JP2019514399A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019514399A5 JP2019514399A5 JP2018557851A JP2018557851A JP2019514399A5 JP 2019514399 A5 JP2019514399 A5 JP 2019514399A5 JP 2018557851 A JP2018557851 A JP 2018557851A JP 2018557851 A JP2018557851 A JP 2018557851A JP 2019514399 A5 JP2019514399 A5 JP 2019514399A5
- Authority
- JP
- Japan
- Prior art keywords
- lmm
- recombinant polypeptide
- cell
- nucleic acid
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 210000004027 cell Anatomy 0.000 claims 18
- 238000000034 method Methods 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 101710159293 Acyl-CoA desaturase 1 Proteins 0.000 claims 4
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims 4
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims 4
- 239000003114 blood coagulation factor Substances 0.000 claims 4
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102100028897 Stearoyl-CoA desaturase Human genes 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 230000023555 blood coagulation Effects 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 230000037356 lipid metabolism Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 229940023143 protein vaccine Drugs 0.000 claims 2
- 102000009822 Sterol Regulatory Element Binding Proteins Human genes 0.000 claims 1
- 108010020396 Sterol Regulatory Element Binding Proteins Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 230000002759 chromosomal effect Effects 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000012092 media component Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662330973P | 2016-05-03 | 2016-05-03 | |
| US62/330,973 | 2016-05-03 | ||
| PCT/EP2017/060484 WO2017191165A1 (en) | 2016-05-03 | 2017-05-03 | Modulation of lipid metabolism for protein production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514399A JP2019514399A (ja) | 2019-06-06 |
| JP2019514399A5 true JP2019514399A5 (cg-RX-API-DMAC7.html) | 2020-06-18 |
| JP6959942B2 JP6959942B2 (ja) | 2021-11-05 |
Family
ID=58745198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557851A Active JP6959942B2 (ja) | 2016-05-03 | 2017-05-03 | タンパク質生成のための脂質代謝のモジュレーション |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10655111B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3452608B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6959942B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102536221B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN109415748A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017259010B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3023038C (cg-RX-API-DMAC7.html) |
| EA (1) | EA201892503A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2938626T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL262646B (cg-RX-API-DMAC7.html) |
| MX (1) | MX2018013499A (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201809626PA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017191165A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3452608B1 (en) * | 2016-05-03 | 2022-11-30 | Lonza Ltd | Modulation of lipid metabolism for protein production |
| US20210324366A1 (en) * | 2018-07-11 | 2021-10-21 | Cornell University | Supported plant plasma membrane lipid bilayer on-a-chip |
| KR20210052389A (ko) | 2018-08-27 | 2021-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 다운스트림 정제에서의 라만 분광법의 사용 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020084528A1 (en) * | 2018-10-24 | 2020-04-30 | Selexis Sa | Expression systems, recombinant cells and uses thereof |
| JP7574206B2 (ja) | 2019-03-20 | 2024-10-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ステロール調節エレメント結合転写因子１（ｓｒｅｂｆ１）阻害剤による上昇した脂質レベルの治療 |
| CN110317799A (zh) * | 2019-07-18 | 2019-10-11 | 江南大学 | 一种人源岩藻糖转移酶8的原核表达方法及其产品 |
| CN114746554A (zh) | 2019-11-14 | 2022-07-12 | 隆萨有限公司 | 细胞选择的方法 |
| CN115029307A (zh) * | 2022-07-28 | 2022-09-09 | 吉林大学 | 一种延缓MSCs衰老的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| ATE386802T1 (de) | 1997-06-12 | 2008-03-15 | Novartis Int Pharm Ltd | Künstliche antikörperpolypeptide |
| JP2003516124A (ja) | 1999-10-15 | 2003-05-13 | ユニバーシティー オブ マサチューセッツ | 標的とした遺伝的干渉の手段としてのｒｎａ干渉経路遺伝子 |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| WO2002095008A2 (en) * | 2001-02-02 | 2002-11-28 | Bayer Corporation | Methods of modulating surfactant phospholipid production |
| US20050106222A1 (en) * | 2003-06-11 | 2005-05-19 | Ailor Eric N. | Method to increase protein production in culture |
| AU2005233326B2 (en) | 2004-04-16 | 2010-09-23 | Dsm Ip Assets B.V. | Fungal promoters for expressing a gene in a fungal cell |
| ES2864039T3 (es) * | 2005-05-20 | 2021-10-13 | Lonza Biologics Plc | Expresión de alto nivel de un anticuerpo recombinante en una célula huésped de mamífero |
| US20080182249A1 (en) * | 2006-09-01 | 2008-07-31 | Fox Brian G | Expression systems for mammalian and mycobacterial desaturases |
| WO2009062789A1 (en) * | 2007-11-13 | 2009-05-22 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Improving the secretory capacity in host cells |
| WO2010057246A1 (en) * | 2008-11-18 | 2010-05-27 | Commonwealth Scientific Industrial Research Organisation | Enzymes and methods for producing omega-3 fatty acids |
| CN105073995A (zh) * | 2013-02-01 | 2015-11-18 | 瑟莱克斯公司 | 增强的转基因表达和加工 |
| JP6676526B2 (ja) * | 2013-08-06 | 2020-04-08 | ロンザ バイオロジクス ピーエルシー | 組換えタンパク質の生産のための哺乳動物生産細胞の生成のための手段及び方法 |
| EP3452608B1 (en) | 2016-05-03 | 2022-11-30 | Lonza Ltd | Modulation of lipid metabolism for protein production |
-
2017
- 2017-05-03 EP EP17724770.7A patent/EP3452608B1/en active Active
- 2017-05-03 WO PCT/EP2017/060484 patent/WO2017191165A1/en not_active Ceased
- 2017-05-03 EA EA201892503A patent/EA201892503A1/ru unknown
- 2017-05-03 SG SG11201809626PA patent/SG11201809626PA/en unknown
- 2017-05-03 ES ES17724770T patent/ES2938626T3/es active Active
- 2017-05-03 MX MX2018013499A patent/MX2018013499A/es unknown
- 2017-05-03 IL IL262646A patent/IL262646B/en unknown
- 2017-05-03 AU AU2017259010A patent/AU2017259010B2/en active Active
- 2017-05-03 CN CN201780039286.6A patent/CN109415748A/zh active Pending
- 2017-05-03 JP JP2018557851A patent/JP6959942B2/ja active Active
- 2017-05-03 IL IL294241A patent/IL294241B2/en unknown
- 2017-05-03 KR KR1020187034453A patent/KR102536221B1/ko active Active
- 2017-05-03 CA CA3023038A patent/CA3023038C/en active Active
- 2017-05-03 US US15/585,570 patent/US10655111B2/en active Active
-
2020
- 2020-03-13 US US16/818,162 patent/US11434474B2/en active Active
-
2022
- 2022-07-27 US US17/815,465 patent/US20230047838A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019514399A5 (cg-RX-API-DMAC7.html) | ||
| MX2023009050A (es) | Vectores virales recombinantes con tropismo modificado y usos de estos para la introduccion dirigida de material genetico a celulas humanas. | |
| MX2019004499A (es) | Sistemas de replicón de virus recombinante y usos de estos. | |
| FI4186920T3 (fi) | Ultrapitkävaikutteisia insuliini-Fc-fuusioproteiineja ja käyttömenetelmiä | |
| PH12020551039A1 (en) | Non-viral dna vectors and uses thereof for antibody and fusion protein production | |
| SA520411173B1 (ar) | Pd-l1 عوامل ربط ترتبط بـ واستخدامها cd137 | |
| SA519402010B1 (ar) | طرق محسنة لتعزيز إنتاجية الأجسام المضادة في مزرعة خلايا الثدييات والحد من حدوت تكتل أثناء العمليات الفرعية والصياغة وصياغات من الأجسام المضادة مستقرة يتم الحصول عليها باستخدام هذه الطرق | |
| WO2006042158A3 (en) | Methods and compositions for improving recombinant protein production | |
| WO2020076977A3 (en) | Dll3 single domain antibodies and therapeutic compositions thereof | |
| EA201492202A1 (ru) | Способ экспрессии гетерологичных белков с использованием рекомбинантного вирусного вектора с минус-нитью рнк | |
| ATE481483T1 (de) | Verfahren zur herstellung eines rekombinanten polyklonalen proteins | |
| RU2020113032A (ru) | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака | |
| MX2014004214A (es) | Moleculas de acido ribonucleico policistronicas auto-replicantes recombinantes. | |
| WO2014097113A3 (en) | Production of therapeutic proteins in genetically modified mammalian cells | |
| EP4434997A3 (en) | Delivery of negatively charged proteins using cationic lipids | |
| JP2017538401A5 (cg-RX-API-DMAC7.html) | ||
| EA201190326A8 (ru) | Полипептиды гормона роста и способы их получения и применения | |
| HK1207575A1 (en) | Bispecific asymmetric heterodimers comprising anti-cd3 constructs | |
| AR080942A1 (es) | Produccion de proteinas heteromultimericas | |
| MX2012005864A (es) | Proteinas de enlace al antígeno anti-orai 1 y usos de las mismas. | |
| JP2016530236A5 (cg-RX-API-DMAC7.html) | ||
| WO2010018444A3 (en) | An expression vector and a method thereof | |
| CN107058235B (zh) | 一种b细胞筛选方法及其在单克隆抗体制备中的应用 | |
| BR112017027702A2 (pt) | anticorpos antirreceptor do fator de crescimento endotelial vascular 2 (vegfr2) | |
| CN104350068B (zh) | 生产型细胞系的增强子 |