JP2019518764A5 - - Google Patents
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- Publication number
- JP2019518764A5 JP2019518764A5 JP2018566834A JP2018566834A JP2019518764A5 JP 2019518764 A5 JP2019518764 A5 JP 2019518764A5 JP 2018566834 A JP2018566834 A JP 2018566834A JP 2018566834 A JP2018566834 A JP 2018566834A JP 2019518764 A5 JP2019518764 A5 JP 2019518764A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acyclic
- alkyl
- cyclopropyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 10
- AHHWIHXENZJRFG-UHFFFAOYSA-N oxetane Chemical compound C1COC1 AHHWIHXENZJRFG-UHFFFAOYSA-N 0.000 claims 10
- 125000006682 monohaloalkyl group Chemical group 0.000 claims 8
- 125000006684 polyhaloalkyl group Polymers 0.000 claims 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 7
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 108010021592 Pantothenate kinase Proteins 0.000 claims 5
- 102100024122 Pantothenate kinase 1 Human genes 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 claims 2
- 239000005516 coenzyme A Substances 0.000 claims 2
- 229940093530 coenzyme a Drugs 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000008482 dysregulation Effects 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 0 CC(C)N1C=*CC*1 Chemical compound CC(C)N1C=*CC*1 0.000 description 6
- PGTQKVQDZHXLOP-UHFFFAOYSA-N CC(C)c1cnc(C)cn1 Chemical compound CC(C)c1cnc(C)cn1 PGTQKVQDZHXLOP-UHFFFAOYSA-N 0.000 description 1
- VEUZQDDGNJYJRU-UHFFFAOYSA-N CCC(C1)N(C(C)C)C(C)CN1C(C)C Chemical compound CCC(C1)N(C(C)C)C(C)CN1C(C)C VEUZQDDGNJYJRU-UHFFFAOYSA-N 0.000 description 1
- OJUIRGBRDTZUKO-UHFFFAOYSA-N CCC(CNC(C)C)NC(C)C Chemical compound CCC(CNC(C)C)NC(C)C OJUIRGBRDTZUKO-UHFFFAOYSA-N 0.000 description 1
- SFMFETJWUJVYSS-UHFFFAOYSA-N CCCNCCNC(C)C Chemical compound CCCNCCNC(C)C SFMFETJWUJVYSS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662354012P | 2016-06-23 | 2016-06-23 | |
| US62/354,012 | 2016-06-23 | ||
| PCT/US2017/039037 WO2017223474A1 (en) | 2016-06-23 | 2017-06-23 | Small molecule modulators of pantothenate kinases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019518764A JP2019518764A (ja) | 2019-07-04 |
| JP2019518764A5 true JP2019518764A5 (enExample) | 2020-08-06 |
| JP7078555B2 JP7078555B2 (ja) | 2022-05-31 |
Family
ID=60783428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566834A Active JP7078555B2 (ja) | 2016-06-23 | 2017-06-23 | パントテン酸キナーゼの小分子調節剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10899734B2 (enExample) |
| EP (1) | EP3474667A4 (enExample) |
| JP (1) | JP7078555B2 (enExample) |
| KR (1) | KR102459256B1 (enExample) |
| CN (1) | CN109561680B (enExample) |
| AU (1) | AU2017281907B2 (enExample) |
| DO (1) | DOP2018000293A (enExample) |
| IL (1) | IL263649B (enExample) |
| MX (1) | MX383697B (enExample) |
| SA (1) | SA518400696B1 (enExample) |
| SG (1) | SG11201811023UA (enExample) |
| WO (1) | WO2017223474A1 (enExample) |
| ZA (1) | ZA201808099B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102459256B1 (ko) | 2016-06-23 | 2022-10-25 | 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 | 판토테네이트 키나제의 소분자 조절제 |
| IL275658B2 (en) * | 2017-12-27 | 2024-04-01 | St Jude Childrens Res Hospital Inc | Small molecule modulators of pantothenate kinases |
| EP3731859B1 (en) * | 2017-12-27 | 2025-08-20 | St. Jude Children's Research Hospital, Inc. | Pyridazine compounds for use to treat disorders associated with castor |
| EP3825303A4 (en) | 2018-07-17 | 2022-07-06 | Nippon Chemiphar Co., Ltd. | T-type calcium channel blocker |
| US12534451B2 (en) * | 2019-03-27 | 2026-01-27 | St. Jude Children's Research Hospital, Inc. | Small molecule modulators of PanK |
| CA3135344A1 (en) * | 2019-03-29 | 2020-10-08 | Nippon Chemiphar Co., Ltd. | Use of t-type calcium channel blocker for treating pruritus |
| JP2022081710A (ja) * | 2019-03-29 | 2022-06-01 | ユーティアイ リミテッド パートナーシップ | 関節リウマチを治療するためのｔ型カルシウムチャネル阻害剤の使用 |
| CN121378271A (zh) | 2019-10-07 | 2026-01-23 | 康蒂内乌姆医疗公司 | 毒蕈碱型乙酰胆碱m1受体拮抗剂 |
| US11752149B2 (en) | 2019-12-02 | 2023-09-12 | Pipeline Therapeutics, Inc. | Muscarinic acetylcholine M1 receptor antagonists |
| US20240115566A1 (en) * | 2020-12-16 | 2024-04-11 | St. Jude Children's Research Hospital, Inc. | Methods of treating disorders associated with castor |
| EP4568951A1 (en) * | 2022-08-08 | 2025-06-18 | Ajax Therapeutics, Inc. | Heterocyclic amide and urea compounds as jak2 inhibitors |
| CN119745886A (zh) * | 2025-01-20 | 2025-04-04 | 中国药科大学 | 4-异丙苯基乙酰哌嗪在制备抗阿尔茨海默病药物中的应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4216212A (en) | 1978-06-08 | 1980-08-05 | The Procter & Gamble Company | Pyrazolidine anti-inflammatory composition and methods of use |
| WO1998035957A1 (en) | 1997-02-14 | 1998-08-20 | Bayer Corporation | Amide derivatives as selective neuropeptide y receptor antagonists |
| JP2004509108A (ja) * | 2000-09-14 | 2004-03-25 | シェーリング コーポレイション | 置換尿素神経ペプチドｙｙ５受容体アンタゴニスト |
| US6894063B2 (en) * | 2000-09-14 | 2005-05-17 | Schering Corporation | Substituted urea neuropeptide Y Y5 Receptor antagonists |
| US20050256130A1 (en) | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| CA2488202C (en) | 2002-06-12 | 2011-03-08 | Chemocentryx, Inc. | 1-aryl-4-substituted piperazine derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders |
| US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| US7582635B2 (en) * | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
| MY142655A (en) * | 2003-06-12 | 2010-12-15 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| BRPI0412343A (pt) * | 2003-07-30 | 2006-09-05 | Xenon Pharmaceuticals Inc | derivados de piridazina e seu uso como agentes terapêuticos |
| US7759348B2 (en) | 2003-07-30 | 2010-07-20 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| EP1758884A2 (en) | 2004-05-20 | 2007-03-07 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
| US7754724B2 (en) | 2005-06-30 | 2010-07-13 | Dow Agrosciences Llc | N-substituted piperazines |
| EP2089018A2 (en) | 2006-11-07 | 2009-08-19 | Lexicon Pharmaceuticals, Inc. | Methods of treating cognitive impairment and dementia |
| AU2008269128B2 (en) | 2007-06-25 | 2012-08-02 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
| AR067413A1 (es) | 2007-07-05 | 2009-10-07 | Genentech Inc | Compuestos heterociclicos que contienen ciclopenta[d]pirimidina inhibidores de proteinquinasas akt, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de las mismas para el tratamiento de enfermedades hiperproliferativas, tales como cancer |
| DE102007035333A1 (de) * | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| US8431608B2 (en) | 2007-08-17 | 2013-04-30 | Icagen Inc. | Heterocycles as potassium channel modulators |
| US20100041663A1 (en) * | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| AU2010232533A1 (en) | 2009-04-02 | 2011-10-13 | University Of Florida Research Foundation, Inc. | Engineering the pathway for succinate production |
| US8741611B2 (en) | 2009-09-01 | 2014-06-03 | Novozymes, Inc. | Methods for improving malic acid production in filamentous fungi |
| US9187772B2 (en) | 2010-09-01 | 2015-11-17 | University Of Florida Research Foundation, Inc. | L-malate production by metabolically engineered escherichia coli |
| PL2621481T5 (pl) | 2010-09-27 | 2023-03-13 | Exelixis, Inc. | Podwójne inhibitory MET i VEGF do leczenia opornego na kastrację raka prostaty i osteoblastycznych przerzutów do kości |
| EP2726470B1 (en) * | 2011-07-01 | 2015-04-29 | reMynd NV | 1,2,4-thiadiazol-5-ylpiperazine derivatives useful in the treatment of neurodegenerative diseases |
| CN104583194A (zh) * | 2012-05-11 | 2015-04-29 | 艾伯维公司 | 作为nampt抑制剂的哒嗪和吡啶衍生物 |
| TW201444821A (zh) * | 2013-03-13 | 2014-12-01 | Janssen Pharmaceutica Nv | 經取代之哌啶化合物及其作為食慾素受體調節劑之用途 |
| US10273228B2 (en) | 2015-04-17 | 2019-04-30 | Indiana University Research And Technology Corporation | Hepatitis B viral assembly effectors |
| KR102459256B1 (ko) | 2016-06-23 | 2022-10-25 | 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 | 판토테네이트 키나제의 소분자 조절제 |
| EP3731859B1 (en) | 2017-12-27 | 2025-08-20 | St. Jude Children's Research Hospital, Inc. | Pyridazine compounds for use to treat disorders associated with castor |
| IL275658B2 (en) | 2017-12-27 | 2024-04-01 | St Jude Childrens Res Hospital Inc | Small molecule modulators of pantothenate kinases |
| WO2019133634A1 (en) | 2017-12-27 | 2019-07-04 | St. Jude Children's Research Hospital | Small molecule modulators of pantothenate kinases |
| EP3825303A4 (en) | 2018-07-17 | 2022-07-06 | Nippon Chemiphar Co., Ltd. | T-type calcium channel blocker |
| US20240115566A1 (en) | 2020-12-16 | 2024-04-11 | St. Jude Children's Research Hospital, Inc. | Methods of treating disorders associated with castor |
-
2017
- 2017-06-23 KR KR1020197000671A patent/KR102459256B1/ko active Active
- 2017-06-23 MX MX2018015170A patent/MX383697B/es unknown
- 2017-06-23 AU AU2017281907A patent/AU2017281907B2/en active Active
- 2017-06-23 JP JP2018566834A patent/JP7078555B2/ja active Active
- 2017-06-23 EP EP17816310.1A patent/EP3474667A4/en active Pending
- 2017-06-23 SG SG11201811023UA patent/SG11201811023UA/en unknown
- 2017-06-23 US US16/307,473 patent/US10899734B2/en active Active
- 2017-06-23 WO PCT/US2017/039037 patent/WO2017223474A1/en not_active Ceased
- 2017-06-23 CN CN201780043423.3A patent/CN109561680B/zh active Active
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2018
- 2018-11-29 ZA ZA2018/08099A patent/ZA201808099B/en unknown
- 2018-12-11 IL IL263649A patent/IL263649B/en unknown
- 2018-12-19 SA SA518400696A patent/SA518400696B1/ar unknown
- 2018-12-21 DO DO2018000293A patent/DOP2018000293A/es unknown
-
2020
- 2020-12-14 US US17/120,800 patent/US12552765B2/en active Active