JP2021502824A5 - - Google Patents
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- JP2021502824A5 JP2021502824A5 JP2020544356A JP2020544356A JP2021502824A5 JP 2021502824 A5 JP2021502824 A5 JP 2021502824A5 JP 2020544356 A JP2020544356 A JP 2020544356A JP 2020544356 A JP2020544356 A JP 2020544356A JP 2021502824 A5 JP2021502824 A5 JP 2021502824A5
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- Prior art keywords
- hematopoietic stem
- optionally substituted
- disease
- composition
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 53
- 239000000203 mixture Substances 0.000 claims 26
- 238000000034 method Methods 0.000 claims 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 20
- 208000035475 disorder Diseases 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 201000001981 dermatomyositis Diseases 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 210000000130 stem cell Anatomy 0.000 claims 7
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 5
- 101710163270 Nuclease Proteins 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000003107 substituted aryl group Chemical group 0.000 claims 5
- 229940123517 Aryl hydrocarbon receptor antagonist Drugs 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 4
- 208000011580 syndromic disease Diseases 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- -1 C1-4 alkyl hydrogen Chemical compound 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 230000006378 damage Effects 0.000 claims 3
- 125000004404 heteroalkyl group Chemical group 0.000 claims 3
- 201000001119 neuropathy Diseases 0.000 claims 3
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- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 208000029483 Acquired immunodeficiency Diseases 0.000 claims 2
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- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
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- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 1
- 208000032467 Aplastic anaemia Diseases 0.000 claims 1
- 102000003984 Aryl Hydrocarbon Receptors Human genes 0.000 claims 1
- 108090000448 Aryl Hydrocarbon Receptors Proteins 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
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- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
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- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
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- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 1
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- 208000023105 Huntington disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
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- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
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- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
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- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
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- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
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- 208000010346 Sphingolipidoses Diseases 0.000 claims 1
- 201000001307 Sphingolipidosis Diseases 0.000 claims 1
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- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000002903 Thalassemia Diseases 0.000 claims 1
- 206010043561 Thrombocytopenic purpura Diseases 0.000 claims 1
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- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
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- 208000006110 Wiskott-Aldrich syndrome Diseases 0.000 claims 1
- 201000001696 X-linked hyper IgM syndrome Diseases 0.000 claims 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 201000009628 adenosine deaminase deficiency Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
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- 206010002022 amyloidosis Diseases 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
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- 208000027625 autoimmune inner ear disease Diseases 0.000 claims 1
- 230000005784 autoimmunity Effects 0.000 claims 1
- 208000036556 autosomal recessive T cell-negative B cell-negative NK cell-negative due to adenosine deaminase deficiency severe combined immunodeficiency Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000001772 blood platelet Anatomy 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 1
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- 229940125782 compound 2 Drugs 0.000 claims 1
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- CKSJXOVLXUMMFF-UHFFFAOYSA-N exalamide Chemical compound CCCCCCOC1=CC=CC=C1C(N)=O CKSJXOVLXUMMFF-UHFFFAOYSA-N 0.000 claims 1
- 229950010333 exalamide Drugs 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 208000007345 glycogen storage disease Diseases 0.000 claims 1
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- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
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Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762579803P | 2017-10-31 | 2017-10-31 | |
| US62/579,803 | 2017-10-31 | ||
| US201762596676P | 2017-12-08 | 2017-12-08 | |
| US62/596,676 | 2017-12-08 | ||
| US201862613383P | 2018-01-03 | 2018-01-03 | |
| US62/613,383 | 2018-01-03 | ||
| US201862625917P | 2018-02-02 | 2018-02-02 | |
| US62/625,917 | 2018-02-02 | ||
| US201862634638P | 2018-02-23 | 2018-02-23 | |
| US62/634,638 | 2018-02-23 | ||
| US201862747068P | 2018-10-17 | 2018-10-17 | |
| US62/747,068 | 2018-10-17 | ||
| PCT/US2018/058553 WO2019089826A1 (en) | 2017-10-31 | 2018-10-31 | Compositions and methods for the expansion of hematopoietic stem and progenitor cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021502824A JP2021502824A (ja) | 2021-02-04 |
| JP2021502824A5 true JP2021502824A5 (enExample) | 2021-12-09 |
| JP7412341B2 JP7412341B2 (ja) | 2024-01-12 |
Family
ID=64317009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544356A Active JP7412341B2 (ja) | 2017-10-31 | 2018-10-31 | 造血幹細胞および前駆細胞の増幅のための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20190314407A1 (enExample) |
| EP (1) | EP3704232A1 (enExample) |
| JP (1) | JP7412341B2 (enExample) |
| CN (1) | CN111542597A (enExample) |
| AU (1) | AU2018358241A1 (enExample) |
| CA (1) | CA3079405A1 (enExample) |
| WO (1) | WO2019089826A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114558032B (zh) | 2012-12-21 | 2025-07-29 | 安斯泰来再生医药协会 | 由多能干细胞制备血小板的方法及其组合物 |
| EP3609890B1 (en) | 2017-04-12 | 2024-09-11 | EdiGene Biotechnology, Inc. | Aryl hydrocarbon receptor antagonists and uses thereof |
| WO2019036657A1 (en) | 2017-08-17 | 2019-02-21 | Kyn Therapeutics | AHR INHIBITORS AND USES THEREOF |
| JP2021509812A (ja) | 2018-01-05 | 2021-04-08 | プレートレット バイオジェネシス， インコーポレイテッド | 巨核球を産生するための組成物および方法 |
| WO2020006539A1 (en) | 2018-06-29 | 2020-01-02 | Platelet Biogenesis, Inc. | Compositions for drug delivery and methods of use thereof |
| CN111187262A (zh) * | 2020-01-21 | 2020-05-22 | 沈阳药科大学 | 咪唑并[1,2-a]吡啶衍生物及其制备方法和应用 |
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| US5021409A (en) | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
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| GB9126677D0 (en) | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| PT752248E (pt) | 1992-11-13 | 2001-01-31 | Idec Pharma Corp | Aplicacao terapeutica de anticorpos quimericos e marcados radioactivamente contra antigenios de diferenciacao restrita de linfocitos b humanos para o tratamento do linfoma de celulas b |
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| US6447766B1 (en) | 1993-06-08 | 2002-09-10 | Smithkline Beecham Corporation | Method of mobilizing hematopoietic stem cells |
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| CN105431521A (zh) * | 2013-02-28 | 2016-03-23 | 哈佛学院校长同事会 | 用于动员干细胞的方法和组合物 |
| US9169287B2 (en) | 2013-03-15 | 2015-10-27 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
| US10117899B2 (en) * | 2013-10-17 | 2018-11-06 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells |
| US9816074B2 (en) * | 2014-07-25 | 2017-11-14 | Sangamo Therapeutics, Inc. | Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells |
| KR20170054445A (ko) * | 2014-09-16 | 2017-05-17 | 상가모 테라퓨틱스, 인코포레이티드 | 뉴클레아제-매개된 게놈 엔지니어링 및 조혈 줄기세포에서의 교정을 위한 방법 및 조성물 |
| EP4049665B1 (en) * | 2016-03-15 | 2025-03-12 | The Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
| EP3609890B1 (en) * | 2017-04-12 | 2024-09-11 | EdiGene Biotechnology, Inc. | Aryl hydrocarbon receptor antagonists and uses thereof |
-
2018
- 2018-10-31 CN CN201880084804.0A patent/CN111542597A/zh active Pending
- 2018-10-31 CA CA3079405A patent/CA3079405A1/en active Pending
- 2018-10-31 EP EP18803842.6A patent/EP3704232A1/en not_active Withdrawn
- 2018-10-31 WO PCT/US2018/058553 patent/WO2019089826A1/en not_active Ceased
- 2018-10-31 AU AU2018358241A patent/AU2018358241A1/en not_active Abandoned
- 2018-10-31 US US16/177,252 patent/US20190314407A1/en not_active Abandoned
- 2018-10-31 JP JP2020544356A patent/JP7412341B2/ja active Active
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