JP7560821B2 - フォン・ビルブラント因子（ｖｗｆ）標的薬剤およびそれを用いる方法 - Google Patents

フォン・ビルブラント因子（ｖｗｆ）標的薬剤およびそれを用いる方法 Download PDF

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JP7560821B2
JP7560821B2 JP2019515294A JP2019515294A JP7560821B2 JP 7560821 B2 JP7560821 B2 JP 7560821B2 JP 2019515294 A JP2019515294 A JP 2019515294A JP 2019515294 A JP2019515294 A JP 2019515294A JP 7560821 B2 JP7560821 B2 JP 7560821B2
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aptamer
nucleotides
polynucleotide
vwf
seq
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JP2019528739A5 (enExample
JP2019528739A (ja
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シャヒド エム ニムジー
ジョージ エイ ピトック
ジュリアナ レイザー
ブルース サレンジャー
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Duke University
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JP2019515294A 2016-09-16 2017-09-18 フォン・ビルブラント因子（ｖｗｆ）標的薬剤およびそれを用いる方法 Active JP7560821B2 (ja)

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US201662395642P 2016-09-16 2016-09-16
US62/395,642 2016-09-16
PCT/US2017/052063 WO2018053427A1 (en) 2016-09-16 2017-09-18 Von willebrand factor (vwf)-targeting agents and methods of using the same

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WO2016176426A1 (en) 2015-04-28 2016-11-03 Duke University Thrombus imaging aptamers and methods of using same
JP2021519093A (ja) * 2018-03-27 2021-08-10 ユーエムシー ユトレヒト ホールディング ビー．ブイ． 微小血管血栓症の処置のための標的化血栓溶解
JP2022044843A (ja) * 2018-12-11 2022-03-18 日産化学株式会社 解毒剤
EP4100121A4 (en) * 2020-02-04 2024-04-10 Band Therapeutics, LLC REGULATION OF THE VON WILLEBRAND FACTOR (VWF)
CN113244381A (zh) * 2021-06-02 2021-08-13 苏州大学 游离的血红蛋白及其衍生物抗血小板聚集的应用
CN122270286A (zh) * 2023-10-06 2026-06-23 俄亥俄州立创新基金会 适体bb-031及其使用方法
CN121896238B (zh) * 2026-03-24 2026-07-17 上海交通大学医学院附属仁济医院 F碱基修饰的血管性血友病因子vWF靶向适配体及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008512098A (ja) 2004-09-07 2008-04-24 アーケミックス コーポレイション フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用
WO2008066621A2 (en) 2006-10-19 2008-06-05 Duke University Reversible platelet inhibition
US20120264815A1 (en) 2006-10-19 2012-10-18 Duke University Reversible platelet inhibition
WO2014169049A1 (en) 2013-04-09 2014-10-16 Duke University 2' fluoro-modified rnas as immunostimulators
WO2016019270A1 (en) 2014-07-31 2016-02-04 Academia Sinica An antagonistic pd-1 aptamer and its applications in cancer therapy related applications

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770198A (en) 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
US6261774B1 (en) 1990-06-11 2001-07-17 Gilead Sciences, Inc. Truncation selex method
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5756291A (en) 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
WO1994009792A1 (en) 1992-10-23 1994-05-11 University Of Massachusetts Medical Center Small molecule inhibition of rna/ligand binding
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
US6780850B1 (en) 1999-06-22 2004-08-24 Triumf Extending the lifetime of anticoagulant oligodeoxynucleotide aptamers in blood
GB0014136D0 (en) 2000-06-10 2000-08-02 Astrazeneca Ab Combination therapy
GB0014134D0 (en) 2000-06-10 2000-08-02 Astrazeneca Ab Combination therapy
US6376190B1 (en) 2000-09-22 2002-04-23 Somalogic, Inc. Modified SELEX processes without purified protein
WO2002026932A2 (en) 2000-09-26 2002-04-04 Duke University Rna aptamers and methods for identifying the same
PT2070939E (pt) 2001-05-25 2014-06-09 Univ Duke Moduladores de agentes farmacológicos
AUPR604101A0 (en) 2001-06-29 2001-07-26 Unisearch Limited Aptamers
US20070071744A1 (en) 2002-06-07 2007-03-29 Gotz Munch Agents which bind to epitopes of glycoprotein VI
EP2380899A1 (en) * 2002-09-23 2011-10-26 E. I. du Pont de Nemours and Company Isolation and use of ryanodine receptors
US20060193821A1 (en) 2004-03-05 2006-08-31 Diener John L Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
CN1980947B (zh) 2004-04-22 2013-01-30 雷加多生物科学公司 改良的凝血因子调节物
US7566701B2 (en) 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
AU2005282380A1 (en) 2004-09-07 2006-03-16 Archemix Corp. Aptamer medicinal chemistry
TWI403334B (zh) 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
US7795009B2 (en) 2005-06-15 2010-09-14 Saint Louis University Three-component biosensors for detecting macromolecules and other analytes
US8367627B2 (en) * 2005-09-15 2013-02-05 Duke University Focused libraries, functional profiling, laser SELEX, and DESELEX
US20100076060A1 (en) 2005-09-15 2010-03-25 Duke University Aptamers as agonists
JP2009538325A (ja) 2006-05-26 2009-11-05 リガド・バイオサイエンシーズ・インコーポレーテツド Ｒｅｇ１抗凝固系の投与
US8372427B2 (en) 2007-03-05 2013-02-12 Abbott Cardiovascular Systems Inc. Therapeutic composition with enhanced endothelium targeting
CA2682580A1 (en) 2007-03-30 2008-10-09 Duke University A method of modulating the activity of a nucleic acid molecule
WO2008150495A2 (en) * 2007-06-01 2008-12-11 Archemix Corp. Vwf aptamer formulations and methods for use
JP5896742B2 (ja) 2008-08-22 2016-03-30 バクスター・ヘルスケヤー・ソシエテ・アノニムＢａｘｔｅｒ Ｈｅａｌｔｈｃａｒｅ ＳＡ 出血性障害を処置するための方法
JP2012528597A (ja) 2009-06-03 2012-11-15 レガド・バイオサイエンシズ・インク 血小板グリコプロテインｖｉの核酸調節因子
KR20220038506A (ko) 2009-06-10 2022-03-28 알닐람 파마슈티칼스 인코포레이티드 향상된 지질 조성물
IN2012DN02345A (enExample) 2009-09-16 2015-08-21 Univ Duke
US9061043B2 (en) 2010-10-13 2015-06-23 Duke University Aptamers to glycoprotein VI
WO2012149024A2 (en) * 2011-04-28 2012-11-01 Mayo Foundation For Medical Education And Research Dna aptamers for promoting remyelination
WO2012151575A2 (en) 2011-05-05 2012-11-08 Duke University A method of controlling coagulation
WO2013043902A1 (en) 2011-09-21 2013-03-28 Nplex Laboratory Inc. Targeted nanoparticles joined to reporter molecules through multiple mechanisms
AU2013340414B2 (en) * 2012-10-23 2019-05-02 Caris Science, Inc. Aptamers and uses thereof
WO2014193800A2 (en) * 2013-05-28 2014-12-04 The Johns Hopkins University Aptamers for the treatment of sickle cell disease
WO2016176426A1 (en) 2015-04-28 2016-11-03 Duke University Thrombus imaging aptamers and methods of using same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008512098A (ja) 2004-09-07 2008-04-24 アーケミックス コーポレイション フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用
WO2008066621A2 (en) 2006-10-19 2008-06-05 Duke University Reversible platelet inhibition
US20120264815A1 (en) 2006-10-19 2012-10-18 Duke University Reversible platelet inhibition
WO2014169049A1 (en) 2013-04-09 2014-10-16 Duke University 2' fluoro-modified rnas as immunostimulators
WO2016019270A1 (en) 2014-07-31 2016-02-04 Academia Sinica An antagonistic pd-1 aptamer and its applications in cancer therapy related applications

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