JP2019510740A5 - - Google Patents
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- Publication number
- JP2019510740A5 JP2019510740A5 JP2018540460A JP2018540460A JP2019510740A5 JP 2019510740 A5 JP2019510740 A5 JP 2019510740A5 JP 2018540460 A JP2018540460 A JP 2018540460A JP 2018540460 A JP2018540460 A JP 2018540460A JP 2019510740 A5 JP2019510740 A5 JP 2019510740A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- rifamycin
- iii
- semi
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OOEZYSSDDKSGEC-RMKNXTFCSA-N CC(C)C(C)(C(NC(/C=C/CCNC(N)=O)C(Nc1ccc(CCl)cc1)=O)=O)NC(CCCCCN(C(C=C1)=O)C1=O)=O Chemical compound CC(C)C(C)(C(NC(/C=C/CCNC(N)=O)C(Nc1ccc(CCl)cc1)=O)=O)NC(CCCCCN(C(C=C1)=O)C1=O)=O OOEZYSSDDKSGEC-RMKNXTFCSA-N 0.000 description 1
- GKRANPZNJXRBRR-ALWPUHSVSA-N C[C@@H](C[C@@H](C)[C@@H]([C@H](C)C/C=C/O[C@](C)(C(c1c2C(C=C3N4)=O)=O)Oc1c(C)c(O)c2C3=O)OC(C)=O)C[C@@H](C)/C=C/C=C(/C)\C4=O Chemical compound C[C@@H](C[C@@H](C)[C@@H]([C@H](C)C/C=C/O[C@](C)(C(c1c2C(C=C3N4)=O)=O)Oc1c(C)c(O)c2C3=O)OC(C)=O)C[C@@H](C)/C=C/C=C(/C)\C4=O GKRANPZNJXRBRR-ALWPUHSVSA-N 0.000 description 1
- MDCULZTYOKLIGU-UHFFFAOYSA-N Nc(c(O)cc(F)c1)c1O Chemical compound Nc(c(O)cc(F)c1)c1O MDCULZTYOKLIGU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662303556P | 2016-03-04 | 2016-03-04 | |
| US62/303,556 | 2016-03-04 | ||
| PCT/US2017/020711 WO2017152083A1 (en) | 2016-03-04 | 2017-03-03 | Process for the preparation of an antibody-rifamycin conjugate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000874A Division JP2020090506A (ja) | 2016-03-04 | 2020-01-07 | 抗体−リファマイシン複合体の製造プロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510740A JP2019510740A (ja) | 2019-04-18 |
| JP2019510740A5 true JP2019510740A5 (cg-RX-API-DMAC10.html) | 2020-02-20 |
| JP6705904B2 JP6705904B2 (ja) | 2020-06-03 |
Family
ID=58361102
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540460A Expired - Fee Related JP6705904B2 (ja) | 2016-03-04 | 2017-03-03 | 抗体−リファマイシン複合体の製造プロセス |
| JP2020000874A Pending JP2020090506A (ja) | 2016-03-04 | 2020-01-07 | 抗体−リファマイシン複合体の製造プロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000874A Pending JP2020090506A (ja) | 2016-03-04 | 2020-01-07 | 抗体−リファマイシン複合体の製造プロセス |
Country Status (13)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018014355A2 (pt) | 2016-03-04 | 2018-12-18 | Genentech, Inc. | processos para a preparação de f-benzoxazinorifamicina i e para a preparação de 2-amino-5-fluorobenzeno-1,3-diol iii |
| CN108047250B (zh) * | 2018-02-12 | 2020-08-14 | 丹诺医药(苏州）有限公司 | 一种利福霉素-硝基咪唑偶联分子的应用 |
| CN110687217B (zh) * | 2018-08-07 | 2021-04-23 | 中国科学院大连化学物理研究所 | 液相色谱测定利福霉素s的方法 |
| CN110687218B (zh) * | 2018-08-07 | 2021-04-23 | 中国科学院大连化学物理研究所 | 液相色谱测定苯并噁嗪利福霉素的方法 |
| WO2020132483A1 (en) * | 2018-12-21 | 2020-06-25 | Regeneron Pharmaceuticals, Inc. | Rifamycin analogs and antibody-drug conjugates thereof |
| EP4387618A4 (en) * | 2021-08-20 | 2025-07-09 | Univ Rutgers | DUAL-TARGETED RNA POLYMERASE INHIBITORS: CONJUGATES OF BENZOXAZINO- AND SPIRO-RIFAMYCINS WITH N-AROYL- N-ARYL-PHENYLALANINAMIDES |
| CN114436864A (zh) * | 2022-02-17 | 2022-05-06 | 浙江鼎龙科技股份有限公司 | 一种2-甲基-5氨基苯酚的制备方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB877732A (en) | 1958-08-12 | 1961-09-20 | Lepetit Spa | The antibiotic rifomycin, its components and methods of preparing same |
| US4690919A (en) | 1984-01-04 | 1987-09-01 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Benzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same |
| JPS63183587A (ja) | 1985-02-05 | 1988-07-28 | Kanegafuchi Chem Ind Co Ltd | ベンゾキサジノリフアマイシン誘導体 |
| CA1304363C (en) | 1988-11-01 | 1992-06-30 | Takehiko Yamane | 3'-hydroxybenzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same |
| US6322788B1 (en) | 1998-08-20 | 2001-11-27 | Stanley Arthur Kim | Anti-bacterial antibodies and methods of use |
| ES2369542T3 (es) | 2002-07-31 | 2011-12-01 | Seattle Genetics, Inc. | Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa. |
| MXPA06002088A (es) | 2003-08-22 | 2006-08-11 | Activbiotics Inc | Analogos de rifamicina y usos de los mismos. |
| ES2605443T3 (es) | 2003-11-06 | 2017-03-14 | Seattle Genetics, Inc. | Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia |
| CN1918172B (zh) | 2003-12-23 | 2011-09-14 | 活跃生物工艺学公司 | 利福霉素类似物及其用途 |
| US7265107B2 (en) | 2004-03-10 | 2007-09-04 | Cumbre Pharmaceuticals Inc. | Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes |
| TR201808537T4 (tr) | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
| MX2008007808A (es) | 2005-12-14 | 2008-09-15 | Activbiotics Pharma Llc | Analogos de rifamicina y usos de ellos. |
| US7678791B2 (en) | 2006-07-12 | 2010-03-16 | Cumbre Ip Ventures, L.P. | Nitroheteroaryl-containing rifamycin derivatives |
| NZ578851A (en) | 2007-03-01 | 2011-09-30 | Symphogen As | Method for cloning cognate antibodies |
| PE20090245A1 (es) | 2007-05-08 | 2009-03-17 | Genentech Inc | Anticuerpos anti-muc16 disenados con cisteina y conjugados de anticuerpos y farmacos |
| BRPI0818780A2 (pt) | 2007-10-19 | 2015-04-22 | Genentech Inc | Anticorpo anti-tenb2 planejados por cisteína e conjugados de medicamento com anticorpos |
| WO2009064792A1 (en) | 2007-11-16 | 2009-05-22 | Cumbre Pharmaceuticals Inc. | Quinolone carboxylic acid-substituted rifamycin derivatives |
| WO2009086277A1 (en) * | 2007-12-20 | 2009-07-09 | Envivo Pharmaceuticals, Inc. | Tetrasubstituted benzenes |
| US8524691B2 (en) | 2008-08-13 | 2013-09-03 | The Medicines Company | Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections |
| CA3220104A1 (en) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| KR20150024315A (ko) | 2012-05-07 | 2015-03-06 | 재단법인 목암생명공학연구소 | 포도상구균 감염 예방용 백신 조성물 |
| EP2975054A4 (en) | 2013-03-12 | 2016-11-23 | Zenyaku Kogyo Kk | ANTIBODIES TO STAPHYLOKOKEN, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF |
| TWI632157B (zh) * | 2013-05-31 | 2018-08-11 | 建南德克公司 | 抗壁磷壁酸抗體（ａｎｔｉ－ｗａｌｌ ｔｅｉｃｈｏｉｃ ａｃｉｄ ａｎｔｉｂｏｄｉｅｓ）及結合物 |
| PE20160715A1 (es) * | 2013-05-31 | 2016-08-01 | Genentech Inc | Anticuerpos frente a acidos teicoicos de pared y conjugados |
| MX369758B (es) | 2013-05-31 | 2019-11-20 | Genentech Inc | Anticuerpos anti-acido teicoico de pared y conjugados. |
| KR20170086536A (ko) * | 2014-12-03 | 2017-07-26 | 제넨테크, 인크. | 항-스타필로코커스 아우레우스 항체 리파마이신 접합체 및 이의 용도 |
| MX2017007231A (es) * | 2014-12-03 | 2017-11-08 | Genentech Inc | Conjugados de rifamicina y anticuerpos contra el staphylococcuss aureus y usos de estos. |
| BR112018014355A2 (pt) | 2016-03-04 | 2018-12-18 | Genentech, Inc. | processos para a preparação de f-benzoxazinorifamicina i e para a preparação de 2-amino-5-fluorobenzeno-1,3-diol iii |
-
2017
- 2017-03-03 BR BR112018014355-3A patent/BR112018014355A2/pt not_active Application Discontinuation
- 2017-03-03 CA CA3012046A patent/CA3012046C/en not_active Expired - Fee Related
- 2017-03-03 MX MX2018010491A patent/MX2018010491A/es unknown
- 2017-03-03 KR KR1020187027989A patent/KR102204805B1/ko not_active Expired - Fee Related
- 2017-03-03 CN CN201780014867.4A patent/CN108713020A/zh active Pending
- 2017-03-03 WO PCT/US2017/020711 patent/WO2017152083A1/en not_active Ceased
- 2017-03-03 JP JP2018540460A patent/JP6705904B2/ja not_active Expired - Fee Related
- 2017-03-03 AU AU2017228468A patent/AU2017228468B2/en not_active Ceased
- 2017-03-03 US US15/448,894 patent/US10336683B2/en not_active Expired - Fee Related
- 2017-03-03 SG SG11201807537RA patent/SG11201807537RA/en unknown
- 2017-03-03 AR ARP170100538A patent/AR107800A1/es unknown
- 2017-03-03 EP EP17712298.3A patent/EP3423457B1/en not_active Not-in-force
-
2018
- 2018-07-08 IL IL260465A patent/IL260465B/en active IP Right Grant
-
2019
- 2019-05-17 US US16/415,612 patent/US10689325B2/en not_active Expired - Fee Related
-
2020
- 2020-01-07 JP JP2020000874A patent/JP2020090506A/ja active Pending
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