JP2019518028A - 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法 - Google Patents

補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法 Download PDF

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JP2019518028A
JP2019518028A JP2018564286A JP2018564286A JP2019518028A JP 2019518028 A JP2019518028 A JP 2019518028A JP 2018564286 A JP2018564286 A JP 2018564286A JP 2018564286 A JP2018564286 A JP 2018564286A JP 2019518028 A JP2019518028 A JP 2019518028A
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eculizumab
once
dose
dsrna agent
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JP2019518028A5 (cg-RX-API-DMAC7.html
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ネイダー・ナジャフィアン
ジェイ・キム
ムスタファ・バログル
ガブリエル・ロビー
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Alnylam Pharmaceuticals Inc
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Priority to JP2021214344A priority Critical patent/JP2022050510A/ja
Priority to JP2023123022A priority patent/JP2023156369A/ja
Priority to JP2025005272A priority patent/JP2025081296A/ja
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JP2018564286A 2016-06-10 2017-06-09 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法 Pending JP2019518028A (ja)

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Application Number Priority Date Filing Date Title
JP2021214344A JP2022050510A (ja) 2016-06-10 2021-12-28 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法
JP2023123022A JP2023156369A (ja) 2016-06-10 2023-07-28 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法
JP2025005272A JP2025081296A (ja) 2016-06-10 2025-01-15 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法

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US201662348564P 2016-06-10 2016-06-10
US62/348,564 2016-06-10
US201662429448P 2016-12-02 2016-12-02
US62/429,448 2016-12-02
PCT/US2017/036775 WO2017214518A1 (en) 2016-06-10 2017-06-09 COMPLETMENT COMPONENT C5 iRNA COMPOSTIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)

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JP2021214344A Division JP2022050510A (ja) 2016-06-10 2021-12-28 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法

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JP2019518028A true JP2019518028A (ja) 2019-06-27
JP2019518028A5 JP2019518028A5 (cg-RX-API-DMAC7.html) 2020-07-09

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JP2018564286A Pending JP2019518028A (ja) 2016-06-10 2017-06-09 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法
JP2021214344A Pending JP2022050510A (ja) 2016-06-10 2021-12-28 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法
JP2023123022A Pending JP2023156369A (ja) 2016-06-10 2023-07-28 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法
JP2025005272A Pending JP2025081296A (ja) 2016-06-10 2025-01-15 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法

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JP2023123022A Pending JP2023156369A (ja) 2016-06-10 2023-07-28 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法
JP2025005272A Pending JP2025081296A (ja) 2016-06-10 2025-01-15 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法

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US (3) US20190256845A1 (cg-RX-API-DMAC7.html)
EP (1) EP3469083A1 (cg-RX-API-DMAC7.html)
JP (4) JP2019518028A (cg-RX-API-DMAC7.html)
WO (1) WO2017214518A1 (cg-RX-API-DMAC7.html)

Cited By (1)

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WO2025143001A1 (ja) * 2023-12-27 2025-07-03 東亞合成株式会社 Ｃ５ ｒｎａ配列に基づく新規二本鎖ｒｎａ及びその利用

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EP3312281A3 (en) 2013-03-14 2018-06-27 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions and methods of use thereof
TW201620526A (zh) 2014-06-17 2016-06-16 愛羅海德研究公司 用於抑制α－１抗胰蛋白酶基因表現之組合物及方法
KR102667023B1 (ko) 2016-06-14 2024-05-21 리제너론 파아마슈티컬스, 인크. 항-c5 항체 및 이의 용도
TWI826365B (zh) 2017-01-10 2023-12-21 美商愛羅海德製藥公司 α-1抗胰蛋白酶 (AAT) RNAi 藥劑、包含AAT RNAi 藥劑之組合物及使用方法
EP3724226A1 (en) 2017-12-13 2020-10-21 Regeneron Pharmaceuticals, Inc. Anti-c5 antibody combinations and uses thereof
WO2019126651A1 (en) * 2017-12-21 2019-06-27 Alnylam Pharmaceuticals, Inc. Chirally-enriched double-stranded rna agents
US10526603B1 (en) * 2018-10-26 2020-01-07 Eisai R&D Management Co., Ltd. Double-stranded ribonucleic acid capable of suppressing expression of complement C5
JP7697889B2 (ja) * 2019-06-06 2025-06-24 アローヘッド ファーマシューティカルズ インコーポレイテッド アルファ－１アンチトリプシン欠乏症（ａａｔｄ）の治療法
CN114867484B (zh) 2019-12-26 2024-08-06 卫材R&D管理有限公司 含有抑制补体c5的表达的双链核糖核酸的药物组合物
JP6918197B2 (ja) * 2019-12-26 2021-08-11 エーザイ・アール・アンド・ディー・マネジメント株式会社 脂質複合体を含む医薬組成物及び脂質ナノ粒子を含む医薬組成物
WO2025148349A1 (zh) * 2024-01-08 2025-07-17 润佳(上海)医药技术有限公司 一种抑制C5基因表达的dsRNA及其用途

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