JP2019522017A5 - - Google Patents
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- Publication number
- JP2019522017A5 JP2019522017A5 JP2019503673A JP2019503673A JP2019522017A5 JP 2019522017 A5 JP2019522017 A5 JP 2019522017A5 JP 2019503673 A JP2019503673 A JP 2019503673A JP 2019503673 A JP2019503673 A JP 2019503673A JP 2019522017 A5 JP2019522017 A5 JP 2019522017A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- tissue
- ulcer
- thermolysin
- bacterial biofilm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001580 bacterial effect Effects 0.000 claims 14
- 210000001519 tissue Anatomy 0.000 claims 11
- 108090001109 Thermolysin Proteins 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 8
- 206010052428 Wound Diseases 0.000 claims 7
- 208000027418 Wounds and injury Diseases 0.000 claims 7
- 206010011985 Decubitus ulcer Diseases 0.000 claims 4
- 208000004210 Pressure Ulcer Diseases 0.000 claims 4
- 208000025865 Ulcer Diseases 0.000 claims 4
- 230000001684 chronic effect Effects 0.000 claims 4
- 231100000397 ulcer Toxicity 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000009854 mucosal lesion Effects 0.000 claims 3
- 206010040882 skin lesion Diseases 0.000 claims 3
- 231100000444 skin lesion Toxicity 0.000 claims 3
- 208000008960 Diabetic foot Diseases 0.000 claims 2
- 208000000558 Varicose Ulcer Diseases 0.000 claims 2
- 230000008030 elimination Effects 0.000 claims 2
- 238000003379 elimination reaction Methods 0.000 claims 2
- 239000002121 nanofiber Substances 0.000 claims 2
- 229920005594 polymer fiber Polymers 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000032770 biofilm formation Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 230000009841 epithelial lesion Effects 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000005003 heart tissue Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000005092 tracheal tissue Anatomy 0.000 claims 1
- 210000001635 urinary tract Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 210000001835 viscera Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022089557A JP2022111186A (ja) | 2016-07-27 | 2022-06-01 | 表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367338P | 2016-07-27 | 2016-07-27 | |
| US62/367,338 | 2016-07-27 | ||
| PCT/IB2017/054535 WO2018020435A1 (en) | 2016-07-27 | 2017-07-26 | Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022089557A Division JP2022111186A (ja) | 2016-07-27 | 2022-06-01 | 表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522017A JP2019522017A (ja) | 2019-08-08 |
| JP2019522017A5 true JP2019522017A5 (https=) | 2020-08-06 |
| JP7127013B2 JP7127013B2 (ja) | 2022-08-29 |
Family
ID=59738382
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503673A Active JP7127013B2 (ja) | 2016-07-27 | 2017-07-26 | 表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用 |
| JP2022089557A Pending JP2022111186A (ja) | 2016-07-27 | 2022-06-01 | 表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022089557A Pending JP2022111186A (ja) | 2016-07-27 | 2022-06-01 | 表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11628207B2 (https=) |
| EP (1) | EP3490588A1 (https=) |
| JP (2) | JP7127013B2 (https=) |
| CN (1) | CN109475609A (https=) |
| AU (1) | AU2017304271B2 (https=) |
| CA (1) | CA3031866A1 (https=) |
| WO (1) | WO2018020435A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017304271B2 (en) * | 2016-07-27 | 2024-07-18 | Smith & Nephew, Inc. | Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces |
| EP3573622B1 (en) | 2017-01-30 | 2023-10-18 | Smith & Nephew, Inc. | Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces |
| WO2020247582A1 (en) * | 2019-06-06 | 2020-12-10 | Danisco Us Inc | Methods and compositions for cleaning |
| WO2022023250A1 (en) * | 2020-07-27 | 2022-02-03 | Unilever Ip Holdings B.V. | Use of an enzyme and surfactant for inhibiting microorganisms |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197291A (en) | 1974-01-08 | 1980-04-08 | Gerold K. V. Klein | Hydrolytic enzyme material |
| JPS5692217A (en) | 1979-12-26 | 1981-07-25 | Kowa Co | Easily absorbable enzyme preparation |
| IT1264322B (it) | 1992-07-30 | 1996-09-23 | Lanfranco Callegaro | Esteri di gellano autoreticolato, procedimento di preparazione e loro applicazioni farmaceutiche e biomedico-sanitarie |
| CA2106609A1 (en) * | 1992-09-28 | 1994-03-29 | Irene Yeatman Aldridge | Proteases to inhibit and remove biofilm |
| US5902600A (en) | 1992-12-21 | 1999-05-11 | Healthpoint, Ltd. | Hydrogel polymer wound dressing |
| DE19857237A1 (de) | 1997-12-23 | 1999-06-24 | Henkel Kgaa | Strahlenhärtbare Kaschierklebestoffe |
| US6395529B1 (en) | 1998-11-10 | 2002-05-28 | Novozymes Biotech, Inc. | Polypeptides having lactonohydrolase activity and nucleic acids encoding same |
| US6548556B2 (en) | 2000-12-27 | 2003-04-15 | Healthpoint, Ltd. | Stable enzymatic wound debrider |
| US6399092B1 (en) | 2000-12-27 | 2002-06-04 | Healthpoint, Ltd. | Anhydrous, hydrophilic absorbent wound dressing (tube) with antimicrobials or other pharmaceutically active agents |
| US20030026794A1 (en) | 2001-07-31 | 2003-02-06 | Howard Fein | Selective enzyme treatment of skin conditions |
| US6479060B1 (en) | 2001-09-04 | 2002-11-12 | Healthpoint, Ltd. | Elegant hydrogenated castor oil ointments |
| US20030198631A1 (en) | 2002-04-18 | 2003-10-23 | Healthpoint, Ltd. | Thermolysin enzymatic wound debrider |
| EP1578935A2 (en) | 2002-10-10 | 2005-09-28 | Diversa Corporation | Proteases, nucleic acids encoding them and methods for making and using them |
| US20050079594A1 (en) * | 2002-10-31 | 2005-04-14 | Karine Marion | Method of removing a biofilm |
| FR2846665B1 (fr) * | 2002-10-31 | 2006-09-08 | Karine Marion | Procede d'elimination du biofilm |
| WO2004061117A2 (en) | 2002-12-20 | 2004-07-22 | University Of Medicine And Dentistry Of New Jersey | Compositions and methods for enzymatic detachment of bacterial and fungal biofilms |
| US8821862B2 (en) | 2002-12-20 | 2014-09-02 | Kane Biotech Inc. | Soluble β-N-acetylglucosaminidase based antibiofilm compositions and uses thereof |
| US20100221237A1 (en) | 2003-03-26 | 2010-09-02 | Biosynexus Incorporated | Enzyme disruption of bacterial biofilms |
| US7785584B2 (en) | 2003-08-13 | 2010-08-31 | Healthpoint, Ltd. | Ointment wound spray |
| WO2005042012A1 (en) | 2003-10-29 | 2005-05-12 | Altus Pharmaceuticals Inc. | Non-pancreatic proteases for controlling plasma cholecystokinin (cck) concentration and for treating pain |
| GB0326194D0 (en) * | 2003-11-10 | 2003-12-17 | Univ Kent Canterbury | Proteins involved in signal transduction |
| US20080177217A1 (en) | 2004-05-14 | 2008-07-24 | Hans-Dietrich Polaschegg | Taurolidine Formulations and Delivery: Therapeutic Treatments and Antimicrobial Protection Against Bacterial Biofilm Formation |
| EP1666075A1 (en) | 2004-10-04 | 2006-06-07 | Switch Biotech Aktiengesellschaft | Wound dressing compositions, especially for delivery of protease inhibitors |
| IL165334A0 (en) | 2004-11-22 | 2006-01-15 | Mediwound Ltd | Debriding composition from bromelain and methods of producing same |
| WO2007047205A2 (en) | 2005-10-11 | 2007-04-26 | Amano Enzyme Usa Co., Ltd. | Enzyme inhibitors of pai-1 |
| WO2008021987A2 (en) | 2006-08-10 | 2008-02-21 | Jon Barron | Proteolytic enzyme formulations |
| AT504159A1 (de) | 2006-08-16 | 2008-03-15 | Marlyn Nutraceuticals Inc | Verwendung von proteasen |
| RU2009139059A (ru) | 2007-03-23 | 2011-04-27 | ДАНИСКО ЮЭс, ИНК., ДЖЕНЕНКОР ДИВИЖН (US) | Улучшенное производство амилазы посредством присоединения к n-концу зрелого белка амилазы |
| JP2008290966A (ja) | 2007-05-24 | 2008-12-04 | Michiharu Sasaki | 養毛剤 |
| HUE034051T2 (en) | 2007-11-27 | 2018-01-29 | Algipharma As | Use of alginate-containing oligomers to combat biofilms |
| AT506095A1 (de) | 2007-12-03 | 2009-06-15 | Volopharm Gmbh | Verwendung von proteasen |
| US8309081B2 (en) | 2008-11-18 | 2012-11-13 | Scarguard Labs, Llc. | Composition and method for treatment of bruising |
| JP2010126710A (ja) * | 2008-12-01 | 2010-06-10 | Kao Corp | バイオフィルム除去剤組成物 |
| WO2010079209A2 (en) | 2009-01-08 | 2010-07-15 | Golub Alexandr A | Compositions for treating wounds and skin conditions |
| GB0905451D0 (en) | 2009-03-31 | 2009-05-13 | Novabiotics Ltd | Biofilms |
| EP2504025A4 (en) | 2009-11-23 | 2013-05-01 | Stephen F Olmstead | COMPOSITIONS AND METHODS USING SERRATIA PEPTIDASE FOR INHIBITING AND TREATING BIOFILMS ASSOCIATED WITH PARTICULAR SUFFERING |
| RU2585373C2 (ru) | 2009-12-08 | 2016-05-27 | Смит & Невью Ортопедикс АГ | Ферментная композиция и способ обработки ран |
| US8796009B2 (en) | 2010-06-21 | 2014-08-05 | Toyota Motor Engineering & Manufacturing North America, Inc. | Clearcoat containing thermolysin-like protease from Bacillus stearothermophilus for cleaning of insect body stains |
| US9121016B2 (en) | 2011-09-09 | 2015-09-01 | Toyota Motor Engineering & Manufacturing North America, Inc. | Coatings containing polymer modified enzyme for stable self-cleaning of organic stains |
| CN103687610A (zh) | 2011-05-12 | 2014-03-26 | 史密夫和内修整形外科股份公司 | 含有蜂蜜曲霉蛋白酶的伤口清创组合物和使用其治疗伤口的方法 |
| US10058596B2 (en) | 2011-12-20 | 2018-08-28 | Kci Licensing, Inc. | Composition for enzymatic debridement |
| WO2013170128A1 (en) | 2012-05-11 | 2013-11-14 | Smith & Nephew, Inc. | Use of seaprose to remove bacterial biofilm |
| EP2919805B1 (en) * | 2012-11-14 | 2022-01-05 | Smith & Nephew, Inc. | Stable thermolysin hydrogel |
| US10159688B2 (en) | 2013-03-15 | 2018-12-25 | M. Alphabet 3, L.L.C. | Methods and compositions for enhancing oxygen levels in tissues |
| AU2014235578B2 (en) | 2013-03-15 | 2017-08-17 | Smith & Nephew, Inc. | Dissolvable gel-forming film for delivery of active agents |
| CN106164237B (zh) | 2014-04-11 | 2021-01-05 | 诺维信公司 | 洗涤剂组合物 |
| JP6987039B2 (ja) | 2015-08-24 | 2021-12-22 | スミス アンド ネフュー インコーポレイテッド | 抗菌剤と組み合わせた中極性油の細菌性バイオフィルムに対する相乗的抗菌活性 |
| AU2017304271B2 (en) * | 2016-07-27 | 2024-07-18 | Smith & Nephew, Inc. | Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces |
| EP3573622B1 (en) * | 2017-01-30 | 2023-10-18 | Smith & Nephew, Inc. | Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces |
-
2017
- 2017-07-26 AU AU2017304271A patent/AU2017304271B2/en active Active
- 2017-07-26 CA CA3031866A patent/CA3031866A1/en active Pending
- 2017-07-26 US US16/319,927 patent/US11628207B2/en active Active
- 2017-07-26 EP EP17758624.5A patent/EP3490588A1/en active Pending
- 2017-07-26 JP JP2019503673A patent/JP7127013B2/ja active Active
- 2017-07-26 CN CN201780046178.1A patent/CN109475609A/zh active Pending
- 2017-07-26 WO PCT/IB2017/054535 patent/WO2018020435A1/en not_active Ceased
-
2022
- 2022-06-01 JP JP2022089557A patent/JP2022111186A/ja active Pending
-
2023
- 2023-03-13 US US18/120,726 patent/US20230346898A1/en active Pending
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