|
IL104314A0
(en)
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
|
|
US5489508A
(en)
|
1992-05-13 |
1996-02-06 |
University Of Texas System Board Of Regents |
Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
|
|
US5643890A
(en)
|
1995-01-31 |
1997-07-01 |
The Board Of Regents Of The University Of Nebraska |
Synthetic oligonucleotides which mimic telomeric sequences for use in treatment of cancer and other diseases
|
|
WO1998055609A1
(en)
|
1997-06-06 |
1998-12-10 |
The Regents Of The University Of California |
Inhibitors of dna immunostimulatory sequence activity
|
|
US6551795B1
(en)
*
|
1998-02-18 |
2003-04-22 |
Genome Therapeutics Corporation |
Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
|
|
PT1181304E
(pt)
|
1999-04-08 |
2008-01-23 |
Antisoma Res Ltd |
Actividade antiproliferativa de oligonucleótidos ricos em g e método de utilização dos mesmos para ligação a nucleolina
|
|
WO2001022972A2
(en)
|
1999-09-25 |
2001-04-05 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acids
|
|
MXPA00011713A
(es)
*
|
2000-11-28 |
2002-05-31 |
Tgt Lab S A De C V |
Vectores recombinantes virales y no virales conteniendo el gen humano del activador de plasminogeno derivado de urocinasa y su utilidad en el tratamiento de diversos tipos de fibrosis hepatica, renal, pulmonar, pancreatica, cardiaca y cicatrices hipe
|
|
US7060690B2
(en)
|
2001-01-22 |
2006-06-13 |
Genta Incorporated |
Methods and compositions for treating a cell-proliferative disorder using CRE decoy oligomers, BCL-2 antisense oligomers, and hybrid oligomers thereof
|
|
WO2004012669A2
(en)
|
2002-08-01 |
2004-02-12 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating inflammatory arthropathies with suppressors of cpg oligonucleotides
|
|
AU2002353783A1
(en)
|
2001-09-24 |
2003-04-07 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of |
SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE
|
|
NZ535952A
(en)
|
2002-04-04 |
2009-01-31 |
Coley Pharm Gmbh |
Immunostimulatory G,U-containing oligoribonucleotides
|
|
US7357928B2
(en)
|
2002-04-08 |
2008-04-15 |
University Of Louisville Research Foundation, Inc. |
Method for the diagnosis and prognosis of malignant diseases
|
|
WO2003103586A2
(en)
|
2002-06-05 |
2003-12-18 |
Coley Pharmaceutical Group, Inc. |
Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids
|
|
US8043622B2
(en)
|
2002-10-08 |
2011-10-25 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides
|
|
US7217807B2
(en)
|
2002-11-26 |
2007-05-15 |
Rosetta Genomics Ltd |
Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
|
|
US20050013812A1
(en)
|
2003-07-14 |
2005-01-20 |
Dow Steven W. |
Vaccines using pattern recognition receptor-ligand:lipid complexes
|
|
US20050239733A1
(en)
|
2003-10-31 |
2005-10-27 |
Coley Pharmaceutical Gmbh |
Sequence requirements for inhibitory oligonucleotides
|
|
WO2005072097A2
(en)
|
2003-12-16 |
2005-08-11 |
University Of Massachusetts |
Toll-like receptor 9 modulators
|
|
AU2005247341B2
(en)
|
2004-05-06 |
2008-05-08 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Methods and compositions for the treatment of uveitis
|
|
WO2008104985A2
(en)
|
2007-03-01 |
2008-09-04 |
Rosetta Genomics Ltd. |
Methods for distingushing between lung squamous carcinoma and other non smallcell lung cancers
|
|
CA2566519C
(en)
|
2004-05-14 |
2020-04-21 |
Rosetta Genomics Ltd. |
Micrornas and uses thereof
|
|
CN101031658A
(zh)
|
2004-05-26 |
2007-09-05 |
罗塞塔金诺米克斯有限公司 |
病毒和病毒相关mirna及其用途
|
|
PL1794174T3
(pl)
|
2004-09-01 |
2012-11-30 |
Dynavax Tech Corp |
Sposoby i kompozycje do hamowania wrodzonych odpowiedzi immunologicznych i autoodporności
|
|
JP2008000001A
(ja)
|
2004-09-30 |
2008-01-10 |
Osaka Univ |
免疫刺激オリゴヌクレオチドおよびその医薬用途
|
|
AU2005316503A1
(en)
|
2004-12-17 |
2006-06-22 |
Dynavax Technologies Corporation |
Methods and compositions for induction or promotion of immune tolerance
|
|
US20070077231A1
(en)
*
|
2005-09-30 |
2007-04-05 |
Contag Christopher H |
Immune effector cells pre-infected with oncolytic virus
|
|
ES2544877T3
(es)
|
2005-10-12 |
2015-09-04 |
Idera Pharmaceuticals |
Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll
|
|
WO2007120368A2
(en)
|
2006-01-09 |
2007-10-25 |
The Regents Of The University Of California |
Immunostimulatory combinations for vaccine adjuvants
|
|
US8298818B2
(en)
|
2006-04-28 |
2012-10-30 |
University Of Florida Research Foundation, Inc. |
Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter
|
|
AU2007260779A1
(en)
|
2006-06-13 |
2007-12-21 |
Bayhill Therapeutics, Inc. |
Polynucleotide therapy
|
|
US8377898B2
(en)
|
2006-10-12 |
2013-02-19 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
|
WO2008076981A2
(en)
|
2006-12-15 |
2008-06-26 |
Board Of Regents, The University Of Texas System |
Inhibitors of ll-37- mediated immune reactivity to self nucleic acids
|
|
WO2009006141A2
(en)
|
2007-07-05 |
2009-01-08 |
Bausch & Lomb Incorporated |
Authority to read as follows: compositions and methods for treating or controlling infections of the eye a sequelae thereof
|
|
US7879812B2
(en)
|
2007-08-06 |
2011-02-01 |
University Of Iowa Research Foundation |
Immunomodulatory oligonucleotides and methods of use therefor
|
|
JP2010536787A
(ja)
|
2007-08-15 |
2010-12-02 |
イデラ ファーマシューティカルズ インコーポレイテッド |
Toll様受容体モジュレータ
|
|
EP2209896B1
(en)
|
2007-10-26 |
2017-03-01 |
Dynavax Technologies Corporation |
Methods and compositions for inhibition of immune responses and autoimmunity
|
|
WO2009089399A2
(en)
|
2008-01-10 |
2009-07-16 |
Bausch & Lomb Incorporated |
Compositions comprising toll-like receptor or coreceptor antagonists and methods for ocular neuroprotection
|
|
WO2009089401A2
(en)
|
2008-01-10 |
2009-07-16 |
Bausch & Lomb Incorporated |
Compositions comprising toll-like receptor or coreceptor antagonists and methods for treating or controlling ocular allergy using same
|
|
EP2278979A4
(en)
|
2008-05-21 |
2012-09-26 |
Us Gov Health & Human Serv |
PROCESS FOR TREATING PNEUMOCONIOSIS WITH OLIGODESOXYNUCLEOTIDES
|
|
JP5415724B2
(ja)
|
2008-08-05 |
2014-02-12 |
長春華普生物技術有限公司 |
一種のオリゴヌクレオチド及びその応用
|
|
US8030289B2
(en)
|
2008-08-06 |
2011-10-04 |
Changchun Huapu Biotechnology Co., Ltd. |
Oligonucleotide and use thereof
|
|
EP2334300B1
(en)
*
|
2008-09-24 |
2016-02-17 |
The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin |
Composition and method for treatment of preterm labor
|
|
GB0906130D0
(en)
|
2008-10-03 |
2009-05-20 |
Procrata Biosystems Ltd |
Transcription factor decoys
|
|
EP3087988A3
(en)
|
2008-10-06 |
2017-03-01 |
Idera Pharmaceuticals, Inc. |
Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
|
|
US8053422B2
(en)
|
2008-12-04 |
2011-11-08 |
The United States Of America As Represented By The Department Of Health And Human Services |
Anti-cancer oligodeoxynucleotides
|
|
WO2010108035A1
(en)
*
|
2009-03-18 |
2010-09-23 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating toxic and proinflammatory effects
|
|
EP2425001A4
(en)
|
2009-04-30 |
2012-11-14 |
Univ California |
ANTI-HIV COMBINATION VECTORS, TARGETING VECTORS AND METHOD OF USE
|
|
US8987221B2
(en)
|
2009-06-01 |
2015-03-24 |
Idera Pharmaceuticals, Inc. |
Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (IRO) antagonists of TLR7 and TLR9
|
|
US20110070241A1
(en)
*
|
2009-06-30 |
2011-03-24 |
Duke University |
Methods for modulating immune responses to aav gene therapy vectors
|
|
EP2451974A2
(en)
|
2009-07-08 |
2012-05-16 |
Idera Pharmaceuticals, Inc. |
Oligonucleotide-based compounds as inhibitors of toll-like receptors
|
|
CN101712957B
(zh)
*
|
2009-11-25 |
2011-11-23 |
中国人民解放军第三军医大学第一附属医院 |
Toll样受体9阻断剂及应用
|
|
US8771669B1
(en)
|
2010-02-09 |
2014-07-08 |
David Gordon Bermudes |
Immunization and/or treatment of parasites and infectious agents by live bacteria
|
|
CA2833912C
(en)
|
2010-04-23 |
2021-09-21 |
University Of Massachusetts |
Aav-based treatment of cholesterol-related disorders
|
|
WO2011159328A1
(en)
|
2010-06-16 |
2011-12-22 |
Dynavax Technologies Corporation |
Methods of treatment using tlr7 and/or tlr9 inhibitors
|
|
CN103153346A
(zh)
|
2010-06-16 |
2013-06-12 |
戴纳瓦克斯技术公司 |
使用tlr7和/或tlr9抑制剂的治疗方法
|
|
GB201014026D0
(en)
|
2010-08-20 |
2010-10-06 |
Ucl Business Plc |
Treatment
|
|
WO2012051491A1
(en)
*
|
2010-10-14 |
2012-04-19 |
The United States Of America, As Represented By The Secretary National Institutes Of Health |
Compositions and methods for controlling neurotropic viral pathogenesis by micro-rna targeting
|
|
CN107012149A
(zh)
|
2010-11-19 |
2017-08-04 |
艾德拉药物股份有限公司 |
调控基于toll‑样受体的免疫应答的免疫调节寡核苷酸(iro)化合物
|
|
US20140378531A1
(en)
|
2012-02-01 |
2014-12-25 |
New York University |
Inhibition of pattern recognition receptors in pancreatic cancer treatment using tlr inhibitors
|
|
AR091569A1
(es)
|
2012-06-28 |
2015-02-11 |
Intervet Int Bv |
Receptores de tipo toll
|
|
PL2900686T3
(pl)
*
|
2012-09-28 |
2021-01-25 |
The University Of North Carolina At Chapel Hill |
Wektory aav ukierunkowane na oligodendrocyty
|
|
CN102925485B
(zh)
|
2012-11-09 |
2014-07-09 |
中国农业科学院兰州兽医研究所 |
双表达的aav重组病毒的制备方法
|
|
JP6106280B2
(ja)
|
2012-11-29 |
2017-03-29 |
Sbiバイオテック株式会社 |
阻害性オリゴヌクレオチド及びその使用
|
|
US9453209B2
(en)
*
|
2012-12-27 |
2016-09-27 |
Sierra Sciences, Llc |
Enhancing health in mammals using telomerase reverse transcriptase gene therapy
|
|
AU2014205544B2
(en)
|
2013-01-08 |
2018-07-12 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
|
US20140271550A1
(en)
|
2013-03-14 |
2014-09-18 |
The Trustees Of The University Of Pennsylvania |
Constructs and Methods for Delivering Molecules via Viral Vectors with Blunted Innate Immune Responses
|
|
US20170035864A1
(en)
|
2013-12-09 |
2017-02-09 |
Bullet Biotechnology, Inc. |
SPECIFIC VIRUS-LIKE PARTICLE-CpG OLIGONUCLEOTIDE VACCINES AND USES THEREOF
|
|
WO2015109391A1
(en)
|
2014-01-24 |
2015-07-30 |
Children's Hospital Of Eastern Ontario Research Institute Inc. |
Smc combination therapy for the treatment of cancer
|
|
WO2015183943A2
(en)
|
2014-05-27 |
2015-12-03 |
Trustees Of Boston University |
Inhibitors of fibroproliferative disorders and cancer
|
|
EP2982756A1
(en)
|
2014-08-04 |
2016-02-10 |
Berlin Cures Holding AG |
Aptamers for use against autoantibody-associated diseases
|
|
AU2015339063A1
(en)
|
2014-10-31 |
2017-06-29 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
TLR9 targeted cytotoxic agents
|
|
WO2016130832A1
(en)
|
2015-02-13 |
2016-08-18 |
Idera Pharmaceuticals, Inc. |
Toll-like receptor 9 antagonist and methods of use thereof
|
|
US20180110777A1
(en)
|
2015-03-19 |
2018-04-26 |
The Johns Hopkins University |
Method for regulation of telomere length
|
|
US10775367B2
(en)
|
2015-04-15 |
2020-09-15 |
Ji Hoon Lee |
Aptasensor and method of detecting target material
|
|
WO2016183370A1
(en)
|
2015-05-13 |
2016-11-17 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Synthetic immunosuppressive oligodeoxynucleotides reduce ischemic tissue damage
|
|
ES2781459T3
(es)
|
2015-07-29 |
2020-09-02 |
Ifom Fondazione St Firc Di Oncologia Molecolare |
Oligonucleótidos terapéuticos
|
|
US10653687B2
(en)
|
2015-11-18 |
2020-05-19 |
INSERM (Institut National de la Santé et de la Recherche Médicale |
Methods and pharmaceutical compostions for treating rhabdomyolysis
|
|
WO2017111045A1
(en)
|
2015-12-25 |
2017-06-29 |
Sbi Biotech Co., Ltd. |
Tlr inhibitory oligonucleotides and their use
|
|
CN105597079A
(zh)
*
|
2016-01-11 |
2016-05-25 |
中国人民解放军第三军医大学第一附属医院 |
用于治疗银屑病的药物
|
|
US10124062B2
(en)
|
2016-02-26 |
2018-11-13 |
The United States Of America As Represented By The Department Of Veterans Affairs |
Methods of treating, inhibiting and/or preventing an auditory impairment
|
|
EP3468605A4
(en)
|
2016-06-08 |
2020-01-08 |
President and Fellows of Harvard College |
MANIPULATED VIRAL VECTOR TO REDUCE INDUCTION OF IGNITION AND IMMUNE REACTIONS
|
|
KR102596343B1
(ko)
|
2016-11-23 |
2023-10-31 |
베를린 큐어스 게엠베하 |
TLR9 활성화의 저해 및/또는 억제에 사용되는 압타머(aptamer)
|
|
JP2021502381A
(ja)
|
2017-11-08 |
2021-01-28 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ウイルスベクター誘発性炎症反応を阻害するための組成物および方法
|