JP6440691B2 - ボツリヌス神経毒を含む医薬組成物およびその使用 - Google Patents

ボツリヌス神経毒を含む医薬組成物およびその使用 Download PDF

Info

Publication number
JP6440691B2
JP6440691B2 JP2016513482A JP2016513482A JP6440691B2 JP 6440691 B2 JP6440691 B2 JP 6440691B2 JP 2016513482 A JP2016513482 A JP 2016513482A JP 2016513482 A JP2016513482 A JP 2016513482A JP 6440691 B2 JP6440691 B2 JP 6440691B2
Authority
JP
Japan
Prior art keywords
botulinum toxin
composition
chitosan
botulinum
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2016513482A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016518442A (ja
JP2016518442A5 (enExample
Inventor
ポクシャロフ、エフゲニー
フォメンコ、ウラディスラフ
サラクディノフ、ナリマン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bosti Trading Ltd
Original Assignee
Bosti Trading Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bosti Trading Ltd filed Critical Bosti Trading Ltd
Publication of JP2016518442A publication Critical patent/JP2016518442A/ja
Publication of JP2016518442A5 publication Critical patent/JP2016518442A5/ja
Application granted granted Critical
Publication of JP6440691B2 publication Critical patent/JP6440691B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893Botulinum neurotoxin (3.4.24.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/722Chitin, chitosan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24069Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016513482A 2013-05-15 2014-05-14 ボツリヌス神経毒を含む医薬組成物およびその使用 Expired - Fee Related JP6440691B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2013122509 2013-05-15
RU2013122509/15A RU2535115C1 (ru) 2013-05-15 2013-05-15 Фармацевтический состав, содержащий нейротоксин ботулина
PCT/IB2014/061417 WO2014184746A1 (en) 2013-05-15 2014-05-14 Pharmaceutical composition comprising a botulinum neurotoxin and uses thereof

Publications (3)

Publication Number Publication Date
JP2016518442A JP2016518442A (ja) 2016-06-23
JP2016518442A5 JP2016518442A5 (enExample) 2017-04-27
JP6440691B2 true JP6440691B2 (ja) 2018-12-19

Family

ID=50841919

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016513482A Expired - Fee Related JP6440691B2 (ja) 2013-05-15 2014-05-14 ボツリヌス神経毒を含む医薬組成物およびその使用

Country Status (10)

Country Link
US (1) US10258673B2 (enExample)
EP (2) EP2996674B1 (enExample)
JP (1) JP6440691B2 (enExample)
CN (1) CN105209014B (enExample)
CA (1) CA2911046C (enExample)
DK (1) DK2996674T3 (enExample)
ES (1) ES2829614T3 (enExample)
HK (1) HK1217173A1 (enExample)
RU (1) RU2535115C1 (enExample)
WO (1) WO2014184746A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2822942T3 (es) * 2014-04-30 2021-05-05 Allergan Inc Formulaciones de productos biológicos para instilación intravesical
US20160030570A1 (en) * 2014-07-31 2016-02-04 Allergan, Inc. Formulations of biologics for intravesical instillation
RU2577296C1 (ru) * 2014-12-24 2016-03-10 Евгения Николаевна Анисимова Способ выбора эффективного и безопасного местного обезболивания у пациентов с артериальной гипертензией на амбулаторном стоматологическом приеме
RU2651044C2 (ru) * 2016-08-22 2018-04-18 федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ им. ак. Е.Н. Мешалкина" Минздрава России) Способ лечения желудочковых нарушений ритма сердца (варианты)
US10369190B2 (en) 2016-09-13 2019-08-06 Allergan, Inc. Non-protein clostridial toxin compositions
EP3644966A4 (en) * 2017-06-29 2021-03-24 Advaite LLC TREATMENT AND DIAGNOSIS OF EYE SURFACE DISORDERS
CN112584856A (zh) * 2018-06-13 2021-03-30 德玛塔疗法有限责任公司 用于治疗皮肤疾患的组合物
CA3112227A1 (en) * 2018-09-13 2020-03-19 Allergan, Inc. Methods for treatment of masseter muscle hypertrophy
US10967052B1 (en) 2019-10-18 2021-04-06 Penland Foundation Treatment of dyslexia using botulinum toxin
US10960060B1 (en) * 2019-10-18 2021-03-30 Penland Foundation Treatment of cardiac arrhythmia using botulinum toxin
US10973873B1 (en) 2019-10-18 2021-04-13 Penland Foundation Treatment of asthma using botulinum toxin
US10987411B1 (en) 2019-10-18 2021-04-27 Penland Foundation Treatment of chronic obstructive pulmonary disease using botulinum toxin
US11090371B1 (en) 2019-10-18 2021-08-17 Penland Foundation Treatment of cirrhosis using botulinum toxin
US11738071B2 (en) 2021-07-12 2023-08-29 Penland Foundation Treatment of acute and chronic kidney disease
US11925677B2 (en) 2021-07-12 2024-03-12 Penland Foundation Treatment of diabetes and chronic pancreatitis using botulinum toxin
CA3154363C (en) 2019-10-18 2024-03-05 Penland Foundation Use of a botulinum toxin for treating autism and/or tolerance to narcotics
US10960061B1 (en) 2019-10-18 2021-03-30 Penland Foundation Treatment of amyotrophic lateral sclerosis using botulinum toxin
US11241479B2 (en) 2019-10-18 2022-02-08 Penland Foundation Treatment methods using botulinum toxins
WO2024102345A1 (en) * 2022-11-07 2024-05-16 Allergan, Inc. Prevention of post-operative atrial fibrillation with a botulinum toxin

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2884358A (en) 1957-04-22 1959-04-28 Southern California Gland Co Process for preparing crude heparin
JPH06192296A (ja) 1992-10-28 1994-07-12 Chiba Pref Gov 治療用医薬品としての結晶a型ボツリヌス毒素の製造法。
US6967088B1 (en) 1995-03-16 2005-11-22 Allergan, Inc. Soluble recombinant botulinum toxin proteins
US20120238504A1 (en) * 1998-09-11 2012-09-20 Solstice Neurosciences, Llc Stable Formulations of Botulinum Toxin in Hydrogels
TW574036B (en) 1998-09-11 2004-02-01 Elan Pharm Inc Stable liquid compositions of botulinum toxin
US6977080B1 (en) * 1999-08-10 2005-12-20 Allergan, Inc. Intrapericardial botulinum toxin treatment for bradycardia
JP2003009897A (ja) 2001-07-03 2003-01-14 Keiji Oguma ボツリヌス毒素の分離・精製法
US20040058313A1 (en) 2002-04-24 2004-03-25 Abreu Marcio Marc Compositions, targets, methods and devices for the therapy of ocular and periocular disorders
US7691394B2 (en) * 2002-05-28 2010-04-06 Botulinum Toxin Research Associates, Inc. High-potency botulinum toxin formulations
US7148041B2 (en) 2003-09-25 2006-12-12 Allergan, Inc. Animal product free media and processes for obtaining a botulinum toxin
JP2007511291A (ja) * 2003-11-13 2007-05-10 シンフォニー メディカル, インコーポレイテッド 心臓の脂肪パッド内の神経伝達の改変による不整脈の制御
US8073538B2 (en) * 2003-11-13 2011-12-06 Cardio Polymers, Inc. Treatment of cardiac arrhythmia by modification of neuronal signaling through fat pads of the heart
US20060228404A1 (en) * 2004-03-04 2006-10-12 Anderson Daniel G Compositions and methods for treatment of hypertrophic tissues
JP2005306746A (ja) * 2004-04-19 2005-11-04 Jiyugaoka Clinic 顔面用シワ治療剤
GB2416122A (en) * 2004-07-12 2006-01-18 Ipsen Ltd Botulinum neurotoxin composition
US20060073208A1 (en) 2004-10-01 2006-04-06 Allergan, Inc. Cosmetic neurotoxin compositions and methods
GB2419817A (en) * 2004-10-29 2006-05-10 Ipsen Ltd Treatment of cardiac fibrillation disorders
WO2007019554A2 (en) * 2005-08-08 2007-02-15 Momenta Pharmaceuticals, Inc. Polysaccharides for delivery of active agents
CA2652295A1 (en) 2006-05-15 2007-11-22 Symphony Medical, Inc. Post-operative control of cardiac arrhythmia by modification of neuronal signaling through fat pads of the heart
AR061669A1 (es) 2006-06-29 2008-09-10 Merz Pharma Gmbh & Co Kgaa Aplicacion de alta frecuencia de terapia con toxina botulinica
EP2155167A2 (en) * 2007-06-04 2010-02-24 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
US9044477B2 (en) 2007-12-12 2015-06-02 Allergan, Inc. Botulinum toxin formulation
JP4999008B2 (ja) 2008-07-15 2012-08-15 楽天株式会社 情報送信装置、情報送信方法、情報送信処理プログラム及び情報送信システム
KR102005930B1 (ko) 2008-12-31 2019-07-31 레반스 테라퓨틱스, 아이엔씨. 주사용 보툴리눔 독소 제제
ES2822942T3 (es) * 2014-04-30 2021-05-05 Allergan Inc Formulaciones de productos biológicos para instilación intravesical

Also Published As

Publication number Publication date
CA2911046C (en) 2021-08-31
EP2996674B1 (en) 2020-08-12
JP2016518442A (ja) 2016-06-23
CA2911046A1 (en) 2014-11-20
EP3750525A1 (en) 2020-12-16
US20160114013A1 (en) 2016-04-28
HK1217173A1 (zh) 2016-12-30
US10258673B2 (en) 2019-04-16
CN105209014A (zh) 2015-12-30
WO2014184746A1 (en) 2014-11-20
ES2829614T3 (es) 2021-06-01
RU2535115C1 (ru) 2014-12-10
CN105209014B (zh) 2018-05-25
DK2996674T3 (da) 2020-10-26
EP2996674A1 (en) 2016-03-23

Similar Documents

Publication Publication Date Title
JP6440691B2 (ja) ボツリヌス神経毒を含む医薬組成物およびその使用
US12171816B2 (en) Non-protein Clostridial toxin compositions
AU2011316111B2 (en) Formulation suitable for stabilizing proteins, which is free of mammalian excipients
JP6113424B2 (ja) 安定化された多糖の処方のための組成物及び方法
EP2358373B1 (en) Injectable polydeoxyribonucleotide composition for the treatment of osteoarticular diseases
CN116392633A (zh) 一种基于重组人源化胶原蛋白的可注射心衰治疗水凝胶及其制备方法
JP2020189870A (ja) 関節を治療するための組成物及びキット
CN107714645A (zh) 纳米颗粒组合物
JPH05506034A (ja) アクチン結合性化合物の療法的使用
KR101464208B1 (ko) 당뇨성 신경병증에서 말초 신경의 형태기능의 복원을 위한 상피 성장인자의 용도
WO2017152039A1 (en) Protection and delivery of multiple therapeutic proteins
JP2022500426A (ja) クロストリジウム毒素−ヒアルロン酸組成物
Sergeevichev et al. Globular chitosan prolongs the effective duration time and decreases the acute toxicity of botulinum neurotoxin after intramuscular injection in rats
JP2688603B2 (ja) 血栓溶解剤
JP2019516784A (ja) 腱変性の処置に使用するための組成物
TWI737972B (zh) 心肌再灌流的方法及套组與減緩或減少心肌再灌流損傷的方法
Gong et al. Injectable Hydrogel for Cardiac Repair via Dual Inhibition of Ferroptosis and Oxidative Stress
KR101906940B1 (ko) 보툴리눔 독소, 4-헥실레조르시놀 및 실크 피브로인을 포함하는 조성물
EP3678688A1 (en) Heparin composition for treating ischemia

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170324

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170324

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180109

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180409

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180710

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181004

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20181030

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20181120

R150 Certificate of patent or registration of utility model

Ref document number: 6440691

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees