JP2019509064A5 - - Google Patents
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- JP2019509064A5 JP2019509064A5 JP2018568189A JP2018568189A JP2019509064A5 JP 2019509064 A5 JP2019509064 A5 JP 2019509064A5 JP 2018568189 A JP2018568189 A JP 2018568189A JP 2018568189 A JP2018568189 A JP 2018568189A JP 2019509064 A5 JP2019509064 A5 JP 2019509064A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- synthetic
- sequence
- mutanase
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 241000196324 Embryophyta Species 0.000 claims 5
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 claims 5
- 108020004705 Codon Proteins 0.000 claims 4
- 210000003763 chloroplast Anatomy 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 241000991587 Enterovirus C Species 0.000 claims 2
- 230000036039 immunity Effects 0.000 claims 2
- 230000009466 transformation Effects 0.000 claims 2
- 108700042778 Antimicrobial Peptides Proteins 0.000 claims 1
- 102000044503 Antimicrobial Peptides Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229940112822 chewing gum Drugs 0.000 claims 1
- 235000015218 chewing gum Nutrition 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 208000002925 dental caries Diseases 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000007505 plaque formation Effects 0.000 claims 1
- 210000002706 plastid Anatomy 0.000 claims 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims 1
- 101150075980 psbA gene Proteins 0.000 claims 1
- 210000003705 ribosome Anatomy 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662310788P | 2016-03-20 | 2016-03-20 | |
| US62/310,788 | 2016-03-20 | ||
| PCT/US2017/023263 WO2017165320A1 (en) | 2016-03-20 | 2017-03-20 | Codon optimization and ribosome profiling for increasing transgene expression in chloroplasts of higher plants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509064A JP2019509064A (ja) | 2019-04-04 |
| JP2019509064A5 true JP2019509064A5 (enExample) | 2020-04-02 |
| JP7145083B2 JP7145083B2 (ja) | 2022-09-30 |
Family
ID=59899714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568189A Active JP7145083B2 (ja) | 2016-03-20 | 2017-03-20 | 高等植物の葉緑体におけるトランス遺伝子発現を増加させるためのコドン最適化及びリボソームプロファイリング |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11332754B2 (enExample) |
| EP (1) | EP3432902B8 (enExample) |
| JP (1) | JP7145083B2 (enExample) |
| CN (1) | CN110603046B (enExample) |
| CA (1) | CA3055900A1 (enExample) |
| WO (1) | WO2017165320A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117224709A (zh) * | 2016-05-12 | 2023-12-15 | 宾夕法尼亚州立大学托管会 | 用于抑制生物膜沉积和产生的组合物和方法 |
| WO2020041599A1 (en) * | 2018-08-22 | 2020-02-27 | The Trustees Of The University Of Pennsylvania | Compositions and methods for production of antibiotic free biopharmaceuticals in lettuce chloroplasts |
| CN112195226B (zh) * | 2019-07-08 | 2022-05-24 | 清华大学 | 极小量细胞核糖体保护的rna片段测序的方法 |
| CN111635935A (zh) * | 2020-06-10 | 2020-09-08 | 华中农业大学 | 一种低成本、高通量间接量化蛋白表达水平的方法及其应用 |
| CN120266212A (zh) * | 2022-11-24 | 2025-07-04 | 南京金斯瑞生物科技有限公司 | 密码子优化 |
| CN117511978B (zh) * | 2024-01-08 | 2024-03-22 | 深圳粒影生物科技有限公司 | 一种提高外源蛋白表达量的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946676A (en) * | 1986-08-27 | 1990-08-07 | De Staat Der Nederlanden | Vaccine comprising an immunogenic protein and, as an adjuvant, a substantially non-immunogenic, sequentially homologous peptide |
| JPH10201483A (ja) * | 1996-11-25 | 1998-08-04 | Lion Corp | ムタナーゼ遺伝子 |
| US20110179530A1 (en) | 2001-01-23 | 2011-07-21 | University Of Central Florida Research Foundation, Inc. | Pharmaceutical Proteins, Human Therapeutics, Human Serum Albumin Insulin, Native Cholera Toxin B Subunit on Transgenic Plastids |
| US7741536B2 (en) | 1997-08-07 | 2010-06-22 | University Of Central Florida Research Foundation, Inc. | Expression of human serum albumin in plastids |
| NL1009834C2 (nl) * | 1998-08-10 | 2000-02-11 | Stanislaus Laurens Johan Woute | Antistoffen voor toepassing in de gerichte en tijdelijke behandeling van mens en dier. |
| BR9915919A (pt) | 1998-10-07 | 2001-08-21 | Syngenta Participations Ag | Proteìnas terapeuticamente ativas em plantas |
| CN1886512A (zh) * | 2002-04-23 | 2006-12-27 | 斯克里普斯研究所 | 多肽在叶绿体中的表达以及用于表达多肽的组合物和方法 |
| JP2005185182A (ja) * | 2003-12-25 | 2005-07-14 | Lion Corp | α−１，３−グルコオリゴ糖の製造方法、該製造方法により得られるα−１，３−グルコオリゴ糖およびこれを含有する製剤組成物 |
| US8043833B2 (en) * | 2005-10-31 | 2011-10-25 | Novo Nordisk A/S | Expression of soluble therapeutic proteins |
| WO2007133558A2 (en) * | 2006-05-09 | 2007-11-22 | The Scripps Research Institute | Robust expression of a bioactive mammalian protein in chlamydomonas chloroplast |
| DK2134853T3 (en) * | 2007-04-03 | 2018-10-08 | Oxyrane Uk Ltd | Glycosylation of molecules |
| GB0911870D0 (en) * | 2009-07-08 | 2009-08-19 | Ucl Business Plc | Optimised coding sequence and promoter |
| US8326547B2 (en) * | 2009-10-07 | 2012-12-04 | Nanjingjinsirui Science & Technology Biology Corp. | Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm |
| US20120309939A1 (en) * | 2009-11-19 | 2012-12-06 | The Scripps Research Institute | Production of Therapeutic Proteins in Photosynthetic Organisms |
| WO2012006623A1 (en) | 2010-07-09 | 2012-01-12 | Biogen Idec Hemophilia Inc. | Systems for factor viii processing and methods thereof |
| CN102146344A (zh) * | 2010-11-02 | 2011-08-10 | 上海师范大学 | 优化密码子提高外源基因表达量和莱茵衣藻制氢量的方法 |
| WO2013063049A1 (en) * | 2011-10-24 | 2013-05-02 | University Of Central Florida Research Foundation, Inc. | Orally-administered plastid expressed cholera toxin b subunit-exendin 4 as treatment for type 2 diabetes |
| WO2013170031A1 (en) * | 2012-05-09 | 2013-11-14 | The Regents Of The University Of California | Method for in silico modeling of gene product expression and metabolism |
| FI3889173T3 (fi) | 2013-02-15 | 2023-10-02 | Bioverativ Therapeutics Inc | Optimoitu tekijä viii:n geeni |
| WO2015073988A1 (en) * | 2013-11-15 | 2015-05-21 | Trustees Of The University Of Pennsylvania | Compositions and methods for suppression of inhibitor formation against factor viii in hemophilia a patients |
-
2017
- 2017-03-20 CN CN201780031137.5A patent/CN110603046B/zh active Active
- 2017-03-20 JP JP2018568189A patent/JP7145083B2/ja active Active
- 2017-03-20 EP EP17770930.0A patent/EP3432902B8/en active Active
- 2017-03-20 WO PCT/US2017/023263 patent/WO2017165320A1/en not_active Ceased
- 2017-03-20 US US16/086,416 patent/US11332754B2/en active Active
- 2017-03-20 CA CA3055900A patent/CA3055900A1/en active Pending
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