JP2019509274A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019509274A5 JP2019509274A5 JP2018543668A JP2018543668A JP2019509274A5 JP 2019509274 A5 JP2019509274 A5 JP 2019509274A5 JP 2018543668 A JP2018543668 A JP 2018543668A JP 2018543668 A JP2018543668 A JP 2018543668A JP 2019509274 A5 JP2019509274 A5 JP 2019509274A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolidine
- carbonyl
- carbonitrile
- optionally substituted
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1602854.0A GB201602854D0 (en) | 2016-02-18 | 2016-02-18 | Novel compounds |
| GB1602854.0 | 2016-02-18 | ||
| PCT/GB2017/050403 WO2017141036A1 (en) | 2016-02-18 | 2017-02-16 | Novel compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509274A JP2019509274A (ja) | 2019-04-04 |
| JP2019509274A5 true JP2019509274A5 (enExample) | 2020-03-26 |
| JP6916197B2 JP6916197B2 (ja) | 2021-08-11 |
Family
ID=55752852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018543668A Active JP6916197B2 (ja) | 2016-02-18 | 2017-02-16 | 新規化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10640498B2 (enExample) |
| EP (1) | EP3416960B1 (enExample) |
| JP (1) | JP6916197B2 (enExample) |
| CN (1) | CN108699035B (enExample) |
| GB (1) | GB201602854D0 (enExample) |
| MA (1) | MA44233A (enExample) |
| WO (1) | WO2017141036A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3277677T (lt) | 2015-03-30 | 2021-05-25 | Mission Therapeutics Limited | 1-ciano-pirolidino junginiai kaip usp30 inhibitoriai |
| EP3322702B1 (en) | 2015-07-14 | 2019-11-20 | Mission Therapeutics Limited | Cyanopyrrolidines as dub inhibitors for the treatment of cancer |
| GB201521109D0 (en) | 2015-11-30 | 2016-01-13 | Mission Therapeutics Ltd | Novel compounds |
| GB201522267D0 (en) | 2015-12-17 | 2016-02-03 | Mission Therapeutics Ltd | Novel compounds |
| GB201522768D0 (en) | 2015-12-23 | 2016-02-03 | Mission Therapeutics Ltd | Novel compounds |
| GB201603779D0 (en) | 2016-03-04 | 2016-04-20 | Mission Therapeutics Ltd | Novel compounds |
| GB201604638D0 (en) | 2016-03-18 | 2016-05-04 | Mission Therapeutics Ltd | Novel compounds |
| GB201604647D0 (en) | 2016-03-18 | 2016-05-04 | Mission Therapeutics Ltd | Novel compounds |
| MA43753A (fr) | 2016-03-24 | 2018-11-28 | Mission Therapeutics Ltd | Dérivés 1-cyano-pyrrolidine comme inhibiteurs de dbu |
| ES2978159T3 (es) * | 2016-09-16 | 2024-09-06 | Hsf Pharmaceuticals | Inhibidores de factores de choque térmico (HSF) y usos de los mismos |
| ES2850349T3 (es) | 2016-09-27 | 2021-08-27 | Mission Therapeutics Ltd | Derivados de cianopirrolidina con actividad como inhibidores de USP30 |
| GB201616511D0 (en) | 2016-09-29 | 2016-11-16 | Mission Therapeutics Limited | Novel compounds |
| GB201616627D0 (en) | 2016-09-30 | 2016-11-16 | Mission Therapeutics Limited | Novel compounds |
| TWI771327B (zh) | 2016-10-05 | 2022-07-21 | 英商使命醫療公司 | 新穎化合物 |
| GB201708652D0 (en) | 2017-05-31 | 2017-07-12 | Mission Therapeutics Ltd | Novel compounds and uses |
| JP7208931B2 (ja) | 2017-06-20 | 2023-01-19 | ミッション セラピューティクス リミティド | Ｄｕｂ阻害剤としての活性をもつ置換シアノピロリジン類 |
| AU2018346597B2 (en) | 2017-10-06 | 2023-07-13 | Forma Therapeutics, Inc. | Inhibiting Ubiquitin Specific Peptidase 30 |
| EP3787612A4 (en) | 2018-05-04 | 2021-11-17 | Remedy Plan, Inc. | CANCER TREATMENTS AGAINST CANCER STEM CELLS |
| IL278291B2 (en) | 2018-05-17 | 2023-10-01 | Forma Therapeutics Inc | Condensed bicyclic compounds are useful as ubiquitin-specific peptidase 30 inhibitors |
| CN112384500B (zh) * | 2018-07-12 | 2024-05-14 | 贝达药业股份有限公司 | 免疫调节剂及其组合物和制备方法 |
| EP3837262B1 (en) | 2018-08-14 | 2026-06-17 | Amgen Inc. | N-cyano-7-azanorbornane derivatives and uses thereof |
| EP4218934B1 (en) * | 2018-10-05 | 2025-06-18 | Forma Therapeutics, Inc. | Inhibiting ubiquitin-specific protease 30 (usp30) |
| EP3897631A4 (en) | 2018-12-20 | 2022-11-23 | C4 Therapeutics, Inc. | TARGETED PROTEIN BREAKDOWN |
| CA3127590A1 (en) | 2019-01-28 | 2020-08-06 | Mitochondria Emotion, Inc. | Mitofusin activators and methods of use thereof |
| EP3917509A4 (en) | 2019-01-28 | 2022-11-09 | Mitochondria Emotion, Inc. | TRANS-4-HYDROXYCYCLOHEXYLPHENYLAMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF |
| CN109776377B (zh) * | 2019-02-01 | 2021-08-24 | 沈阳药科大学 | 吲哚啉类化合物及其制备方法和应用 |
| GB201905375D0 (en) | 2019-04-16 | 2019-05-29 | Mission Therapeutics Ltd | Novel compounds |
| GB201905371D0 (en) | 2019-04-16 | 2019-05-29 | Mission Therapeutics Ltd | Novel compounds |
| GB201912674D0 (en) | 2019-09-04 | 2019-10-16 | Mission Therapeutics Ltd | Novel compounds |
| PH12022551081A1 (en) | 2019-11-06 | 2024-06-19 | Remedy Plan Inc | Cancer treatments targeting cancer stem cells |
| CN115515579B (zh) * | 2020-02-05 | 2025-09-30 | 洛克菲勒大学 | 吡咯并[2,3-b]吡啶-3-甲酰胺组合物和改善听力损失的方法 |
| MX2022012578A (es) | 2020-04-08 | 2022-11-07 | Mission Therapeutics Ltd | N-cianopirrolidinas con actividad como inhibidores de usp30. |
| KR20230016674A (ko) | 2020-05-28 | 2023-02-02 | 미션 테라퓨틱스 엘티디 | 미토콘드리아 기능장애의 치료를 위한 usp30 억제제로서 n-(1-시아노피롤리딘-3-일)-5-(3-(트라이플루오로메틸)페닐)옥사졸-2-카복스아미드 유도체 및 상응하는 옥사다이아졸 유도체 |
| WO2021245186A1 (en) | 2020-06-04 | 2021-12-09 | Mission Therapeutics Limited | N-cyanopyrrolidines with activity as usp30 inhibitors |
| RS67140B1 (sr) | 2020-06-08 | 2025-09-30 | Mission Therapeutics Ltd | 1-(5-(2-cijanopiridin-4-il)oksazol-2-karbonil)-4-metilheksahidropirolo[3,4-b]pirol-5(1h)-karbonitril kao usp30 inhibitor za primenu u lečenju mitohondrijske disfunkcije, kancera i fibroze |
| GB202016800D0 (en) | 2020-10-22 | 2020-12-09 | Mission Therapeutics Ltd | Novel compounds |
| WO2023099561A1 (en) | 2021-12-01 | 2023-06-08 | Mission Therapeutics Limited | Substituted n-cyanopyrrolidines with activity as usp30 inhibitors |
| US20250320196A1 (en) * | 2024-04-15 | 2025-10-16 | Maze Therapeutics, Inc. | Apol1 inhibitors and methods of uses thereof |
| GB202408928D0 (en) | 2024-06-21 | 2024-08-07 | Mission Therapeutics Ltd | Novel compounds |
| GB202411060D0 (en) | 2024-07-29 | 2024-09-11 | Mission Therapeutics Ltd | Novel compounds |
| GB202500610D0 (en) | 2025-01-16 | 2025-03-05 | Mission Therapeutics Ltd | Novel compounds |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003530384A (ja) | 2000-04-06 | 2003-10-14 | メルク フロスト カナダ アンド カンパニー | カテプシンシステインプロテアーゼ阻害薬 |
| EP2565186A1 (en) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| GB201416754D0 (en) * | 2014-09-23 | 2014-11-05 | Mission Therapeutics Ltd | Novel compounds |
| LT3277677T (lt) * | 2015-03-30 | 2021-05-25 | Mission Therapeutics Limited | 1-ciano-pirolidino junginiai kaip usp30 inhibitoriai |
| JP2018091344A (ja) * | 2015-03-31 | 2018-06-14 | 日立オートモティブシステムズ株式会社 | 鉄道車両用ダンパ |
| EP3322702B1 (en) * | 2015-07-14 | 2019-11-20 | Mission Therapeutics Limited | Cyanopyrrolidines as dub inhibitors for the treatment of cancer |
| GB201521109D0 (en) | 2015-11-30 | 2016-01-13 | Mission Therapeutics Ltd | Novel compounds |
| GB201522267D0 (en) * | 2015-12-17 | 2016-02-03 | Mission Therapeutics Ltd | Novel compounds |
| GB201522768D0 (en) | 2015-12-23 | 2016-02-03 | Mission Therapeutics Ltd | Novel compounds |
| GB201603779D0 (en) | 2016-03-04 | 2016-04-20 | Mission Therapeutics Ltd | Novel compounds |
| GB201604647D0 (en) | 2016-03-18 | 2016-05-04 | Mission Therapeutics Ltd | Novel compounds |
| GB201604638D0 (en) | 2016-03-18 | 2016-05-04 | Mission Therapeutics Ltd | Novel compounds |
| MA43753A (fr) | 2016-03-24 | 2018-11-28 | Mission Therapeutics Ltd | Dérivés 1-cyano-pyrrolidine comme inhibiteurs de dbu |
| ES2850349T3 (es) | 2016-09-27 | 2021-08-27 | Mission Therapeutics Ltd | Derivados de cianopirrolidina con actividad como inhibidores de USP30 |
| GB201616511D0 (en) | 2016-09-29 | 2016-11-16 | Mission Therapeutics Limited | Novel compounds |
| GB201616627D0 (en) | 2016-09-30 | 2016-11-16 | Mission Therapeutics Limited | Novel compounds |
| TWI771327B (zh) | 2016-10-05 | 2022-07-21 | 英商使命醫療公司 | 新穎化合物 |
-
2016
- 2016-02-18 GB GBGB1602854.0A patent/GB201602854D0/en not_active Ceased
-
2017
- 2017-02-16 JP JP2018543668A patent/JP6916197B2/ja active Active
- 2017-02-16 EP EP17706864.0A patent/EP3416960B1/en active Active
- 2017-02-16 US US16/070,936 patent/US10640498B2/en active Active
- 2017-02-16 MA MA044233A patent/MA44233A/fr unknown
- 2017-02-16 WO PCT/GB2017/050403 patent/WO2017141036A1/en not_active Ceased
- 2017-02-16 CN CN201780011427.3A patent/CN108699035B/zh active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7299837B2 (ja) | 化合物、組成物、および使用方法 | |
| JP6708661B2 (ja) | Ｕｓｐ３０阻害剤としての１−シアノ−ピロリジン化合物 | |
| EP3338781B1 (en) | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators | |
| JP2024508235A (ja) | 三環－アミド－二環ｐｒｍｔ５阻害剤 | |
| JP2019504009A5 (enExample) | ||
| JP2019532945A5 (enExample) | ||
| JP2019533659A5 (enExample) | ||
| HK1250014A1 (en) | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators | |
| EP2958923A1 (de) | 4-substituierte pyrrolo- und pyrazolo-diazepine | |
| JP2010529195A (ja) | プロテインキナーゼの阻害剤としてのイミダゾピラジン | |
| JP2018524367A5 (enExample) | ||
| KR20150127197A (ko) | 돌연변이 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온 | |
| EP2958922A1 (de) | Pyrrolo- und pyrazolo-triazolodiazepine als bet-proteininhibitoren zur behandlung von hyper-proliferativen erkrankungen | |
| WO2014147586A1 (en) | 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh | |
| JP2011529504A5 (enExample) | ||
| RS60468B1 (sr) | Nova jedinjenja | |
| JP2009515883A (ja) | サイクリン依存性キナーゼ阻害剤としての新規イミダゾピラジン | |
| JP2013533868A (ja) | タンパク質チロシンキナーゼ阻害剤としての新規ホモピペラジン誘導体およびそれらの医薬使用 | |
| JP2012508702A (ja) | アミノアルキル置換基を有するアリール化合物およびそれらの使用 | |
| JP2019537590A5 (enExample) | ||
| TW201217375A (en) | Diaza-spiro[5.5]undecanes | |
| JP5847362B1 (ja) | シクロヘキシルピリジン誘導体 | |
| US12344600B2 (en) | c-Myc mRNA translation modulators and uses thereof in the treatment of cancer | |
| CA2565689A1 (en) | Substituted pyrrolidine-2-ones | |
| US20220041606A1 (en) | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 |