JP2019520797A5 - - Google Patents
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- JP2019520797A5 JP2019520797A5 JP2018557864A JP2018557864A JP2019520797A5 JP 2019520797 A5 JP2019520797 A5 JP 2019520797A5 JP 2018557864 A JP2018557864 A JP 2018557864A JP 2018557864 A JP2018557864 A JP 2018557864A JP 2019520797 A5 JP2019520797 A5 JP 2019520797A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- seq
- binding protein
- amino acid
- bispecific binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004169 proteins and genes Human genes 0.000 claims description 50
- 108090000623 proteins and genes Proteins 0.000 claims description 50
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 41
- 108091008324 binding proteins Proteins 0.000 claims description 22
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims description 8
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 8
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 8
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 2
- 206010057644 Testis cancer Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 201000010536 head and neck cancer Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims description 2
- 201000003120 testicular cancer Diseases 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 206010046766 uterine cancer Diseases 0.000 claims description 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 26
- 102000023732 binding proteins Human genes 0.000 description 13
- 239000002904 solvent Substances 0.000 description 8
- 101710089372 Programmed cell death protein 1 Proteins 0.000 description 7
- 108010074708 B7-H1 Antigen Proteins 0.000 description 6
- 102000008096 B7-H1 Antigen Human genes 0.000 description 6
- 210000004899 c-terminal region Anatomy 0.000 description 6
- 239000012634 fragment Substances 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 5
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 4
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000033581 fucosylation Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021158292A JP7171867B2 (ja) | 2016-05-06 | 2021-09-28 | 二重特異性結合タンパク質およびその使用 |
| JP2022177063A JP2023012528A (ja) | 2016-05-06 | 2022-11-04 | 二重特異性結合タンパク質およびその使用 |
| JP2024005009A JP7651022B2 (ja) | 2016-05-06 | 2024-01-17 | 二重特異性結合タンパク質およびその使用 |
| JP2025039002A JP2025090743A (ja) | 2016-05-06 | 2025-03-12 | 二重特異性結合タンパク質およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662332788P | 2016-05-06 | 2016-05-06 | |
| US62/332,788 | 2016-05-06 | ||
| PCT/US2017/031356 WO2017193032A2 (en) | 2016-05-06 | 2017-05-05 | Bispecific binding proteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021158292A Division JP7171867B2 (ja) | 2016-05-06 | 2021-09-28 | 二重特異性結合タンパク質およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520797A JP2019520797A (ja) | 2019-07-25 |
| JP2019520797A5 true JP2019520797A5 (enExample) | 2020-06-18 |
| JP6952716B2 JP6952716B2 (ja) | 2021-10-20 |
Family
ID=60203374
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557864A Active JP6952716B2 (ja) | 2016-05-06 | 2017-05-05 | 二重特異性結合タンパク質およびその使用 |
| JP2021158292A Active JP7171867B2 (ja) | 2016-05-06 | 2021-09-28 | 二重特異性結合タンパク質およびその使用 |
| JP2022177063A Pending JP2023012528A (ja) | 2016-05-06 | 2022-11-04 | 二重特異性結合タンパク質およびその使用 |
| JP2024005009A Active JP7651022B2 (ja) | 2016-05-06 | 2024-01-17 | 二重特異性結合タンパク質およびその使用 |
| JP2025039002A Pending JP2025090743A (ja) | 2016-05-06 | 2025-03-12 | 二重特異性結合タンパク質およびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021158292A Active JP7171867B2 (ja) | 2016-05-06 | 2021-09-28 | 二重特異性結合タンパク質およびその使用 |
| JP2022177063A Pending JP2023012528A (ja) | 2016-05-06 | 2022-11-04 | 二重特異性結合タンパク質およびその使用 |
| JP2024005009A Active JP7651022B2 (ja) | 2016-05-06 | 2024-01-17 | 二重特異性結合タンパク質およびその使用 |
| JP2025039002A Pending JP2025090743A (ja) | 2016-05-06 | 2025-03-12 | 二重特異性結合タンパク質およびその使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US10457732B2 (enExample) |
| EP (1) | EP3452089B1 (enExample) |
| JP (5) | JP6952716B2 (enExample) |
| KR (3) | KR102490183B1 (enExample) |
| CN (1) | CN109152835B (enExample) |
| AR (1) | AR108377A1 (enExample) |
| AU (3) | AU2017260365B2 (enExample) |
| CL (1) | CL2018003136A1 (enExample) |
| CO (1) | CO2018012415A2 (enExample) |
| DK (1) | DK3452089T3 (enExample) |
| FI (1) | FI3452089T3 (enExample) |
| IL (3) | IL321475A (enExample) |
| MA (1) | MA44885B1 (enExample) |
| MX (2) | MX2018013548A (enExample) |
| MY (1) | MY200335A (enExample) |
| NZ (3) | NZ787944A (enExample) |
| RU (2) | RU2766199C2 (enExample) |
| SG (1) | SG11201809089QA (enExample) |
| TW (3) | TWI890267B (enExample) |
| WO (1) | WO2017193032A2 (enExample) |
| ZA (1) | ZA201808160B (enExample) |
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| CN107847589B (zh) | 2015-04-01 | 2022-03-29 | 安奈普泰斯生物有限公司 | 针对t细胞免疫球蛋白和粘蛋白蛋白3(tim-3)的抗体 |
| CN114591433A (zh) | 2015-07-13 | 2022-06-07 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
| CN108699136B (zh) | 2015-12-07 | 2022-03-18 | Xencor股份有限公司 | 结合cd3和psma的异二聚抗体 |
| EA201891178A1 (ru) | 2015-12-14 | 2019-01-31 | Макродженикс, Инк. | Биспецифичные молекулы, обладающие иммунореактивностью в отношении pd-1 и ctla-4, и способы их применения |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| IL321475A (en) * | 2016-05-06 | 2025-08-01 | Medimmune Llc | Bispecific binding proteins and their uses |
| CA3026151A1 (en) | 2016-06-14 | 2017-12-21 | Xencor, Inc. | Bispecific checkpoint inhibitor antibodies |
| TW201831513A (zh) | 2016-06-20 | 2018-09-01 | Ｆ星貝塔有限公司 | 結合物件(一) |
| CN109983033B (zh) * | 2016-09-23 | 2023-10-31 | 美勒斯公司 | 调节细胞表达的生物活性的结合分子 |
| BR112019008861A2 (pt) | 2016-11-01 | 2019-07-09 | Tesaro, Inc. | anticorpos direcionados contra imunoglobulina de células t e proteína de mucina 3 (tim-3) |
| SG10201913083SA (en) | 2017-01-09 | 2020-03-30 | Tesaro Inc | Methods of treating cancer with anti-tim-3 antibodies |
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| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
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| BR112021008795A2 (pt) * | 2018-11-13 | 2021-08-31 | Compass Therapeutics Llc | Construtos de ligação multiespecíficos contra moléculas de ponto de verificação e seus usos |
| CN113795516A (zh) * | 2019-03-28 | 2021-12-14 | Ab工作室有限公司 | 异多聚体蛋白质及其使用方法 |
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| JP2022553176A (ja) * | 2019-10-17 | 2022-12-22 | 江蘇康寧杰瑞生物制薬有限公司 | Ｏｘ４０／ｐｄ－ｌ１二重特異性抗体 |
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| WO2023170549A1 (en) * | 2022-03-07 | 2023-09-14 | Medimmune Llc | Treatment methods using ctla-4 and pd-1 bispecific antibodies |
| MA71637A (fr) * | 2022-07-28 | 2025-05-30 | Medimmune, Llc | Polythérapies pour le traitement du cancer |
| TW202412859A (zh) | 2022-07-28 | 2024-04-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物及雙特異性檢查點抑制劑之組合 |
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| CN121335929A (zh) * | 2023-04-13 | 2026-01-13 | 免疫医疗有限责任公司 | 用于癌症治疗的pd-1/tigit结合蛋白 |
| KR20260013474A (ko) | 2023-05-17 | 2026-01-28 | 아스트라제네카 아베 | 자궁경부암을 치료하기 위한 방법 및 조합 |
| TW202511292A (zh) * | 2023-05-23 | 2025-03-16 | 美商麥迪紐有限責任公司 | 用於治療ＮＳＣＬＣ及ｃＨＬ之ＰＤ－１／ＴＩＭ－３結合蛋白 |
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