/JP6440691B2/ja not_active Expired - Fee Related
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