JP2019525936A5 - - Google Patents
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- JP2019525936A5 JP2019525936A5 JP2019504110A JP2019504110A JP2019525936A5 JP 2019525936 A5 JP2019525936 A5 JP 2019525936A5 JP 2019504110 A JP2019504110 A JP 2019504110A JP 2019504110 A JP2019504110 A JP 2019504110A JP 2019525936 A5 JP2019525936 A5 JP 2019525936A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367389P | 2016-07-27 | 2016-07-27 | |
| US62/367,389 | 2016-07-27 | ||
| PCT/US2017/044194 WO2018022897A1 (en) | 2016-07-27 | 2017-07-27 | Covalent inhibitors of pad4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525936A JP2019525936A (ja) | 2019-09-12 |
| JP2019525936A5 true JP2019525936A5 (enExample) | 2020-09-03 |
| JP6987843B2 JP6987843B2 (ja) | 2022-01-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504110A Active JP6987843B2 (ja) | 2016-07-27 | 2017-07-27 | Ｐａｄ４の共有結合性阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10703741B2 (enExample) |
| EP (1) | EP3490989B1 (enExample) |
| JP (1) | JP6987843B2 (enExample) |
| KR (1) | KR102398941B1 (enExample) |
| CN (1) | CN109790162B (enExample) |
| ES (1) | ES2828623T3 (enExample) |
| WO (1) | WO2018022897A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3419969B1 (en) | 2016-02-23 | 2019-12-18 | Padlock Therapeutics, Inc. | Heteroaryl inhibitors of pad4 |
| CN110248934B (zh) | 2016-09-12 | 2022-05-24 | 帕德罗科治疗公司 | 杂芳基pad4抑制剂 |
| KR20210042933A (ko) * | 2018-08-08 | 2021-04-20 | 브리스톨-마이어스 스큅 컴퍼니 | Pad 효소의 벤즈이미다졸 억제제 |
| CN112566916B (zh) | 2018-08-08 | 2023-10-20 | 百时美施贵宝公司 | 作为pad4抑制剂的经取代的噻吩并吡咯 |
| EP3833440A1 (en) | 2018-08-08 | 2021-06-16 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of pad enzymes |
| MX2021001471A (es) * | 2018-08-08 | 2021-04-28 | Bristol Myers Squibb Co | Benzimidazoles sustituidos como inhibidores de peptidil arginina deiminasa 4 (pad4). |
| WO2020085493A1 (ja) | 2018-10-26 | 2020-04-30 | 大鵬薬品工業株式会社 | 新規なインダゾール化合物又はその塩 |
| UA129778C2 (uk) | 2019-10-28 | 2025-07-30 | Мерк Шарп Енд Доум Елелсі | Низькомолекулярні інгібітори g12c-мутантного kras |
| WO2021084765A1 (en) * | 2019-10-31 | 2021-05-06 | Taiho Pharmaceutical Co., Ltd | 4-aminobut-2-enamide derivatives and salts thereof |
| WO2021102361A1 (en) * | 2019-11-22 | 2021-05-27 | The Regents Of The University Of California | Caspase 6 inhibitors and uses thereof |
| US12479834B2 (en) | 2019-11-29 | 2025-11-25 | Taiho Pharmaceutical Co., Ltd. | Phenol compound or salt thereof |
| WO2021158840A1 (en) * | 2020-02-06 | 2021-08-12 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| PE20230488A1 (es) | 2020-04-30 | 2023-03-21 | Gilead Sciences Inc | Inhibidores macrociclicos de las peptidilarginina deiminasas |
| US12240862B2 (en) | 2020-12-22 | 2025-03-04 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| EP4267562A1 (en) | 2020-12-22 | 2023-11-01 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| EP4329750A4 (en) * | 2021-04-27 | 2025-06-18 | Merck Sharp & Dohme LLC | Small-molecule inhibitors of the KRAS G12C mutant |
| CN119604287A (zh) * | 2022-05-26 | 2025-03-11 | 细胞基因公司 | 杂环pad4抑制剂 |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| TW202535891A (zh) | 2023-10-20 | 2025-09-16 | 美商默沙東有限責任公司 | Ｋｒａｓ蛋白之小分子抑制劑 |
Family Cites Families (11)
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|---|---|---|---|---|
| AU778689B2 (en) | 2000-02-09 | 2004-12-16 | Akzo Nobel N.V. | Pulping process |
| CA2555199A1 (en) * | 2004-02-04 | 2005-08-18 | Yokohama City University | Peptidylarginine deiminase 4 inhibitor |
| RU2424233C2 (ru) * | 2006-06-29 | 2011-07-20 | Ф.Хоффманн-Ля Рош Аг | Производные бензимидазола, методы их получения, применение их в качестве агонистов фарнезоид-х-рецептора (fxr) и содержащие их фармацевтические препараты |
| KR20090029827A (ko) * | 2006-07-20 | 2009-03-23 | 제네랩스 테크놀로지스, 인코포레이티드 | 폴리사이클릭 바이러스 억제제 |
| WO2014015905A1 (en) * | 2012-07-26 | 2014-01-30 | Glaxo Group Limited | 2 - (azaindol- 2 -yl) benz imidazoles as pad4 inhibitors |
| KR20150133172A (ko) * | 2013-03-15 | 2015-11-27 | 셀진 아빌로믹스 리서치, 인코포레이티드 | Mk2 억제제 및 이의 용도 |
| CA3199601A1 (en) * | 2015-05-21 | 2016-11-24 | Glaxosmithkline Intellectual Property Development Limited | Benzoimidazole derivatives as pad4 inhibitors |
| AR107030A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
| AR107032A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| EP3419969B1 (en) | 2016-02-23 | 2019-12-18 | Padlock Therapeutics, Inc. | Heteroaryl inhibitors of pad4 |
| CN110248934B (zh) | 2016-09-12 | 2022-05-24 | 帕德罗科治疗公司 | 杂芳基pad4抑制剂 |
-
2017
- 2017-07-27 WO PCT/US2017/044194 patent/WO2018022897A1/en not_active Ceased
- 2017-07-27 EP EP17749074.5A patent/EP3490989B1/en active Active
- 2017-07-27 JP JP2019504110A patent/JP6987843B2/ja active Active
- 2017-07-27 CN CN201780059309.XA patent/CN109790162B/zh active Active
- 2017-07-27 ES ES17749074T patent/ES2828623T3/es active Active
- 2017-07-27 KR KR1020197005300A patent/KR102398941B1/ko active Active
- 2017-07-27 US US16/319,006 patent/US10703741B2/en active Active
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