|
GB9206016D0
(en)
|
1992-03-19 |
1992-04-29 |
Sandoz Ltd |
Improvements in or relating to organic compounds
|
|
US6306829B1
(en)
|
1995-12-08 |
2001-10-23 |
Hybridon, Inc. |
Modified VEGF oligonucleotides for treatment of skin disorders
|
|
US5639872A
(en)
|
1993-07-27 |
1997-06-17 |
Hybridon, Inc. |
Human VEGF-specific oligonucleotides
|
|
US6440425B1
(en)
*
|
1995-05-01 |
2002-08-27 |
Aventis Pasteur Limited |
High molecular weight major outer membrane protein of moraxella
|
|
US6001650A
(en)
|
1995-08-03 |
1999-12-14 |
Avigen, Inc. |
High-efficiency wild-type-free AAV helper functions
|
|
US6096548A
(en)
|
1996-03-25 |
2000-08-01 |
Maxygen, Inc. |
Method for directing evolution of a virus
|
|
EP0927044A4
(en)
|
1996-04-16 |
1999-09-08 |
Immusol Inc |
DEFINED TARGET VIRAL VECTORS
|
|
US6710036B2
(en)
|
1997-07-25 |
2004-03-23 |
Avigen, Inc. |
Induction of immune response to antigens expressed by recombinant adeno-associated virus
|
|
WO1999014354A1
(en)
|
1997-09-19 |
1999-03-25 |
The Trustees Of The University Of The Pennsylvania |
Methods and vector constructs useful for production of recombinant aav
|
|
EP1030861A4
(en)
|
1997-10-31 |
2001-09-05 |
Maxygen Inc |
MODIFICATION OF VIRUSTROPISMIUS AND THE ECONOMIC SPECTRUM BY VIRAL GENOM MIXING
|
|
US6410300B1
(en)
|
1998-01-12 |
2002-06-25 |
The University Of North Carolina At Chapel Hill |
Methods and formulations for mediating adeno-associated virus (AAV) attachment and infection and methods for purifying AAV
|
|
US6551795B1
(en)
|
1998-02-18 |
2003-04-22 |
Genome Therapeutics Corporation |
Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
|
|
DE19827457C1
(de)
|
1998-06-19 |
2000-03-02 |
Medigene Ag |
Strukturprotein von AAV, seine Herstellung und Verwendung
|
|
AU5819599A
(en)
|
1998-09-11 |
2000-04-03 |
Regents Of The University Of California, The |
Recombinant adenovirus for tissue specific expression in heart
|
|
AU780231B2
(en)
|
1998-11-10 |
2005-03-10 |
University Of North Carolina At Chapel Hill, The |
Virus vectors and methods of making and administering the same
|
|
US6943153B1
(en)
|
1999-03-15 |
2005-09-13 |
The Regents Of The University Of California |
Use of recombinant gene delivery vectors for treating or preventing diseases of the eye
|
|
US6498244B1
(en)
|
1999-05-28 |
2002-12-24 |
Cell Genesys, Inc. |
Adeno-associated virus capsid immunologic determinants
|
|
US7314912B1
(en)
|
1999-06-21 |
2008-01-01 |
Medigene Aktiengesellschaft |
AAv scleroprotein, production and use thereof
|
|
DE19933288A1
(de)
|
1999-07-15 |
2001-01-18 |
Medigene Ag |
Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung
|
|
DE19933719A1
(de)
|
1999-07-19 |
2001-01-25 |
Medigene Ag |
Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung
|
|
US8232081B2
(en)
*
|
1999-09-21 |
2012-07-31 |
Basf Se |
Methods and microorganisms for production of panto-compounds
|
|
US6855314B1
(en)
|
2000-03-22 |
2005-02-15 |
The United States Of America As Represented By The Department Of Health And Human Services |
AAV5 vector for transducing brain cells and lung cells
|
|
US7749492B2
(en)
|
2001-01-05 |
2010-07-06 |
Nationwide Children's Hospital, Inc. |
AAV vectors and methods
|
|
WO2002053703A2
(en)
|
2001-01-05 |
2002-07-11 |
Children's Hospital, Inc. |
Aav2 vectors and methods
|
|
EP1386004A4
(en)
|
2001-04-05 |
2005-02-16 |
Ribozyme Pharm Inc |
MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID
|
|
US20030144221A1
(en)
|
2001-07-17 |
2003-07-31 |
Isis Pharmaceuticals Inc. |
Antisense modulation of BCL2-associated X protein expression
|
|
US20030129203A1
(en)
|
2001-08-27 |
2003-07-10 |
Nautilus Biotech S.A. |
Mutant recombinant adeno-associated viruses
|
|
US7647184B2
(en)
|
2001-08-27 |
2010-01-12 |
Hanall Pharmaceuticals, Co. Ltd |
High throughput directed evolution by rational mutagenesis
|
|
WO2003042361A2
(en)
|
2001-11-09 |
2003-05-22 |
Government Of The United States Of America, Department Of Health And Human Services |
Production of adeno-associated virus in insect cells
|
|
MX359371B
(es)
|
2001-11-13 |
2018-09-25 |
Univ Pennsylvania |
Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo.
|
|
EP1456383B1
(en)
|
2001-12-21 |
2014-03-12 |
Medigene AG |
A library of modified structural genes or capsid modified particles useful for the identification of viral clones with desired cell tropism
|
|
AU2003221733A1
(en)
|
2002-04-17 |
2003-11-03 |
University Of Florida Research Foundation, Inc. |
Improved raav vectors
|
|
AU2003223766A1
(en)
|
2002-04-30 |
2003-11-17 |
University Of North Carolina At Chapel Hill |
Secretion signal vectors
|
|
US7858367B2
(en)
|
2002-04-30 |
2010-12-28 |
Duke University |
Viral vectors and methods for producing and using the same
|
|
US20040142416A1
(en)
|
2002-04-30 |
2004-07-22 |
Laipis Philip J. |
Treatment for phenylketonuria
|
|
US7254489B2
(en)
|
2002-05-31 |
2007-08-07 |
Microsoft Corporation |
Systems, methods and apparatus for reconstructing phylogentic trees
|
|
US7148342B2
(en)
|
2002-07-24 |
2006-12-12 |
The Trustees Of The University Of Pennyslvania |
Compositions and methods for sirna inhibition of angiogenesis
|
|
AU2003265855A1
(en)
|
2002-08-28 |
2004-03-19 |
University Of Florida |
Modified aav
|
|
US20070172460A1
(en)
|
2003-03-19 |
2007-07-26 |
Jurgen Kleinschmidt |
Random peptide library displayed on aav vectors
|
|
WO2004108922A2
(en)
|
2003-04-25 |
2004-12-16 |
The Trustees Of The University Of Pennsylvania |
Use of aav comprising a capsid protein from aav7 or aav8 for the delivery of genes encoding apoprotein a or e genes to the liver
|
|
EP1486567A1
(en)
|
2003-06-11 |
2004-12-15 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Improved adeno-associated virus (AAV) vector for gene therapy
|
|
SI1633772T1
(sl)
|
2003-06-19 |
2016-06-30 |
Genzyme Corporation |
AAV virioni z zmanjšano imunoreaktivnostjo in uporaba za ta namen
|
|
US7368428B2
(en)
|
2003-06-23 |
2008-05-06 |
A&G Pharmaceutical, Inc. |
Compositions and methods for restoring sensitivity of tumor cells to antitumor therapy and inducing apoptosis
|
|
US9441244B2
(en)
|
2003-06-30 |
2016-09-13 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US9233131B2
(en)
|
2003-06-30 |
2016-01-12 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US20050019927A1
(en)
|
2003-07-13 |
2005-01-27 |
Markus Hildinger |
DECREASING GENE EXPRESSION IN A MAMMALIAN SUBJECT IN VIVO VIA AAV-MEDIATED RNAi EXPRESSION CASSETTE TRANSFER
|
|
US8106180B2
(en)
|
2003-08-07 |
2012-01-31 |
Whitehead Institute For Biomedical Research |
Methods and products for expression of micro RNAs
|
|
US20050142581A1
(en)
|
2003-09-04 |
2005-06-30 |
Griffey Richard H. |
Microrna as ligands and target molecules
|
|
CA2539947A1
(en)
|
2003-09-24 |
2005-04-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Igf-1 instructs multipotent adult cns neural stem cells to an oligodendroglial lineage
|
|
EP2345731B1
(en)
|
2003-09-30 |
2015-10-21 |
The Trustees of the University of Pennsylvania |
Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof
|
|
WO2005056761A2
(en)
|
2003-12-05 |
2005-06-23 |
Massachusetts Institute Of Technology |
REAGENTS AND METHODS FOR IDENTIFICATION OF RNAi PATHWAY GENES AND CHEMICAL MODULATORS OF RNAi
|
|
ES2423060T3
(es)
|
2004-03-12 |
2013-09-17 |
Alnylam Pharmaceuticals, Inc. |
Agentes iRNA que tienen como diana al VEGF
|
|
KR100614827B1
(ko)
|
2004-05-06 |
2006-08-25 |
재단법인서울대학교산학협력재단 |
양방향 은닉 마코프 모델을 이용한 완숙한마이크로알엔에이 위치예측방법 및 이를 구현하기 위한컴퓨터 프로그램을 기록한 저장매체
|
|
US7427396B2
(en)
|
2004-06-03 |
2008-09-23 |
Genzyme Corporation |
AAV vectors for gene delivery to the lung
|
|
JP5136766B2
(ja)
|
2004-12-15 |
2013-02-06 |
ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
キメラベクター
|
|
WO2006101634A1
(en)
|
2005-02-17 |
2006-09-28 |
The Regents Of The University Of California |
Müller cell specific gene therapy
|
|
ES2525067T3
(es)
|
2005-04-07 |
2014-12-17 |
The Trustees Of The University Of Pennsylvania |
Método de incremento de la función de un vector de AAV
|
|
EP1919497B1
(en)
|
2005-07-22 |
2020-02-12 |
The Board of Trustees of the Leland Stanford Junior University |
Light-activated cation channel and uses thereof
|
|
US7867484B2
(en)
|
2006-01-27 |
2011-01-11 |
University Of North Carolina At Chapel Hill |
Heparin and heparan sulfate binding chimeric vectors
|
|
US7588772B2
(en)
|
2006-03-30 |
2009-09-15 |
Board Of Trustees Of The Leland Stamford Junior University |
AAV capsid library and AAV capsid proteins
|
|
CN101484005A
(zh)
|
2006-05-04 |
2009-07-15 |
韦恩州立大学 |
通过向体内递送视紫红质核酸恢复视觉响应
|
|
FI123071B
(fi)
|
2006-07-28 |
2012-10-31 |
Stora Enso Oyj |
Eteenimetyyliakrylaattikopolymeerin käyttö D-limoneenin imeytymisen pienentämiseen sitrusmehusta
|
|
US7872118B2
(en)
|
2006-09-08 |
2011-01-18 |
Opko Ophthalmics, Llc |
siRNA and methods of manufacture
|
|
ITMI20061816A1
(it)
|
2006-09-26 |
2008-03-27 |
Marina Anna Brivio |
Pompa peristaltica
|
|
CN1966082B
(zh)
|
2006-11-03 |
2010-06-30 |
许瑞安 |
一种防治结直肠癌的基因药物及其制备方法和用途
|
|
US9725485B2
(en)
*
|
2012-05-15 |
2017-08-08 |
University Of Florida Research Foundation, Inc. |
AAV vectors with high transduction efficiency and uses thereof for gene therapy
|
|
CA2683443A1
(en)
|
2007-04-13 |
2008-10-23 |
Catalyst Biosciences, Inc. |
Modified factor vii polypeptides and uses thereof
|
|
EP1985708B1
(en)
|
2007-04-27 |
2015-04-15 |
Universität Rostock |
Selective targeting of viruses to neural precursor cells
|
|
WO2009137006A2
(en)
|
2008-04-30 |
2009-11-12 |
The University Of North Carolina At Chapel Hill |
Directed evolution and in vivo panning of virus vectors
|
|
WO2010011404A2
(en)
|
2008-05-20 |
2010-01-28 |
Eos Neuroscience, Inc. |
Vectors for delivery of light-sensitive proteins and methods of use
|
|
WO2009154452A1
(en)
|
2008-06-17 |
2009-12-23 |
Amsterdam Molecular Therapeutics B.V. |
Parvoviral capsid with incorporated Gly-Ala repeat region
|
|
WO2010093784A2
(en)
|
2009-02-11 |
2010-08-19 |
The University Of North Carolina At Chapel Hill |
Modified virus vectors and methods of making and using the same
|
|
CN101532024A
(zh)
|
2009-04-30 |
2009-09-16 |
许瑞安 |
一种用于基因治疗的新型细胞特异性内含microRNA结合序列的基因HAAVmir
|
|
US8734809B2
(en)
|
2009-05-28 |
2014-05-27 |
University Of Massachusetts |
AAV's and uses thereof
|
|
US8586526B2
(en)
|
2010-05-17 |
2013-11-19 |
Sangamo Biosciences, Inc. |
DNA-binding proteins and uses thereof
|
|
EP2547762B1
(en)
|
2010-03-17 |
2018-04-25 |
The Board of Trustees of the Leland Stanford Junior University |
Light-sensitive ion-passing molecules
|
|
US9546112B2
(en)
|
2010-03-22 |
2017-01-17 |
Association Institut De Myologie |
Methods of increasing efficiency of vector penetration of target tissue
|
|
US8663624B2
(en)
|
2010-10-06 |
2014-03-04 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsid and methods of use thereof
|
|
EP2635111B1
(en)
|
2010-11-05 |
2018-05-23 |
The Board of Trustees of the Leland Stanford Junior University |
Stabilized step function opsin proteins and methods of using the same
|
|
WO2012061679A2
(en)
|
2010-11-05 |
2012-05-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
Light-activated chimeric opsins and methods of using the same
|
|
CN105755044A
(zh)
|
2011-04-22 |
2016-07-13 |
加利福尼亚大学董事会 |
具有变异衣壳的腺相关病毒病毒体及其使用方法
|
|
ES2857773T5
(es)
|
2011-08-24 |
2024-06-04 |
Univ Leland Stanford Junior |
Nuevas proteínas de la cápside de AAV para la transferencia de ácidos nucleicos
|
|
WO2013170078A1
(en)
|
2012-05-09 |
2013-11-14 |
Oregon Health & Science University |
Adeno associated virus plasmids and vectors
|
|
TWI698240B
(zh)
|
2012-05-15 |
2020-07-11 |
澳大利亞商艾佛蘭屈澳洲私營有限公司 |
使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd)
|
|
CA2877493C
(en)
*
|
2012-07-24 |
2020-08-25 |
Natera, Inc. |
Highly multiplex pcr methods and compositions
|
|
US9938541B2
(en)
|
2012-12-25 |
2018-04-10 |
Takara Bio Inc. |
AAV variant
|
|
US9567376B2
(en)
*
|
2013-02-08 |
2017-02-14 |
The Trustees Of The University Of Pennsylvania |
Enhanced AAV-mediated gene transfer for retinal therapies
|
|
EP3004339B1
(en)
|
2013-05-29 |
2021-07-07 |
Cellectis |
New compact scaffold of cas9 in the type ii crispr system
|
|
EP3003391B1
(en)
|
2013-05-31 |
2021-09-22 |
The Regents of The University of California |
Adeno-associated virus variants and methods of use thereof
|
|
WO2014200910A2
(en)
|
2013-06-10 |
2014-12-18 |
Iogenetics, Llc |
Bioinformatic processes for determination of peptide binding
|
|
WO2014207190A1
(en)
|
2013-06-28 |
2014-12-31 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for expressing a polynucleotide of interest in the retina of a subject
|
|
WO2015048534A1
(en)
|
2013-09-26 |
2015-04-02 |
University Of Florida Research Foundation, Inc. |
Synthetic combinatorial aav capsid library for targeted gene therapy
|
|
CN106232618A
(zh)
|
2013-10-11 |
2016-12-14 |
马萨诸塞眼科耳科诊所 |
预测祖先病毒序列的方法及其用途
|
|
GB201403684D0
(en)
|
2014-03-03 |
2014-04-16 |
King S College London |
Vector
|
|
EP3800191B1
(en)
|
2014-03-17 |
2025-08-20 |
Adverum Biotechnologies, Inc. |
Compositions and methods for enhanced gene expression in cone cells
|
|
LT3137497T
(lt)
|
2014-05-02 |
2021-07-26 |
Genzyme Corporation |
Aav vektoriai, skirti tinklainės ir cns genų terapijai
|
|
EP3155116A4
(en)
*
|
2014-06-10 |
2017-12-27 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
AU2016219789B2
(en)
|
2015-02-20 |
2021-03-25 |
Fondazione Telethon |
Methods and compositions for treating genetic eye diseases
|
|
US11021519B2
(en)
|
2015-03-02 |
2021-06-01 |
Adverum Biotechnologies, Inc. |
Compositions and methods for intravitreal delivery of polynucleotides to retinal cones
|
|
EP3748007B1
(en)
|
2015-03-06 |
2024-06-26 |
Massachusetts Eye & Ear Infirmary |
Gene augmentation therapies for inherited retinal degeneration caused by mutations in the prpf31 gene
|
|
JP6836999B2
(ja)
|
2015-03-24 |
2021-03-03 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ |
アデノ随伴ウイルス変異体及びその使用方法
|
|
US20190000940A1
(en)
|
2015-07-31 |
2019-01-03 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of aadc deficiency
|
|
CN105330732B
(zh)
*
|
2015-11-02 |
2019-03-15 |
重庆高圣生物医药有限责任公司 |
腺相关病毒介导的人低氧诱导因子1α突变体及其应用
|
|
US11364308B2
(en)
*
|
2016-05-13 |
2022-06-21 |
4D Molecular Therapeutics Inc. |
Adeno-associated virus variant capsids and methods of use thereof
|
|
MA44546B1
(fr)
*
|
2016-06-15 |
2021-03-31 |
Univ California |
Virus adéno-associés variants et procédés d'utilisation
|
|
AU2017302013B2
(en)
|
2016-07-29 |
2022-05-26 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsid and methods of use thereof
|
|
JP2020534788A
(ja)
|
2017-08-28 |
2020-12-03 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
アデノ随伴ウイルスカプシド変異体及びその使用方法
|