JP2019509044A5 - - Google Patents
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- JP2019509044A5 JP2019509044A5 JP2018546868A JP2018546868A JP2019509044A5 JP 2019509044 A5 JP2019509044 A5 JP 2019509044A5 JP 2018546868 A JP2018546868 A JP 2018546868A JP 2018546868 A JP2018546868 A JP 2018546868A JP 2019509044 A5 JP2019509044 A5 JP 2019509044A5
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022116002A JP7413455B2 (ja) | 2016-03-08 | 2022-07-21 | 外傷性脳傷害のバイオマーカー |
| JP2023220147A JP7654769B2 (ja) | 2016-03-08 | 2023-12-27 | 外傷性脳傷害のバイオマーカー |
| JP2025044721A JP2025098112A (ja) | 2016-03-08 | 2025-03-19 | 外傷性脳傷害のバイオマーカー |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1603967.9 | 2016-03-08 | ||
| GBGB1603967.9A GB201603967D0 (en) | 2016-03-08 | 2016-03-08 | Biomarkers of traumatic brain injury |
| PCT/GB2017/050231 WO2017153710A1 (en) | 2016-03-08 | 2017-01-30 | Biomarkers of traumatic brain injury |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022116002A Division JP7413455B2 (ja) | 2016-03-08 | 2022-07-21 | 外傷性脳傷害のバイオマーカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509044A JP2019509044A (ja) | 2019-04-04 |
| JP2019509044A5 true JP2019509044A5 (cg-RX-API-DMAC7.html) | 2020-03-05 |
| JP7111619B2 JP7111619B2 (ja) | 2022-08-02 |
Family
ID=55859162
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546868A Active JP7111619B2 (ja) | 2016-03-08 | 2017-01-30 | 外傷性脳傷害のバイオマーカー |
| JP2019539924A Active JP7132224B2 (ja) | 2016-03-08 | 2017-12-22 | 外傷性脳傷害のバイオマーカー |
| JP2022116002A Active JP7413455B2 (ja) | 2016-03-08 | 2022-07-21 | 外傷性脳傷害のバイオマーカー |
| JP2023220147A Active JP7654769B2 (ja) | 2016-03-08 | 2023-12-27 | 外傷性脳傷害のバイオマーカー |
| JP2025044721A Pending JP2025098112A (ja) | 2016-03-08 | 2025-03-19 | 外傷性脳傷害のバイオマーカー |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539924A Active JP7132224B2 (ja) | 2016-03-08 | 2017-12-22 | 外傷性脳傷害のバイオマーカー |
| JP2022116002A Active JP7413455B2 (ja) | 2016-03-08 | 2022-07-21 | 外傷性脳傷害のバイオマーカー |
| JP2023220147A Active JP7654769B2 (ja) | 2016-03-08 | 2023-12-27 | 外傷性脳傷害のバイオマーカー |
| JP2025044721A Pending JP2025098112A (ja) | 2016-03-08 | 2025-03-19 | 外傷性脳傷害のバイオマーカー |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US20190085395A1 (cg-RX-API-DMAC7.html) |
| EP (7) | EP3426796B1 (cg-RX-API-DMAC7.html) |
| JP (5) | JP7111619B2 (cg-RX-API-DMAC7.html) |
| KR (4) | KR20240167935A (cg-RX-API-DMAC7.html) |
| CN (4) | CN109415769B (cg-RX-API-DMAC7.html) |
| AU (3) | AU2017231845B2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA3015150A1 (cg-RX-API-DMAC7.html) |
| ES (4) | ES2967073T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB201603967D0 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ782016A (cg-RX-API-DMAC7.html) |
| PL (2) | PL3712277T3 (cg-RX-API-DMAC7.html) |
| UA (1) | UA127918C2 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2017153710A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201805982B (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3122905B1 (en) | 2014-03-27 | 2020-09-09 | Yale University | Circulating micrornas as biomarkers for endometriosis |
| GB201603967D0 (en) | 2016-03-08 | 2016-04-20 | Univ Birmingham | Biomarkers of traumatic brain injury |
| US10982282B2 (en) * | 2016-08-30 | 2021-04-20 | Yale University | MicroRNAs as biomarkers for endometriosis |
| KR102621064B1 (ko) * | 2017-03-23 | 2024-01-03 | 콰드런트 바이오사이언시즈 인코포레이티드 | 외상성 뇌 손상 및 뇌진탕 증상의 분석 및 예측 |
| US11739323B2 (en) * | 2017-06-08 | 2023-08-29 | Temple University-Of The Commonwealth System Of Higher Education | Micro-RNAs as biomarkers for subconcussive and concussive injury and therapeutic applications |
| MA52796A (fr) | 2018-05-31 | 2021-04-14 | Amydis Inc | Compositions et procédés de détection d'une lésion cérébrale traumatique |
| SG10201807529VA (en) * | 2018-09-03 | 2020-04-29 | Nec Asia Pacific Pte Ltd | Systems and methods for predicting recovery of a patient |
| US11315660B2 (en) | 2018-10-31 | 2022-04-26 | Dot Laboratories, Inc. | Method of detecting and treating endometriosis in a female subject |
| BR112021015845A2 (pt) | 2019-02-14 | 2021-10-05 | Marker Diagnostics Uk Limited | Biomarcadores salivares de lesão cerebral |
| KR102184840B1 (ko) * | 2019-05-20 | 2020-11-30 | 이화여자대학교 산학협력단 | 외상 후 스트레스 장애 진단 또는 예측용 바이오마커 및 그의 용도 |
| US11965879B2 (en) * | 2019-08-23 | 2024-04-23 | Mcmaster University | Method for diagnosing and assessing endometriosis |
| KR102272915B1 (ko) | 2019-09-27 | 2021-07-06 | 주식회사 이지다이아텍 | 새로운 외상성 뇌손상 및 감염병 poct 진단시스템 |
| CN110684835A (zh) * | 2019-10-12 | 2020-01-14 | 山东大学齐鲁医院 | miR-21在诊治蛛网膜下腔出血中的应用 |
| CN111419866A (zh) * | 2020-03-02 | 2020-07-17 | 南通大学 | miR-29a-3p在制备治疗周围神经损伤药物中的应用 |
| US12157918B2 (en) * | 2020-09-04 | 2024-12-03 | University Of Kentucky Research Foundation | Clinical assessment of cerebral vasospasm risk following aneurysmal subarachnoid hemorrhage |
| IL307369A (en) | 2021-04-02 | 2023-11-01 | Marker Holdings Ag | Biomarkers of muscle and skeletal injury |
| CN116219019A (zh) * | 2023-03-02 | 2023-06-06 | 圣湘生物科技股份有限公司 | 一种用于结直肠癌诊断的microRNA标志物组合物及检测试剂、检测试剂盒 |
| WO2024242411A1 (ko) | 2023-05-19 | 2024-11-28 | 주식회사 이지다이아텍 | 자동 항체 커플링 및 이를 확인하는 장치 |
| WO2025039033A1 (en) * | 2023-08-21 | 2025-02-27 | Glia Diagnostics Pty Ltd | Methods and reagents for diagnosis and/or prognosis of traumatic brain injury |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH31414A (en) | 1994-02-24 | 1998-10-29 | Boehringer Ingelheim Int | Method of diagnosing cancer precancerous state, orsusceptibility to other forms of diseases by anal ysis of irf-1 specific rna in biopsy samples. |
| EP1038259B1 (de) | 1997-12-18 | 2003-04-09 | Infineon Technologies AG | Vorrichtung zur bilderfassung |
| RU66524U1 (ru) | 2007-05-03 | 2007-09-10 | Федор Андреевич Егоров | Сооружение, в котором обеспечена возможность комплексного мониторинга сооружения |
| CN101424640B (zh) | 2007-11-02 | 2012-07-25 | 江苏命码生物科技有限公司 | 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法 |
| DE102008017652A1 (de) | 2008-04-04 | 2009-10-08 | Leonhard Kurz Stiftung & Co. Kg | Sicherheitselement sowie Verfahren zur Herstellung eines Sicherheitselements |
| WO2011109440A1 (en) | 2010-03-01 | 2011-09-09 | Caris Life Sciences Luxembourg Holdings | Biomarkers for theranostics |
| EP2336353A1 (en) | 2009-12-17 | 2011-06-22 | febit holding GmbH | miRNA fingerprints in the diagnosis of diseases |
| WO2011032155A2 (en) | 2009-09-14 | 2011-03-17 | Banyan Biomarkers, Inc. | Micro-rna, autoantibody and protein markers for diagnosis of neuronal injury |
| RU93660U1 (ru) | 2010-02-08 | 2010-05-10 | Государственное образовательное учреждение высшего профессионального образования "Ростовский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО "РостГМУ Росздрава") | Тест-полоска для диагностики нефропатии |
| AU2013248981B2 (en) * | 2012-04-20 | 2018-11-29 | Aptamir Therapeutics, Inc. | Mirna modulators of thermogenesis |
| WO2014004889A2 (en) | 2012-06-27 | 2014-01-03 | Musc Foundation For Research Development | Plasma analytes predict diagnosis and prognosis of thoracic aortic aneurysm |
| GB201223243D0 (en) * | 2012-12-21 | 2013-02-06 | King S College London | Detection method |
| WO2014152773A1 (en) | 2013-03-15 | 2014-09-25 | The Trustees Of The University Of Pennsylvania | Blood biomarkers that predict persistent cognitive dysfunction after concussion |
| US9890428B2 (en) * | 2013-05-14 | 2018-02-13 | Ohio State Innovation Foundation | MiRNA biomarkers for radiation biodosimetry |
| US9434945B2 (en) * | 2013-08-02 | 2016-09-06 | University Of Maryland, Baltimore | Use of miR-23a-3p and/or miR-27a-3p mimics as therapeutic agents for inhibition of neuronal apoptosis following brain injury |
| CN103667445A (zh) * | 2013-10-16 | 2014-03-26 | 石磊 | 一种脑梗塞早期诊断标志物及其应用 |
| ES2813699T3 (es) * | 2013-11-18 | 2021-03-24 | Diamir Llc | Métodos de uso de miARN de fluidos corporales para la detección y monitoreo de la enfermedad de Parkinson (PD) |
| US9801257B2 (en) * | 2014-02-26 | 2017-10-24 | Philips Lighting Holding B.V. | Light reflectance based detection |
| WO2015134551A1 (en) * | 2014-03-03 | 2015-09-11 | Banyan Biomarkers, Inc. | Micro rna markers for diagnosis of a neurological condition |
| US9605315B2 (en) * | 2014-03-26 | 2017-03-28 | The University Of Montana | Detection of traumatic brain injury |
| WO2015153864A2 (en) | 2014-04-02 | 2015-10-08 | Hopkins Patricia T | Methods for treating inflammatory conditions |
| US10370717B2 (en) * | 2014-04-22 | 2019-08-06 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods for the measurement of post-traumatic stress disorder microRNA markers |
| WO2015196191A1 (en) * | 2014-06-20 | 2015-12-23 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Microrna biomarkers for traumatic brain injury and methods of use thereof |
| ES2558262B2 (es) | 2014-08-01 | 2016-07-14 | Universidad Católica De Valencia "San Vicente Mártir" | Método de diagnóstico de fibromialgia basado en microRNAs |
| CN104293791B (zh) * | 2014-10-22 | 2018-01-12 | 首都医科大学附属北京友谊医院 | miR‑200b在制备Rac‑1蛋白表达抑制剂中的新用途 |
| US20180216187A1 (en) * | 2015-07-29 | 2018-08-02 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Microrna biomarkers for traumatic brain injury and methods of use thereof |
| EP3347493B1 (en) * | 2015-09-08 | 2022-03-30 | The Translational Genomics Research Institute | Biomarkers and methods of diagnosing mild traumatic brain injuries |
| GB201603967D0 (en) | 2016-03-08 | 2016-04-20 | Univ Birmingham | Biomarkers of traumatic brain injury |
| AU2018239339A1 (en) | 2017-03-23 | 2019-10-03 | Penn State Research Foundation | Method for diagnosing or monitoring conditions characterized by abnormal temporal variations method of normalizing epigenetic data to compensate for temporal variations |
| KR102621064B1 (ko) * | 2017-03-23 | 2024-01-03 | 콰드런트 바이오사이언시즈 인코포레이티드 | 외상성 뇌 손상 및 뇌진탕 증상의 분석 및 예측 |
| BR112021015845A2 (pt) | 2019-02-14 | 2021-10-05 | Marker Diagnostics Uk Limited | Biomarcadores salivares de lesão cerebral |
-
2016
- 2016-03-08 GB GBGB1603967.9A patent/GB201603967D0/en not_active Ceased
-
2017
- 2017-01-30 US US16/083,178 patent/US20190085395A1/en not_active Abandoned
- 2017-01-30 ES ES17703217T patent/ES2967073T3/es active Active
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