JP2019528081A5 - - Google Patents
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- JP2019528081A5 JP2019528081A5 JP2019511953A JP2019511953A JP2019528081A5 JP 2019528081 A5 JP2019528081 A5 JP 2019528081A5 JP 2019511953 A JP2019511953 A JP 2019511953A JP 2019511953 A JP2019511953 A JP 2019511953A JP 2019528081 A5 JP2019528081 A5 JP 2019528081A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- mirna
- endometriosis
- suspected
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 23
- 108091070501 miRNA Proteins 0.000 claims 16
- 239000002679 microRNA Substances 0.000 claims 16
- 201000009273 Endometriosis Diseases 0.000 claims 15
- 239000000523 sample Substances 0.000 claims 9
- 239000002299 complementary DNA Substances 0.000 claims 5
- 230000001105 regulatory effect Effects 0.000 claims 5
- 238000012544 monitoring process Methods 0.000 claims 4
- 238000003745 diagnosis Methods 0.000 claims 3
- 108091062221 miR-18a stem-loop Proteins 0.000 claims 3
- 108091065175 miR-3613 stem-loop Proteins 0.000 claims 3
- 238000010839 reverse transcription Methods 0.000 claims 3
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 claims 2
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 claims 2
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 claims 2
- 108091073532 miR-143 stem-loop Proteins 0.000 claims 2
- 108091053592 miR-145-1 stem-loop Proteins 0.000 claims 2
- 108091056559 miR-145-2 stem-loop Proteins 0.000 claims 2
- 108091090860 miR-150 stem-loop Proteins 0.000 claims 2
- 108091038080 miR-18a-1 stem-loop Proteins 0.000 claims 2
- 108091055145 miR-342 stem-loop Proteins 0.000 claims 2
- 108091032770 miR-451 stem-loop Proteins 0.000 claims 2
- 108091030646 miR-451a stem-loop Proteins 0.000 claims 2
- 108091043157 miR-500a stem-loop Proteins 0.000 claims 2
- 108091049400 miR-6755 stem-loop Proteins 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 1
- 108091007772 MIRLET7C Proteins 0.000 claims 1
- 108091046841 MiR-150 Proteins 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000000052 comparative effect Effects 0.000 claims 1
- 229940124558 contraceptive agent Drugs 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- 238000009830 intercalation Methods 0.000 claims 1
- 108091023663 let-7 stem-loop Proteins 0.000 claims 1
- 108091063478 let-7-1 stem-loop Proteins 0.000 claims 1
- 108091049777 let-7-2 stem-loop Proteins 0.000 claims 1
- 108091091807 let-7a stem-loop Proteins 0.000 claims 1
- 108091057746 let-7a-4 stem-loop Proteins 0.000 claims 1
- 108091028376 let-7a-5 stem-loop Proteins 0.000 claims 1
- 108091024393 let-7a-6 stem-loop Proteins 0.000 claims 1
- 108091091174 let-7a-7 stem-loop Proteins 0.000 claims 1
- 108091007423 let-7b Proteins 0.000 claims 1
- 108091033753 let-7d stem-loop Proteins 0.000 claims 1
- 108091024449 let-7e stem-loop Proteins 0.000 claims 1
- 108091044227 let-7e-1 stem-loop Proteins 0.000 claims 1
- 108091071181 let-7e-2 stem-loop Proteins 0.000 claims 1
- 108091063986 let-7f stem-loop Proteins 0.000 claims 1
- 108091007427 let-7g Proteins 0.000 claims 1
- 108091084619 miR-125b-1 stem-loop Proteins 0.000 claims 1
- 108091063409 miR-125b-2 stem-loop Proteins 0.000 claims 1
- 108091050014 miR-125b-3 stem-loop Proteins 0.000 claims 1
- 108091058688 miR-141 stem-loop Proteins 0.000 claims 1
- 108091041042 miR-18 stem-loop Proteins 0.000 claims 1
- 108091059199 miR-200a stem-loop Proteins 0.000 claims 1
- 108091089775 miR-200b stem-loop Proteins 0.000 claims 1
- 108091090583 miR-34c stem-loop Proteins 0.000 claims 1
- 108091082133 miR-34c-1 stem-loop Proteins 0.000 claims 1
- 108091037327 miR-449 stem-loop Proteins 0.000 claims 1
- 108091040525 miR-449a stem-loop Proteins 0.000 claims 1
- 108091055732 miR-4668 stem-loop Proteins 0.000 claims 1
- 108091038400 miR-553 stem-loop Proteins 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022147738A JP2022188086A (ja) | 2016-08-30 | 2022-09-16 | 子宮内膜症についてのバイオマーカーとしてのマイクロｒｎａ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662381130P | 2016-08-30 | 2016-08-30 | |
| US62/381,130 | 2016-08-30 | ||
| PCT/US2017/049284 WO2018044979A1 (en) | 2016-08-30 | 2017-08-30 | Micrornas as biomarkers for endometriosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022147738A Division JP2022188086A (ja) | 2016-08-30 | 2022-09-16 | 子宮内膜症についてのバイオマーカーとしてのマイクロｒｎａ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019528081A JP2019528081A (ja) | 2019-10-10 |
| JP2019528081A5 true JP2019528081A5 (cg-RX-API-DMAC7.html) | 2020-10-08 |
Family
ID=61301726
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511953A Pending JP2019528081A (ja) | 2016-08-30 | 2017-08-30 | 子宮内膜症についてのバイオマーカーとしてのマイクロｒｎａ |
| JP2022147738A Pending JP2022188086A (ja) | 2016-08-30 | 2022-09-16 | 子宮内膜症についてのバイオマーカーとしてのマイクロｒｎａ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022147738A Pending JP2022188086A (ja) | 2016-08-30 | 2022-09-16 | 子宮内膜症についてのバイオマーカーとしてのマイクロｒｎａ |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10982282B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3506912B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2019528081A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20190057305A (cg-RX-API-DMAC7.html) |
| CN (1) | CN109890394A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017319325A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112019004075A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3035429A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2019002425A (cg-RX-API-DMAC7.html) |
| SG (2) | SG11201901834WA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018044979A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3122905B1 (en) | 2014-03-27 | 2020-09-09 | Yale University | Circulating micrornas as biomarkers for endometriosis |
| US10982282B2 (en) | 2016-08-30 | 2021-04-20 | Yale University | MicroRNAs as biomarkers for endometriosis |
| CA3073829A1 (en) * | 2017-08-30 | 2019-03-07 | Dot Laboratories, Inc. | Methods and compositions for detecting and treating endometriosis |
| WO2020014566A2 (en) * | 2018-07-13 | 2020-01-16 | Yale University | Compositions and methods for treating endometriosis |
| KR102089559B1 (ko) * | 2018-08-31 | 2020-03-16 | 차의과학대학교 산학협력단 | 난소의 fsh에 대한 반응성의 진단 또는 예측용 바이오마커 및 이의 용도 |
| MX2021005046A (es) * | 2018-10-31 | 2021-06-15 | Univ Yale | Un algoritmo cuantitativo para la endometriosis. |
| US11315660B2 (en) | 2018-10-31 | 2022-04-26 | Dot Laboratories, Inc. | Method of detecting and treating endometriosis in a female subject |
| WO2020146544A1 (en) * | 2019-01-09 | 2020-07-16 | Research Institute At Nationwide Children's Hospital | A novel method for monitoring endometriosis and associated disorders |
| WO2020179895A1 (ja) | 2019-03-07 | 2020-09-10 | 東レ株式会社 | 子宮平滑筋肉腫の検出のためのキット、デバイス及び方法 |
| ES2787725A1 (es) * | 2019-04-15 | 2020-10-16 | Univ Granada | Metodo de obtencion de datos utiles para diagnosticar telangiectasia hemorragica hereditaria |
| CN110144394A (zh) * | 2019-04-18 | 2019-08-20 | 辽宁省肿瘤医院 | 一种子宫内膜异位症诊断、预后标志物及其应用 |
| BR112022000945A2 (pt) * | 2019-07-22 | 2022-03-08 | Hoffmann La Roche | Métodos para avaliar se uma paciente tem endometriose ou está em risco de desenvolver endometriose, para selecionar uma paciente para terapia e para monitorar uma paciente que sofre de endometriose ou que está sendo tratada para endometriose |
| KR20220016210A (ko) * | 2019-07-22 | 2022-02-08 | 에프. 호프만-라 로슈 아게 | 자궁내막증의 비-침습적 진단용 혈액 생물표지자로써 s100a9 |
| EP4004551A1 (en) * | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | Substance p as blood biomarker for the non-invasive diagnosis of endometriosis |
| US11965879B2 (en) * | 2019-08-23 | 2024-04-23 | Mcmaster University | Method for diagnosing and assessing endometriosis |
| KR102242639B1 (ko) * | 2020-01-28 | 2021-04-21 | 고려대학교 산학협력단 | 간 섬유화 진단용 바이오마커 miRNA4668-5p |
| KR102316507B1 (ko) * | 2020-02-28 | 2021-10-22 | 차의과학대학교 산학협력단 | 난소 예비력 바이오마커 및 이의 용도 |
| CN111909997B (zh) * | 2020-09-09 | 2021-09-28 | 上海交通大学 | miRNA标志物在制备奥氮平治疗精神分裂症疗效评估方面的产品中的应用及试剂盒 |
| JP2022063860A (ja) * | 2020-10-12 | 2022-04-22 | 学校法人近畿大学 | ホウ素化合物およびその製造方法 |
| KR20240084586A (ko) * | 2022-12-06 | 2024-06-14 | 연세대학교 산학협력단 | 자궁내막증 진단용 조성물 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009143181A2 (en) | 2008-05-19 | 2009-11-26 | The Regents Of The University Of California | Micro-rna profile in human saliva and its use for detection of oral cancer |
| WO2011109440A1 (en) * | 2010-03-01 | 2011-09-09 | Caris Life Sciences Luxembourg Holdings | Biomarkers for theranostics |
| EP2730662A1 (en) | 2008-11-12 | 2014-05-14 | Caris Life Sciences Luxembourg Holdings | Methods and systems of using exosomes for determining phenotypes |
| US20120093936A1 (en) | 2009-04-07 | 2012-04-19 | Velin-Pharma A/S | Method and device for treatment of conditions associated with inflammation or undesirable activation of the immune system |
| WO2012103355A2 (en) | 2011-01-26 | 2012-08-02 | Cepheid | Methods of detecting lung cancer |
| WO2012112883A1 (en) | 2011-02-18 | 2012-08-23 | Yale University | The kras-variant and endometriosis |
| FR2984358A1 (fr) * | 2011-12-16 | 2013-06-21 | Genethon | Methodes pour le diagnostic de dystrophies musculaires |
| WO2013148151A1 (en) | 2012-03-29 | 2013-10-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Plasma microribonucleic acids as biomarkers for endometriosis and endometriosis-associated ovarian cancer |
| WO2015050875A1 (en) | 2013-10-01 | 2015-04-09 | The Regents Of The University Of California | Endometriosis classifier |
| ES2813699T3 (es) * | 2013-11-18 | 2021-03-24 | Diamir Llc | Métodos de uso de miARN de fluidos corporales para la detección y monitoreo de la enfermedad de Parkinson (PD) |
| GB201403489D0 (en) * | 2014-02-27 | 2014-04-16 | Univ London Queen Mary | Biomarkers for endometriosis |
| US9650676B2 (en) | 2014-03-19 | 2017-05-16 | University Of South Carolina | Leukocyte MicroRNAS for use in diagnosis and treatment of endometriosis |
| EP3122905B1 (en) | 2014-03-27 | 2020-09-09 | Yale University | Circulating micrornas as biomarkers for endometriosis |
| EP2924126B1 (en) * | 2014-03-28 | 2018-04-18 | Tervisetehnoloogiate Arenduskeskus AS | Method for using microRNA (miRNA) for detection of endometriosis |
| GB201603967D0 (en) * | 2016-03-08 | 2016-04-20 | Univ Birmingham | Biomarkers of traumatic brain injury |
| US10982282B2 (en) | 2016-08-30 | 2021-04-20 | Yale University | MicroRNAs as biomarkers for endometriosis |
| CA3073829A1 (en) | 2017-08-30 | 2019-03-07 | Dot Laboratories, Inc. | Methods and compositions for detecting and treating endometriosis |
| US11315660B2 (en) | 2018-10-31 | 2022-04-26 | Dot Laboratories, Inc. | Method of detecting and treating endometriosis in a female subject |
| MX2021005046A (es) | 2018-10-31 | 2021-06-15 | Univ Yale | Un algoritmo cuantitativo para la endometriosis. |
| BR112021021866A2 (pt) | 2019-04-29 | 2021-12-21 | Dot Laboraties Inc | Classificadores para a detecção de endometriose |
-
2017
- 2017-08-30 US US16/329,436 patent/US10982282B2/en active Active
- 2017-08-30 WO PCT/US2017/049284 patent/WO2018044979A1/en not_active Ceased
- 2017-08-30 CA CA3035429A patent/CA3035429A1/en active Pending
- 2017-08-30 SG SG11201901834WA patent/SG11201901834WA/en unknown
- 2017-08-30 SG SG10202102509TA patent/SG10202102509TA/en unknown
- 2017-08-30 BR BR112019004075A patent/BR112019004075A2/pt unknown
- 2017-08-30 KR KR1020197009115A patent/KR20190057305A/ko not_active Ceased
- 2017-08-30 MX MX2019002425A patent/MX2019002425A/es unknown
- 2017-08-30 CN CN201780066779.9A patent/CN109890394A/zh active Pending
- 2017-08-30 AU AU2017319325A patent/AU2017319325A1/en not_active Abandoned
- 2017-08-30 JP JP2019511953A patent/JP2019528081A/ja active Pending
- 2017-08-30 EP EP17847431.8A patent/EP3506912B1/en active Active
-
2021
- 2021-02-25 US US17/184,894 patent/US11220713B2/en active Active
- 2021-11-02 US US17/517,014 patent/US12077803B2/en active Active
-
2022
- 2022-09-16 JP JP2022147738A patent/JP2022188086A/ja active Pending
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