JP2019525936A5 - - Google Patents
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- JP2019525936A5 JP2019525936A5 JP2019504110A JP2019504110A JP2019525936A5 JP 2019525936 A5 JP2019525936 A5 JP 2019525936A5 JP 2019504110 A JP2019504110 A JP 2019504110A JP 2019504110 A JP2019504110 A JP 2019504110A JP 2019525936 A5 JP2019525936 A5 JP 2019525936A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367389P | 2016-07-27 | 2016-07-27 | |
| US62/367,389 | 2016-07-27 | ||
| PCT/US2017/044194 WO2018022897A1 (en) | 2016-07-27 | 2017-07-27 | Covalent inhibitors of pad4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525936A JP2019525936A (ja) | 2019-09-12 |
| JP2019525936A5 true JP2019525936A5 (enExample) | 2020-09-03 |
| JP6987843B2 JP6987843B2 (ja) | 2022-01-05 |
Family
ID=59523326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504110A Active JP6987843B2 (ja) | 2016-07-27 | 2017-07-27 | Ｐａｄ４の共有結合性阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10703741B2 (enExample) |
| EP (1) | EP3490989B1 (enExample) |
| JP (1) | JP6987843B2 (enExample) |
| KR (1) | KR102398941B1 (enExample) |
| CN (1) | CN109790162B (enExample) |
| ES (1) | ES2828623T3 (enExample) |
| WO (1) | WO2018022897A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201807021UA (en) | 2016-02-23 | 2018-09-27 | Padlock Therapeutics Inc | Heteroaryl inhibitors of pad4 |
| KR102502992B1 (ko) | 2016-09-12 | 2023-02-24 | 패들락 테라퓨틱스, 인코포레이티드 | Pad4의 헤테로아릴 억제제 |
| MX2021001471A (es) * | 2018-08-08 | 2021-04-28 | Bristol Myers Squibb Co | Benzimidazoles sustituidos como inhibidores de peptidil arginina deiminasa 4 (pad4). |
| EP3833440A1 (en) | 2018-08-08 | 2021-06-16 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of pad enzymes |
| ES2956090T3 (es) | 2018-08-08 | 2023-12-13 | Bristol Myers Squibb Co | Inhibidores de bencimidazol de enzimas PAD |
| ES2929200T3 (es) | 2018-08-08 | 2022-11-25 | Bristol Myers Squibb Co | Tienopirroles sustituidos como inhibidores de PAD4 |
| WO2020085504A1 (ja) | 2018-10-26 | 2020-04-30 | 大鵬薬品工業株式会社 | 光照射ザンドマイヤー反応を用いたクロロアゾールカルボキシレート誘導体の製造方法 |
| MD4051678T2 (en) | 2019-10-28 | 2026-07-31 | Merck Sharp & Dohme Llc | Small molecule inhibitors of the KRAS G12C mutant |
| WO2021084765A1 (en) * | 2019-10-31 | 2021-05-06 | Taiho Pharmaceutical Co., Ltd | 4-aminobut-2-enamide derivatives and salts thereof |
| WO2021085653A1 (en) | 2019-10-31 | 2021-05-06 | Taiho Pharmaceutical Co., Ltd. | 4-aminobut-2-enamide derivatives and salts thereof |
| EP4061341A4 (en) * | 2019-11-22 | 2024-04-10 | The Regents of the University of California | CASPASE6 INHIBITORS AND USES THEREOF |
| EP4067343A4 (en) | 2019-11-29 | 2024-01-03 | Taiho Pharmaceutical Co., Ltd. | NEW PHENOLIC COMPOUND OR SALT THEREOF |
| CN115298175B (zh) * | 2020-02-06 | 2024-05-07 | 百时美施贵宝公司 | 可用作免疫抑制剂的大环pad4抑制剂 |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| US12702658B2 (en) | 2020-04-24 | 2026-08-11 | Taiho Pharmaceutical Co., Ltd. | Anticancer combination therapy with N-(1-acryloyl-azetidin-3-yl)-2-((1H-indazol-3-yl)amino)methyl)-1H-imidazole-5-carboxamide inhibitor of KRAS-G12C |
| WO2021215544A1 (en) | 2020-04-24 | 2021-10-28 | Taiho Pharmaceutical Co., Ltd. | Kras g12d protein inhibitors |
| MX2022013615A (es) | 2020-04-30 | 2022-11-16 | Gilead Sciences Inc | Inhibidores de macrociclo de peptidilarginina deiminasas. |
| WO2022109487A1 (en) | 2020-11-23 | 2022-05-27 | Merck Sharp & Dohme Corp. | Spirocyclic-substituted 6,7-dihydro-pyrano[2,3-d]pyrimidine inhibitors of kras g12c mutant |
| TW202233174A (zh) | 2020-12-22 | 2022-09-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| EP4267562A1 (en) | 2020-12-22 | 2023-11-01 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| WO2022232320A1 (en) * | 2021-04-27 | 2022-11-03 | Merck Sharp & Dohme Corp. | Small molecule inhibitors of kras g12c mutant |
| EP4531849A4 (en) * | 2022-05-26 | 2026-05-20 | Celgene Corp | HETEROCYCLIC PAD4 INHIBITORS |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| KR20260096846A (ko) | 2023-10-20 | 2026-06-24 | 머크 샤프 앤드 돔 엘엘씨 | Kras 단백질의 소분자 억제제 |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1264038A2 (en) | 2000-02-09 | 2002-12-11 | Akzo Nobel N.V. | Pulping process |
| JPWO2005075414A1 (ja) * | 2004-02-04 | 2007-10-11 | 公立大学法人横浜市立大学 | ペプチジルアルギニンデイミナーゼ４阻害剤 |
| BRPI0713946A2 (pt) * | 2006-06-29 | 2012-12-04 | Hoffmann La Roche | compostos, composições farmacêuticas que os compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por agonistas de fxr, e uso dos compostos |
| PE20081113A1 (es) * | 2006-07-20 | 2008-10-03 | Genelabs Tech Inc | Inhibidores virales policiclicos |
| RU2611010C2 (ru) * | 2012-07-26 | 2017-02-17 | Глаксо Груп Лимитед | 2-(Азаиндол-2-ил)бензимидазолы в качестве ингибиторов PAD4 |
| US10138256B2 (en) * | 2013-03-15 | 2018-11-27 | Celgene Car Llc | MK2 inhibitors and uses thereof |
| WO2016185279A1 (en) * | 2015-05-21 | 2016-11-24 | Glaxosmithkline Intellectual Property Development Limited | Benzoimidazole derivatives as pad4 inhibitors |
| AR107030A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
| AR107032A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| SG11201807021UA (en) | 2016-02-23 | 2018-09-27 | Padlock Therapeutics Inc | Heteroaryl inhibitors of pad4 |
| KR102502992B1 (ko) | 2016-09-12 | 2023-02-24 | 패들락 테라퓨틱스, 인코포레이티드 | Pad4의 헤테로아릴 억제제 |
-
2017
- 2017-07-27 US US16/319,006 patent/US10703741B2/en active Active
- 2017-07-27 JP JP2019504110A patent/JP6987843B2/ja active Active
- 2017-07-27 WO PCT/US2017/044194 patent/WO2018022897A1/en not_active Ceased
- 2017-07-27 ES ES17749074T patent/ES2828623T3/es active Active
- 2017-07-27 EP EP17749074.5A patent/EP3490989B1/en active Active
- 2017-07-27 CN CN201780059309.XA patent/CN109790162B/zh active Active
- 2017-07-27 KR KR1020197005300A patent/KR102398941B1/ko active Active
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