|
IL104314A0
(en)
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
|
|
US5489508A
(en)
|
1992-05-13 |
1996-02-06 |
University Of Texas System Board Of Regents |
Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
|
|
US5643890A
(en)
|
1995-01-31 |
1997-07-01 |
The Board Of Regents Of The University Of Nebraska |
Synthetic oligonucleotides which mimic telomeric sequences for use in treatment of cancer and other diseases
|
|
ATE432348T1
(de)
*
|
1997-06-06 |
2009-06-15 |
Univ California |
Inhibitoren von immunstimulatorischen dna sequenz aktivität
|
|
US6551795B1
(en)
|
1998-02-18 |
2003-04-22 |
Genome Therapeutics Corporation |
Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
|
|
WO2000061597A1
(en)
|
1999-04-08 |
2000-10-19 |
Uab Research Foundation |
Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin
|
|
SK287400B6
(sk)
|
1999-09-25 |
2010-08-09 |
University Of Iowa Research Foundation |
Prostriedok s obsahom imunostimulačnej nukleovej kyseliny a jeho použitie na stimuláciu imunitnej reakcie
|
|
MXPA00011713A
(es)
*
|
2000-11-28 |
2002-05-31 |
Tgt Lab S A De C V |
Vectores recombinantes virales y no virales conteniendo el gen humano del activador de plasminogeno derivado de urocinasa y su utilidad en el tratamiento de diversos tipos de fibrosis hepatica, renal, pulmonar, pancreatica, cardiaca y cicatrices hipe
|
|
AU2002241952A1
(en)
|
2001-01-22 |
2002-07-30 |
Genta Incorporated |
Cell-proliferative disorder treatments using cre decoy oligomers, bcl-2 antisense and hybrid oligomers
|
|
WO2003027313A2
(en)
|
2001-09-24 |
2003-04-03 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE
|
|
EP1499187B1
(en)
|
2002-04-04 |
2015-06-17 |
Zoetis Belgium S.A. |
Immunostimulatory g,u-containing oligoribonucleotides
|
|
US7357928B2
(en)
|
2002-04-08 |
2008-04-15 |
University Of Louisville Research Foundation, Inc. |
Method for the diagnosis and prognosis of malignant diseases
|
|
WO2003103586A2
(en)
|
2002-06-05 |
2003-12-18 |
Coley Pharmaceutical Group, Inc. |
Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids
|
|
AU2003263963A1
(en)
|
2002-08-01 |
2004-02-23 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of |
Method of treating inflammatory arthropathies with suppressors of cpg oligonucleotides
|
|
US8043622B2
(en)
|
2002-10-08 |
2011-10-25 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides
|
|
US7790867B2
(en)
|
2002-12-05 |
2010-09-07 |
Rosetta Genomics Inc. |
Vaccinia virus-related nucleic acids and microRNA
|
|
US20050013812A1
(en)
|
2003-07-14 |
2005-01-20 |
Dow Steven W. |
Vaccines using pattern recognition receptor-ligand:lipid complexes
|
|
US20050239733A1
(en)
|
2003-10-31 |
2005-10-27 |
Coley Pharmaceutical Gmbh |
Sequence requirements for inhibitory oligonucleotides
|
|
US20050208470A1
(en)
|
2003-12-16 |
2005-09-22 |
University Of Massachusetts |
Toll-like receptor assays
|
|
EP1751612B1
(en)
|
2004-05-06 |
2009-02-25 |
The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services |
Methods and compositions for the treatment of uveitis
|
|
CA2566519C
(en)
|
2004-05-14 |
2020-04-21 |
Rosetta Genomics Ltd. |
Micrornas and uses thereof
|
|
AU2005248149A1
(en)
|
2004-05-26 |
2005-12-08 |
Rosetta Genomics Ltd. |
Viral and viral associated miRNAs and uses thereof
|
|
SI1794174T1
(sl)
|
2004-09-01 |
2012-09-28 |
Dynavax Tech Corp |
Postopki in sestavki za inhibiranje prirojenih imunskih odzivov in avtoimunosti
|
|
JP2008000001A
(ja)
|
2004-09-30 |
2008-01-10 |
Osaka Univ |
免疫刺激オリゴヌクレオチドおよびその医薬用途
|
|
AU2005316503A1
(en)
|
2004-12-17 |
2006-06-22 |
Dynavax Technologies Corporation |
Methods and compositions for induction or promotion of immune tolerance
|
|
US20070077231A1
(en)
*
|
2005-09-30 |
2007-04-05 |
Contag Christopher H |
Immune effector cells pre-infected with oncolytic virus
|
|
EP2341059A1
(en)
|
2005-10-12 |
2011-07-06 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
|
AU2007239095B2
(en)
|
2006-01-09 |
2012-05-03 |
The Regents Of The University Of California |
Immunostimulatory combinations for vaccine adjuvants
|
|
US8298818B2
(en)
*
|
2006-04-28 |
2012-10-30 |
University Of Florida Research Foundation, Inc. |
Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter
|
|
EP2034833A2
(en)
|
2006-06-13 |
2009-03-18 |
Bayhill Therapeutics, Inc. |
Polynucleotide therapy
|
|
US8377898B2
(en)
|
2006-10-12 |
2013-02-19 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
|
US20110033448A1
(en)
|
2006-12-15 |
2011-02-10 |
Michel Gilliet |
Inhibitors of LL-37 Mediated Immune Reactivity to Self Nucleic Acids
|
|
JP2010519899A
(ja)
|
2007-03-01 |
2010-06-10 |
ロゼッタ ゲノミックス エルティーディー． |
肺扁平上皮癌とその他の非小細胞肺癌とを見分けるための方法
|
|
WO2009006141A2
(en)
|
2007-07-05 |
2009-01-08 |
Bausch & Lomb Incorporated |
Authority to read as follows: compositions and methods for treating or controlling infections of the eye a sequelae thereof
|
|
US7879812B2
(en)
|
2007-08-06 |
2011-02-01 |
University Of Iowa Research Foundation |
Immunomodulatory oligonucleotides and methods of use therefor
|
|
EP2179061B1
(en)
|
2007-08-15 |
2012-10-03 |
Idera Pharmaceuticals, Inc. |
Toll like receptor modulators
|
|
EP2209896B1
(en)
|
2007-10-26 |
2017-03-01 |
Dynavax Technologies Corporation |
Methods and compositions for inhibition of immune responses and autoimmunity
|
|
WO2009089401A2
(en)
|
2008-01-10 |
2009-07-16 |
Bausch & Lomb Incorporated |
Compositions comprising toll-like receptor or coreceptor antagonists and methods for treating or controlling ocular allergy using same
|
|
WO2009089399A2
(en)
|
2008-01-10 |
2009-07-16 |
Bausch & Lomb Incorporated |
Compositions comprising toll-like receptor or coreceptor antagonists and methods for ocular neuroprotection
|
|
US8222225B2
(en)
|
2008-05-21 |
2012-07-17 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating pneumoconiosis with oligodeoxynucleotides
|
|
JP5415724B2
(ja)
*
|
2008-08-05 |
2014-02-12 |
長春華普生物技術有限公司 |
一種のオリゴヌクレオチド及びその応用
|
|
US8030289B2
(en)
|
2008-08-06 |
2011-10-04 |
Changchun Huapu Biotechnology Co., Ltd. |
Oligonucleotide and use thereof
|
|
US8933011B2
(en)
|
2008-09-24 |
2015-01-13 |
The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin |
Treatment of preterm labor with toll-like receptor 9 antagonists
|
|
GB0906130D0
(en)
|
2008-10-03 |
2009-05-20 |
Procrata Biosystems Ltd |
Transcription factor decoys
|
|
JP2012505221A
(ja)
|
2008-10-06 |
2012-03-01 |
イデラ ファーマシューティカルズ インコーポレイテッド |
高コレステロール血症および高脂血症ならびにそれらに関連する疾患の予防および処置におけるトル様受容体の阻害剤の使用
|
|
US8053422B2
(en)
|
2008-12-04 |
2011-11-08 |
The United States Of America As Represented By The Department Of Health And Human Services |
Anti-cancer oligodeoxynucleotides
|
|
WO2010108035A1
(en)
*
|
2009-03-18 |
2010-09-23 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating toxic and proinflammatory effects
|
|
US8728458B2
(en)
|
2009-04-30 |
2014-05-20 |
The Regents Of The University Of California |
Combination anti-HIV vectors, targeting vectors, and methods of use
|
|
JP6275380B2
(ja)
|
2009-06-01 |
2018-02-07 |
イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
Ｔｌｒ７およびｔｌｒ９の免疫調節オリゴヌクレオチド（ｉｒｏ）アンタゴニストによる自己免疫および炎症性疾患治療の強化
|
|
US20110070241A1
(en)
|
2009-06-30 |
2011-03-24 |
Duke University |
Methods for modulating immune responses to aav gene therapy vectors
|
|
EP2451974A2
(en)
|
2009-07-08 |
2012-05-16 |
Idera Pharmaceuticals, Inc. |
Oligonucleotide-based compounds as inhibitors of toll-like receptors
|
|
CN101712957B
(zh)
|
2009-11-25 |
2011-11-23 |
中国人民解放军第三军医大学第一附属医院 |
Toll样受体9阻断剂及应用
|
|
US8771669B1
(en)
*
|
2010-02-09 |
2014-07-08 |
David Gordon Bermudes |
Immunization and/or treatment of parasites and infectious agents by live bacteria
|
|
WO2011133901A2
(en)
|
2010-04-23 |
2011-10-27 |
University Of Massachusetts |
Aav-based treatment of cholesterol-related disorders
|
|
JP5921535B2
(ja)
|
2010-06-16 |
2016-05-24 |
ディナバックス テクノロジーズ コーポレイション |
Ｔｌｒ７および／またはｔｌｒ９阻害剤を用いる治療の方法
|
|
EA201291357A1
(ru)
|
2010-06-16 |
2013-11-29 |
Дайнэвокс Текнолоджиз Корпорейшн |
Способы лечения с применением ингибиторов tlr7 и/или tlr9
|
|
GB201014026D0
(en)
|
2010-08-20 |
2010-10-06 |
Ucl Business Plc |
Treatment
|
|
WO2012051491A1
(en)
*
|
2010-10-14 |
2012-04-19 |
The United States Of America, As Represented By The Secretary National Institutes Of Health |
Compositions and methods for controlling neurotropic viral pathogenesis by micro-rna targeting
|
|
EP3213770B1
(en)
|
2010-11-19 |
2021-02-24 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
|
|
WO2013116590A1
(en)
|
2012-02-01 |
2013-08-08 |
George Miller |
Inhibition of pattern recognition receptors in pancreatic cancer treatment using tlr inhibitors
|
|
AR091569A1
(es)
|
2012-06-28 |
2015-02-11 |
Intervet Int Bv |
Receptores de tipo toll
|
|
US9636370B2
(en)
|
2012-09-28 |
2017-05-02 |
The University Of North Carolina At Chapel Hill |
AAV vectors targeted to oligodendrocytes
|
|
CN102925485B
(zh)
|
2012-11-09 |
2014-07-09 |
中国农业科学院兰州兽医研究所 |
双表达的aav重组病毒的制备方法
|
|
JP6106280B2
(ja)
|
2012-11-29 |
2017-03-29 |
Ｓｂｉバイオテック株式会社 |
阻害性オリゴヌクレオチド及びその使用
|
|
US9453209B2
(en)
|
2012-12-27 |
2016-09-27 |
Sierra Sciences, Llc |
Enhancing health in mammals using telomerase reverse transcriptase gene therapy
|
|
AU2014205544B2
(en)
|
2013-01-08 |
2018-07-12 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
|
US20140271550A1
(en)
*
|
2013-03-14 |
2014-09-18 |
The Trustees Of The University Of Pennsylvania |
Constructs and Methods for Delivering Molecules via Viral Vectors with Blunted Innate Immune Responses
|
|
US20170035864A1
(en)
|
2013-12-09 |
2017-02-09 |
Bullet Biotechnology, Inc. |
SPECIFIC VIRUS-LIKE PARTICLE-CpG OLIGONUCLEOTIDE VACCINES AND USES THEREOF
|
|
WO2015109391A1
(en)
|
2014-01-24 |
2015-07-30 |
Children's Hospital Of Eastern Ontario Research Institute Inc. |
Smc combination therapy for the treatment of cancer
|
|
WO2015183943A2
(en)
|
2014-05-27 |
2015-12-03 |
Trustees Of Boston University |
Inhibitors of fibroproliferative disorders and cancer
|
|
EP2982756A1
(en)
|
2014-08-04 |
2016-02-10 |
Berlin Cures Holding AG |
Aptamers for use against autoantibody-associated diseases
|
|
US20170333565A1
(en)
|
2014-10-31 |
2017-11-23 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Tlr9 targeted cytotoxic agents
|
|
US9688993B2
(en)
|
2015-02-13 |
2017-06-27 |
Idera Pharmaceuticals, Inc. |
Toll-like receptor 9 antagonist and methods of use thereof
|
|
US11156599B2
(en)
|
2015-03-19 |
2021-10-26 |
The Johns Hopkins University |
Assay for telomere length regulators
|
|
US10775367B2
(en)
|
2015-04-15 |
2020-09-15 |
Ji Hoon Lee |
Aptasensor and method of detecting target material
|
|
WO2016183370A1
(en)
|
2015-05-13 |
2016-11-17 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Synthetic immunosuppressive oligodeoxynucleotides reduce ischemic tissue damage
|
|
EP3329004B1
(en)
|
2015-07-29 |
2020-01-15 |
IFOM Fondazione Istituto Firc di Oncologia Molecolare |
Therapeutic oligonucleotides
|
|
ES2770367T3
(es)
|
2015-11-18 |
2020-07-01 |
Inserm - Institut National De La Santé Et De La Rech Médicale |
Métodos y composiciones farmacéuticas para tratar la rabdomiólisis
|
|
KR20180089531A
(ko)
|
2015-12-25 |
2018-08-08 |
에스비아이 바이오테크 가부시키가이샤 |
Tlr 저해성 올리고뉴클레오티드 및 그의 용도
|
|
CN105597079A
(zh)
*
|
2016-01-11 |
2016-05-25 |
中国人民解放军第三军医大学第一附属医院 |
用于治疗银屑病的药物
|
|
US10124062B2
(en)
|
2016-02-26 |
2018-11-13 |
The United States Of America As Represented By The Department Of Veterans Affairs |
Methods of treating, inhibiting and/or preventing an auditory impairment
|
|
CN109451729B
(zh)
|
2016-06-08 |
2022-03-22 |
哈佛学院院长及董事 |
工程化病毒载体减少了炎症和免疫反应的诱导
|
|
CN117653654A
(zh)
|
2016-11-23 |
2024-03-08 |
柏林制药股份有限公司 |
用于抑制和/或压制tlr9激活的适体
|
|
EP3707262A1
(en)
|
2017-11-08 |
2020-09-16 |
President and Fellows of Harvard College |
Compositions and methods for inhibiting viral vector-induced inflammatory responses
|