CN109475609A - 使用嗜热菌蛋白酶减少或消除来自表面的细菌生物膜 - Google Patents

使用嗜热菌蛋白酶减少或消除来自表面的细菌生物膜 Download PDF

Info

Publication number
CN109475609A
CN109475609A CN201780046178.1A CN201780046178A CN109475609A CN 109475609 A CN109475609 A CN 109475609A CN 201780046178 A CN201780046178 A CN 201780046178A CN 109475609 A CN109475609 A CN 109475609A
Authority
CN
China
Prior art keywords
tissue
thermolysin
composition
wound
ulcer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780046178.1A
Other languages
English (en)
Chinese (zh)
Inventor
石磊
凯瑟琳·范德卡尔
阿列克萨·约万诺维奇
埃里克·罗奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith and Nephew Inc
Original Assignee
Smith and Nephew Richards Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith and Nephew Richards Inc filed Critical Smith and Nephew Richards Inc
Publication of CN109475609A publication Critical patent/CN109475609A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds containing nitrogen-to-oxygen bonds
    • A01N33/18—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24027—Thermolysin (3.4.24.27)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
CN201780046178.1A 2016-07-27 2017-07-26 使用嗜热菌蛋白酶减少或消除来自表面的细菌生物膜 Pending CN109475609A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662367338P 2016-07-27 2016-07-27
US62/367,338 2016-07-27
PCT/IB2017/054535 WO2018020435A1 (en) 2016-07-27 2017-07-26 Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces

Publications (1)

Publication Number Publication Date
CN109475609A true CN109475609A (zh) 2019-03-15

Family

ID=59738382

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780046178.1A Pending CN109475609A (zh) 2016-07-27 2017-07-26 使用嗜热菌蛋白酶减少或消除来自表面的细菌生物膜

Country Status (7)

Country Link
US (2) US11628207B2 (https=)
EP (1) EP3490588A1 (https=)
JP (2) JP7127013B2 (https=)
CN (1) CN109475609A (https=)
AU (1) AU2017304271B2 (https=)
CA (1) CA3031866A1 (https=)
WO (1) WO2018020435A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116057158A (zh) * 2020-07-27 2023-05-02 联合利华知识产权控股有限公司 酶和表面活性剂用于抑制微生物的用途

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3031866A1 (en) * 2016-07-27 2018-02-01 Smith & Nephew, Inc. Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
WO2018140707A1 (en) 2017-01-30 2018-08-02 Smith & Nephew, Inc. Synergistic combination of thermolysin and an antibacterial agent to reduce eliminate bacterial biofilms from surfaces
US20220306968A1 (en) * 2019-06-06 2022-09-29 Danisco Us Inc Methods and compositions for cleaning

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0590746A1 (en) * 1992-09-28 1994-04-06 W.R. Grace & Co.-Conn. Proteases to inhibit and remove biofilm
US20050079594A1 (en) * 2002-10-31 2005-04-14 Karine Marion Method of removing a biofilm
WO2005047514A1 (en) * 2003-11-10 2005-05-26 University Of Kent Proteins involved in signal transduction
JP2006504835A (ja) * 2002-10-31 2006-02-09 カリーヌ マリオン、 バイオフィルムの除去方法
JP2010126710A (ja) * 2008-12-01 2010-06-10 Kao Corp バイオフィルム除去剤組成物
US20100305062A1 (en) * 2007-11-27 2010-12-02 Algipharma Ipr As Use of alginate oligomers in combating biofilms
JP2013531103A (ja) * 2010-06-21 2013-08-01 トヨタ モーター エンジニアリング アンド マニュファクチャリング ノース アメリカ，インコーポレイティド 虫の体汚染の簡易洗浄のためのサモアーゼｃ１６０（登録商標）含有クリアコート
WO2014078581A1 (en) * 2012-11-14 2014-05-22 Smith & Nephew, Inc. Stable thermolysin hydrogel

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197291A (en) 1974-01-08 1980-04-08 Gerold K. V. Klein Hydrolytic enzyme material
JPS5692217A (en) 1979-12-26 1981-07-25 Kowa Co Easily absorbable enzyme preparation
IT1264322B (it) 1992-07-30 1996-09-23 Lanfranco Callegaro Esteri di gellano autoreticolato, procedimento di preparazione e loro applicazioni farmaceutiche e biomedico-sanitarie
US5902600A (en) 1992-12-21 1999-05-11 Healthpoint, Ltd. Hydrogel polymer wound dressing
DE19857237A1 (de) 1997-12-23 1999-06-24 Henkel Kgaa Strahlenhärtbare Kaschierklebestoffe
US6395529B1 (en) 1998-11-10 2002-05-28 Novozymes Biotech, Inc. Polypeptides having lactonohydrolase activity and nucleic acids encoding same
US6399092B1 (en) 2000-12-27 2002-06-04 Healthpoint, Ltd. Anhydrous, hydrophilic absorbent wound dressing (tube) with antimicrobials or other pharmaceutically active agents
US6548556B2 (en) 2000-12-27 2003-04-15 Healthpoint, Ltd. Stable enzymatic wound debrider
US20030026794A1 (en) 2001-07-31 2003-02-06 Howard Fein Selective enzyme treatment of skin conditions
US6479060B1 (en) 2001-09-04 2002-11-12 Healthpoint, Ltd. Elegant hydrogenated castor oil ointments
US20030198631A1 (en) 2002-04-18 2003-10-23 Healthpoint, Ltd. Thermolysin enzymatic wound debrider
MX282672B (es) 2002-10-10 2011-01-10 Diversa Corp Proteasas, acidos nucleicos que los codifican, y metodos de hacer y usar los mismos.
US8821862B2 (en) 2002-12-20 2014-09-02 Kane Biotech Inc. Soluble β-N-acetylglucosaminidase based antibiofilm compositions and uses thereof
NZ540731A (en) 2002-12-20 2008-04-30 Univ New Jersey Med Compositions and methods for enzymatic detachment of bacterial and fungal biofilms
US20100221237A1 (en) 2003-03-26 2010-09-02 Biosynexus Incorporated Enzyme disruption of bacterial biofilms
US7785584B2 (en) 2003-08-13 2010-08-31 Healthpoint, Ltd. Ointment wound spray
KR20060127857A (ko) 2003-10-29 2006-12-13 알투스 파마슈티컬스 인코포레이티드 혈장 콜레시스토키닌(ｃｃｋ) 농도 조절 및 통증 치료를위한 비-췌장 프로테아제
WO2005115357A2 (en) 2004-05-14 2005-12-08 Hans-Dietrich Polaschegg Taurolidine formulations and delivery
EP1666075A1 (en) 2004-10-04 2006-06-07 Switch Biotech Aktiengesellschaft Wound dressing compositions, especially for delivery of protease inhibitors
IL165334A0 (en) 2004-11-22 2006-01-15 Mediwound Ltd Debriding composition from bromelain and methods of producing same
WO2007047205A2 (en) 2005-10-11 2007-04-26 Amano Enzyme Usa Co., Ltd. Enzyme inhibitors of pai-1
WO2008021987A2 (en) 2006-08-10 2008-02-21 Jon Barron Proteolytic enzyme formulations
AT504159A1 (de) 2006-08-16 2008-03-15 Marlyn Nutraceuticals Inc Verwendung von proteasen
BRPI0809096A2 (pt) 2007-03-23 2014-09-09 Danisco Us Inc Genecor Division Produção aumentada de amilase através da adição n-terminal à proteína amilase madura
JP2008290966A (ja) 2007-05-24 2008-12-04 Michiharu Sasaki 養毛剤
AT506095A1 (de) 2007-12-03 2009-06-15 Volopharm Gmbh Verwendung von proteasen
US8309081B2 (en) 2008-11-18 2012-11-13 Scarguard Labs, Llc. Composition and method for treatment of bruising
WO2010079209A2 (en) 2009-01-08 2010-07-15 Golub Alexandr A Compositions for treating wounds and skin conditions
GB0905451D0 (en) 2009-03-31 2009-05-13 Novabiotics Ltd Biofilms
WO2011063394A2 (en) 2009-11-23 2011-05-26 Olmstead Stephen F Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions
CN102711808B (zh) 2009-12-08 2015-08-19 史密夫和内修整形外科股份公司 具有增强的酶活性的酶学伤口清创组合物
US9121016B2 (en) 2011-09-09 2015-09-01 Toyota Motor Engineering & Manufacturing North America, Inc. Coatings containing polymer modified enzyme for stable self-cleaning of organic stains
AU2012253379A1 (en) 2011-05-12 2013-11-21 Healthpoint, Ltd. Wound debridement compositions containing seaprose and methods of wound treatment using same
WO2013096337A1 (en) 2011-12-20 2013-06-27 Kci Licensing, Inc. Composition for enzymatic debridement
MX2014013745A (es) 2012-05-11 2016-05-05 Smith & Nephew Inc Uso de seaprose para eliminar la pelicula biologica bacteriana.
RU2015137174A (ru) * 2013-03-15 2017-04-24 Смит энд Невью, Инк. Растворимая образующая гель плёнка и способ очистки раны
CA2907175C (en) 2013-03-15 2022-11-08 M. Alphabet 3, L.L.C. Methods and compositions for enhancing oxygen levels in tissues
WO2015155351A1 (en) 2014-04-11 2015-10-15 Novozymes A/S Detergent composition
JP6987039B2 (ja) 2015-08-24 2021-12-22 スミス アンド ネフュー インコーポレイテッド 抗菌剤と組み合わせた中極性油の細菌性バイオフィルムに対する相乗的抗菌活性
CA3031866A1 (en) * 2016-07-27 2018-02-01 Smith & Nephew, Inc. Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
WO2018140707A1 (en) * 2017-01-30 2018-08-02 Smith & Nephew, Inc. Synergistic combination of thermolysin and an antibacterial agent to reduce eliminate bacterial biofilms from surfaces

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0590746A1 (en) * 1992-09-28 1994-04-06 W.R. Grace & Co.-Conn. Proteases to inhibit and remove biofilm
US20050079594A1 (en) * 2002-10-31 2005-04-14 Karine Marion Method of removing a biofilm
JP2006504835A (ja) * 2002-10-31 2006-02-09 カリーヌ マリオン、 バイオフィルムの除去方法
WO2005047514A1 (en) * 2003-11-10 2005-05-26 University Of Kent Proteins involved in signal transduction
US20100305062A1 (en) * 2007-11-27 2010-12-02 Algipharma Ipr As Use of alginate oligomers in combating biofilms
JP2010126710A (ja) * 2008-12-01 2010-06-10 Kao Corp バイオフィルム除去剤組成物
JP2013531103A (ja) * 2010-06-21 2013-08-01 トヨタ モーター エンジニアリング アンド マニュファクチャリング ノース アメリカ，インコーポレイティド 虫の体汚染の簡易洗浄のためのサモアーゼｃ１６０（登録商標）含有クリアコート
WO2014078581A1 (en) * 2012-11-14 2014-05-22 Smith & Nephew, Inc. Stable thermolysin hydrogel

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHRISTOPHER ATTINGER 等: "Clinically Addressing Biofilm in Chronic Wounds", 《ADVANCES IN WOUND CARE》 *
SHINYA SUGIMOTO 等: "Staphylococcus epidermidis Esp Degrades Specific Proteins Associated with Staphylococcus aureus Biofilm Formation and Host-Pathogen Interaction", 《JOURNAL OF BACTERIOLOGY》 *
黄云超 等: "金属蛋白酶对涤纶材料表面金黄色葡萄球菌生物膜形成的影响", 《中国胸心血管外科临床杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116057158A (zh) * 2020-07-27 2023-05-02 联合利华知识产权控股有限公司 酶和表面活性剂用于抑制微生物的用途

Also Published As

Publication number Publication date
US20190262437A1 (en) 2019-08-29
JP2022111186A (ja) 2022-07-29
US20230346898A1 (en) 2023-11-02
EP3490588A1 (en) 2019-06-05
JP7127013B2 (ja) 2022-08-29
AU2017304271A1 (en) 2019-02-28
CA3031866A1 (en) 2018-02-01
WO2018020435A1 (en) 2018-02-01
JP2019522017A (ja) 2019-08-08
US11628207B2 (en) 2023-04-18
AU2017304271B2 (en) 2024-07-18

Similar Documents

Publication Publication Date Title
US20230346898A1 (en) Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
US12588675B2 (en) Synergistic antibacterial activity of medium polarity oils in combination with antibacterial agents on bacterial biofilms
US11957698B2 (en) Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces
EP2515869B1 (en) Wound care products
JP7118022B2 (ja) 細菌性バイオフィルムを除去するためのセアプローゼの使用
CN110072391A (zh) 抗微生物组合物
EP4707344A2 (en) New high-efficiency antimicrobial composition
EP4618972A1 (en) Biofilm treatment
WO2022112591A1 (en) A method for removing a biofilm.

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination