JP2019518756A5 - - Google Patents
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- JP2019518756A5 JP2019518756A5 JP2018564884A JP2018564884A JP2019518756A5 JP 2019518756 A5 JP2019518756 A5 JP 2019518756A5 JP 2018564884 A JP2018564884 A JP 2018564884A JP 2018564884 A JP2018564884 A JP 2018564884A JP 2019518756 A5 JP2019518756 A5 JP 2019518756A5
- Authority
- JP
- Japan
- Prior art keywords
- crystal
- former
- sodium benzoate
- disorder
- benzoate compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000010234 sodium benzoate Nutrition 0.000 claims 15
- 239000004299 sodium benzoate Substances 0.000 claims 15
- -1 sodium benzoate compound Chemical class 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 13
- 239000002904 solvent Substances 0.000 claims 7
- 239000000243 solution Substances 0.000 claims 6
- 238000000634 powder X-ray diffraction Methods 0.000 claims 5
- 238000003756 stirring Methods 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000005418 aryl aryl group Chemical group 0.000 claims 3
- 125000004452 carbocyclyl group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 206010061227 Lipid metabolism disease Diseases 0.000 claims 2
- 230000000875 corresponding Effects 0.000 claims 2
- 201000001420 glucose metabolism disease Diseases 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- 239000012047 saturated solution Substances 0.000 claims 2
- 206010001897 Alzheimer's disease Diseases 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 206010001954 Amnestic disease Diseases 0.000 claims 1
- 206010002026 Amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 206010002855 Anxiety Diseases 0.000 claims 1
- 206010057666 Anxiety disease Diseases 0.000 claims 1
- 201000006062 Asperger syndrome Diseases 0.000 claims 1
- 206010003484 Asperger's disease Diseases 0.000 claims 1
- 206010003736 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 206010004938 Bipolar disease Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000006093 Closed Head Injury Diseases 0.000 claims 1
- 206010057668 Cognitive disease Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 208000009576 Hypercholesterolemia Diseases 0.000 claims 1
- 206010062060 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010024094 Learning disease Diseases 0.000 claims 1
- 206010061284 Mental disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010061536 Parkinson's disease Diseases 0.000 claims 1
- 206010034721 Personality disease Diseases 0.000 claims 1
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 1
- 206010043835 Tic disease Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 201000007185 autism spectrum disease Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 150000001875 compounds Chemical group 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 201000006180 eating disease Diseases 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 235000013402 health food Nutrition 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 201000003723 learning disability Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000008430 obsessive-compulsive disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 201000008839 post-traumatic stress disease Diseases 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
Claims (27)
- 前記安息香酸ナトリウム化合物及び前記共形成剤が、1:10〜10:1の分子比率の範囲で前記共結晶中に存在する、請求項1に記載の共結晶。
- Lが、C=C又はC=C-C=Cであり、及びAが、C1-C6アルキル、アリール、又はヘテロアリールである、請求項1又は2に記載の共結晶。
- Lが、C=C-C=Cであり、Aが、メチルであり、及びXが、Oである、請求項3に記載の共結晶。
- 前記安息香酸ナトリウム化合物及び前記共形成剤が、1:2の分子比率で前記共結晶中に存在する、請求項4に記載の共結晶。
- 前記安息香酸ナトリウム化合物及び前記共形成剤が、1:1の分子比率で前記共結晶中に存在する、請求項4に記載の共結晶。
- Lが、C=Cであり、Aが、フェニルであり、及びXが、Oである、請求項3に記載の共結晶。
- 前記安息香酸ナトリウム化合物及び前記共形成剤が、1:2の分子比率で前記共結晶中に存在する、請求項10に記載の共結晶。
- Lが、不存在であり、Aが、ピリジルであり、及びXが、Oである、請求項3に記載の共結晶。
- 前記安息香酸ナトリウム化合物及び前記共形成剤が、1:1の分子比率で前記共結晶中に存在する、請求項13に記載の共結晶。
- 有効量の請求項1〜15の何れか1項に記載の共結晶及び担体を含む、組成物。
- 前記組成物が、医薬組成物、栄養補助組成物、健康食品、又は医療用食品である、請求項16に記載の組成物。
- 治療有効量の請求項1〜15の何れか1項に記載の共結晶を含む対象の精神神経疾患を治療する又はそのリスクを低減させる組成物。
- 前記精神神経疾患が、統合失調症、精神障害、アルツハイマー病、認知症、軽度認知障害、良性健忘症、閉鎖性頭部外傷、自閉症スペクトル障害、アスペルガー症候群、注意欠陥・多動性障害、強迫性障害、チック症、幼年期学習障害、月経前症候群、うつ病、双極性障害、不安症、心的外傷後ストレス障害、慢性疼痛、摂食障害、依存症、パーソナリティ障害、パーキンソン病、ハンチントン病及び筋萎縮性側索硬化症、からなる群から選択される、請求項18に記載の組成物。
- 治療有効量の請求項1〜15の何れか1項に記載の共結晶を含むグルコース若しくは脂質代謝障害を治療する又はそのリスクを低減させる組成物。
- 前記グルコース又は脂質代謝障害が、肥満、糖尿病、高コレステロール血症、高血圧、及び高脂血症、からなる群から選択される、請求項20に記載の組成物。
- 共結晶を調製する方法であって、当該方法が、
(i)約40〜110℃の温度で、前記安息香酸ナトリウム化合物及び前記共形成剤を溶媒中で混合し、飽和溶液を形成する工程、ここで、前記安息香酸ナトリウム化合物及び前記共形成剤が、1:10〜10:1のモル比率であり;
(ii)約70〜150℃の温度で前記溶液を加熱及び撹拌し、前記共結晶を形成させる工程; 及び
(iii)(ii)で形成された前記共結晶を回収する工程、
を含む、請求項1〜15の何れか1項に記載の共結晶の調製方法。 - 工程(i)が、前記安息香酸ナトリウム化合物及び前記共形成剤に前記溶媒を滴下し、形成された混合物を撹拌することによって行われ、このような方法で前記安息香酸ナトリウム化合物及び前記共形成剤を前記溶媒中に溶解させる、請求項22に記載の方法。
- (i)約40〜110℃の温度で、前記安息香酸ナトリウム化合物及び前記共形成剤を溶媒中で混合し、飽和溶液を形成する工程、ここで、前記安息香酸ナトリウム化合物及び前記共形成剤が、1:10〜10:1のモル比率であり;
(ii)前記溶液を室温まで冷却する工程;
(iii)前記安息香酸ナトリウム化合物及び前記共形成剤の種(seed)共結晶を、(ii)の前記溶液に加えて混合物を形成する工程;
(iv)前記混合物を、室温に静置し、前記共結晶を形成させる工程; 及び
(v)(iv)で形成された前記共結晶を回収する工程、
を含む、請求項1〜15の何れか1項に記載の共結晶の調製方法。 - 工程(i)が、前記安息香酸ナトリウム化合物及び前記共形成剤に前記溶媒を滴下し、形成された混合物を撹拌することによって行われ、このような方法で前記安息香酸ナトリウム化合物及び前記共形成剤を前記溶媒中に溶解させる、請求項24に記載の方法。
- (i)請求項1〜15の何れか1項に記載の共結晶を提供する工程;
(ii)約35〜100℃の範囲の温度で、前記共結晶を溶媒に溶解して溶液を形成する工程;
(iii)前記溶液を約40〜110℃の温度で第1の期間撹拌し、前記共結晶を形成させる工程; ここで、前記第1の期間は、約1〜10日であり; 及び
(iv)前記共結晶を回収する工程、
を含む、請求項1〜15の何れか1項に記載の共結晶を調製するための方法。 - 工程(iii)に続いて、前記溶液を約40〜110℃の温度で第2の期間撹拌することをさらに含み、ここで、第2の期間は、約1〜10日である、
請求項26に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662349578P | 2016-06-13 | 2016-06-13 | |
US62/349,578 | 2016-06-13 | ||
PCT/CN2017/088045 WO2017215593A1 (en) | 2016-06-13 | 2017-06-13 | Co-crystals of sodium benzoate and uses thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2019518756A JP2019518756A (ja) | 2019-07-04 |
JP2019518756A5 true JP2019518756A5 (ja) | 2019-10-17 |
JP6958922B2 JP6958922B2 (ja) | 2021-11-02 |
Family
ID=60663996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018564884A Active JP6958922B2 (ja) | 2016-06-13 | 2017-06-13 | 安息香酸ナトリウムの共結晶及びその使用 |
Country Status (13)
Country | Link |
---|---|
US (2) | US11008277B2 (ja) |
EP (1) | EP3468944B1 (ja) |
JP (1) | JP6958922B2 (ja) |
KR (1) | KR102403048B1 (ja) |
CN (1) | CN109563018A (ja) |
CA (1) | CA3027297A1 (ja) |
DK (1) | DK3468944T3 (ja) |
ES (1) | ES2936094T3 (ja) |
FI (1) | FI3468944T3 (ja) |
IL (1) | IL263492B (ja) |
MX (1) | MX2018015397A (ja) |
TW (1) | TWI671287B (ja) |
WO (1) | WO2017215593A1 (ja) |
Families Citing this family (3)
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CN109563024B (zh) | 2016-06-13 | 2023-06-06 | 心悦生医股份有限公司 | 苯甲酸锂的共晶及其用途 |
KR20230047509A (ko) * | 2017-11-22 | 2023-04-07 | 치에-신 린 | 우울증의 예방 또는 치료용 벤조익산 또는 이의 염 및 유도체 |
WO2021245697A1 (en) | 2020-06-01 | 2021-12-09 | Celagenex Research (India) Pvt. Ltd. | Novel synergistic medicinal compositions for treating dysfunctional d-serine signaling |
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