EA201892503A1 - Модуляция метаболизма липидов для продуцирования белков - Google Patents
Модуляция метаболизма липидов для продуцирования белковInfo
- Publication number
- EA201892503A1 EA201892503A1 EA201892503A EA201892503A EA201892503A1 EA 201892503 A1 EA201892503 A1 EA 201892503A1 EA 201892503 A EA201892503 A EA 201892503A EA 201892503 A EA201892503 A EA 201892503A EA 201892503 A1 EA201892503 A1 EA 201892503A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- lipid metabolism
- modulation
- cell
- present
- protein production
- Prior art date
Links
- 230000037356 lipid metabolism Effects 0.000 title abstract 4
- 230000014616 translation Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 4
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 210000004671 cell-free system Anatomy 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0097—Oxidoreductases (1.) acting on reduced flavodoxin as donor (1.19)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19001—Stearoyl-CoA 9-desaturase (1.14.19.1), i.e. DELTA9-desaturase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662330973P | 2016-05-03 | 2016-05-03 | |
| PCT/EP2017/060484 WO2017191165A1 (en) | 2016-05-03 | 2017-05-03 | Modulation of lipid metabolism for protein production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201892503A1 true EA201892503A1 (ru) | 2019-09-30 |
Family
ID=58745198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201892503A EA201892503A1 (ru) | 2016-05-03 | 2017-05-03 | Модуляция метаболизма липидов для продуцирования белков |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10655111B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3452608B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6959942B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102536221B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN109415748A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017259010B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3023038C (cg-RX-API-DMAC7.html) |
| EA (1) | EA201892503A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2938626T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL262646B (cg-RX-API-DMAC7.html) |
| MX (1) | MX2018013499A (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201809626PA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017191165A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3452608B1 (en) * | 2016-05-03 | 2022-11-30 | Lonza Ltd | Modulation of lipid metabolism for protein production |
| US20210324366A1 (en) * | 2018-07-11 | 2021-10-21 | Cornell University | Supported plant plasma membrane lipid bilayer on-a-chip |
| KR20210052389A (ko) | 2018-08-27 | 2021-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 다운스트림 정제에서의 라만 분광법의 사용 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020084528A1 (en) * | 2018-10-24 | 2020-04-30 | Selexis Sa | Expression systems, recombinant cells and uses thereof |
| JP7574206B2 (ja) | 2019-03-20 | 2024-10-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ステロール調節エレメント結合転写因子１（ｓｒｅｂｆ１）阻害剤による上昇した脂質レベルの治療 |
| CN110317799A (zh) * | 2019-07-18 | 2019-10-11 | 江南大学 | 一种人源岩藻糖转移酶8的原核表达方法及其产品 |
| CN114746554A (zh) | 2019-11-14 | 2022-07-12 | 隆萨有限公司 | 细胞选择的方法 |
| CN115029307A (zh) * | 2022-07-28 | 2022-09-09 | 吉林大学 | 一种延缓MSCs衰老的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| ATE386802T1 (de) | 1997-06-12 | 2008-03-15 | Novartis Int Pharm Ltd | Künstliche antikörperpolypeptide |
| JP2003516124A (ja) | 1999-10-15 | 2003-05-13 | ユニバーシティー オブ マサチューセッツ | 標的とした遺伝的干渉の手段としてのｒｎａ干渉経路遺伝子 |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| WO2002095008A2 (en) * | 2001-02-02 | 2002-11-28 | Bayer Corporation | Methods of modulating surfactant phospholipid production |
| US20050106222A1 (en) * | 2003-06-11 | 2005-05-19 | Ailor Eric N. | Method to increase protein production in culture |
| AU2005233326B2 (en) | 2004-04-16 | 2010-09-23 | Dsm Ip Assets B.V. | Fungal promoters for expressing a gene in a fungal cell |
| ES2864039T3 (es) * | 2005-05-20 | 2021-10-13 | Lonza Biologics Plc | Expresión de alto nivel de un anticuerpo recombinante en una célula huésped de mamífero |
| US20080182249A1 (en) * | 2006-09-01 | 2008-07-31 | Fox Brian G | Expression systems for mammalian and mycobacterial desaturases |
| WO2009062789A1 (en) * | 2007-11-13 | 2009-05-22 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Improving the secretory capacity in host cells |
| WO2010057246A1 (en) * | 2008-11-18 | 2010-05-27 | Commonwealth Scientific Industrial Research Organisation | Enzymes and methods for producing omega-3 fatty acids |
| CN105073995A (zh) * | 2013-02-01 | 2015-11-18 | 瑟莱克斯公司 | 增强的转基因表达和加工 |
| JP6676526B2 (ja) * | 2013-08-06 | 2020-04-08 | ロンザ バイオロジクス ピーエルシー | 組換えタンパク質の生産のための哺乳動物生産細胞の生成のための手段及び方法 |
| EP3452608B1 (en) | 2016-05-03 | 2022-11-30 | Lonza Ltd | Modulation of lipid metabolism for protein production |
-
2017
- 2017-05-03 EP EP17724770.7A patent/EP3452608B1/en active Active
- 2017-05-03 WO PCT/EP2017/060484 patent/WO2017191165A1/en not_active Ceased
- 2017-05-03 EA EA201892503A patent/EA201892503A1/ru unknown
- 2017-05-03 SG SG11201809626PA patent/SG11201809626PA/en unknown
- 2017-05-03 ES ES17724770T patent/ES2938626T3/es active Active
- 2017-05-03 MX MX2018013499A patent/MX2018013499A/es unknown
- 2017-05-03 IL IL262646A patent/IL262646B/en unknown
- 2017-05-03 AU AU2017259010A patent/AU2017259010B2/en active Active
- 2017-05-03 CN CN201780039286.6A patent/CN109415748A/zh active Pending
- 2017-05-03 JP JP2018557851A patent/JP6959942B2/ja active Active
- 2017-05-03 IL IL294241A patent/IL294241B2/en unknown
- 2017-05-03 KR KR1020187034453A patent/KR102536221B1/ko active Active
- 2017-05-03 CA CA3023038A patent/CA3023038C/en active Active
- 2017-05-03 US US15/585,570 patent/US10655111B2/en active Active
-
2020
- 2020-03-13 US US16/818,162 patent/US11434474B2/en active Active
-
2022
- 2022-07-27 US US17/815,465 patent/US20230047838A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019514399A (ja) | 2019-06-06 |
| ES2938626T3 (es) | 2023-04-13 |
| MX2018013499A (es) | 2019-09-11 |
| CN109415748A (zh) | 2019-03-01 |
| EP3452608A1 (en) | 2019-03-13 |
| SG11201809626PA (en) | 2018-11-29 |
| BR112018072434A2 (pt) | 2019-02-19 |
| US10655111B2 (en) | 2020-05-19 |
| US11434474B2 (en) | 2022-09-06 |
| KR102536221B1 (ko) | 2023-05-23 |
| KR20190003651A (ko) | 2019-01-09 |
| US20200231944A1 (en) | 2020-07-23 |
| IL294241B2 (en) | 2023-10-01 |
| US20170321194A1 (en) | 2017-11-09 |
| IL294241B1 (en) | 2023-06-01 |
| IL262646A (en) | 2018-12-31 |
| JP6959942B2 (ja) | 2021-11-05 |
| IL294241A (en) | 2022-08-01 |
| EP3452608B1 (en) | 2022-11-30 |
| CA3023038A1 (en) | 2017-11-09 |
| US20230047838A1 (en) | 2023-02-16 |
| AU2017259010A1 (en) | 2018-11-22 |
| WO2017191165A1 (en) | 2017-11-09 |
| CA3023038C (en) | 2023-03-14 |
| AU2017259010B2 (en) | 2021-04-22 |
| IL262646B (en) | 2022-08-01 |
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