JP2019528290A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019528290A5 JP2019528290A5 JP2019510593A JP2019510593A JP2019528290A5 JP 2019528290 A5 JP2019528290 A5 JP 2019528290A5 JP 2019510593 A JP2019510593 A JP 2019510593A JP 2019510593 A JP2019510593 A JP 2019510593A JP 2019528290 A5 JP2019528290 A5 JP 2019528290A5
- Authority
- JP
- Japan
- Prior art keywords
- diazaspiro
- thioxo
- benzamide
- pyridyl
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 150000003839 salts Chemical group 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 239000005557 antagonist Substances 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- BAANHOAPFBHUDX-UHFFFAOYSA-N 4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide Chemical compound C1=C(F)C(C(=O)N)=CC=C1N1C2(CCC2)C(=O)N(C=2C=C(C(C#N)=NC=2)C(F)(F)F)C1=S BAANHOAPFBHUDX-UHFFFAOYSA-N 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662377932P | 2016-08-22 | 2016-08-22 | |
| US62/377,932 | 2016-08-22 | ||
| PCT/IB2017/055063 WO2018037342A1 (en) | 2016-08-22 | 2017-08-22 | Thiohydantoin androgen receptor antagonists for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019528290A JP2019528290A (ja) | 2019-10-10 |
| JP2019528290A5 true JP2019528290A5 (enExample) | 2020-10-01 |
Family
ID=60009664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019510593A Pending JP2019528290A (ja) | 2016-08-22 | 2017-08-22 | 癌の治療のためのチオヒダントインアンドロゲン受容体アンタゴニスト |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20190209539A1 (enExample) |
| EP (1) | EP3500259A1 (enExample) |
| JP (1) | JP2019528290A (enExample) |
| KR (1) | KR20190040030A (enExample) |
| CN (1) | CN109640986A (enExample) |
| AU (1) | AU2017316756A1 (enExample) |
| BR (1) | BR112019003406A2 (enExample) |
| CA (1) | CA3034449A1 (enExample) |
| MA (1) | MA45992A (enExample) |
| MX (1) | MX2019002097A (enExample) |
| RU (1) | RU2019108092A (enExample) |
| WO (1) | WO2018037342A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111032644B (zh) * | 2017-08-07 | 2021-08-10 | 正大天晴药业集团股份有限公司 | 用作雄激素受体拮抗剂的二芳基硫代乙内酰脲化合物 |
| AU2019387367A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Diarylhydantoin compounds and methods of use thereof |
| BR112021015122A2 (pt) | 2019-02-01 | 2021-09-28 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd | Cristal de composto de diariltio-hidantoína |
| CN115403624B (zh) * | 2022-09-30 | 2024-08-27 | 上海应用技术大学 | 一种二芳基硫代乙内酰脲化合物及其制备方法与应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA028869B1 (ru) * | 2010-02-16 | 2018-01-31 | Арагон Фармасьютикалс, Инк. | Модуляторы рецептора андрогенов и их применение |
| EP2911666B1 (en) * | 2012-10-26 | 2022-08-24 | Memorial Sloan-Kettering Cancer Center | Modulators of resistant androgen receptor |
-
2017
- 2017-08-22 EP EP17778334.7A patent/EP3500259A1/en not_active Withdrawn
- 2017-08-22 CN CN201780051671.2A patent/CN109640986A/zh active Pending
- 2017-08-22 CA CA3034449A patent/CA3034449A1/en not_active Abandoned
- 2017-08-22 BR BR112019003406-4A patent/BR112019003406A2/pt not_active Application Discontinuation
- 2017-08-22 MX MX2019002097A patent/MX2019002097A/es unknown
- 2017-08-22 MA MA045992A patent/MA45992A/fr unknown
- 2017-08-22 KR KR1020197007833A patent/KR20190040030A/ko not_active Ceased
- 2017-08-22 WO PCT/IB2017/055063 patent/WO2018037342A1/en not_active Ceased
- 2017-08-22 RU RU2019108092A patent/RU2019108092A/ru not_active Application Discontinuation
- 2017-08-22 JP JP2019510593A patent/JP2019528290A/ja active Pending
- 2017-08-22 AU AU2017316756A patent/AU2017316756A1/en not_active Abandoned
- 2017-08-22 US US16/327,703 patent/US20190209539A1/en not_active Abandoned