JP2019525922A - 癌を治療するための方法および組成物 - Google Patents

癌を治療するための方法および組成物 Download PDF

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Publication number
JP2019525922A
JP2019525922A JP2019503470A JP2019503470A JP2019525922A JP 2019525922 A JP2019525922 A JP 2019525922A JP 2019503470 A JP2019503470 A JP 2019503470A JP 2019503470 A JP2019503470 A JP 2019503470A JP 2019525922 A JP2019525922 A JP 2019525922A
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imdk
hydrogen
inhibitor
cells
hours
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JP2019503470A
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Japanese (ja)
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JP2019525922A5 (enExample
Inventor
拓也 深澤
拓也 深澤
ウィトセット、ジェフリー、エー．
前田　豊
豊 前田
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Cincinnati Childrens Hospital Medical Center
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Cincinnati Childrens Hospital Medical Center
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Publication of JP2019525922A publication Critical patent/JP2019525922A/ja
Publication of JP2019525922A5 publication Critical patent/JP2019525922A5/ja
Priority to JP2022006978A priority Critical patent/JP2022064923A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2019503470A 2016-07-28 2017-07-28 癌を治療するための方法および組成物 Pending JP2019525922A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022006978A JP2022064923A (ja) 2016-07-28 2022-01-20 癌を治療するための方法および組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662367832P 2016-07-28 2016-07-28
US62/367,832 2016-07-28
PCT/US2017/044335 WO2018022973A1 (en) 2016-07-28 2017-07-28 Methods and compositions to treat cancer

Related Child Applications (1)

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JP2022006978A Division JP2022064923A (ja) 2016-07-28 2022-01-20 癌を治療するための方法および組成物

Publications (2)

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JP2019525922A true JP2019525922A (ja) 2019-09-12
JP2019525922A5 JP2019525922A5 (enExample) 2020-09-03

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JP2019503470A Pending JP2019525922A (ja) 2016-07-28 2017-07-28 癌を治療するための方法および組成物
JP2022006978A Pending JP2022064923A (ja) 2016-07-28 2022-01-20 癌を治療するための方法および組成物

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JP2022006978A Pending JP2022064923A (ja) 2016-07-28 2022-01-20 癌を治療するための方法および組成物

Country Status (5)

Country Link
US (4) US10668078B2 (enExample)
EP (1) EP3490555A4 (enExample)
JP (2) JP2019525922A (enExample)
AU (1) AU2017302617A1 (enExample)
WO (1) WO2018022973A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3490555A4 (en) 2016-07-28 2020-07-08 Children's Hospital Medical Center METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
JP2022553820A (ja) 2019-11-05 2022-12-26 アッヴィ・インコーポレイテッド 骨髄線維症及びｍｐｎ関連障害をナビトクラクスで処置する際に使用するための投与レジメン
AU2023255538A1 (en) * 2022-04-22 2024-10-31 Astellas Engineered Small Molecules US, Incorporated Transcription factor eb activators and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010127191A1 (en) * 2009-04-30 2010-11-04 Abbott Laboratories Solid oral formulation of abt-263
WO2014081633A1 (en) * 2012-11-20 2014-05-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Assay to measure midkine or pleiotrophin level for diagnosing a growth
WO2014205132A2 (en) * 2013-06-20 2014-12-24 Children's Hospital Medical Center Methods and compositions to treat cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010094009A2 (en) 2009-02-13 2010-08-19 Children's Hospital Medical Center Methods and compositions for the treatment of ras associated disorders
US20130085157A1 (en) 2011-09-30 2013-04-04 Emilie D. Smith Arylsubstituted thiazolotriazoles and thiazoloimidazoles
WO2014190163A2 (en) 2013-05-22 2014-11-27 Children's Hospital Medical Center Combination therapy for mds
EP3490555A4 (en) 2016-07-28 2020-07-08 Children's Hospital Medical Center METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010127191A1 (en) * 2009-04-30 2010-11-04 Abbott Laboratories Solid oral formulation of abt-263
WO2014081633A1 (en) * 2012-11-20 2014-05-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Assay to measure midkine or pleiotrophin level for diagnosing a growth
WO2014205132A2 (en) * 2013-06-20 2014-12-24 Children's Hospital Medical Center Methods and compositions to treat cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CANCER RESEARCH, vol. Vol.77(13 Suppl), JPN6021014554, April 2017 (2017-04-01), pages 2085, ISSN: 0004597283 *
CANCER SCIENCE, vol. 104, no. 11, JPN6021014559, 2013, pages 1433 - 1439, ISSN: 0004597285 *
PLOS ONE, vol. 8, no. 8, JPN6021014557, 2013, pages 71093, ISSN: 0004597284 *

Also Published As

Publication number Publication date
US20200276205A1 (en) 2020-09-03
US10668078B2 (en) 2020-06-02
WO2018022973A1 (en) 2018-02-01
US20230285403A1 (en) 2023-09-14
US11672806B2 (en) 2023-06-13
JP2022064923A (ja) 2022-04-26
US20210315903A1 (en) 2021-10-14
EP3490555A4 (en) 2020-07-08
AU2017302617A1 (en) 2019-02-07
EP3490555A1 (en) 2019-06-05
US12303513B2 (en) 2025-05-20
US20190134053A1 (en) 2019-05-09
US11026950B2 (en) 2021-06-08

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