|
CH652145A5
(de)
|
1982-01-22 |
1985-10-31 |
Sandoz Ag |
Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
|
|
US4634666A
(en)
|
1984-01-06 |
1987-01-06 |
The Board Of Trustees Of The Leland Stanford Junior University |
Human-murine hybridoma fusion partner
|
|
US5208036A
(en)
|
1985-01-07 |
1993-05-04 |
Syntex (U.S.A.) Inc. |
N-(ω, (ω-1)-dialkyloxy)- and N-(ω, (ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
EP0279582A3
(en)
|
1987-02-17 |
1989-10-18 |
Pharming B.V. |
Dna sequences to target proteins to the mammary gland for efficient secretion
|
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
|
US5057540A
(en)
|
1987-05-29 |
1991-10-15 |
Cambridge Biotech Corporation |
Saponin adjuvant
|
|
US4912094B1
(en)
|
1988-06-29 |
1994-02-15 |
Ribi Immunochem Research Inc. |
Modified lipopolysaccharides and process of preparation
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5633076A
(en)
|
1989-12-01 |
1997-05-27 |
Pharming Bv |
Method of producing a transgenic bovine or transgenic bovine embryo
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
EP1690934A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US5279833A
(en)
|
1990-04-04 |
1994-01-18 |
Yale University |
Liposomal transfection of nucleic acids into animal cells
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
EP0585287B1
(en)
|
1990-07-10 |
1999-10-13 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
ATE300615T1
(de)
|
1990-08-29 |
2005-08-15 |
Genpharm Int |
Transgene mäuse fähig zur produktion heterologer antikörper
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5194594A
(en)
|
1990-09-07 |
1993-03-16 |
Techniclone, Inc. |
Modified antibodies
|
|
US5858657A
(en)
|
1992-05-15 |
1999-01-12 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
US5871907A
(en)
|
1991-05-15 |
1999-02-16 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
US5283185A
(en)
|
1991-08-28 |
1994-02-01 |
University Of Tennessee Research Corporation |
Method for delivering nucleic acids into cells
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
CA2124967C
(en)
|
1991-12-17 |
2008-04-08 |
Nils Lonberg |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
WO1994012629A1
(en)
|
1992-12-02 |
1994-06-09 |
Baylor College Of Medicine |
Episomal vectors for gene therapy
|
|
ATE199392T1
(de)
|
1992-12-04 |
2001-03-15 |
Medical Res Council |
Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
|
|
AU698962B2
(en)
|
1993-09-14 |
1998-11-12 |
Epimmune, Inc. |
Alteration of immune response using pan DR-binding peptides
|
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
|
US5877218A
(en)
|
1994-01-10 |
1999-03-02 |
Teva Pharmaceutical Industries, Ltd. |
Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
|
|
US5505947A
(en)
|
1994-05-27 |
1996-04-09 |
The University Of North Carolina At Chapel Hill |
Attenuating mutations in Venezuelan Equine Encephalitis virus
|
|
US5786464C1
(en)
|
1994-09-19 |
2012-04-24 |
Gen Hospital Corp |
Overexpression of mammalian and viral proteins
|
|
US7427392B1
(en)
*
|
1994-11-14 |
2008-09-23 |
Elan Pharmaceuticals, Inc. |
Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau
|
|
US7153510B1
(en)
|
1995-05-04 |
2006-12-26 |
Yale University |
Recombinant vesiculoviruses and their uses
|
|
DE19539493A1
(de)
|
1995-10-24 |
1997-04-30 |
Thomae Gmbh Dr K |
Starker homologer Promotor aus Hamster
|
|
US5834597A
(en)
|
1996-05-20 |
1998-11-10 |
Protein Design Labs, Inc. |
Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
|
|
US6114148C1
(en)
|
1996-09-20 |
2012-05-01 |
Gen Hospital Corp |
High level expression of proteins
|
|
AUPO390396A0
(en)
|
1996-11-29 |
1996-12-19 |
Csl Limited |
Novel promiscuous T helper cell epitopes
|
|
AU753688B2
(en)
|
1997-03-10 |
2002-10-24 |
Ottawa Civic Loeb Research Institute |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
US5888809A
(en)
|
1997-05-01 |
1999-03-30 |
Icos Corporation |
Hamster EF-1α transcriptional regulatory DNA
|
|
US7964192B1
(en)
|
1997-12-02 |
2011-06-21 |
Janssen Alzheimer Immunotherapy |
Prevention and treatment of amyloidgenic disease
|
|
WO2000046750A1
(en)
|
1999-02-05 |
2000-08-10 |
Samsung Electronics Co., Ltd. |
Image texture retrieving method and apparatus thereof
|
|
TWI255272B
(en)
|
2000-12-06 |
2006-05-21 |
Guriq Basi |
Humanized antibodies that recognize beta amyloid peptide
|
|
MXPA05000511A
(es)
|
2001-07-12 |
2005-09-30 |
Jefferson Foote |
Anticuepros super humanizados.
|
|
CA2471849A1
(en)
|
2001-12-28 |
2003-07-17 |
Abgenix, Inc. |
Antibodies against the muc18 antigen
|
|
KR101149777B1
(ko)
|
2002-11-29 |
2012-06-11 |
베링거 잉겔하임 파르마 게엠베하 운트 코 카게 |
신규한 네오마이신 포스포트랜스퍼라제 유전자 및 고생산성 재조합 세포의 선별 방법
|
|
DE10338531A1
(de)
|
2003-08-19 |
2005-04-07 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Reklonierung von Produktionszellen
|
|
AU2005291486A1
(en)
|
2004-10-01 |
2006-04-13 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Novel antibodies directed to the mammalian EAG1 ion channel protein
|
|
WO2006051065A2
(en)
|
2004-11-10 |
2006-05-18 |
Boehringer Ingelheim Pharma Gmbh & Co.Kg |
Use of flow-cytometric analysis to optimize cell banking strategies for cho cells
|
|
CA2591665C
(en)
|
2004-12-20 |
2015-05-05 |
Crucell Holland B.V. |
Binding molecules capable of neutralizing west nile virus and uses thereof
|
|
US7855276B2
(en)
|
2004-12-30 |
2010-12-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Framework residue substituted humanized COL-1 antibodies and their use
|
|
US8236933B2
(en)
*
|
2005-04-13 |
2012-08-07 |
Garvan Institute Of Medical Research |
Modified animal lacking functional PYY gene, monoclonal antibodies that bind PYY isoforms and uses therefor
|
|
US8012936B2
(en)
|
2006-03-29 |
2011-09-06 |
New York University |
Tau fragments for immunotherapy
|
|
CA2655379A1
(en)
|
2006-06-22 |
2007-12-27 |
Walter And Eliza Hall Institute Of Medical Research |
Structure of the insulin receptor ectodomain
|
|
US20080124760A1
(en)
|
2006-07-26 |
2008-05-29 |
Barbara Enenkel |
Regulatory Nucleic Acid Elements
|
|
KR101552735B1
(ko)
|
2006-12-01 |
2015-09-14 |
메다렉스, 엘.엘.시. |
씨디22에 결합하는 인간 항체 및 이의 용도
|
|
WO2008070593A2
(en)
|
2006-12-01 |
2008-06-12 |
Seattle Genetics, Inc. |
Variant target binding agents and uses thereof
|
|
KR20120017469A
(ko)
|
2007-01-05 |
2012-02-28 |
유니버시티 오브 취리히 |
질환 특이적 결합 분자 및 표적을 제공하는 방법
|
|
PL2118300T3
(pl)
|
2007-02-23 |
2015-11-30 |
Prothena Biosciences Ltd |
Zapobieganie i leczenie synukleinopatii i amyloidozy
|
|
EP2522729A1
(en)
|
2007-03-02 |
2012-11-14 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Improvement of protein production
|
|
EP2031064A1
(de)
|
2007-08-29 |
2009-03-04 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Verfahren zur Steigerung von Proteintitern
|
|
JP2009056790A
(ja)
|
2007-09-03 |
2009-03-19 |
Takao Otogawa |
ファイル用ポケット
|
|
TW200927761A
(en)
|
2007-09-26 |
2009-07-01 |
U3 Pharma Ag |
Heparin-binding epidermal growth factor-like growth factor antigen binding proteins
|
|
UA104132C2
(en)
|
2007-11-13 |
2014-01-10 |
Тева Биофармасьютикалз Юесей, Инк. |
Humanized antibodies against tl1a
|
|
JP2010014691A
(ja)
|
2008-06-20 |
2010-01-21 |
Igaku Seibutsugaku Kenkyusho:Kk |
腹水中のメソテリン及び／又は巨核球増強因子を検出するための方法、キット、試薬及び装置
|
|
JP5685535B2
(ja)
|
2008-08-18 |
2015-03-18 |
ファイザー インコーポレイティッド |
Ｃｃｒ２に対する抗体
|
|
US9605054B2
(en)
|
2009-02-23 |
2017-03-28 |
The Board Of Trustees Of The University Of Illinois |
Composition and method for treating a tauopathy
|
|
EP2998405B1
(en)
|
2009-05-13 |
2019-12-11 |
Genzyme Corporation |
Anti-human cd52 immunoglobulins
|
|
CA3239368A1
(en)
|
2009-06-10 |
2010-12-16 |
New York University |
Immunological targeting of pathological tau proteins
|
|
WO2011006000A1
(en)
|
2009-07-08 |
2011-01-13 |
Haiyan Liu |
Berberine derivatives useful for modulating lipid levels and their methods of synthesis
|
|
US20110045534A1
(en)
|
2009-08-20 |
2011-02-24 |
Cell Signaling Technology, Inc. |
Nucleic Acid Cassette For Producing Recombinant Antibodies
|
|
WO2011075636A2
(en)
|
2009-12-18 |
2011-06-23 |
Amgen Inc. |
Wise binding agents and epitopes
|
|
EP2522360B1
(en)
|
2010-01-08 |
2016-11-16 |
Kyoto University |
Vaccine for treatment of tauopathy
|
|
TWI429453B
(zh)
|
2010-02-23 |
2014-03-11 |
建南德克公司 |
抗tat419抗體及其用途
|
|
ES2684475T3
(es)
|
2010-04-15 |
2018-10-03 |
Abbvie Inc. |
Proteínas que se unen a beta amiloide
|
|
ITRM20100320A1
(it)
|
2010-06-11 |
2011-12-11 |
Consiglio Nazionale Ricerche |
Metodo per la diagnostica e il trattamento delle taupatie
|
|
US20120023911A1
(en)
|
2010-07-28 |
2012-02-02 |
Gm Global Technology Operations, Inc. |
Detection of exhaust particulate filter substrate failure
|
|
BR112013008765B8
(pt)
|
2010-10-11 |
2023-05-02 |
Biogen Idec Int Neuroscience Gmbh |
Anticorpos monoclonais anti-tau humano isolados ou um fragmento de ligação à tau dos mesmos, métodos de preparação dos mesmos, polinucleotídeo ou polinucleotídeos, vetor ou vetores, composição, método in vitro de diagnóstico ou monitoramento da progressão de uma tauopatia neurodegenerativa em um indivíduo humano, método in vitro para diagnosticar uma tauopatia neurodegenerativa em um indivíduo humano, e kit útil para o diagnóstico de uma tauopatia neurodegenerativa
|
|
EP2673635A4
(en)
|
2011-02-07 |
2015-08-12 |
Neotope Biosciences Ltd |
IMMUNOTHERAPY THROUGH APOE
|
|
WO2012149365A2
(en)
|
2011-04-27 |
2012-11-01 |
Northwestern University |
Antibodies selective for pathological tau dimers and prefibrillar pathological tau oligomers and their uses in treatment, diagnosis and monitoring of tauopathies
|
|
GB201109238D0
(en)
|
2011-06-01 |
2011-07-13 |
Antitope Ltd |
Antibodies
|
|
GB201111361D0
(en)
|
2011-07-04 |
2011-08-17 |
Nordic Bioscience As |
Biochemical markers for neurodegenerative conditions
|
|
GB201112056D0
(en)
|
2011-07-14 |
2011-08-31 |
Univ Leuven Kath |
Antibodies
|
|
US9505847B2
(en)
|
2011-08-22 |
2016-11-29 |
Cnj Holdings Inc |
Clostridium difficile antibodies
|
|
ES2656442T3
(es)
|
2011-09-19 |
2018-02-27 |
Axon Neuroscience Se |
Terapia basada en proteínas y diagnóstico de una patología mediada por tau en la enfermedad de Alzheimer
|
|
RU2639537C2
(ru)
|
2011-10-07 |
2017-12-21 |
Ац Иммуне С.А. |
Фосфоспецифичные антитела, распознающие тау
|
|
RS57413B1
(sr)
|
2012-03-28 |
2018-09-28 |
Sanofi Sa |
Antitela za ligande bradikinin b1 receptora
|
|
JP6293731B2
(ja)
|
2012-04-05 |
2018-03-14 |
エーシー イミューン エス．エー． |
ヒト化タウ抗体
|
|
US9428864B2
(en)
|
2012-04-18 |
2016-08-30 |
E I Du Pont De Nemours And Company |
Multilayered sheet
|
|
HK1209768A1
(en)
|
2012-07-03 |
2016-04-08 |
Washington University |
Antibodies to tau
|
|
PE20150646A1
(es)
|
2012-08-16 |
2015-05-21 |
Ipierian Inc |
Metodos de tratamiento de una tauopatia
|
|
US20140056901A1
(en)
|
2012-08-21 |
2014-02-27 |
The Institute For Molecular Medicine |
Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies
|
|
WO2014059442A2
(en)
|
2012-10-12 |
2014-04-17 |
Arizona Board Agents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University |
Antibody based reagents that specifically recognize toxic oligomeric forms of tau
|
|
US9200068B2
(en)
|
2012-12-18 |
2015-12-01 |
Regents Of The University Of Minnesota |
Compositions and methods related to tauopathy
|
|
PT2935326T
(pt)
*
|
2012-12-21 |
2020-09-14 |
Biogen Ma Inc |
Anticorpos anti-tau humanos
|
|
CA2902026C
(en)
|
2013-03-13 |
2023-08-29 |
Prothena Biosciences Limited |
Tau immunotherapy
|
|
EP2968548B1
(en)
*
|
2013-03-15 |
2020-09-09 |
Beth Israel Deaconess Medical Center, Inc. |
Methods and compositions for the generation and use of conformation-specific antibodies
|
|
CA2939692C
(en)
|
2013-03-15 |
2022-10-18 |
The Trustees Of The University Of Pennsylvania |
Blood biomarkers that predict persistent cognitive dysfunction after concussion
|
|
CA2921805C
(en)
|
2013-08-22 |
2023-03-07 |
Acceleron Pharma, Inc. |
Tgf-beta receptor type ii variants and uses thereof
|
|
UA129760C2
(uk)
|
2013-12-17 |
2025-07-30 |
Дженентек, Інк. |
Анти-cd3 антитіло та спосіб його застосування
|
|
US9629801B2
(en)
|
2014-01-10 |
2017-04-25 |
Wisconsin Alumni Research Foundation |
Blood-brain barrier targeting antibodies
|
|
US20150253341A1
(en)
|
2014-02-10 |
2015-09-10 |
Merck Sharp & Dohme Corp. |
Quantification of tau in biological samples by immunoaffinity enrichment and mass spectrometry
|
|
TWI664190B
(zh)
|
2014-06-27 |
2019-07-01 |
美商Ｃ２Ｎ醫療診斷有限責任公司 |
人類化抗－ｔａｕ抗體
|
|
SI3221349T1
(sl)
*
|
2014-11-19 |
2021-02-26 |
Axon Neuroscience Se |
Humanizirano tau protitelo pri alzheimerjevi bolezni
|
|
CA2874083C
(en)
|
2014-12-05 |
2024-01-02 |
Universite Laval |
Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
|
|
AU2016334051B2
(en)
|
2015-10-06 |
2023-10-26 |
Alector Llc |
Anti-TREM2 antibodies and methods of use thereof
|
|
EP3452507B1
(en)
|
2016-05-02 |
2022-10-19 |
Prothena Biosciences Limited |
Tau immunotherapy
|
|
CA3022515A1
(en)
|
2016-05-02 |
2017-11-09 |
Prothena Biosciences Limited |
Antibodies recognizing tau
|
|
PE20190208A1
(es)
|
2016-05-02 |
2019-02-07 |
Prothena Biosciences Ltd |
Anticuerpos que reconocen tau
|
|
JP7165995B2
(ja)
|
2017-02-21 |
2022-11-07 |
アールイーエムディー バイオセラピューティクス，インコーポレイテッド |
細胞傷害性ｔリンパ球抗原－４（ｃｔｌａ－４）に結合する抗体を使用した癌治療
|
|
CN110881274B
(zh)
|
2017-05-02 |
2024-11-15 |
普罗塞纳生物科学有限公司 |
识别tau的抗体
|
|
CA3118818A1
(en)
|
2018-11-08 |
2020-05-14 |
Prothena Biosciences Limited |
Antibodies recognizing tau
|
|
SG11202104549TA
(en)
|
2018-11-08 |
2021-05-28 |
Prothena Biosciences Ltd |
Antibodies recognizing tau
|
|
WO2020163817A1
(en)
|
2019-02-08 |
2020-08-13 |
Prothena Biosciences Limited |
Antibodies recognizing tau
|
|
EP3935083A4
(en)
|
2019-03-03 |
2022-11-30 |
Prothena Biosciences Limited |
Antibodies recognizing tau
|