JP2019520797A5 - - Google Patents
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- JP2019520797A5 JP2019520797A5 JP2018557864A JP2018557864A JP2019520797A5 JP 2019520797 A5 JP2019520797 A5 JP 2019520797A5 JP 2018557864 A JP2018557864 A JP 2018557864A JP 2018557864 A JP2018557864 A JP 2018557864A JP 2019520797 A5 JP2019520797 A5 JP 2019520797A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- seq
- binding protein
- amino acid
- bispecific binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004169 proteins and genes Human genes 0.000 claims description 50
- 108090000623 proteins and genes Proteins 0.000 claims description 50
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 41
- 108091008324 binding proteins Proteins 0.000 claims description 22
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims description 8
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 8
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 8
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 2
- 206010057644 Testis cancer Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 201000010536 head and neck cancer Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims description 2
- 201000003120 testicular cancer Diseases 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 206010046766 uterine cancer Diseases 0.000 claims description 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 26
- 102000023732 binding proteins Human genes 0.000 description 13
- 239000002904 solvent Substances 0.000 description 8
- 101710089372 Programmed cell death protein 1 Proteins 0.000 description 7
- 108010074708 B7-H1 Antigen Proteins 0.000 description 6
- 102000008096 B7-H1 Antigen Human genes 0.000 description 6
- 210000004899 c-terminal region Anatomy 0.000 description 6
- 239000012634 fragment Substances 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 5
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 4
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000033581 fucosylation Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021158292A JP7171867B2 (ja) | 2016-05-06 | 2021-09-28 | 二重特異性結合タンパク質およびその使用 |
| JP2022177063A JP2023012528A (ja) | 2016-05-06 | 2022-11-04 | 二重特異性結合タンパク質およびその使用 |
| JP2024005009A JP7651022B2 (ja) | 2016-05-06 | 2024-01-17 | 二重特異性結合タンパク質およびその使用 |
| JP2025039002A JP2025090743A (ja) | 2016-05-06 | 2025-03-12 | 二重特異性結合タンパク質およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662332788P | 2016-05-06 | 2016-05-06 | |
| US62/332,788 | 2016-05-06 | ||
| PCT/US2017/031356 WO2017193032A2 (en) | 2016-05-06 | 2017-05-05 | Bispecific binding proteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021158292A Division JP7171867B2 (ja) | 2016-05-06 | 2021-09-28 | 二重特異性結合タンパク質およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520797A JP2019520797A (ja) | 2019-07-25 |
| JP2019520797A5 true JP2019520797A5 (enExample) | 2020-06-18 |
| JP6952716B2 JP6952716B2 (ja) | 2021-10-20 |
Family
ID=60203374
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557864A Active JP6952716B2 (ja) | 2016-05-06 | 2017-05-05 | 二重特異性結合タンパク質およびその使用 |
| JP2021158292A Active JP7171867B2 (ja) | 2016-05-06 | 2021-09-28 | 二重特異性結合タンパク質およびその使用 |
| JP2022177063A Pending JP2023012528A (ja) | 2016-05-06 | 2022-11-04 | 二重特異性結合タンパク質およびその使用 |
| JP2024005009A Active JP7651022B2 (ja) | 2016-05-06 | 2024-01-17 | 二重特異性結合タンパク質およびその使用 |
| JP2025039002A Pending JP2025090743A (ja) | 2016-05-06 | 2025-03-12 | 二重特異性結合タンパク質およびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021158292A Active JP7171867B2 (ja) | 2016-05-06 | 2021-09-28 | 二重特異性結合タンパク質およびその使用 |
| JP2022177063A Pending JP2023012528A (ja) | 2016-05-06 | 2022-11-04 | 二重特異性結合タンパク質およびその使用 |
| JP2024005009A Active JP7651022B2 (ja) | 2016-05-06 | 2024-01-17 | 二重特異性結合タンパク質およびその使用 |
| JP2025039002A Pending JP2025090743A (ja) | 2016-05-06 | 2025-03-12 | 二重特異性結合タンパク質およびその使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US10457732B2 (enExample) |
| EP (2) | EP3452089B1 (enExample) |
| JP (5) | JP6952716B2 (enExample) |
| KR (3) | KR102490183B1 (enExample) |
| CN (1) | CN109152835B (enExample) |
| AR (1) | AR108377A1 (enExample) |
| AU (3) | AU2017260365B2 (enExample) |
| CL (1) | CL2018003136A1 (enExample) |
| CO (1) | CO2018012415A2 (enExample) |
| DK (1) | DK3452089T3 (enExample) |
| ES (1) | ES3065767T3 (enExample) |
| FI (1) | FI3452089T3 (enExample) |
| HR (1) | HRP20260393T1 (enExample) |
| IL (3) | IL321475A (enExample) |
| LT (1) | LT3452089T (enExample) |
| MA (1) | MA44885B1 (enExample) |
| MX (2) | MX2018013548A (enExample) |
| MY (1) | MY200335A (enExample) |
| NZ (3) | NZ787945A (enExample) |
| PT (1) | PT3452089T (enExample) |
| RS (1) | RS67897B1 (enExample) |
| RU (2) | RU2766199C2 (enExample) |
| SG (1) | SG11201809089QA (enExample) |
| SM (1) | SMT202600124T1 (enExample) |
| TW (3) | TWI831124B (enExample) |
| WO (1) | WO2017193032A2 (enExample) |
| ZA (1) | ZA201808160B (enExample) |
Families Citing this family (50)
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| JP7058219B2 (ja) | 2015-12-07 | 2022-04-21 | ゼンコア インコーポレイテッド | Ｃｄ３及びｐｓｍａに結合するヘテロ二量体抗体 |
| JP6955507B2 (ja) | 2015-12-14 | 2021-10-27 | マクロジェニクス，インコーポレーテッド | Ｐｄ‐１及びｃｔｌａ‐４との免疫応答性を有する二重特異性並びにその使用方法 |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| AR108377A1 (es) | 2016-05-06 | 2018-08-15 | Medimmune Llc | Proteínas de unión biespecíficas y sus usos |
| MA45255A (fr) | 2016-06-14 | 2019-04-17 | Xencor Inc | Anticorps inhibiteurs de points de contrôle bispécifiques |
| BR112018076525A2 (pt) | 2016-06-20 | 2019-04-02 | F-Star Beta Limited | membros de ligação a lag-3 |
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| SG11201903867YA (en) * | 2016-11-01 | 2019-05-30 | Anaptysbio Inc | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
| JP7118073B2 (ja) | 2017-01-09 | 2022-08-15 | テサロ， インコーポレイテッド | 抗ｔｉｍ－３抗体を用いてがんを処置する方法 |
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| GB201811408D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | CD137 Binding Molecules |
| PL3820569T3 (pl) | 2018-07-12 | 2025-07-14 | Invox Pharma Limited | Cząsteczki przeciwciał, które wiążą PD-L1 oraz CD137 |
| WO2020102387A1 (en) * | 2018-11-13 | 2020-05-22 | Compass Therapeutics Llc | Multispecific binding constructs against checkpoint molecules and uses thereof |
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| CN110229232B (zh) | 2019-06-19 | 2020-05-19 | 北京智仁美博生物科技有限公司 | 双特异性抗体及其用途 |
| CN114616247B (zh) * | 2019-10-17 | 2024-06-28 | 江苏康宁杰瑞生物制药有限公司 | Ox40/pd-l1双特异性抗体 |
| CN114786720B (zh) * | 2019-12-05 | 2025-08-22 | 艾贝乐医药科技有限公司 | TriAx抗体的组合物及其制备和使用方法 |
| JP7489468B2 (ja) * | 2020-03-20 | 2024-05-23 | レメゲン シーオー．，エルティーディー． | 二重特異性融合タンパク質及びその応用 |
| JP7014250B2 (ja) | 2020-03-27 | 2022-02-01 | フジテック株式会社 | エレベータのドア装置用の動作設定装置、及び該動作設定装置を用いたドア装置の開閉動作の設定方法。 |
| CN116134053A (zh) * | 2020-07-27 | 2023-05-16 | 宏观基因有限公司 | 用于使用PD-1 x CTLA-4双特异性分子的方法 |
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| CR20230476A (es) | 2021-04-30 | 2024-01-30 | Medimmune Llc | Proteínas de unión a pd-1 y tigit biespecíficas y usos de estas |
| JP2025508024A (ja) * | 2022-03-07 | 2025-03-21 | メディミューン，エルエルシー | Ｃｔｌａ－４及びｐｄ－１二重特異性抗体を使用した治療方法 |
| CA3262449A1 (en) | 2022-07-28 | 2024-02-01 | Astrazeneca Uk Limited | COMBINATION OF AN ANTIBODY-DRUG CONJUGATE AND A BISPECIFIC CHECKPOINT INHIBITOR |
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| WO2024241246A1 (en) * | 2023-05-23 | 2024-11-28 | Medimmune, Llc | PD-1/TIM-3 BINDING PROTEINS FOR TREATMENT OF NSCLC AND cHL |
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