|
US4469863A
(en)
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US4751219A
(en)
|
1985-02-05 |
1988-06-14 |
Nederlandse Centrale Organisatie Voor Toegepast-Natuur-Wetenschappelijk Onderzoek |
Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides
|
|
NL9201440A
(nl)
|
1992-08-11 |
1994-03-01 |
Univ Leiden |
Triantennaire clusterglycosiden, hun bereiding en toepassing.
|
|
US6908903B1
(en)
|
1994-12-07 |
2005-06-21 |
Aletheon Pharmaceuticals, Inc. |
Cluster clearing agents
|
|
US6172045B1
(en)
|
1994-12-07 |
2001-01-09 |
Neorx Corporation |
Cluster clearing agents
|
|
TW520293B
(en)
|
1995-11-22 |
2003-02-11 |
Univ Johns Hopkins Med |
Delivery system to enhance cellular uptake of biomolecules
|
|
US20030119724A1
(en)
|
1995-11-22 |
2003-06-26 |
Ts`O Paul O.P. |
Ligands to enhance cellular uptake of biomolecules
|
|
US5998203A
(en)
|
1996-04-16 |
1999-12-07 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
|
|
US6620916B1
(en)
|
1996-09-26 |
2003-09-16 |
Ajinomoto Co., Inc. |
Modified physiologically active proteins and medicinal compositions containing the same
|
|
US6300319B1
(en)
|
1998-06-16 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Targeted oligonucleotide conjugates
|
|
MXPA01004239A
(es)
*
|
1998-10-30 |
2002-06-04 |
Daiichi Seiyaku Co |
Compuesto dds y metodo para la medicion del mismo.
|
|
US6383812B1
(en)
|
1999-05-28 |
2002-05-07 |
Academia Sinica |
Anti liver disease drug R-YEEE and method of synthesizing branched galactose-terminal glycoproteins
|
|
US20080281041A1
(en)
|
1999-06-07 |
2008-11-13 |
Rozema David B |
Reversibly Masked Polymers
|
|
US8541548B2
(en)
|
1999-06-07 |
2013-09-24 |
Arrowhead Madison Inc. |
Compounds and methods for reversible modification of biologically active molecules
|
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
|
US7491805B2
(en)
|
2001-05-18 |
2009-02-17 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
|
KR20080023768A
(ko)
|
2000-03-30 |
2008-03-14 |
화이트헤드 인스티튜트 포 바이오메디칼 리서치 |
Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체
|
|
CN100406065C
(zh)
|
2000-12-01 |
2008-07-30 |
细胞工厂治疗公司 |
糖基化/半乳糖基化肽、双官能接头和核苷酸单体/多聚体的缀合物以及相关的组合物和使用方法
|
|
CN100523215C
(zh)
|
2000-12-01 |
2009-08-05 |
马普科技促进协会 |
介导rna干涉的小rna分子
|
|
EP1386004A4
(en)
|
2001-04-05 |
2005-02-16 |
Ribozyme Pharm Inc |
MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID
|
|
EP1389209B1
(en)
|
2001-04-24 |
2009-04-08 |
Purdue Research Foundation |
Folate mimetics and folate-receptor binding conjugates thereof
|
|
EP3231445A1
(en)
|
2001-05-18 |
2017-10-18 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
|
US7109165B2
(en)
|
2001-05-18 |
2006-09-19 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
|
WO2003008628A2
(en)
|
2001-07-20 |
2003-01-30 |
Ribozyme Pharmacuticals, Inc. |
Enzymatic nucleic acid peptide conjugates
|
|
US7439043B2
(en)
|
2001-10-10 |
2008-10-21 |
Neose Technologies, Inc. |
Galactosyl nucleotide sugars
|
|
US20100240730A1
(en)
|
2002-02-20 |
2010-09-23 |
Merck Sharp And Dohme Corp. |
RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA)
|
|
CA2498772A1
(en)
|
2002-09-11 |
2004-03-25 |
Santaris Pharma A/S |
Modified pna molecules
|
|
CA2518475C
(en)
|
2003-03-07 |
2014-12-23 |
Alnylam Pharmaceuticals, Inc. |
Irna agents comprising asymmetrical modifications
|
|
JP2006522158A
(ja)
|
2003-04-03 |
2006-09-28 |
アルナイラム ファーマシューティカルズ インコーポレイテッド |
ｉＲＮＡ複合体
|
|
US7723509B2
(en)
|
2003-04-17 |
2010-05-25 |
Alnylam Pharmaceuticals |
IRNA agents with biocleavable tethers
|
|
US7851615B2
(en)
|
2003-04-17 |
2010-12-14 |
Alnylam Pharmaceuticals, Inc. |
Lipophilic conjugated iRNA agents
|
|
EP2669377A3
(en)
|
2003-04-17 |
2015-10-14 |
Alnylam Pharmaceuticals Inc. |
Modified iRNA agents
|
|
WO2004101619A1
(ja)
|
2003-05-15 |
2004-11-25 |
Shionogi Co., Ltd. |
機能的糖ペプチドの合理的設計および合成
|
|
EP2990410A1
(en)
|
2004-08-10 |
2016-03-02 |
Alnylam Pharmaceuticals Inc. |
Chemically modified oligonucleotides
|
|
WO2006031461A2
(en)
|
2004-09-09 |
2006-03-23 |
Isis Pharmaceuticals, Inc. |
Pyrrolidinyl groups for attaching conjugates to oligomeric compounds
|
|
US20060148740A1
(en)
|
2005-01-05 |
2006-07-06 |
Prosensa B.V. |
Mannose-6-phosphate receptor mediated gene transfer into muscle cells
|
|
EP1841867A1
(en)
|
2005-01-24 |
2007-10-10 |
Avaris AB |
COMPLEX CONTAINING SiRNA, ShRNA OR ANTISENSE MOLECULE AND FUNCTIONAL ENTITY, FOR IMPROVED SPECIFICITY AND DELIVERY
|
|
US8658211B2
(en)
|
2006-08-18 |
2014-02-25 |
Arrowhead Madison Inc. |
Polyconjugates for in vivo delivery of polynucleotides
|
|
CN101500548A
(zh)
|
2006-08-18 |
2009-08-05 |
弗·哈夫曼-拉罗切有限公司 |
用于体内递送多核苷酸的多缀合物
|
|
EP2606911A1
(en)
|
2007-02-16 |
2013-06-26 |
KTB Tumorforschungsgesellschaft mbH |
Receptor And Antigen Targeted Prodrug
|
|
WO2008131419A2
(en)
|
2007-04-23 |
2008-10-30 |
Alnylam Pharmaceuticals, Inc. |
Glycoconjugates of rna interference agents
|
|
EP2229186A2
(en)
|
2007-12-04 |
2010-09-22 |
Alnylam Pharmaceuticals Inc. |
Carbohydrate conjugates as delivery agents for oligonucleotides
|
|
US8507455B2
(en)
|
2007-12-04 |
2013-08-13 |
Alnylam Pharmaceuticals, Inc. |
Folate conjugates
|
|
CA2713379A1
(en)
|
2008-01-31 |
2009-11-05 |
Alnylam Pharmaceuticals, Inc. |
Optimized methods for delivery of dsrna targeting the pcsk9 gene
|
|
WO2009120878A2
(en)
|
2008-03-26 |
2009-10-01 |
Alnylam Pharmaceuticals, Inc. |
Non-natural ribonucleotides, and methods of use thereof
|
|
US8575123B2
(en)
|
2008-04-11 |
2013-11-05 |
Tekmira Pharmaceuticals Corporation |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
WO2010039548A2
(en)
|
2008-09-23 |
2010-04-08 |
Alnylam Pharmaceuticals, Inc. |
Chemical modifications of monomers and oligonucleotides with cycloaddition
|
|
EP2937418B1
(en)
|
2008-10-20 |
2017-10-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of transthyretin
|
|
EP2447274B1
(en)
|
2008-10-24 |
2017-10-04 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
EP3699172A3
(en)
|
2008-11-10 |
2020-11-18 |
Arbutus Biopharma Corporation |
Novel lipids and compositions for the delivery of therapeutics
|
|
CA3042927C
(en)
|
2009-05-05 |
2022-05-17 |
Arbutus Biopharma Corporation |
Lipid compositions for the delivery of therapeutic agents
|
|
KR20220038506A
(ko)
|
2009-06-10 |
2022-03-28 |
알닐람 파마슈티칼스 인코포레이티드 |
향상된 지질 조성물
|
|
WO2011005980A1
(en)
|
2009-07-09 |
2011-01-13 |
Intradigm Corporation |
Novel heterobifunctional polyethylene glycol reagents, their preparation and uses thereof
|
|
WO2011038356A2
(en)
|
2009-09-25 |
2011-03-31 |
Johns Hopkins University |
Novel liver-targeting agents and their synthesis
|
|
TWI391144B
(zh)
|
2009-10-26 |
2013-04-01 |
Iner Aec Executive Yuan |
一種定量肝殘餘功能的檢驗方法與其新穎肝受體造影檢驗藥劑
|
|
TWI388338B
(zh)
|
2009-10-26 |
2013-03-11 |
Iner Aec Executive Yuan |
對聚合醣鏈進行放射標誌以作為肝受體造影劑之方法
|
|
WO2011072290A2
(en)
|
2009-12-11 |
2011-06-16 |
The Regents Of The University Of Michigan |
Targeted dendrimer-drug conjugates
|
|
PH12012501596A1
(en)
*
|
2010-02-24 |
2017-02-03 |
Arrowhead Res Corporation |
Compositions for targeted delivery of sirna
|
|
US8349308B2
(en)
|
2010-03-26 |
2013-01-08 |
Mersana Therapeutics, Inc. |
Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
|
|
WO2011163121A1
(en)
|
2010-06-21 |
2011-12-29 |
Alnylam Pharmaceuticals, Inc. |
Multifunctional copolymers for nucleic acid delivery
|
|
US9290760B2
(en)
|
2010-09-15 |
2016-03-22 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
|
WO2012068187A1
(en)
*
|
2010-11-19 |
2012-05-24 |
Merck Sharp & Dohme Corp. |
Poly(amide) polymers for the delivery of oligonucleotides
|
|
RU2013117288A
(ru)
|
2010-12-17 |
2015-01-27 |
Эрроухэд Рисерч Корпорейшн |
СОДЕРЖАЩАЯ ГАЛАКТОЗНЫЙ КЛАСТЕР НАЦЕЛИВАЮЩАЯ ГРУППА ДЛЯ миРНК, МОДУЛИРУЮЩАЯ ФОРМАКОКИНЕТИЧЕСКИЕ СВОЙСТВА
|
|
US8501930B2
(en)
|
2010-12-17 |
2013-08-06 |
Arrowhead Madison Inc. |
Peptide-based in vivo siRNA delivery system
|
|
RU2582235C2
(ru)
|
2010-12-29 |
2016-04-20 |
Ф.Хоффманн-Ля Рош Аг |
Низкомолекулярные конъюгаты для внутриклеточной доставки нуклеиновых кислот
|
|
SI3505528T1
(sl)
|
2011-04-21 |
2021-04-30 |
Glaxo Group Limited |
Modulacija izražanja virusa hepatitisa B (HBV)
|
|
PT2726613T
(pt)
*
|
2011-06-30 |
2018-10-26 |
Arrowhead Pharmaceuticals Inc |
Composições e métodos para inibição da expressão de genes do vírus da hepatite b
|
|
CA2842039A1
(en)
|
2011-08-26 |
2013-03-07 |
Arrowhead Research Corporation |
Poly(vinyl ester) polymers for in vivo nucleic acid delivery
|
|
US10023861B2
(en)
|
2011-08-29 |
2018-07-17 |
Ionis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
|
MX2014001965A
(es)
*
|
2012-04-18 |
2014-03-31 |
Arrowhead Res Corp |
Polimeros de poli(acrilato) para suministro de acido nucleico in vivo.
|
|
TWI595885B
(zh)
|
2012-05-02 |
2017-08-21 |
喜納製藥公司 |
包含四ｇａｌｎａｃ之新穎結合物及傳送寡核苷酸之方法
|
|
EP3919620A1
(en)
|
2012-05-02 |
2021-12-08 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
|
AR090905A1
(es)
|
2012-05-02 |
2014-12-17 |
Merck Sharp & Dohme |
Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica
|
|
US9150602B2
(en)
*
|
2012-07-24 |
2015-10-06 |
Atomic Energy Council, Institute Of Nuclear Energy Research |
Precursor used for labeling hepatorcyte receptor and containing trisaccharide and diamide demercaptide ligand, method for preparing the same, radiotracer and pharmaceutical composition of the same
|
|
EP4253395A3
(en)
|
2012-08-06 |
2023-11-29 |
Alnylam Pharmaceuticals, Inc. |
Processes for the preparation of carbohydrate conjugated rna agents
|
|
CA2889044A1
(en)
|
2012-11-15 |
2014-05-22 |
Roche Innovation Center Copenhagen A/S |
Anti apob antisense conjugate compounds
|
|
CA2893801A1
(en)
|
2013-01-30 |
2014-08-07 |
F. Hoffmann-La Roche Ag |
Lna oligonucleotide carbohydrate conjugates
|
|
WO2014118272A1
(en)
|
2013-01-30 |
2014-08-07 |
Santaris Pharma A/S |
Antimir-122 oligonucleotide carbohydrate conjugates
|
|
PL2992098T3
(pl)
|
2013-05-01 |
2019-09-30 |
Ionis Pharmaceuticals, Inc. |
Kompozycje i sposoby modulowania ekspresji hbv i ttr
|
|
JP2016518842A
(ja)
|
2013-05-01 |
2016-06-30 |
レグルス セラピューティクス インコーポレイテッド |
マイクロＲＮＡ化合物およびｍｉＲ−１２２をモジュレートする方法
|
|
WO2015006740A2
(en)
|
2013-07-11 |
2015-01-15 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotide-ligand conjugates and process for their preparation
|
|
WO2015069587A2
(en)
|
2013-11-06 |
2015-05-14 |
Merck Sharp & Dohme Corp. |
Peptide containing conjugates for dual molecular delivery of oligonucleotides
|
|
WO2015168618A2
(en)
|
2014-05-01 |
2015-11-05 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulating growth hormone receptor expression
|
|
EP3151839A4
(en)
|
2014-06-06 |
2018-02-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for enhanced intestinal absorption of conjugated oligomeric compounds
|
|
TW201620526A
(zh)
|
2014-06-17 |
2016-06-16 |
愛羅海德研究公司 |
用於抑制α－１抗胰蛋白酶基因表現之組合物及方法
|
|
RU2017101140A
(ru)
|
2014-07-01 |
2018-08-02 |
Джима Тт С.П.А. |
Упаковка для курительных изделий
|
|
US20160078088A1
(en)
|
2014-09-15 |
2016-03-17 |
Rajat Venkatesh |
Systems and Methods for Providing Metadata Aware Background Caching in Data Analysis
|
|
AU2015329974B2
(en)
|
2014-10-10 |
2019-06-20 |
F. Hoffmann-La Roche Ag |
GaINAc phosphoramidites, nucleic acid conjugates thereof and their use
|
|
US20160272970A1
(en)
*
|
2015-03-17 |
2016-09-22 |
Arrowhead Madison Inc. |
RNA Interference Agents
|
|
MX2017011422A
(es)
*
|
2015-03-17 |
2017-11-10 |
Arrowhead Pharmaceuticals Inc |
Composiciones y metodos para inhibir la expresion del gen del factor xii.
|
|
CN115957337A
(zh)
*
|
2015-08-07 |
2023-04-14 |
箭头药业股份有限公司 |
乙型肝炎病毒感染的RNAi疗法
|
|
JOP20160211B1
(ar)
*
|
2015-10-01 |
2021-08-17 |
Arrowhead Pharmaceuticals Inc |
تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
|
|
JOP20170057B1
(ar)
*
|
2016-03-07 |
2022-03-14 |
Arrowhead Pharmaceuticals Inc |
مركبات ترابطية مستهدفة كمركبات علاجية
|
|
JOP20170056B1
(ar)
|
2016-09-02 |
2021-08-17 |
Arrowhead Pharmaceuticals Inc |
مركبات ترابطية مستهدفة
|
|
US10450565B2
(en)
*
|
2017-01-10 |
2019-10-22 |
Arrowhead Pharmaceuticals, Inc. |
Alpha-1 antitrypsin (AAT) RNAi agents, compositions including AAT RNAi agents, and methods of use
|
|
CN110234326B
(zh)
|
2017-01-30 |
2024-11-12 |
箭头药业股份有限公司 |
用于抑制因子xii基因表达的组合物和方法
|