MA51844A - Méthodes de traitement du cancer avec des anticorps anti pd-1 et des anticorps anti ctla4 - Google Patents

Méthodes de traitement du cancer avec des anticorps anti pd-1 et des anticorps anti ctla4

Info

Publication number
MA51844A
MA51844A MA051844A MA51844A MA51844A MA 51844 A MA51844 A MA 51844A MA 051844 A MA051844 A MA 051844A MA 51844 A MA51844 A MA 51844A MA 51844 A MA51844 A MA 51844A
Authority
MA
Morocco
Prior art keywords
antibodies
cancer treatment
treatment methods
ctla4
ctla4 antibodies
Prior art date
Application number
MA051844A
Other languages
English (en)
Inventor
Rachel Allison Altura
Lokesh Jain
Mallika Lala
Mengyao Li
Archie Ngai-Chiu Tse
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA51844A publication Critical patent/MA51844A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA051844A 2018-02-13 2019-02-08 Méthodes de traitement du cancer avec des anticorps anti pd-1 et des anticorps anti ctla4 MA51844A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862630038P 2018-02-13 2018-02-13
US201862732828P 2018-09-18 2018-09-18
US201862740741P 2018-10-03 2018-10-03

Publications (1)

Publication Number Publication Date
MA51844A true MA51844A (fr) 2021-05-19

Family

ID=67620098

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051844A MA51844A (fr) 2018-02-13 2019-02-08 Méthodes de traitement du cancer avec des anticorps anti pd-1 et des anticorps anti ctla4

Country Status (11)

Country Link
US (1) US20210047409A1 (fr)
EP (1) EP3752193A4 (fr)
JP (2) JP2021513540A (fr)
KR (1) KR20200119845A (fr)
CN (1) CN111727056A (fr)
AU (2) AU2019222517A1 (fr)
BR (1) BR112020015915A8 (fr)
CA (1) CA3090996A1 (fr)
MA (1) MA51844A (fr)
MX (1) MX2020008446A (fr)
WO (1) WO2019160755A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2170959B1 (fr) 2007-06-18 2013-10-02 Merck Sharp & Dohme B.V. Anticorps dirigés contre le récepteur humain de mort programmée pd-1
CN113244385A (zh) * 2020-02-07 2021-08-13 上海君实生物医药科技股份有限公司 抗pd-1抗体在治疗恶性肿瘤中的用途
KR20220149740A (ko) * 2020-03-05 2022-11-08 머크 샤프 앤드 돔 엘엘씨 Pd-1 길항제, ctla4 길항제 및 렌바티닙 또는 그의 제약상 허용되는 염의 조합물을 사용하여 암을 치료하는 방법
EP4114863A4 (fr) * 2020-03-05 2024-04-24 Merck Sharp & Dohme LLC Méthodes de traitement du cancer ou d'une infection faisant appel à une association d'un anticorps anti-pd-1, d'un anticorps anti-ctla4 et d'un anticorps anti-tigit
WO2021213523A1 (fr) * 2020-04-24 2021-10-28 信达生物制药(苏州)有限公司 Utilisations d'une combinaison d'anticorps anti-pd-1 et d'anticorps anti-ctla-4 dans la prévention ou le traitement du cancer
TW202305009A (zh) * 2021-04-08 2023-02-01 美商默沙東有限責任公司 以皮下投予抗pd1抗體治療癌症之方法
TW202325738A (zh) * 2021-10-29 2023-07-01 美商昂科C4公司 抗ctla-4抗體給藥方案
CN113933520B (zh) * 2021-11-15 2023-06-20 邹灵龙 一种通用型抗体药血药浓度检测的单克隆抗体试剂组合、检测方法和试剂盒
WO2024002074A1 (fr) * 2022-06-28 2024-01-04 齐鲁制药有限公司 Composition pharmaceutique comprenant un anticorps mixte d'anti-ctla4 et anti-pd1 et son utilisation thérapeutique
WO2024055005A2 (fr) * 2022-09-09 2024-03-14 Adagene Pte. Ltd. Anticorps anti-ctla4 activables pour le traitement du cancer

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3214175A1 (fr) * 1999-08-24 2017-09-06 E. R. Squibb & Sons, L.L.C. Anticorps ctla-4 humains et leurs utilisations
NZ563193A (en) * 2005-05-09 2010-05-28 Ono Pharmaceutical Co Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
EP2170959B1 (fr) * 2007-06-18 2013-10-02 Merck Sharp & Dohme B.V. Anticorps dirigés contre le récepteur humain de mort programmée pd-1
AR095199A1 (es) * 2013-03-15 2015-09-30 Genzyme Corp Anticuerpos anti-cd52
CN105296433B (zh) * 2014-08-01 2018-02-09 中山康方生物医药有限公司 一种ctla4抗体、其药物组合物及其用途
EP3185866A1 (fr) * 2014-08-25 2017-07-05 Pfizer Inc. Combinaison d'un antagoniste de pd-1 et d'un inhibiteur d'alk dans le traitement du cancer
US20160362489A1 (en) * 2015-04-28 2016-12-15 Bristol-Myers Squibb Company Treatment of PD-L1-Positive Melanoma Using an Anti-PD-1 Antibody
EP3858859A1 (fr) * 2015-07-14 2021-08-04 Bristol-Myers Squibb Company Méthode de traitement du cancer à l'aide de contrôle immunitaire ; anticorps qui se lie à une mort programmée-1 receptor (pd-1) ou mort programmée ligand 1 (pd-l1)
US20180222989A1 (en) * 2015-08-04 2018-08-09 Glaxosmithkline Intellectual Property Development Limited Combination treatments and uses and methods thereof
US20180230431A1 (en) * 2015-08-07 2018-08-16 Glaxosmithkline Intellectual Property Development Limited Combination Therapy
AU2016369537B2 (en) * 2015-12-17 2024-03-14 Novartis Ag Antibody molecules to PD-1 and uses thereof
EP3213768A1 (fr) * 2016-03-01 2017-09-06 LODOCO CLINICAL Kft Combination d'une dose base d'une blockade de checkpoint immnunologique avec une dose élevée de il-2 pour le traitement du cancer métastatique
WO2017210453A1 (fr) * 2016-06-02 2017-12-07 Bristol-Myers Squibb Company Blocage de pd-1 avec du nivolumab dans le lymphome de hodgkin réfractaire
CN109476753A (zh) * 2016-06-03 2019-03-15 百时美施贵宝公司 用于治疗肿瘤的方法的抗-pd-1抗体
KR102515509B1 (ko) * 2016-06-03 2023-03-28 브리스톨-마이어스 스큅 컴퍼니 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도
JP2020518598A (ja) * 2017-05-02 2020-06-25 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 単独およびプログラム死受容体1(pd−1)抗体と組み合わされた抗ctla4抗体の安定な製剤、ならびにその使用方法

Also Published As

Publication number Publication date
AU2019222517A1 (en) 2020-08-13
CN111727056A (zh) 2020-09-29
RU2020129075A (ru) 2022-03-14
BR112020015915A8 (pt) 2023-01-31
BR112020015915A2 (pt) 2020-12-15
AU2023208115A1 (en) 2024-01-18
JP2024038250A (ja) 2024-03-19
MX2020008446A (es) 2020-09-28
WO2019160755A1 (fr) 2019-08-22
KR20200119845A (ko) 2020-10-20
US20210047409A1 (en) 2021-02-18
JP2021513540A (ja) 2021-05-27
CA3090996A1 (fr) 2019-08-22
EP3752193A1 (fr) 2020-12-23
EP3752193A4 (fr) 2022-02-23

Similar Documents

Publication Publication Date Title
MA51844A (fr) Méthodes de traitement du cancer avec des anticorps anti pd-1 et des anticorps anti ctla4
MA52962A (fr) Méthodes de traitement du cancer avec des anticorps bispécifiques anti-cd3xmuc16 et des anticorps anti-pd-1
MA52789A (fr) Méthodes de traitement du cancer avec des anticorps anti-pd-1
MA51631A (fr) Anticorps anti-pd1 et méthodes de traitement
MA47206A (fr) Méthodes de traitement du cancer au moyen d'anticorps anti-tim-3
MA51208A (fr) Anticorps (masqués) contre cd47 et leurs utilisations pour le traîtement du cancer
MA47208A (fr) Procédés de traitement du cancer à l'aide d'anticorps anti-pd-1
RS61510B1 (sr) Anti pd-1 i anti-lag3 antitela za lečenje kancera
MA51815A (fr) Méthodes de traitement ou de prévention de migraines avec anticorps contra le receptor de cgrp
MA49144A (fr) Polythérapies pour le traitement du cancer
MA40682B1 (fr) Anticorps anti-ox40 et procédés d'utilisation correspondants
MA53506A (fr) Méthodes de traitement du cancer avec des inhibiteurs de pd-l1 à petites molécules
EA201991214A1 (ru) Антитела против pd-1 и их композиции
MA56212A (fr) Compositions et méthodes de traitement du cancer
MA40576B1 (fr) Anticorps et immunoconjugués anti-her2
MA51677A (fr) Méthodes de traitement du cancer à l'aide d'anticorps anti-pd-1
BR112017009297A2 (pt) anticorpos antifator de complemento c1q humanizados e usos dos mesmos
MA45675A (fr) Méthodes et compositions permettant le traitement du cancer
MA47604A (fr) Anticorps anti-pd-1 pour le traitement du cancer du poumon
MA47613A (fr) Compositions et procédés de traitement du cancer
MA46842A (fr) Méthodes de traitement de l'obésité au moyen d'anticorps anti-angptl8
EA201990778A1 (ru) Анти-il-33 антитела и их применение
MA48637A (fr) Polythérapies pour le traitement du cancer
EA201790529A1 (ru) Новые антитела против mfi2 и способы их применения
MA47362A (fr) Anticorps anti-tnf, compositions et méthodes pour le traitement du rhumatisme psoriasique actif