JP7560821B2 - フォン・ビルブラント因子(vwf)標的薬剤およびそれを用いる方法 - Google Patents
フォン・ビルブラント因子(vwf)標的薬剤およびそれを用いる方法 Download PDFInfo
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- JP7560821B2 JP7560821B2 JP2019515294A JP2019515294A JP7560821B2 JP 7560821 B2 JP7560821 B2 JP 7560821B2 JP 2019515294 A JP2019515294 A JP 2019515294A JP 2019515294 A JP2019515294 A JP 2019515294A JP 7560821 B2 JP7560821 B2 JP 7560821B2
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- aptamer
- nucleotides
- polynucleotide
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
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- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022176918A JP7675990B2 (ja) | 2016-09-16 | 2022-11-04 | フォン・ビルブラント因子(vwf)標的薬剤およびそれを用いる方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662395642P | 2016-09-16 | 2016-09-16 | |
| US62/395,642 | 2016-09-16 | ||
| PCT/US2017/052063 WO2018053427A1 (en) | 2016-09-16 | 2017-09-18 | Von willebrand factor (vwf)-targeting agents and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022176918A Division JP7675990B2 (ja) | 2016-09-16 | 2022-11-04 | フォン・ビルブラント因子(vwf)標的薬剤およびそれを用いる方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528739A JP2019528739A (ja) | 2019-10-17 |
| JP2019528739A5 JP2019528739A5 (enExample) | 2020-11-12 |
| JP7560821B2 true JP7560821B2 (ja) | 2024-10-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019515294A Active JP7560821B2 (ja) | 2016-09-16 | 2017-09-18 | フォン・ビルブラント因子(vwf)標的薬剤およびそれを用いる方法 |
| JP2022176918A Active JP7675990B2 (ja) | 2016-09-16 | 2022-11-04 | フォン・ビルブラント因子(vwf)標的薬剤およびそれを用いる方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022176918A Active JP7675990B2 (ja) | 2016-09-16 | 2022-11-04 | フォン・ビルブラント因子(vwf)標的薬剤およびそれを用いる方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US10889816B2 (enExample) |
| EP (1) | EP3512526A4 (enExample) |
| JP (2) | JP7560821B2 (enExample) |
| CN (1) | CN109982707A (enExample) |
| WO (1) | WO2018053427A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10660973B2 (en) | 2015-04-28 | 2020-05-26 | Duke University | Thrombus imaging aptamers and methods of using same |
| CN112384236A (zh) * | 2018-03-27 | 2021-02-19 | Umc乌得勒支控股有限公司 | 用于治疗微血管血栓形成的靶向溶栓 |
| JP2022044843A (ja) * | 2018-12-11 | 2022-03-18 | 日産化学株式会社 | 解毒剤 |
| EP4100121A4 (en) * | 2020-02-04 | 2024-04-10 | Band Therapeutics, LLC | REGULATION OF THE VON WILLEBRAND FACTOR (VWF) |
| CN113244381A (zh) * | 2021-06-02 | 2021-08-13 | 苏州大学 | 游离的血红蛋白及其衍生物抗血小板聚集的应用 |
| WO2025076424A1 (en) * | 2023-10-06 | 2025-04-10 | Ohio State Innovation Foundation | Aptamer bb-031 and methods of using thereof |
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| JP2008512098A (ja) | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用 |
| WO2008066621A2 (en) | 2006-10-19 | 2008-06-05 | Duke University | Reversible platelet inhibition |
| US20120264815A1 (en) | 2006-10-19 | 2012-10-18 | Duke University | Reversible platelet inhibition |
| WO2014169049A1 (en) | 2013-04-09 | 2014-10-16 | Duke University | 2' fluoro-modified rnas as immunostimulators |
| WO2016019270A1 (en) | 2014-07-31 | 2016-02-04 | Academia Sinica | An antagonistic pd-1 aptamer and its applications in cancer therapy related applications |
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| AU2001296305B2 (en) | 2000-09-26 | 2007-12-06 | Duke University | RNA aptamers and methods for identifying the same |
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| AUPR604101A0 (en) | 2001-06-29 | 2001-07-26 | Unisearch Limited | Aptamers |
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| US20060193821A1 (en) | 2004-03-05 | 2006-08-31 | Diener John L | Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics |
| CN103045601B (zh) | 2004-04-22 | 2015-04-01 | 雷加多生物科学公司 | 改良的凝血因子调节物 |
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| JP2023014102A (ja) | 2023-01-26 |
| JP7675990B2 (ja) | 2025-05-14 |
| US20190218553A1 (en) | 2019-07-18 |
| EP3512526A1 (en) | 2019-07-24 |
| WO2018053427A1 (en) | 2018-03-22 |
| US10889816B2 (en) | 2021-01-12 |
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| EP3512526A4 (en) | 2020-05-27 |
| JP2019528739A (ja) | 2019-10-17 |
| CN109982707A (zh) | 2019-07-05 |
| US20240318178A1 (en) | 2024-09-26 |
| US20210222170A1 (en) | 2021-07-22 |
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