PL3604527T3 - Zastosowanie programowalnych białek wiążących dna do wzmocnienia celowanej modyfikacji genomu - Google Patents

Zastosowanie programowalnych białek wiążących dna do wzmocnienia celowanej modyfikacji genomu

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Publication number
PL3604527T3
PL3604527T3 PL19186629T PL19186629T PL3604527T3 PL 3604527 T3 PL3604527 T3 PL 3604527T3 PL 19186629 T PL19186629 T PL 19186629T PL 19186629 T PL19186629 T PL 19186629T PL 3604527 T3 PL3604527 T3 PL 3604527T3
Authority
PL
Poland
Prior art keywords
strengthen
binding proteins
dna binding
genome modification
programmable dna
Prior art date
Application number
PL19186629T
Other languages
English (en)
Inventor
Fuqiang Chen
Original Assignee
Sigma-Aldrich Co., Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Aldrich Co., Llc filed Critical Sigma-Aldrich Co., Llc
Publication of PL3604527T3 publication Critical patent/PL3604527T3/pl

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01048—Histone acetyltransferase (2.3.1.48)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04001—Cytosine deaminase (3.5.4.1)
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
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  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
PL19186629T 2016-06-02 2017-02-20 Zastosowanie programowalnych białek wiążących dna do wzmocnienia celowanej modyfikacji genomu PL3604527T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662344858P 2016-06-02 2016-06-02
US201662358415P 2016-07-05 2016-07-05
EP17157024.5A EP3272867B1 (en) 2016-06-02 2017-02-20 Using programmable dna binding proteins to enhance targeted genome modification
EP19186629.2A EP3604527B1 (en) 2016-06-02 2017-02-20 Using programmable dna binding proteins to enhance targeted genome modification

Publications (1)

Publication Number Publication Date
PL3604527T3 true PL3604527T3 (pl) 2021-09-06

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Application Number Title Priority Date Filing Date
PL19186629T PL3604527T3 (pl) 2016-06-02 2017-02-20 Zastosowanie programowalnych białek wiążących dna do wzmocnienia celowanej modyfikacji genomu
PL17157024T PL3272867T3 (pl) 2016-06-02 2017-02-20 Wykorzystanie programowalnych białek wiążących dna w celu wzmocnienia celowanej modyfikacji genomu

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PL17157024T PL3272867T3 (pl) 2016-06-02 2017-02-20 Wykorzystanie programowalnych białek wiążących dna w celu wzmocnienia celowanej modyfikacji genomu

Country Status (17)

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US (3) US10266851B2 (pl)
EP (3) EP3272867B1 (pl)
JP (3) JP6878468B2 (pl)
KR (2) KR102811233B1 (pl)
CN (2) CN116064529A (pl)
AU (4) AU2017274145B2 (pl)
BR (1) BR112018074531B1 (pl)
CA (2) CA3026321C (pl)
DK (2) DK3604527T3 (pl)
ES (2) ES2881355T3 (pl)
GB (3) GB2552861B (pl)
IL (5) IL295358B2 (pl)
LT (1) LT3604527T (pl)
PL (2) PL3604527T3 (pl)
PT (2) PT3604527T (pl)
SG (1) SG11201810003UA (pl)
WO (1) WO2017209809A1 (pl)

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