JP2019517868A - 自己集合性ペプチドヒドロゲルを有する止血用パウダー - Google Patents
自己集合性ペプチドヒドロゲルを有する止血用パウダー Download PDFInfo
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Abstract
Description
この実施例は、本明細書に論じられる通り図1に関して、ある特定の止血用パウダーとある特定の自己集合性ペプチドヒドロゲルの使用を示す。(1)では、メスルアーロックを有するシリンジに入れた吸収性ゼラチンパウダー(Surgiflo(登録商標)、Ethicon)およびオスルアーロックを有する別のシリンジに入れた自己集合性ペプチド(PuraMatrix(登録商標))を提供する。(2)では、2つのシリンジを接続し、それぞれのプランジャーが、例えば6回行き来するように押すことによって混合する。(3)では、出血が標的部位に観測され、血液を標的部位から除去し、ゼラチンパウダーおよびPuraMatrix(登録商標)の混合物を、標的部位に適用する。(4)では、過剰量の混合物を、標的部位に提供する。(5)では、止血が達成されるまで、指または手によって圧力を混合物上に適用する。ガーゼを使用してこの材料および創傷を被覆した後、圧力を適用する。(6)では、止血が達成される。
(実施例2)
(実施例3)
(実施例4)
(実施例5)
(実施例6)
(実施例7)
Claims (20)
- 止血のためのキットであって、
止血を促進するために生理的条件下でヒドロゲルを形成するのに使用するための、有効量および有効濃度の約7〜32の間のアミノ酸を含む自己集合性ペプチドを含む溶液と、
世界保健機関(WHO)出血スケールで評価して、2またはそれよりも高い初期出血スコアを有する創傷の止血を促進することができる混合物を形成するための、該溶液に混和性の止血用パウダーと
を含む、キット。 - 前記混合物が、世界保健機関(WHO)出血スケールで評価して、3またはそれよりも高い初期出血スコアを有する創傷の止血を促進することができる、請求項1に記載のキット。
- 前記自己集合性ペプチドが、RADA16およびIEIK13からなる群から選択される、請求項1に記載のキット。
- 前記自己集合性ペプチドが、KLD12を含む、請求項1に記載のキット。
- 前記止血用パウダーが、ミクロスフェアおよび/またはミクロフィブリルを含む、請求項1に記載のキット。
- 前記止血用パウダーが、生体吸収性材料を含む、請求項1に記載のキット。
- 前記止血用パウダーが、コラーゲン、ゼラチン、キトサン、多糖類、デンプン、ヒアルロン酸、絹フィブロイン、または酸化再生セルロースを含む、請求項6に記載のキット。
- 前記止血用パウダーが、合成生体材料を含む、請求項1に記載のキット。
- 前記合成生体材料が、ポリ(ラクチド−co−グリコリド)(PLGA)、(PLGA)−ポリ(エチレングリコール)−ブロック−コポリマー、および(PLGA−b−PEG)からなる群から選択される、請求項8に記載のキット。
- 前記溶液および前記止血用パウダーを混合するためのシリンジシステムをさらに含む、請求項1に記載のキット。
- 前記溶液および前記止血用パウダーを、標的部位に投与するための指示をさらに含む、請求項1に記載のキット。
- 前記指示が、前記溶液および前記止血用パウダーを、重量で止血用パウダー1g当たり溶液約0.1〜20mLの割合で混合するための使用法を提供する、請求項1に記載のキット。
- 前記指示が、前記溶液および前記止血用パウダーを、重量で止血用パウダー1g当たり溶液約0.5〜7mLの割合で混合するための使用法を提供する、請求項12に記載のキット。
- 前記指示が、前記溶液および前記止血用パウダーの混合物を、前記標的部位に過剰で適用し、次に該標的部位をガーゼで被覆するための使用法を提供する、請求項11に記載のキット。
- 前記指示が、触圧を前記ガーゼに適用するためのさらなる使用法を提供する、請求項14に記載のキット。
- オスルアーロックシリンジ、メスルアーロックシリンジ、送達ノズル、ボトル、スプレッダー、容器、およびガーゼの少なくとも1つをさらに含む、請求項1に記載のキット。
- 前記送達ノズルの内径が、約0.5mm〜約10mmであり、該ノズルの長さが、約0.5cm〜約30cmである、請求項16に記載のキット。
- 前記ノズルが、可撓性である、請求項17に記載のキット。
- 止血用パウダーおよび複数の自己集合性ペプチドから本質的になる、肉眼的足場であって、該自己集合性ペプチドのそれぞれが約7〜約32の間のアミノ酸を含み、有効量で標的領域の止血を促進する、肉眼的足場。
- 前記自己集合性ペプチドが、RADA16およびIEIK13からなる群から選択される、請求項19に記載の肉眼的足場。
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US201662344181P | 2016-06-01 | 2016-06-01 | |
US62/344,181 | 2016-06-01 | ||
PCT/US2017/035431 WO2017210421A1 (en) | 2016-06-01 | 2017-06-01 | Hemostatic powders with self-assembling peptide hydrogels |
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US11679177B2 (en) * | 2017-08-08 | 2023-06-20 | Baxter International Inc. | Polymeric compositions, delivery devices, and methods |
WO2019094702A1 (en) | 2017-11-10 | 2019-05-16 | Cocoon Biotech Inc. | Ocular applications of silk-based products |
JP7442196B2 (ja) | 2018-07-03 | 2024-03-04 | 株式会社スリー・ディー・マトリックス | イオン性自己組織化ペプチド |
CN110256572B (zh) * | 2019-05-07 | 2022-11-01 | 西北大学 | 一种rhc-(rada)4融合蛋白 |
CN110448719B (zh) * | 2019-06-28 | 2020-05-22 | 浙江大学 | 一种促进凝血的丝素-多肽电纺膜及其制备方法 |
CN112386737B (zh) * | 2020-11-23 | 2022-07-26 | 上海交通大学 | 一种限制伤口部位的体液溢出的组合物 |
CN112494712A (zh) * | 2020-12-18 | 2021-03-16 | 广州创赛生物医用材料有限公司 | 一种具有止血和促骨愈合功能的可吸收海绵状骨蜡及其制备方法 |
CN113633823B (zh) * | 2021-07-19 | 2022-12-06 | 陕西未来多肽生物科技有限公司 | 功能性自组装纳米多肽水凝胶、制备方法、用途和制剂 |
CN115105645B (zh) * | 2022-06-28 | 2023-05-26 | 北京化工大学 | 一种复合微球、伤口修复敷料的制备方法 |
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JP2009535338A (ja) * | 2006-04-25 | 2009-10-01 | マサチューセッツ・インスティテュート・オブ・テクノロジー | 汚染因子、体液または他の実体の動きに影響を及ぼし、そして/あるいは他の生理学的状態に影響を及ぼすための組成物および方法 |
WO2010041636A1 (ja) * | 2008-10-06 | 2010-04-15 | 株式会社スリー・ディー・マトリックス | 組織閉塞剤 |
JP2014523312A (ja) * | 2011-06-30 | 2014-09-11 | エシコン・インコーポレイテッド | 凝血促進剤ペプチド及びその誘導体並びにその使用 |
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CN101036780A (zh) * | 2007-04-27 | 2007-09-19 | 四川大学 | 自组装短肽在治疗烧伤创面的药物中的应用 |
CN101514225B (zh) * | 2008-10-13 | 2011-09-14 | 西安蓝晶生物科技有限公司 | 自聚体多肽及其制备方法和应用 |
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EP3116896B1 (en) * | 2014-03-10 | 2018-12-19 | 3-D Matrix Ltd. | Self-assembling peptide compositions |
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WO2010041636A1 (ja) * | 2008-10-06 | 2010-04-15 | 株式会社スリー・ディー・マトリックス | 組織閉塞剤 |
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