JP2019520328A5 - - Google Patents
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- JP2019520328A5 JP2019520328A5 JP2018560588A JP2018560588A JP2019520328A5 JP 2019520328 A5 JP2019520328 A5 JP 2019520328A5 JP 2018560588 A JP2018560588 A JP 2018560588A JP 2018560588 A JP2018560588 A JP 2018560588A JP 2019520328 A5 JP2019520328 A5 JP 2019520328A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- tissue
- formula
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 6
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000012544 monitoring process Methods 0.000 claims 3
- 238000002600 positron emission tomography Methods 0.000 claims 3
- 230000005855 radiation Effects 0.000 claims 3
- 230000002285 radioactive effect Effects 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010061818 Disease progression Diseases 0.000 claims 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000005750 disease progression Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000009033 hematopoietic malignancy Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662338872P | 2016-05-19 | 2016-05-19 | |
| US62/338,872 | 2016-05-19 | ||
| PCT/US2017/033004 WO2017201111A1 (en) | 2016-05-19 | 2017-05-17 | Pet-imaging immunomodulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520328A JP2019520328A (ja) | 2019-07-18 |
| JP2019520328A5 true JP2019520328A5 (https=) | 2020-06-25 |
| JP6953444B2 JP6953444B2 (ja) | 2021-10-27 |
Family
ID=59021563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018560588A Active JP6953444B2 (ja) | 2016-05-19 | 2017-05-17 | Ｐｅｔイメージング用免疫修飾因子 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11103605B2 (https=) |
| EP (2) | EP3458111B1 (https=) |
| JP (1) | JP6953444B2 (https=) |
| KR (1) | KR102378288B1 (https=) |
| CN (1) | CN109414514B (https=) |
| AU (1) | AU2017268291B2 (https=) |
| BR (1) | BR112018073642A2 (https=) |
| CA (1) | CA3024844A1 (https=) |
| CY (1) | CY1124241T1 (https=) |
| DK (1) | DK3458111T3 (https=) |
| EA (1) | EA038019B1 (https=) |
| ES (1) | ES2864091T3 (https=) |
| HR (1) | HRP20210644T8 (https=) |
| HU (1) | HUE054306T2 (https=) |
| IL (1) | IL262962B (https=) |
| LT (1) | LT3458111T (https=) |
| MA (1) | MA53402A (https=) |
| MX (1) | MX2018014028A (https=) |
| PL (1) | PL3458111T3 (https=) |
| PT (1) | PT3458111T (https=) |
| RS (1) | RS61742B1 (https=) |
| SG (1) | SG11201810177VA (https=) |
| SI (1) | SI3458111T1 (https=) |
| SM (1) | SMT202100238T1 (https=) |
| WO (1) | WO2017201111A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9856292B2 (en) | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
| US10143746B2 (en) | 2016-03-04 | 2018-12-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US10358463B2 (en) | 2016-04-05 | 2019-07-23 | Bristol-Myers Squibb Company | Immunomodulators |
| US11857352B2 (en) | 2016-09-06 | 2024-01-02 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for bacterial infection |
| EP3548515B1 (en) | 2016-12-01 | 2026-01-21 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging |
| BR112019012986A2 (pt) * | 2016-12-23 | 2019-12-03 | Univ Johns Hopkins | imageamento de tumores e de células imunes com base na expressão de pd-l1 |
| CA3053348A1 (en) | 2017-02-10 | 2018-08-16 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-lag3 antibodies for immuno-pet imaging |
| CN110997698B (zh) | 2017-06-23 | 2023-12-26 | 百时美施贵宝公司 | 充当pd-1拮抗剂的免疫调节剂 |
| KR102880156B1 (ko) | 2017-07-24 | 2025-11-05 | 리제너론 파마슈티칼스 인코포레이티드 | 항cd8 항체 및 이의 용도 |
| US11492375B2 (en) | 2017-10-03 | 2022-11-08 | Bristol-Myers Squibb Company | Cyclic peptide immunomodulators |
| CN110504017B (zh) * | 2019-07-30 | 2022-06-10 | 哈尔滨医科大学 | 一种示踪剂的制备和使用方法 |
| US11896682B2 (en) | 2019-09-16 | 2024-02-13 | Regeneron Pharmaceuticals, Inc. | Radiolabeled MET binding proteins for immuno-PET imaging and methods of use thereof |
| EP4087857B1 (en) | 2020-01-06 | 2023-11-01 | Bristol-Myers Squibb Company | Immunomodulators |
| JP2023517736A (ja) * | 2020-03-16 | 2023-04-26 | ブリストル－マイヤーズ スクイブ カンパニー | 免疫調節剤 |
| CN115362166A (zh) | 2020-03-30 | 2022-11-18 | 百时美施贵宝公司 | 免疫调节剂 |
| US12159403B2 (en) * | 2021-06-18 | 2024-12-03 | The United States Government As Represented By The Department Of Veteran Affairs | Combination of features from biopsies and scans to predict prognosis in SCLC |
| CN120500493A (zh) * | 2022-12-12 | 2025-08-15 | 默沙东有限责任公司 | 作为颗粒酶b的pet成像剂的环肽 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
| US5101827A (en) | 1985-07-05 | 1992-04-07 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
| US5776093A (en) | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
| US4735210A (en) | 1985-07-05 | 1988-04-05 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
| US5128119A (en) | 1989-06-12 | 1992-07-07 | Immunomedics, Inc. | Methods for technetium/rhenium labeling of f(ab1)2 fragments |
| US5328679A (en) | 1988-04-01 | 1994-07-12 | Immunomedics, Inc. | Methods for technetium/rhenium labeling of proteins |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| IL113610A0 (en) | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
| US5746996A (en) | 1994-06-03 | 1998-05-05 | Immunomedics, Inc. | Thiolation of peptides for radionuclide-based radiodetection and radiotherapy |
| US5869451A (en) | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US5753206A (en) | 1995-06-07 | 1998-05-19 | Immunomedics, Inc. | Radiometal-binding analogues of luteinizing hormone releasing hormone |
| AU717020B2 (en) | 1996-05-03 | 2000-03-16 | Immunomedics Inc. | Targeted combination immunotherapy of cancer |
| EP0975374B1 (en) | 1996-07-12 | 2007-12-05 | Immunomedics, Inc. | Radiometal-binding peptide analogues |
| US6277818B1 (en) | 1998-10-29 | 2001-08-21 | Angstrom Pharmaceuticals, Inc. | Cyclic peptide ligands that target urokinase plasminogen activator receptor |
| US6187284B1 (en) | 1997-09-03 | 2001-02-13 | Immunomedics, Inc. | Fluorination of proteins and peptides for F-18 positron emission tomography |
| EP2141175B1 (en) | 2007-03-26 | 2016-07-27 | The University of Tokyo | Process for synthesizing cyclic peptide compound |
| WO2010098788A2 (en) | 2008-08-25 | 2010-09-02 | Amplimmune, Inc. | Pd-i antagonists and methods for treating infectious disease |
| US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| JP5818237B2 (ja) | 2010-09-09 | 2015-11-18 | 国立大学法人 東京大学 | Ｎ−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法 |
| US10195578B2 (en) | 2010-12-03 | 2019-02-05 | The University Of Tokyo | Peptide library production method, peptide library, and screening method |
| CN103732238A (zh) | 2011-06-08 | 2014-04-16 | 奥瑞基尼探索技术有限公司 | 用于免疫调节的治疗性化合物 |
| WO2013010573A1 (en) * | 2011-07-18 | 2013-01-24 | Universitaet Muenster | Compounds with matrix-metalloproteinase inhibitory activity |
| AU2013239366A1 (en) | 2012-03-29 | 2014-10-16 | Aurigene Discovery Technologies Limited | Immunomodulating cyclic compounds from the BC loop of human PD1 |
| JP6047231B2 (ja) | 2012-06-06 | 2016-12-21 | ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ | β−ヘアピンペプチド模倣薬 |
| JP2013253842A (ja) | 2012-06-06 | 2013-12-19 | Univ Of Tokyo | ｐＨ依存的に標的分子に結合するペプチドのスクリーニング方法 |
| US9308236B2 (en) * | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| KR102389677B1 (ko) | 2013-03-15 | 2022-04-21 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
| EP3041468B1 (en) | 2013-09-06 | 2018-06-13 | Aurigene Discovery Technologies Limited | Cyclic peptidomimetic compounds as immunomodulators |
| WO2015044900A1 (en) | 2013-09-27 | 2015-04-02 | Aurigene Discovery Technologies Limited | Therapeutic immunomodulating compounds |
| TN2017000084A1 (en) | 2014-09-11 | 2018-07-04 | Bristol Myers Squibb Co | Macrocyclic inhibitors of the pd-1/pd-l1 and cd80 (b7-1)/pd-li protein/protein interactions |
| US9732119B2 (en) | 2014-10-10 | 2017-08-15 | Bristol-Myers Squibb Company | Immunomodulators |
| US9856292B2 (en) * | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
| ES2981335T3 (es) * | 2014-11-25 | 2024-10-08 | Bristol Myers Squibb Co | Novedosos polipéptidos de unión a PD-L1 para obtención de imágenes |
| MX385081B (es) | 2014-11-25 | 2025-03-14 | Bristol Myers Squibb Co | Métodos y composiciones para radioetiquetado con 18f de productos biológicos. |
| US9861680B2 (en) | 2014-12-18 | 2018-01-09 | Bristol-Myers Squibb Company | Immunomodulators |
| US9944678B2 (en) | 2014-12-19 | 2018-04-17 | Bristol-Myers Squibb Company | Immunomodulators |
| US20160222060A1 (en) | 2015-02-04 | 2016-08-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US9809625B2 (en) | 2015-03-18 | 2017-11-07 | Bristol-Myers Squibb Company | Immunomodulators |
| US10143746B2 (en) | 2016-03-04 | 2018-12-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US10358463B2 (en) | 2016-04-05 | 2019-07-23 | Bristol-Myers Squibb Company | Immunomodulators |
| US10994033B2 (en) | 2016-06-01 | 2021-05-04 | Bristol-Myers Squibb Company | Imaging methods using 18F-radiolabeled biologics |
| KR102526034B1 (ko) | 2016-11-07 | 2023-04-25 | 브리스톨-마이어스 스큅 컴퍼니 | 면역조정제 |
| CN110997698B (zh) | 2017-06-23 | 2023-12-26 | 百时美施贵宝公司 | 充当pd-1拮抗剂的免疫调节剂 |
| US11492375B2 (en) | 2017-10-03 | 2022-11-08 | Bristol-Myers Squibb Company | Cyclic peptide immunomodulators |
-
2017
- 2017-05-17 HU HUE17728696A patent/HUE054306T2/hu unknown
- 2017-05-17 US US16/098,765 patent/US11103605B2/en active Active
- 2017-05-17 CN CN201780042462.1A patent/CN109414514B/zh active Active
- 2017-05-17 MA MA053402A patent/MA53402A/fr unknown
- 2017-05-17 ES ES17728696T patent/ES2864091T3/es active Active
- 2017-05-17 WO PCT/US2017/033004 patent/WO2017201111A1/en not_active Ceased
- 2017-05-17 AU AU2017268291A patent/AU2017268291B2/en active Active
- 2017-05-17 PL PL17728696T patent/PL3458111T3/pl unknown
- 2017-05-17 BR BR112018073642-2A patent/BR112018073642A2/pt unknown
- 2017-05-17 DK DK17728696.0T patent/DK3458111T3/da active
- 2017-05-17 RS RS20210499A patent/RS61742B1/sr unknown
- 2017-05-17 HR HRP20210644TT patent/HRP20210644T8/hr unknown
- 2017-05-17 SG SG11201810177VA patent/SG11201810177VA/en unknown
- 2017-05-17 JP JP2018560588A patent/JP6953444B2/ja active Active
- 2017-05-17 KR KR1020187036396A patent/KR102378288B1/ko active Active
- 2017-05-17 MX MX2018014028A patent/MX2018014028A/es unknown
- 2017-05-17 LT LTEP17728696.0T patent/LT3458111T/lt unknown
- 2017-05-17 EA EA201892635A patent/EA038019B1/ru unknown
- 2017-05-17 EP EP17728696.0A patent/EP3458111B1/en active Active
- 2017-05-17 CA CA3024844A patent/CA3024844A1/en active Pending
- 2017-05-17 SI SI201730690T patent/SI3458111T1/sl unknown
- 2017-05-17 PT PT177286960T patent/PT3458111T/pt unknown
- 2017-05-17 SM SM20210238T patent/SMT202100238T1/it unknown
- 2017-05-17 EP EP21152813.8A patent/EP3827849A1/en not_active Withdrawn
-
2018
- 2018-11-12 IL IL262962A patent/IL262962B/en active IP Right Grant
-
2021
- 2021-04-29 CY CY20211100375T patent/CY1124241T1/el unknown
- 2021-08-26 US US17/412,612 patent/US20210386876A1/en not_active Abandoned
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