JP2019517512A - 結腸直腸癌を有する患者の処置における抗ｐｄ−１抗体の使用 - Google Patents

結腸直腸癌を有する患者の処置における抗ｐｄ−１抗体の使用 Download PDF

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JP2019517512A
JP2019517512A JP2018563110A JP2018563110A JP2019517512A JP 2019517512 A JP2019517512 A JP 2019517512A JP 2018563110 A JP2018563110 A JP 2018563110A JP 2018563110 A JP2018563110 A JP 2018563110A JP 2019517512 A JP2019517512 A JP 2019517512A
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antibody
ctla
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JP2019517512A5 (cg-RX-API-DMAC7.html
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マイケル・アクセルソン
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2019517512A publication Critical patent/JP2019517512A/ja
Publication of JP2019517512A5 publication Critical patent/JP2019517512A5/ja
Priority to JP2022155878A priority Critical patent/JP7721494B2/ja
Priority to JP2025093572A priority patent/JP2025143276A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018563110A 2016-06-03 2017-06-02 結腸直腸癌を有する患者の処置における抗ｐｄ−１抗体の使用 Pending JP2019517512A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022155878A JP7721494B2 (ja) 2016-06-03 2022-09-29 結腸直腸癌を有する患者の処置における抗ｐｄ－１抗体の使用
JP2025093572A JP2025143276A (ja) 2016-06-03 2025-06-04 結腸直腸癌を有する患者の処置における抗ｐｄ－１抗体の使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662345662P 2016-06-03 2016-06-03
US62/345,662 2016-06-03
PCT/US2017/035822 WO2017210637A1 (en) 2016-06-03 2017-06-02 Use of anti-pd-1 antibody in the treatment of patients with colorectal cancer

Related Child Applications (1)

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JP2022155878A Division JP7721494B2 (ja) 2016-06-03 2022-09-29 結腸直腸癌を有する患者の処置における抗ｐｄ－１抗体の使用

Publications (2)

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JP2019517512A true JP2019517512A (ja) 2019-06-24
JP2019517512A5 JP2019517512A5 (cg-RX-API-DMAC7.html) 2020-07-16

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JP2018563110A Pending JP2019517512A (ja) 2016-06-03 2017-06-02 結腸直腸癌を有する患者の処置における抗ｐｄ−１抗体の使用
JP2022155878A Active JP7721494B2 (ja) 2016-06-03 2022-09-29 結腸直腸癌を有する患者の処置における抗ｐｄ－１抗体の使用
JP2025093572A Pending JP2025143276A (ja) 2016-06-03 2025-06-04 結腸直腸癌を有する患者の処置における抗ｐｄ－１抗体の使用

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JP2022155878A Active JP7721494B2 (ja) 2016-06-03 2022-09-29 結腸直腸癌を有する患者の処置における抗ｐｄ－１抗体の使用
JP2025093572A Pending JP2025143276A (ja) 2016-06-03 2025-06-04 結腸直腸癌を有する患者の処置における抗ｐｄ－１抗体の使用

Country Status (7)

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US (3) US11332529B2 (cg-RX-API-DMAC7.html)
EP (2) EP3464373B1 (cg-RX-API-DMAC7.html)
JP (3) JP2019517512A (cg-RX-API-DMAC7.html)
KR (3) KR102515509B1 (cg-RX-API-DMAC7.html)
CN (1) CN109476754A (cg-RX-API-DMAC7.html)
ES (1) ES2897964T3 (cg-RX-API-DMAC7.html)
WO (1) WO2017210637A1 (cg-RX-API-DMAC7.html)

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JP2022545504A (ja) * 2019-08-22 2022-10-27 アマゼンティス エスアー ウロリチンと免疫療法治療との組み合わせ

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ES2813580T3 (es) * 2015-04-17 2021-03-24 Bristol Myers Squibb Co Composiciones que comprenden una combinación de ipilimumab y nivolumab
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UA124379C2 (uk) 2015-08-11 2021-09-08 Усі Байолоджікс Айрленд Лімітед Нові антитіла проти білка pd-1
US10392442B2 (en) 2015-12-17 2019-08-27 Bristol-Myers Squibb Company Use of anti-PD-1 antibody in combination with anti-CD27 antibody in cancer treatment
ES2897964T3 (es) 2016-06-03 2022-03-03 Bristol Myers Squibb Co Uso del anticuerpo anti-PD-1 en el tratamiento de pacientes con cáncer colorrectal
EP3737696A1 (en) 2018-01-12 2020-11-18 Bristol-Myers Squibb Company Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
MA51844A (fr) * 2018-02-13 2021-05-19 Merck Sharp & Dohme Méthodes de traitement du cancer avec des anticorps anti pd-1 et des anticorps anti ctla4
WO2020033283A1 (en) * 2018-08-09 2020-02-13 Merck Sharp & Dohme Corp. Compositions and methods for treating cancer with a combination of programmed death receptor (pd-1) antibodies and vicriviroc
AU2019337547A1 (en) * 2018-09-13 2021-03-18 Merck Sharp & Dohme Llc Combination of PD-1 antagonist and LAG3 antagonist for treating non-microsatellite instablity-high/proficient mismatch repair colorectal cancer
EP3946625A1 (en) * 2019-03-28 2022-02-09 Bristol-Myers Squibb Company Methods of treating tumor
CN110656179A (zh) * 2019-10-29 2020-01-07 至本医疗科技（上海）有限公司 免疫敏感性预测的生物标志组成物及用途、试剂盒设备存储介质
CN115569193B (zh) * 2021-10-09 2024-04-02 施慧达药业集团(吉林)有限公司 戈氏梭菌芽孢联合帕博利珠单抗的应用及治疗结肠癌药物和戈氏梭菌芽孢冻干粉制备方法
EP4612182A1 (en) * 2022-10-31 2025-09-10 Agenus Inc. Methods of treating colorectal cancer using an anti-ctla4 antibody
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022545504A (ja) * 2019-08-22 2022-10-27 アマゼンティス エスアー ウロリチンと免疫療法治療との組み合わせ

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WO2017210637A1 (en) 2017-12-07
KR20240134249A (ko) 2024-09-06
EP3464373A1 (en) 2019-04-10
EP3988570A1 (en) 2022-04-27
ES2897964T3 (es) 2022-03-03
JP7721494B2 (ja) 2025-08-12
KR102515509B1 (ko) 2023-03-28
KR102702675B1 (ko) 2024-09-05
JP2023002567A (ja) 2023-01-10
US20250026831A1 (en) 2025-01-23
CN109476754A (zh) 2019-03-15
US20220356254A1 (en) 2022-11-10
US11332529B2 (en) 2022-05-17
EP3464373B1 (en) 2021-10-27
JP2025143276A (ja) 2025-10-01
US20190153100A1 (en) 2019-05-23
KR20230047498A (ko) 2023-04-07
KR20190015406A (ko) 2019-02-13

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