JP2019509015A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019509015A5 JP2019509015A5 JP2018530698A JP2018530698A JP2019509015A5 JP 2019509015 A5 JP2019509015 A5 JP 2019509015A5 JP 2018530698 A JP2018530698 A JP 2018530698A JP 2018530698 A JP2018530698 A JP 2018530698A JP 2019509015 A5 JP2019509015 A5 JP 2019509015A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- adapter
- target nucleic
- strand
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 51
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 24
- 238000000034 method Methods 0.000 claims 24
- 108020004707 nucleic acids Proteins 0.000 claims 19
- 102000039446 nucleic acids Human genes 0.000 claims 19
- 108091035707 Consensus sequence Proteins 0.000 claims 9
- 239000007801 affinity label Substances 0.000 claims 9
- 239000002773 nucleotide Substances 0.000 claims 9
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 8
- 229960002685 biotin Drugs 0.000 claims 6
- 239000011616 biotin Substances 0.000 claims 6
- 238000012163 sequencing technique Methods 0.000 claims 5
- 235000020958 biotin Nutrition 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 4
- 102000005720 Glutathione transferase Human genes 0.000 claims 2
- 108010070675 Glutathione transferase Proteins 0.000 claims 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 239000001226 triphosphate Substances 0.000 claims 2
- 108010073254 Colicins Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 230000005684 electric field Effects 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 235000021317 phosphate Nutrition 0.000 claims 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 230000001502 supplementing effect Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021179334A JP7548579B2 (ja) | 2015-12-08 | 2021-11-02 | 二本鎖配列決定のための改善されたアダプター、方法、及び組成物 |
| JP2023184524A JP2024010122A (ja) | 2015-12-08 | 2023-10-27 | 二本鎖配列決定のための改善されたアダプター、方法、及び組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562264822P | 2015-12-08 | 2015-12-08 | |
| US62/264,822 | 2015-12-08 | ||
| US201662281917P | 2016-01-22 | 2016-01-22 | |
| US62/281,917 | 2016-01-22 | ||
| PCT/US2016/065605 WO2017100441A1 (en) | 2015-12-08 | 2016-12-08 | Improved adapters, methods, and compositions for duplex sequencing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021179334A Division JP7548579B2 (ja) | 2015-12-08 | 2021-11-02 | 二本鎖配列決定のための改善されたアダプター、方法、及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509015A JP2019509015A (ja) | 2019-04-04 |
| JP2019509015A5 true JP2019509015A5 (https=) | 2020-01-23 |
| JP6975507B2 JP6975507B2 (ja) | 2021-12-01 |
Family
ID=57750605
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530698A Active JP6975507B2 (ja) | 2015-12-08 | 2016-12-08 | 二本鎖配列決定のための改善されたアダプター、方法、及び組成物 |
| JP2021179334A Active JP7548579B2 (ja) | 2015-12-08 | 2021-11-02 | 二本鎖配列決定のための改善されたアダプター、方法、及び組成物 |
| JP2023184524A Pending JP2024010122A (ja) | 2015-12-08 | 2023-10-27 | 二本鎖配列決定のための改善されたアダプター、方法、及び組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021179334A Active JP7548579B2 (ja) | 2015-12-08 | 2021-11-02 | 二本鎖配列決定のための改善されたアダプター、方法、及び組成物 |
| JP2023184524A Pending JP2024010122A (ja) | 2015-12-08 | 2023-10-27 | 二本鎖配列決定のための改善されたアダプター、方法、及び組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11332784B2 (https=) |
| EP (2) | EP3387152B1 (https=) |
| JP (3) | JP6975507B2 (https=) |
| CN (1) | CN109072294A (https=) |
| AU (1) | AU2016366231B2 (https=) |
| CA (1) | CA3006792A1 (https=) |
| ES (1) | ES2911421T3 (https=) |
| IL (1) | IL259788B2 (https=) |
| PL (1) | PL3387152T3 (https=) |
| PT (1) | PT3387152T (https=) |
| WO (1) | WO2017100441A1 (https=) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9260753B2 (en) | 2011-03-24 | 2016-02-16 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| DK2814959T3 (en) | 2012-02-17 | 2018-04-23 | Hutchinson Fred Cancer Res | COMPOSITIONS AND PROCEDURES FOR EXACTLY IDENTIFYING MUTATIONS |
| EP3744857A1 (en) | 2012-03-20 | 2020-12-02 | University Of Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| GB2533006B (en) | 2012-09-04 | 2017-06-07 | Guardant Health Inc | Systems and methods to detect copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| TWI707038B (zh) | 2013-08-05 | 2020-10-11 | 美商扭轉生物科技有限公司 | 重新合成之基因庫 |
| ES2660989T3 (es) | 2013-12-28 | 2018-03-27 | Guardant Health, Inc. | Métodos y sistemas para detectar variantes genéticas |
| CN107124888B (zh) | 2014-11-21 | 2021-08-06 | 深圳华大智造科技股份有限公司 | 鼓泡状接头元件和使用其构建测序文库的方法 |
| WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| US10844428B2 (en) | 2015-04-28 | 2020-11-24 | Illumina, Inc. | Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS) |
| KR20180050411A (ko) | 2015-09-18 | 2018-05-14 | 트위스트 바이오사이언스 코포레이션 | 올리고핵산 변이체 라이브러리 및 그의 합성 |
| KR102794025B1 (ko) | 2015-09-22 | 2025-04-09 | 트위스트 바이오사이언스 코포레이션 | 핵산 합성을 위한 가요성 기판 |
| CN115920796A (zh) | 2015-12-01 | 2023-04-07 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
| PL3387152T3 (pl) | 2015-12-08 | 2022-05-09 | Twinstrand Biosciences, Inc. | Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego |
| WO2017106768A1 (en) | 2015-12-17 | 2017-06-22 | Guardant Health, Inc. | Methods to determine tumor gene copy number by analysis of cell-free dna |
| US11384382B2 (en) | 2016-04-14 | 2022-07-12 | Guardant Health, Inc. | Methods of attaching adapters to sample nucleic acids |
| EP4488686A3 (en) | 2016-04-14 | 2025-04-30 | Guardant Health, Inc. | Methods for early detection of cancer |
| US11821028B2 (en) | 2016-07-12 | 2023-11-21 | QIAGEN Sciences, LLP | Single end duplex DNA sequencing |
| CN109312391B (zh) | 2016-07-18 | 2022-06-03 | 豪夫迈·罗氏有限公司 | 生成用于单分子测序的单链环状dna文库的方法 |
| WO2018031588A1 (en) * | 2016-08-09 | 2018-02-15 | Takara Bio Usa, Inc. | Nucleic acid adaptors with molecular identification sequences and use thereof |
| JP6854340B2 (ja) | 2016-08-22 | 2021-04-07 | ツイスト バイオサイエンス コーポレーション | デノボ合成された核酸ライブラリ |
| US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
| KR102514213B1 (ko) | 2016-12-16 | 2023-03-27 | 트위스트 바이오사이언스 코포레이션 | 면역 시냅스의 변이체 라이브러리 및 그의 합성 |
| EP3562961A4 (en) * | 2016-12-28 | 2021-01-06 | Quest Diagnostics Investments LLC | COMPOSITIONS AND METHODS FOR DETECTION OF CIRCULATING TUMOR DNA |
| US10844429B2 (en) | 2017-01-18 | 2020-11-24 | Illumina, Inc. | Methods and systems for generation and error-correction of unique molecular index sets with heterogeneous molecular lengths |
| CN110892485B (zh) | 2017-02-22 | 2024-03-22 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
| WO2018170169A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| EP4134444B1 (en) | 2017-03-23 | 2024-10-02 | University of Washington | Methods for targeted nucleic acid sequence enrichment with applications to error corrected nucleic acid sequencing |
| US11584958B2 (en) | 2017-03-31 | 2023-02-21 | Grail, Llc | Library preparation and use thereof for sequencing based error correction and/or variant identification |
| US11028435B2 (en) | 2017-05-01 | 2021-06-08 | Illumina, Inc. | Optimal index sequences for multiplex massively parallel sequencing |
| ES2989056T3 (es) | 2017-05-08 | 2024-11-25 | Illumina Inc | Método de secuenciación usando adaptadores cortos universales para la indexación de muestras de polinucleótidos |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| US10696965B2 (en) | 2017-06-12 | 2020-06-30 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| CN111566125A (zh) | 2017-09-11 | 2020-08-21 | 特韦斯特生物科学公司 | Gpcr结合蛋白及其合成 |
| US11447818B2 (en) * | 2017-09-15 | 2022-09-20 | Illumina, Inc. | Universal short adapters with variable length non-random unique molecular identifiers |
| CN111565834B (zh) | 2017-10-20 | 2022-08-26 | 特韦斯特生物科学公司 | 用于多核苷酸合成的加热的纳米孔 |
| AU2018359670B2 (en) | 2017-11-06 | 2021-08-26 | Illumina, Inc. | Nucleic acid indexing techniques |
| SG11202003885UA (en) | 2017-11-08 | 2020-05-28 | Twinstrand Biosciences Inc | Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters |
| KR102804057B1 (ko) | 2018-01-04 | 2025-05-07 | 트위스트 바이오사이언스 코포레이션 | Dna 기반 디지털 정보 저장 |
| CN108300716B (zh) * | 2018-01-05 | 2020-06-30 | 武汉康测科技有限公司 | 接头元件、其应用和基于不对称多重pcr进行靶向测序文库构建的方法 |
| CA3093846A1 (en) | 2018-03-15 | 2019-09-19 | Twinstrand Biosciences, Inc. | Methods and reagents for enrichment of nucleic acid material for sequencing applications and other nucleic acid material interrogations |
| GB201804641D0 (en) | 2018-03-22 | 2018-05-09 | Inivata Ltd | Methods of sequencing nucleic acids and error correction of sequence reads |
| WO2019183640A1 (en) | 2018-03-23 | 2019-09-26 | Board Of Regents, The University Of Texas System | Efficient sequencing of dsdna with extremely low level of errors |
| CN112218956A (zh) * | 2018-05-16 | 2021-01-12 | 特温斯特兰德生物科学有限公司 | 用于解析核酸混合物和混合细胞群体的方法和试剂及相关应用 |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| WO2020014693A1 (en) * | 2018-07-12 | 2020-01-16 | Twinstrand Biosciences, Inc. | Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications |
| WO2020043803A1 (en) * | 2018-08-28 | 2020-03-05 | Sophia Genetics S.A. | Methods for asymmetric dna library generation and optionally integrated duplex sequencing |
| US12270125B2 (en) | 2018-09-21 | 2025-04-08 | Roche Sequencing Solutions, Inc. | System and method for modular and combinatorial nucleic acid sample preparation for sequencing |
| WO2020081743A1 (en) | 2018-10-16 | 2020-04-23 | Twinstrand Biosciences, Inc. | Methods and reagents for efficient genotyping of large numbers of samples via pooling |
| US12357959B2 (en) | 2018-12-26 | 2025-07-15 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| CN111378557B (zh) | 2018-12-26 | 2023-06-06 | 财团法人工业技术研究院 | 用于产生液珠的管状结构及液珠产生方法 |
| AU2020227672A1 (en) * | 2019-02-25 | 2021-10-07 | Twist Bioscience Corporation | Compositions and methods for next generation sequencing |
| CN113766930B (zh) | 2019-02-26 | 2025-07-22 | 特韦斯特生物科学公司 | Glp1受体的变异核酸文库 |
| CA3131691A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
| AU2020298294A1 (en) | 2019-06-21 | 2022-02-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| CN114502742A (zh) * | 2019-08-01 | 2022-05-13 | 特温斯特兰德生物科学有限公司 | 用于核酸测序及相关应用的方法和试剂 |
| JP2022548309A (ja) | 2019-09-23 | 2022-11-17 | ツイスト バイオサイエンス コーポレーション | Ｃｒｔｈ２のバリアント核酸ライブラリー |
| WO2021061842A1 (en) | 2019-09-23 | 2021-04-01 | Twist Bioscience Corporation | Variant nucleic acid libraries for single domain antibodies |
| CN112176419B (zh) * | 2019-10-16 | 2022-03-22 | 中国医学科学院肿瘤医院 | 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法 |
| WO2021092476A1 (en) | 2019-11-06 | 2021-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and systems for analyzing nucleic acid molecules |
| IL293670A (en) | 2019-12-09 | 2022-08-01 | Twist Bioscience Corp | Variable nucleic acid libraries for adenosine receptors |
| US11783912B2 (en) | 2021-05-05 | 2023-10-10 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and systems for analyzing nucleic acid molecules |
| EP4555084A2 (en) * | 2022-07-12 | 2025-05-21 | University of Washington | Systems and methods for variant detection in cells |
| WO2024022207A1 (en) * | 2022-07-25 | 2024-02-01 | Mgi Tech Co., Ltd. | Methods of in-solution positional co-barcoding for sequencing long dna molecules |
Family Cites Families (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US5308751A (en) | 1992-03-23 | 1994-05-03 | General Atomics | Method for sequencing double-stranded DNA |
| JP2002503954A (ja) * | 1997-04-01 | 2002-02-05 | グラクソ、グループ、リミテッド | 核酸増幅法 |
| US6087099A (en) | 1997-09-08 | 2000-07-11 | Myriad Genetics, Inc. | Method for sequencing both strands of a double stranded DNA in a single sequencing reaction |
| WO2000024939A1 (en) | 1998-10-27 | 2000-05-04 | Affymetrix, Inc. | Complexity management and analysis of genomic dna |
| US6958225B2 (en) | 1999-10-27 | 2005-10-25 | Affymetrix, Inc. | Complexity management of genomic DNA |
| US7300751B2 (en) | 2000-06-30 | 2007-11-27 | Syngenta Participations Ag | Method for identification of genetic markers |
| US6632611B2 (en) | 2001-07-20 | 2003-10-14 | Affymetrix, Inc. | Method of target enrichment and amplification |
| US7297778B2 (en) | 2001-07-25 | 2007-11-20 | Affymetrix, Inc. | Complexity management of genomic DNA |
| EP1463825B1 (en) | 2001-10-15 | 2017-12-06 | BioArray Solutions Ltd. | Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection |
| US7406385B2 (en) | 2001-10-25 | 2008-07-29 | Applera Corporation | System and method for consensus-calling with per-base quality values for sample assemblies |
| US7459273B2 (en) | 2002-10-04 | 2008-12-02 | Affymetrix, Inc. | Methods for genotyping selected polymorphism |
| US7452699B2 (en) | 2003-01-15 | 2008-11-18 | Dana-Farber Cancer Institute, Inc. | Amplification of DNA in a hairpin structure, and applications |
| US20040209299A1 (en) | 2003-03-07 | 2004-10-21 | Rubicon Genomics, Inc. | In vitro DNA immortalization and whole genome amplification using libraries generated from randomly fragmented DNA |
| JP2007524410A (ja) | 2004-01-23 | 2007-08-30 | リングヴィテ エーエス | ポリヌクレオチドライゲーション反応の改良 |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| WO2006113422A2 (en) | 2005-04-13 | 2006-10-26 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Services | Human sweet and umami taste receptor variants |
| ES2393318T3 (es) | 2005-06-23 | 2012-12-20 | Keygene N.V. | Estrategias para la identificación y detección de alto rendimiento de polimorfismos |
| US20090170713A1 (en) | 2005-09-29 | 2009-07-02 | Keygene N.V. | High throughput screening of mutagenized populations |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
| US20070172839A1 (en) | 2006-01-24 | 2007-07-26 | Smith Douglas R | Asymmetrical adapters and methods of use thereof |
| DK3239304T3 (da) | 2006-04-04 | 2020-10-26 | Keygene Nv | Højgennemløbsdetektering af molekylære markører baseret på AFLP og sekventering med højt gennemløb |
| WO2008093098A2 (en) * | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
| WO2009036525A2 (en) | 2007-09-21 | 2009-03-26 | Katholieke Universiteit Leuven | Tools and methods for genetic tests using next generation sequencing |
| MX2010010600A (es) | 2008-03-28 | 2011-03-30 | Pacific Biosciences California Inc | Composiciones y metodos para secuenciacion de acidos nucleicos. |
| WO2009133466A2 (en) | 2008-04-30 | 2009-11-05 | Population Genetics Technologies Ltd. | Asymmetric adapter library construction |
| US8383345B2 (en) | 2008-09-12 | 2013-02-26 | University Of Washington | Sequence tag directed subassembly of short sequencing reads into long sequencing reads |
| US20110301042A1 (en) | 2008-11-11 | 2011-12-08 | Helicos Biosciences Corporation | Methods of sample encoding for multiplex analysis of samples by single molecule sequencing |
| JP5843614B2 (ja) | 2009-01-30 | 2016-01-13 | オックスフォード ナノポア テクノロジーズ リミテッド | 膜貫通配列決定における核酸構築物のためのアダプター |
| US20100331204A1 (en) | 2009-02-13 | 2010-12-30 | Jeff Jeddeloh | Methods and systems for enrichment of target genomic sequences |
| US20120165202A1 (en) | 2009-04-30 | 2012-06-28 | Good Start Genetics, Inc. | Methods and compositions for evaluating genetic markers |
| WO2010127186A1 (en) | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| EP2248914A1 (en) | 2009-05-05 | 2010-11-10 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | The use of class IIB restriction endonucleases in 2nd generation sequencing applications |
| EP2467479B1 (en) | 2009-08-20 | 2016-01-06 | Population Genetics Technologies Ltd | Compositions and methods for intramolecular nucleic acid rearrangement |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| DK3425062T3 (da) | 2010-06-09 | 2023-09-04 | Keygene Nv | Stregkoder med kombinatorisk sekvens til høj gennemløbsscreening |
| US20120238738A1 (en) | 2010-07-19 | 2012-09-20 | New England Biolabs, Inc. | Oligonucleotide Adapters: Compositions and Methods of Use |
| US20120244525A1 (en) * | 2010-07-19 | 2012-09-27 | New England Biolabs, Inc. | Oligonucleotide Adapters: Compositions and Methods of Use |
| CA2811185C (en) | 2010-09-21 | 2020-09-22 | Population Genetics Technologies Ltd. | Increasing confidence of allele calls with molecular counting |
| WO2012042374A2 (en) | 2010-10-01 | 2012-04-05 | Anssi Jussi Nikolai Taipale | Method of determining number or concentration of molecules |
| CA2821299C (en) | 2010-11-05 | 2019-02-12 | Frank J. Steemers | Linking sequence reads using paired code tags |
| US9074251B2 (en) * | 2011-02-10 | 2015-07-07 | Illumina, Inc. | Linking sequence reads using paired code tags |
| WO2012083225A2 (en) | 2010-12-16 | 2012-06-21 | Gigagen, Inc. | System and methods for massively parallel analysis of nycleic acids in single cells |
| EP3736281A1 (en) | 2011-02-18 | 2020-11-11 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| US9260753B2 (en) | 2011-03-24 | 2016-02-16 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| ES2625288T3 (es) | 2011-04-15 | 2017-07-19 | The Johns Hopkins University | Sistema de secuenciación segura |
| ES2556580T3 (es) | 2011-07-08 | 2016-01-19 | Keygene N.V. | Genotipado a base de secuencias en base a ensayos de ligación a oligonucleótidos |
| EP3620533B1 (en) | 2011-09-06 | 2023-01-18 | Gen-Probe Incorporated | Closed nucleic acid structures |
| GB2496016B (en) * | 2011-09-09 | 2016-03-16 | Univ Leland Stanford Junior | Methods for obtaining a sequence |
| JP5418579B2 (ja) | 2011-12-06 | 2014-02-19 | 株式会社デンソー | 開閉眼検出装置 |
| US20160153039A1 (en) | 2012-01-26 | 2016-06-02 | Nugen Technologies, Inc. | Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation |
| EP4372084A3 (en) | 2012-01-26 | 2024-08-14 | Tecan Genomics, Inc. | Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation |
| US9528107B2 (en) * | 2012-01-31 | 2016-12-27 | Pacific Biosciences Of California, Inc. | Compositions and methods for selection of nucleic acids |
| DK2814959T3 (en) | 2012-02-17 | 2018-04-23 | Hutchinson Fred Cancer Res | COMPOSITIONS AND PROCEDURES FOR EXACTLY IDENTIFYING MUTATIONS |
| EP2820174B1 (en) | 2012-02-27 | 2019-12-25 | The University of North Carolina at Chapel Hill | Methods and uses for molecular tags |
| US9670529B2 (en) | 2012-02-28 | 2017-06-06 | Population Genetics Technologies Ltd. | Method for attaching a counter sequence to a nucleic acid sample |
| NO2694769T3 (https=) * | 2012-03-06 | 2018-03-03 | ||
| US9862995B2 (en) | 2012-03-13 | 2018-01-09 | Abhijit Ajit Patel | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
| EP3744857A1 (en) | 2012-03-20 | 2020-12-02 | University Of Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing |
| EP4026912A1 (en) | 2012-05-10 | 2022-07-13 | The General Hospital Corporation | Methods for determining a nucleotide sequence |
| AU2013267609C1 (en) | 2012-05-31 | 2019-01-03 | Board Of Regents, The University Of Texas System | Method for accurate sequencing of DNA |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| GB2533006B (en) | 2012-09-04 | 2017-06-07 | Guardant Health Inc | Systems and methods to detect copy number variation |
| CN102877136B (zh) * | 2012-09-24 | 2014-03-12 | 上海交通大学 | 基于基因组简化与二代测序dna文库构建方法及试剂盒 |
| WO2014142850A1 (en) | 2013-03-13 | 2014-09-18 | Illumina, Inc. | Methods and compositions for nucleic acid sequencing |
| US9290800B2 (en) * | 2013-03-15 | 2016-03-22 | Pacific Biosciences Of California, Inc. | Targeted rolling circle amplification |
| US10087481B2 (en) * | 2013-03-19 | 2018-10-02 | New England Biolabs, Inc. | Enrichment of target sequences |
| US11414695B2 (en) | 2013-05-29 | 2022-08-16 | Agilent Technologies, Inc. | Nucleic acid enrichment using Cas9 |
| JP6506768B2 (ja) * | 2013-09-24 | 2019-04-24 | ソマロジック・インコーポレーテッド | 多重アプタマー標的の検出 |
| ES2660989T3 (es) * | 2013-12-28 | 2018-03-27 | Guardant Health, Inc. | Métodos y sistemas para detectar variantes genéticas |
| KR102321956B1 (ko) | 2014-01-31 | 2021-11-08 | 스위프트 바이오사이언시스 인코포레이티드 | Dna 기질을 처리하는 개선 방법 |
| EP3191628B1 (en) | 2014-09-12 | 2022-05-25 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acids |
| WO2016118883A1 (en) | 2015-01-23 | 2016-07-28 | Washington University | Detection of rare sequence variants, methods and compositions therefor |
| WO2016133044A1 (ja) | 2015-02-20 | 2016-08-25 | 日本電気株式会社 | 受信装置、受信方法 |
| US10844428B2 (en) | 2015-04-28 | 2020-11-24 | Illumina, Inc. | Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS) |
| JP6698708B2 (ja) | 2015-06-09 | 2020-05-27 | ライフ テクノロジーズ コーポレーション | 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体 |
| US10465241B2 (en) | 2015-06-15 | 2019-11-05 | The Board Of Trustees Of The Leleand Stanford Junior University | High resolution STR analysis using next generation sequencing |
| GB201515557D0 (en) | 2015-09-02 | 2015-10-14 | 14M Genomics Ltd | Method of sequencing |
| EP3377656B1 (en) | 2015-11-18 | 2025-07-02 | Pacific Biosciences of California, Inc. | Loading nucleic acids onto substrates |
| PL3387152T3 (pl) | 2015-12-08 | 2022-05-09 | Twinstrand Biosciences, Inc. | Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego |
| EP3405573A4 (en) | 2016-01-22 | 2019-09-18 | Grail, Inc. | METHOD AND SYSTEMS FOR HIGH-FIDELITY SEQUENCING |
| EP3405574A4 (en) | 2016-01-22 | 2019-10-02 | Grail, Inc. | VARIANTS-BASED SICKNESS DIAGNOSTICS AND PURSUIT |
| US11821028B2 (en) | 2016-07-12 | 2023-11-21 | QIAGEN Sciences, LLP | Single end duplex DNA sequencing |
| EP3800461A1 (en) | 2016-07-29 | 2021-04-07 | Sysmex Corporation | Smear analysis system and method |
| WO2018031588A1 (en) | 2016-08-09 | 2018-02-15 | Takara Bio Usa, Inc. | Nucleic acid adaptors with molecular identification sequences and use thereof |
| US10487358B2 (en) | 2016-09-23 | 2019-11-26 | Grail, Inc. | Methods of preparing and analyzing cell-free nucleic acid sequencing libraries |
| WO2018119399A1 (en) | 2016-12-23 | 2018-06-28 | Grail, Inc. | Methods for high efficiency library preparation using double-stranded adapters |
| EP4134444B1 (en) | 2017-03-23 | 2024-10-02 | University of Washington | Methods for targeted nucleic acid sequence enrichment with applications to error corrected nucleic acid sequencing |
| US11584958B2 (en) | 2017-03-31 | 2023-02-21 | Grail, Llc | Library preparation and use thereof for sequencing based error correction and/or variant identification |
| SG11202003885UA (en) | 2017-11-08 | 2020-05-28 | Twinstrand Biosciences Inc | Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters |
| CA3091022A1 (en) | 2018-02-13 | 2019-08-22 | Twinstrand Biosciences, Inc. | Methods and reagents for detecting and assessing genotoxicity |
| CA3093846A1 (en) | 2018-03-15 | 2019-09-19 | Twinstrand Biosciences, Inc. | Methods and reagents for enrichment of nucleic acid material for sequencing applications and other nucleic acid material interrogations |
| WO2019183640A1 (en) | 2018-03-23 | 2019-09-26 | Board Of Regents, The University Of Texas System | Efficient sequencing of dsdna with extremely low level of errors |
| CN112218956A (zh) | 2018-05-16 | 2021-01-12 | 特温斯特兰德生物科学有限公司 | 用于解析核酸混合物和混合细胞群体的方法和试剂及相关应用 |
| WO2020014693A1 (en) | 2018-07-12 | 2020-01-16 | Twinstrand Biosciences, Inc. | Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications |
| KR102662200B1 (ko) | 2019-07-15 | 2024-04-29 | 엘지디스플레이 주식회사 | 유기발광표시장치 |
-
2016
- 2016-12-08 PL PL16822832T patent/PL3387152T3/pl unknown
- 2016-12-08 ES ES16822832T patent/ES2911421T3/es active Active
- 2016-12-08 US US15/372,761 patent/US11332784B2/en active Active
- 2016-12-08 AU AU2016366231A patent/AU2016366231B2/en active Active
- 2016-12-08 WO PCT/US2016/065605 patent/WO2017100441A1/en not_active Ceased
- 2016-12-08 EP EP16822832.8A patent/EP3387152B1/en active Active
- 2016-12-08 JP JP2018530698A patent/JP6975507B2/ja active Active
- 2016-12-08 PT PT168228328T patent/PT3387152T/pt unknown
- 2016-12-08 EP EP21217292.8A patent/EP4043584A1/en active Pending
- 2016-12-08 CN CN201680080120.4A patent/CN109072294A/zh active Pending
- 2016-12-08 CA CA3006792A patent/CA3006792A1/en active Pending
-
2018
- 2018-06-03 IL IL259788A patent/IL259788B2/en unknown
-
2021
- 2021-11-02 JP JP2021179334A patent/JP7548579B2/ja active Active
-
2022
- 2022-04-12 US US17/719,147 patent/US20220267841A1/en not_active Abandoned
-
2023
- 2023-10-27 JP JP2023184524A patent/JP2024010122A/ja active Pending
-
2025
- 2025-03-21 US US19/087,128 patent/US20250313888A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019509015A5 (https=) | ||
| US20220267841A1 (en) | Adapters, methods, and compositions for duplex sequencing | |
| Ouellet et al. | Hi‐Fi SELEX: a high‐fidelity digital‐PCR based therapeutic aptamer discovery platform | |
| CN112020562A (zh) | 基于crispr效应系统的诊断 | |
| CA3075303A1 (en) | Multi-effector crispr based diagnostic systems | |
| JP6758474B2 (ja) | 等温増幅の成分およびプロセス | |
| WO2016131030A4 (en) | Methods for highly parallel and accurate measurement of nucleic acids | |
| Mizanur Rahman et al. | The aromatic stacking interactions between proteins and their macromolecular ligands | |
| JP2018514230A5 (https=) | ||
| US20130116129A1 (en) | Method for detecting target molecules | |
| CN107207570A (zh) | 突变csgg孔 | |
| US9957548B2 (en) | Methods of capturing sperm nucleic acids | |
| JP2017060513A (ja) | 富化ライブラリーを作製する方法 | |
| JP2013540440A5 (https=) | ||
| CN103074329B (zh) | 一种聚合酶链反应增强方法 | |
| CN108103151A (zh) | 一种基于序列特异性核酸结合蛋白的核酸检测和分型的方法及其应用 | |
| JP2016517275A5 (https=) | ||
| CN108004246A (zh) | 利用金属亲和法快速进行液相靶标selex筛选的方法 | |
| JP2017529062A5 (https=) | ||
| Gaines et al. | RNA capture pin technology: Investigating long-term stability and mRNA purification specificity of oligonucleotide immobilization on gold and streptavidin surfaces | |
| RU2736789C1 (ru) | Способ селекции одноцепочечных олигонуклеотидов с повышенной аффинностью к молекулярной мишени | |
| JP2016098198A (ja) | Ｄｎａライブラリの製造方法、ｄｎａライブラリ、スクリーニング方法及びスクリーニングキット | |
| RU2723373C1 (ru) | Способ термической диссоциации для проведения селекции ДНК-аптамеров | |
| JP2012143197A (ja) | Ｄｎａアプタマーの選択方法およびｄｎａアプタマー | |
| Ma et al. | Interrogation of CRISPR Dynamics with Fluorescent Single Guide RNAs in Live Cells |