JP2019525922A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019525922A5 JP2019525922A5 JP2019503470A JP2019503470A JP2019525922A5 JP 2019525922 A5 JP2019525922 A5 JP 2019525922A5 JP 2019503470 A JP2019503470 A JP 2019503470A JP 2019503470 A JP2019503470 A JP 2019503470A JP 2019525922 A5 JP2019525922 A5 JP 2019525922A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- hydrogen
- composition according
- pharmaceutical
- chlorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000006178 malignant mesothelioma Diseases 0.000 claims description 4
- JLYAXFNOILIKPP-KXQOOQHDSA-N navitoclax Chemical compound C([C@@H](NC1=CC=C(C=C1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)C1=CC=C(C=C1)N1CCN(CC1)CC1=C(CCC(C1)(C)C)C=1C=CC(Cl)=CC=1)CSC=1C=CC=CC=1)CN1CCOCC1 JLYAXFNOILIKPP-KXQOOQHDSA-N 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 30
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 239000000460 chlorine Substances 0.000 claims 6
- 239000012664 BCL-2-inhibitor Substances 0.000 claims 5
- 229940123711 Bcl2 inhibitor Drugs 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 229950004847 navitoclax Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 102000016776 Midkine Human genes 0.000 claims 2
- 108010092801 Midkine Proteins 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- -1 -OCH 3 Inorganic materials 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 102000051485 Bcl-2 family Human genes 0.000 description 1
- 108700038897 Bcl-2 family Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 239000010425 asbestos Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 201000005282 malignant pleural mesothelioma Diseases 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022006978A JP2022064923A (ja) | 2016-07-28 | 2022-01-20 | 癌を治療するための方法および組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367832P | 2016-07-28 | 2016-07-28 | |
| US62/367,832 | 2016-07-28 | ||
| PCT/US2017/044335 WO2018022973A1 (en) | 2016-07-28 | 2017-07-28 | Methods and compositions to treat cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022006978A Division JP2022064923A (ja) | 2016-07-28 | 2022-01-20 | 癌を治療するための方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019525922A JP2019525922A (ja) | 2019-09-12 |
| JP2019525922A5 true JP2019525922A5 (enExample) | 2020-09-03 |
Family
ID=61017221
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503470A Pending JP2019525922A (ja) | 2016-07-28 | 2017-07-28 | 癌を治療するための方法および組成物 |
| JP2022006978A Pending JP2022064923A (ja) | 2016-07-28 | 2022-01-20 | 癌を治療するための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022006978A Pending JP2022064923A (ja) | 2016-07-28 | 2022-01-20 | 癌を治療するための方法および組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US10668078B2 (enExample) |
| EP (1) | EP3490555A4 (enExample) |
| JP (2) | JP2019525922A (enExample) |
| AU (1) | AU2017302617A1 (enExample) |
| WO (1) | WO2018022973A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3490555A4 (en) | 2016-07-28 | 2020-07-08 | Children's Hospital Medical Center | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER |
| JP2022553820A (ja) | 2019-11-05 | 2022-12-26 | アッヴィ・インコーポレイテッド | 骨髄線維症及びｍｐｎ関連障害をナビトクラクスで処置する際に使用するための投与レジメン |
| AU2023255538A1 (en) * | 2022-04-22 | 2024-10-31 | Astellas Engineered Small Molecules US, Incorporated | Transcription factor eb activators and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010094009A2 (en) | 2009-02-13 | 2010-08-19 | Children's Hospital Medical Center | Methods and compositions for the treatment of ras associated disorders |
| US20100278921A1 (en) | 2009-04-30 | 2010-11-04 | Fischer Cristina M | Solid oral formulation of abt-263 |
| US20130085157A1 (en) | 2011-09-30 | 2013-04-04 | Emilie D. Smith | Arylsubstituted thiazolotriazoles and thiazoloimidazoles |
| EP2923203B1 (en) * | 2012-11-20 | 2018-10-03 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Assay to measure midkine or pleiotrophin level for diagnosing a growth |
| WO2014190163A2 (en) | 2013-05-22 | 2014-11-27 | Children's Hospital Medical Center | Combination therapy for mds |
| EP3010504B1 (en) * | 2013-06-20 | 2018-10-31 | Children's Hospital Medical Center | Methods and compositions to treat cancer |
| EP3490555A4 (en) | 2016-07-28 | 2020-07-08 | Children's Hospital Medical Center | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER |
-
2017
- 2017-07-28 EP EP17835328.0A patent/EP3490555A4/en not_active Withdrawn
- 2017-07-28 US US16/312,478 patent/US10668078B2/en active Active
- 2017-07-28 JP JP2019503470A patent/JP2019525922A/ja active Pending
- 2017-07-28 AU AU2017302617A patent/AU2017302617A1/en not_active Abandoned
- 2017-07-28 WO PCT/US2017/044335 patent/WO2018022973A1/en not_active Ceased
-
2020
- 2020-04-24 US US16/857,285 patent/US11026950B2/en active Active
-
2021
- 2021-05-05 US US17/308,179 patent/US11672806B2/en active Active
-
2022
- 2022-01-20 JP JP2022006978A patent/JP2022064923A/ja active Pending
-
2023
- 2023-05-02 US US18/142,308 patent/US12303513B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2477723C2 (ru) | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе | |
| JP2016518328A5 (enExample) | ||
| JOP20220069A1 (ar) | عوامل محللة لـ brd9 ثنائية الوظيفة وطرق لاستخدامها | |
| JP2017511377A5 (enExample) | ||
| JP2016518437A5 (enExample) | ||
| JP2020536888A5 (enExample) | ||
| CN103402519B (zh) | 肿瘤治疗剂 | |
| JP2015024998A5 (enExample) | ||
| JP2015508103A5 (enExample) | ||
| JP2018518537A5 (enExample) | ||
| JP2019524883A5 (enExample) | ||
| JP2016518434A5 (enExample) | ||
| RU2007139634A (ru) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения | |
| JP2016520618A5 (enExample) | ||
| JP2020507589A5 (enExample) | ||
| JP2018503663A5 (enExample) | ||
| JP2019525922A5 (enExample) | ||
| JP2019501879A5 (enExample) | ||
| JP2020502047A5 (enExample) | ||
| JP2018531987A5 (enExample) | ||
| CN112368281A (zh) | 作为pde3/pde4双重抑制剂的三并环类化合物 | |
| JP2019535723A5 (enExample) | ||
| JP2015508068A5 (enExample) | ||
| JP2010521516A5 (enExample) | ||
| JP2018502824A5 (enExample) |