PL3387152T3 - Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego - Google Patents

Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego

Info

Publication number
PL3387152T3
PL3387152T3 PL16822832T PL16822832T PL3387152T3 PL 3387152 T3 PL3387152 T3 PL 3387152T3 PL 16822832 T PL16822832 T PL 16822832T PL 16822832 T PL16822832 T PL 16822832T PL 3387152 T3 PL3387152 T3 PL 3387152T3
Authority
PL
Poland
Prior art keywords
compositions
methods
duplex sequencing
improved adapters
adapters
Prior art date
Application number
PL16822832T
Other languages
English (en)
Inventor
Lawrence A. Loeb
Michael W. Schmitt
Jesse J. SALK
Original Assignee
Twinstrand Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Twinstrand Biosciences, Inc. filed Critical Twinstrand Biosciences, Inc.
Publication of PL3387152T3 publication Critical patent/PL3387152T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855—Ligating adaptors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL16822832T 2015-12-08 2016-12-08 Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego PL3387152T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562264822P 2015-12-08 2015-12-08
US201662281917P 2016-01-22 2016-01-22
PCT/US2016/065605 WO2017100441A1 (en) 2015-12-08 2016-12-08 Improved adapters, methods, and compositions for duplex sequencing
EP16822832.8A EP3387152B1 (en) 2015-12-08 2016-12-08 Improved adapters, methods, and compositions for duplex sequencing

Publications (1)

Publication Number Publication Date
PL3387152T3 true PL3387152T3 (pl) 2022-05-09

Family

ID=57750605

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16822832T PL3387152T3 (pl) 2015-12-08 2016-12-08 Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego

Country Status (11)

Country Link
US (3) US11332784B2 (pl)
EP (2) EP4043584A1 (pl)
JP (3) JP6975507B2 (pl)
CN (1) CN109072294A (pl)
AU (1) AU2016366231B2 (pl)
CA (1) CA3006792A1 (pl)
ES (1) ES2911421T3 (pl)
IL (1) IL259788B2 (pl)
PL (1) PL3387152T3 (pl)
PT (1) PT3387152T (pl)
WO (1) WO2017100441A1 (pl)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
US10011871B2 (en) 2012-02-17 2018-07-03 Fred Hutchinson Cancer Research Center Compositions and methods for accurately identifying mutations
EP2828218B9 (en) 2012-03-20 2021-04-07 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
CA2883901C (en) 2012-09-04 2023-04-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
SG11201600853UA (en) 2013-08-05 2016-03-30 Twist Bioscience Corp De novo synthesized gene libraries
JP6571665B2 (ja) 2013-12-28 2019-09-04 ガーダント ヘルス， インコーポレイテッド 遺伝的バリアントを検出するための方法およびシステム
WO2016078095A1 (zh) 2014-11-21 2016-05-26 深圳华大基因科技有限公司 鼓泡状接头元件和使用其构建测序文库的方法
CA2975852A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
EA201890763A1 (ru) 2015-09-18 2018-08-31 Твист Байосайенс Корпорейшн Библиотеки вариантных олигонуклеиновых кислот и их синтез
KR102794025B1 (ko) 2015-09-22 2025-04-09 트위스트 바이오사이언스 코포레이션 핵산 합성을 위한 가요성 기판
WO2017095958A1 (en) 2015-12-01 2017-06-08 Twist Bioscience Corporation Functionalized surfaces and preparation thereof
PL3387152T3 (pl) 2015-12-08 2022-05-09 Twinstrand Biosciences, Inc. Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego
CN108603228B (zh) 2015-12-17 2023-09-01 夸登特健康公司 通过分析无细胞dna确定肿瘤基因拷贝数的方法
EP3443066B1 (en) 2016-04-14 2024-10-02 Guardant Health, Inc. Methods for early detection of cancer
US11384382B2 (en) 2016-04-14 2022-07-12 Guardant Health, Inc. Methods of attaching adapters to sample nucleic acids
EP3485033B1 (en) 2016-07-12 2022-09-28 Qiagen Sciences, LLC Single end duplex dna sequencing
WO2018015318A1 (en) 2016-07-18 2018-01-25 F. Hoffmann-La Roche Ag Method for generating single-stranded circular dna libraries for single molecule sequencing
WO2018031588A1 (en) * 2016-08-09 2018-02-15 Takara Bio Usa, Inc. Nucleic acid adaptors with molecular identification sequences and use thereof
WO2018038772A1 (en) 2016-08-22 2018-03-01 Twist Bioscience Corporation De novo synthesized nucleic acid libraries
EP3516528B1 (en) 2016-09-21 2025-10-15 Atlas Data Storage, Inc. Nucleic acid based data storage
GB2573069A (en) 2016-12-16 2019-10-23 Twist Bioscience Corp Variant libraries of the immunological synapse and synthesis thereof
CN117004721A (zh) * 2016-12-28 2023-11-07 奎斯特诊断投资有限责任公司 用于检测循环肿瘤dna的组合物和方法
EP3889962B1 (en) 2017-01-18 2025-03-05 Illumina, Inc. Methods and systems for generation and error-correction of unique molecular index sets with heterogeneous molecular lengths
JP2020508661A (ja) 2017-02-22 2020-03-26 ツイスト バイオサイエンス コーポレーション 核酸ベースのデータ保存
CN110913865A (zh) 2017-03-15 2020-03-24 特韦斯特生物科学公司 免疫突触的变体文库及其合成
AU2018240559B2 (en) 2017-03-23 2025-02-13 University Of Washington Methods for targeted nucleic acid sequence enrichment with applications to error corrected nucleic acid sequencing
WO2018183942A1 (en) * 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
SG11201909697TA (en) 2017-05-01 2019-11-28 Illumina Inc Optimal index sequences for multiplex massively parallel sequencing
CN110832087B (zh) 2017-05-08 2025-03-18 伊鲁米那股份有限公司 用于多核苷酸样品的索引的通用短衔接子
SG11201912057RA (en) 2017-06-12 2020-01-30 Twist Bioscience Corp Methods for seamless nucleic acid assembly
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
CN111566125A (zh) 2017-09-11 2020-08-21 特韦斯特生物科学公司 Gpcr结合蛋白及其合成
US11447818B2 (en) 2017-09-15 2022-09-20 Illumina, Inc. Universal short adapters with variable length non-random unique molecular identifiers
KR102637566B1 (ko) 2017-10-20 2024-02-16 트위스트 바이오사이언스 코포레이션 폴리뉴클레오타이드 합성을 위한 가열된 나노웰
CA3067421C (en) 2017-11-06 2023-08-15 Illumina, Inc. Nucleic acid indexing techniques
AU2018366213B2 (en) 2017-11-08 2025-05-15 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
CN112041438B (zh) 2018-01-04 2025-05-23 特韦斯特生物科学公司 基于dna的数字信息存储
CN108300716B (zh) * 2018-01-05 2020-06-30 武汉康测科技有限公司 接头元件、其应用和基于不对称多重pcr进行靶向测序文库构建的方法
WO2019178577A1 (en) 2018-03-15 2019-09-19 Twinstrand Biosciences, Inc. Methods and reagents for enrichment of nucleic acid material for sequencing applications and other nucleic acid material interrogations
GB201804641D0 (en) * 2018-03-22 2018-05-09 Inivata Ltd Methods of sequencing nucleic acids and error correction of sequence reads
WO2019183640A1 (en) * 2018-03-23 2019-09-26 Board Of Regents, The University Of Texas System Efficient sequencing of dsdna with extremely low level of errors
WO2019222560A1 (en) * 2018-05-16 2019-11-21 Twinstrand Biosciences, Inc. Methods and reagents for resolving nucleic acid mixtures and mixed cell populations and associated applications
CN118957038A (zh) 2018-05-18 2024-11-15 特韦斯特生物科学公司 用于核酸杂交的多核苷酸、试剂和方法
CN112673099A (zh) * 2018-07-12 2021-04-16 特温斯特兰德生物科学有限公司 用于表征基因组编辑、克隆扩增的方法和试剂及相关应用
WO2020043803A1 (en) * 2018-08-28 2020-03-05 Sophia Genetics S.A. Methods for asymmetric dna library generation and optionally integrated duplex sequencing
US12270125B2 (en) 2018-09-21 2025-04-08 Roche Sequencing Solutions, Inc. System and method for modular and combinatorial nucleic acid sample preparation for sequencing
CN113439125A (zh) 2018-10-16 2021-09-24 特温斯特兰德生物科学有限公司 用于通过汇集对大量样品进行高效基因分型的方法和试剂
US11358137B2 (en) 2018-12-26 2022-06-14 Industrial Technology Research Institute Tubular structure for producing droplets and method for producing droplets
CA3124980A1 (en) 2018-12-26 2020-07-02 Twist Bioscience Corporation Highly accurate de novo polynucleotide synthesis
EP3938505A4 (en) * 2019-02-25 2022-11-30 Twist Bioscience Corporation COMPOSITIONS AND METHODS FOR SEQUENCING THE NEXT GENERATION
JP2022521551A (ja) 2019-02-26 2022-04-08 ツイスト バイオサイエンス コーポレーション Ｇｌｐ１受容体の変異体核酸ライブラリ
WO2020176680A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for antibody optimization
WO2020257612A1 (en) 2019-06-21 2020-12-24 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
WO2021022237A1 (en) * 2019-08-01 2021-02-04 Twinstrand Biosciences, Inc. Methods and reagents for nucleic acid sequencing and associated applications
JP2022548783A (ja) 2019-09-23 2022-11-21 ツイスト バイオサイエンス コーポレーション 単一ドメイン抗体のバリアント核酸ライブラリー
WO2021061829A1 (en) 2019-09-23 2021-04-01 Twist Bioscience Corporation Variant nucleic acid libraries for crth2
CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
DE112020005433T5 (de) 2019-11-06 2022-10-06 The Board Of Trustees Of The Leland Stanford Junior University Verfahren und Systeme zur Analyse von Nukleinsäuremolekülen
US11783912B2 (en) 2021-05-05 2023-10-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for analyzing nucleic acid molecules
EP4555084A2 (en) * 2022-07-12 2025-05-21 University of Washington Systems and methods for variant detection in cells
AU2023316513A1 (en) * 2022-07-25 2025-02-13 Mgi Tech Co., Ltd. Methods of in-solution positional co-barcoding for sequencing long dna molecules

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5308751A (en) 1992-03-23 1994-05-03 General Atomics Method for sequencing double-stranded DNA
EP1591541B1 (en) * 1997-04-01 2012-02-15 Illumina Cambridge Limited Method of nucleic acid sequencing
US6087099A (en) 1997-09-08 2000-07-11 Myriad Genetics, Inc. Method for sequencing both strands of a double stranded DNA in a single sequencing reaction
DE69929542T2 (de) 1998-10-27 2006-09-14 Affymetrix, Inc., Santa Clara Komplexitätsmanagement und analyse genomischer dna
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
US7300751B2 (en) 2000-06-30 2007-11-27 Syngenta Participations Ag Method for identification of genetic markers
US6632611B2 (en) 2001-07-20 2003-10-14 Affymetrix, Inc. Method of target enrichment and amplification
US7297778B2 (en) 2001-07-25 2007-11-20 Affymetrix, Inc. Complexity management of genomic DNA
ES2661167T3 (es) 2001-10-15 2018-03-27 Bioarray Solutions Ltd. Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
US7406385B2 (en) 2001-10-25 2008-07-29 Applera Corporation System and method for consensus-calling with per-base quality values for sample assemblies
US7459273B2 (en) 2002-10-04 2008-12-02 Affymetrix, Inc. Methods for genotyping selected polymorphism
US7452699B2 (en) 2003-01-15 2008-11-18 Dana-Farber Cancer Institute, Inc. Amplification of DNA in a hairpin structure, and applications
US20040209299A1 (en) 2003-03-07 2004-10-21 Rubicon Genomics, Inc. In vitro DNA immortalization and whole genome amplification using libraries generated from randomly fragmented DNA
EP1709203A2 (en) 2004-01-23 2006-10-11 Lingvitae AS Improving polynucleotide ligation reactions
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US8796441B2 (en) 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
CN105039313B (zh) 2005-06-23 2018-10-23 科因股份有限公司 用于多态性的高通量鉴定和检测的策略
CA2910861C (en) 2005-09-29 2018-08-07 Michael Josephus Theresia Van Eijk High throughput screening of mutagenized populations
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
US20070172839A1 (en) 2006-01-24 2007-07-26 Smith Douglas R Asymmetrical adapters and methods of use thereof
EP2963127B1 (en) 2006-04-04 2017-08-16 Keygene N.V. High throughput detection of molecular markers based on restriction fragments
WO2008093098A2 (en) * 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
WO2009036525A2 (en) 2007-09-21 2009-03-26 Katholieke Universiteit Leuven Tools and methods for genetic tests using next generation sequencing
CA2719747C (en) 2008-03-28 2018-02-20 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
WO2009133466A2 (en) 2008-04-30 2009-11-05 Population Genetics Technologies Ltd. Asymmetric adapter library construction
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
WO2010056728A1 (en) 2008-11-11 2010-05-20 Helicos Biosciences Corporation Nucleic acid encoding for multiplex analysis
US20120058468A1 (en) 2009-01-30 2012-03-08 Oxford Nanopore Technolgies Limited Adaptors for nucleic acid constructs in transmembrane sequencing
US20100331204A1 (en) 2009-02-13 2010-12-30 Jeff Jeddeloh Methods and systems for enrichment of target genomic sequences
US20120165202A1 (en) 2009-04-30 2012-06-28 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
EP2248914A1 (en) 2009-05-05 2010-11-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. The use of class IIB restriction endonucleases in 2nd generation sequencing applications
WO2011021102A2 (en) 2009-08-20 2011-02-24 Population Genetics Technologies Ltd Compositions and methods for intramolecular nucleic acid rearrangement
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9080210B2 (en) 2010-06-09 2015-07-14 Keygene N.V. High throughput screening using combinatorial sequence barcodes
US20120244525A1 (en) * 2010-07-19 2012-09-27 New England Biolabs, Inc. Oligonucleotide Adapters: Compositions and Methods of Use
US20120238738A1 (en) 2010-07-19 2012-09-20 New England Biolabs, Inc. Oligonucleotide Adapters: Compositions and Methods of Use
CN110878345A (zh) 2010-09-21 2020-03-13 安捷伦科技有限公司 通过分子计数提高等位基因调用的置信度
WO2012042374A2 (en) 2010-10-01 2012-04-05 Anssi Jussi Nikolai Taipale Method of determining number or concentration of molecules
WO2012061832A1 (en) 2010-11-05 2012-05-10 Illumina, Inc. Linking sequence reads using paired code tags
US9074251B2 (en) * 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
ES2615733T3 (es) 2010-12-16 2017-06-08 Gigagen, Inc. Métodos para el análisis masivo paralelo de ácidos nucleicos en células individuales
EP3736281A1 (en) 2011-02-18 2020-11-11 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
EP3907297A1 (en) 2011-04-15 2021-11-10 The Johns Hopkins University Safe sequencing system
EP2980226A1 (en) 2011-07-08 2016-02-03 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays
AU2012304537B2 (en) 2011-09-06 2015-08-20 Gen-Probe Incorporated Closed nucleic acid structures
EP2753715A4 (en) * 2011-09-09 2015-05-20 Univ Leland Stanford Junior METHOD FOR OBTAINING A SEQUENCE
JP5418579B2 (ja) 2011-12-06 2014-02-19 株式会社デンソー 開閉眼検出装置
US20160153039A1 (en) 2012-01-26 2016-06-02 Nugen Technologies, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
WO2013112923A1 (en) 2012-01-26 2013-08-01 Nugen Technologies, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
US9528107B2 (en) * 2012-01-31 2016-12-27 Pacific Biosciences Of California, Inc. Compositions and methods for selection of nucleic acids
US10011871B2 (en) 2012-02-17 2018-07-03 Fred Hutchinson Cancer Research Center Compositions and methods for accurately identifying mutations
US11177020B2 (en) 2012-02-27 2021-11-16 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
EP2820155B1 (en) 2012-02-28 2017-07-26 Population Genetics Technologies Ltd. Method for attaching a counter sequence to a nucleic acid sample
NO2694769T3 (pl) * 2012-03-06 2018-03-03
CA2867293C (en) 2012-03-13 2020-09-01 Abhijit Ajit PATEL Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
EP2828218B9 (en) 2012-03-20 2021-04-07 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
EP2847353B1 (en) 2012-05-10 2022-01-19 The General Hospital Corporation Methods for determining a nucleotide sequence
CA2872141C (en) 2012-05-31 2016-01-19 Board Of Regents, The University Of Texas System Method for accurate sequencing of dna
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
CA2883901C (en) 2012-09-04 2023-04-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
CN102877136B (zh) * 2012-09-24 2014-03-12 上海交通大学 基于基因组简化与二代测序dna文库构建方法及试剂盒
CA3094792A1 (en) * 2013-03-13 2014-09-18 Illumina, Inc. Methods and compositions for nucleic acid sequencing
US9290800B2 (en) * 2013-03-15 2016-03-22 Pacific Biosciences Of California, Inc. Targeted rolling circle amplification
US10087481B2 (en) * 2013-03-19 2018-10-02 New England Biolabs, Inc. Enrichment of target sequences
US11414695B2 (en) 2013-05-29 2022-08-16 Agilent Technologies, Inc. Nucleic acid enrichment using Cas9
CA2924987C (en) * 2013-09-24 2022-08-16 Somalogic, Inc. Multiaptamer target detection
JP6571665B2 (ja) * 2013-12-28 2019-09-04 ガーダント ヘルス， インコーポレイテッド 遺伝的バリアントを検出するための方法およびシステム
EP3099796B1 (en) 2014-01-31 2018-08-29 Swift Biosciences, Inc. Improved methods for processing dna substrates
US11085084B2 (en) 2014-09-12 2021-08-10 The Board Of Trustees Of The Leland Stanford Junior University Identification and use of circulating nucleic acids
US11149305B2 (en) 2015-01-23 2021-10-19 Washington University Detection of rare sequence variants, methods and compositions therefor
JPWO2016133044A1 (ja) 2015-02-20 2017-12-14 日本電気株式会社 受信装置、受信方法
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
EP3653728B1 (en) 2015-06-09 2023-02-01 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging
US10465241B2 (en) 2015-06-15 2019-11-05 The Board Of Trustees Of The Leleand Stanford Junior University High resolution STR analysis using next generation sequencing
GB201515557D0 (en) 2015-09-02 2015-10-14 14M Genomics Ltd Method of sequencing
WO2017087702A1 (en) 2015-11-18 2017-05-26 Pacific Biosciences Of California, Inc. Loading nucleic acids onto substrates
PL3387152T3 (pl) 2015-12-08 2022-05-09 Twinstrand Biosciences, Inc. Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego
US20170213008A1 (en) 2016-01-22 2017-07-27 Grail, Inc. Variant based disease diagnostics and tracking
EP3405573A4 (en) 2016-01-22 2019-09-18 Grail, Inc. METHOD AND SYSTEMS FOR HIGH-FIDELITY SEQUENCING
EP3485033B1 (en) 2016-07-12 2022-09-28 Qiagen Sciences, LLC Single end duplex dna sequencing
US10598677B2 (en) 2016-07-29 2020-03-24 Sysmex Corporation Smear transporting apparatus, smear image capture system, and smear analysis system
WO2018031588A1 (en) 2016-08-09 2018-02-15 Takara Bio Usa, Inc. Nucleic acid adaptors with molecular identification sequences and use thereof
US10487358B2 (en) 2016-09-23 2019-11-26 Grail, Inc. Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
US10982351B2 (en) 2016-12-23 2021-04-20 Grail, Inc. Methods for high efficiency library preparation using double-stranded adapters
AU2018240559B2 (en) 2017-03-23 2025-02-13 University Of Washington Methods for targeted nucleic acid sequence enrichment with applications to error corrected nucleic acid sequencing
WO2018183942A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
AU2018366213B2 (en) 2017-11-08 2025-05-15 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
MX2020008472A (es) 2018-02-13 2020-11-11 Twinstrand Biosciences Inc Metodos y reactivos para detectar y evaluar la genotoxicidad.
WO2019178577A1 (en) 2018-03-15 2019-09-19 Twinstrand Biosciences, Inc. Methods and reagents for enrichment of nucleic acid material for sequencing applications and other nucleic acid material interrogations
WO2019183640A1 (en) 2018-03-23 2019-09-26 Board Of Regents, The University Of Texas System Efficient sequencing of dsdna with extremely low level of errors
WO2019222560A1 (en) 2018-05-16 2019-11-21 Twinstrand Biosciences, Inc. Methods and reagents for resolving nucleic acid mixtures and mixed cell populations and associated applications
CN112673099A (zh) 2018-07-12 2021-04-16 特温斯特兰德生物科学有限公司 用于表征基因组编辑、克隆扩增的方法和试剂及相关应用
KR102662200B1 (ko) 2019-07-15 2024-04-29 엘지디스플레이 주식회사 유기발광표시장치

Also Published As

Publication number Publication date
EP3387152A1 (en) 2018-10-17
EP4043584A1 (en) 2022-08-17
AU2016366231B2 (en) 2022-12-15
US20170211140A1 (en) 2017-07-27
IL259788B1 (en) 2023-01-01
CA3006792A1 (en) 2017-06-15
JP2024010122A (ja) 2024-01-23
AU2016366231A1 (en) 2018-06-14
IL259788A (en) 2018-07-31
EP3387152B1 (en) 2022-01-26
US20250313888A1 (en) 2025-10-09
US20220267841A1 (en) 2022-08-25
US11332784B2 (en) 2022-05-17
JP7548579B2 (ja) 2024-09-10
JP6975507B2 (ja) 2021-12-01
JP2019509015A (ja) 2019-04-04
JP2022017453A (ja) 2022-01-25
WO2017100441A1 (en) 2017-06-15
IL259788B2 (en) 2023-05-01
ES2911421T3 (es) 2022-05-19
PT3387152T (pt) 2022-04-19
CN109072294A (zh) 2018-12-21

Similar Documents

Publication Publication Date Title
PL3387152T3 (pl) Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego
IL264454A (en) Novel compositions, uses and methods for making them
HRP20180501T1 (hr) Pripravci koje sadrže bakterijske sojeve
DK3102722T3 (da) Genom fraktionering
BR112016016020A2 (pt) anticorpos dirigidos contra interleucina-33 (il-33)
EP3405163C0 (en) LUER-LOCK ADAPTER
EP4001672C0 (en) CONNECTOR
EP3397884A4 (en) CLUTCH ADAPTER
IL258956A (en) Compositions and methods for tumor transduction
EP3369145C0 (fr) Connecteur multipolaire
EP3275476A4 (en) Adapter
PL3400269T3 (pl) Zastosowanie 4-bora-3a,4a-diaza-s-indacenów do zabezpieczania
EP3341117C0 (en) Reactor
EP3392982A4 (en) INTERCONNECTS
EP3308781A4 (en) BLOOD PRESSURE CENTER
HUE053624T2 (hu) Ciklosporint tartalmazó készítmények
HUE043622T2 (hu) Tároló
IL254783A0 (en) Anthelmintic combinations and methods of use thereof
HUE054749T2 (hu) Kevert készítmények
EP3392981A4 (en) INTERCONNECTS
DK3331498T3 (da) Nasalsammensætning
PL3799932T3 (pl) Kompozycja środka wspomagającego golenie
EP3308892A4 (en) REIBE
DK3394346T3 (da) Adapter
DK3251063T3 (da) Samkørselssystem