RU2019108092A - Тиогидантоиновые антагонисты андрогеновых рецепторов для лечения рака - Google Patents
Тиогидантоиновые антагонисты андрогеновых рецепторов для лечения рака Download PDFInfo
- Publication number
- RU2019108092A RU2019108092A RU2019108092A RU2019108092A RU2019108092A RU 2019108092 A RU2019108092 A RU 2019108092A RU 2019108092 A RU2019108092 A RU 2019108092A RU 2019108092 A RU2019108092 A RU 2019108092A RU 2019108092 A RU2019108092 A RU 2019108092A
- Authority
- RU
- Russia
- Prior art keywords
- thiogydantoin
- antagonists
- cancer treatment
- androgen receptors
- subject
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (4)
- Способ лечения и/или облегчения заболеваний, синдромов, расстройств или состояний, ассоциированных с мутантными рецепторами АР, связанными с кастрационно–резистентным раком предстательной железы, у субъекта, включая нуждающегося в этом млекопитающего и/или человека, который продемонстрировал резистентность к антагонисту АР первого или второго поколения, включающий, состоящий из и/или по существу состоящий из, введения нуждающемуся в этом субъекту терапевтически эффективного количества 4–[6–[6–циано–5–(трифторметил)–3–пиридил]–5–оксо–7–тиоксо–6,8–диазаспиро[3.4]октан–8–ил]–2–фторбензамида (соединения 80),
-
- соединения 80
- или его фармацевтически приемлемой солевой формы.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662377932P | 2016-08-22 | 2016-08-22 | |
| US62/377,932 | 2016-08-22 | ||
| PCT/IB2017/055063 WO2018037342A1 (en) | 2016-08-22 | 2017-08-22 | Thiohydantoin androgen receptor antagonists for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019108092A true RU2019108092A (ru) | 2020-09-22 |
| RU2019108092A3 RU2019108092A3 (ru) | 2020-11-30 |
Family
ID=60009664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019108092A RU2019108092A (ru) | 2016-08-22 | 2017-08-22 | Тиогидантоиновые антагонисты андрогеновых рецепторов для лечения рака |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20190209539A1 (ru) |
| EP (1) | EP3500259A1 (ru) |
| JP (1) | JP2019528290A (ru) |
| KR (1) | KR20190040030A (ru) |
| CN (1) | CN109640986A (ru) |
| AU (1) | AU2017316756A1 (ru) |
| BR (1) | BR112019003406A2 (ru) |
| CA (1) | CA3034449A1 (ru) |
| MA (1) | MA45992A (ru) |
| MX (1) | MX2019002097A (ru) |
| RU (1) | RU2019108092A (ru) |
| WO (1) | WO2018037342A1 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111032644B (zh) * | 2017-08-07 | 2021-08-10 | 正大天晴药业集团股份有限公司 | 用作雄激素受体拮抗剂的二芳基硫代乙内酰脲化合物 |
| AU2019387367A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Diarylhydantoin compounds and methods of use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011103202A2 (en) * | 2010-02-16 | 2011-08-25 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and uses thereof |
| US9365542B2 (en) * | 2012-10-26 | 2016-06-14 | Memorial Sloan-Kettering Cancer Center | Modulators of resistant androgen receptor |
-
2017
- 2017-08-22 RU RU2019108092A patent/RU2019108092A/ru not_active Application Discontinuation
- 2017-08-22 WO PCT/IB2017/055063 patent/WO2018037342A1/en unknown
- 2017-08-22 CA CA3034449A patent/CA3034449A1/en not_active Abandoned
- 2017-08-22 EP EP17778334.7A patent/EP3500259A1/en not_active Withdrawn
- 2017-08-22 JP JP2019510593A patent/JP2019528290A/ja active Pending
- 2017-08-22 CN CN201780051671.2A patent/CN109640986A/zh active Pending
- 2017-08-22 KR KR1020197007833A patent/KR20190040030A/ko not_active Application Discontinuation
- 2017-08-22 AU AU2017316756A patent/AU2017316756A1/en not_active Abandoned
- 2017-08-22 MA MA045992A patent/MA45992A/fr unknown
- 2017-08-22 US US16/327,703 patent/US20190209539A1/en not_active Abandoned
- 2017-08-22 BR BR112019003406-4A patent/BR112019003406A2/pt not_active Application Discontinuation
- 2017-08-22 MX MX2019002097A patent/MX2019002097A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2019108092A3 (ru) | 2020-11-30 |
| JP2019528290A (ja) | 2019-10-10 |
| AU2017316756A1 (en) | 2019-02-21 |
| MA45992A (fr) | 2019-06-26 |
| WO2018037342A1 (en) | 2018-03-01 |
| CA3034449A1 (en) | 2018-03-01 |
| KR20190040030A (ko) | 2019-04-16 |
| EP3500259A1 (en) | 2019-06-26 |
| CN109640986A (zh) | 2019-04-16 |
| MX2019002097A (es) | 2019-05-15 |
| US20190209539A1 (en) | 2019-07-11 |
| BR112019003406A2 (pt) | 2019-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20211025 |