PL3387152T3 - Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego - Google Patents

Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego

Info

Publication number
PL3387152T3
PL3387152T3 PL16822832T PL16822832T PL3387152T3 PL 3387152 T3 PL3387152 T3 PL 3387152T3 PL 16822832 T PL16822832 T PL 16822832T PL 16822832 T PL16822832 T PL 16822832T PL 3387152 T3 PL3387152 T3 PL 3387152T3
Authority
PL
Poland
Prior art keywords
compositions
methods
duplex sequencing
improved adapters
adapters
Prior art date
Application number
PL16822832T
Other languages
English (en)
Inventor
Lawrence A. Loeb
Michael W. Schmitt
Jesse J. SALK
Original Assignee
Twinstrand Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Twinstrand Biosciences, Inc. filed Critical Twinstrand Biosciences, Inc.
Publication of PL3387152T3 publication Critical patent/PL3387152T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855—Ligating adaptors

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL16822832T 2015-12-08 2016-12-08 Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego PL3387152T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562264822P 2015-12-08 2015-12-08
US201662281917P 2016-01-22 2016-01-22
PCT/US2016/065605 WO2017100441A1 (en) 2015-12-08 2016-12-08 Improved adapters, methods, and compositions for duplex sequencing
EP16822832.8A EP3387152B1 (en) 2015-12-08 2016-12-08 Improved adapters, methods, and compositions for duplex sequencing

Publications (1)

Publication Number Publication Date
PL3387152T3 true PL3387152T3 (pl) 2022-05-09

Family

ID=57750605

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16822832T PL3387152T3 (pl) 2015-12-08 2016-12-08 Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego

Country Status (11)

Country Link
US (2) US11332784B2 (pl)
EP (2) EP4043584A1 (pl)
JP (3) JP6975507B2 (pl)
CN (1) CN109072294A (pl)
AU (1) AU2016366231B2 (pl)
CA (1) CA3006792A1 (pl)
ES (1) ES2911421T3 (pl)
IL (1) IL259788B2 (pl)
PL (1) PL3387152T3 (pl)
PT (1) PT3387152T (pl)
WO (1) WO2017100441A1 (pl)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
ES2665071T3 (es) 2012-02-17 2018-04-24 Fred Hutchinson Cancer Research Center Composiciones y métodos para identificar mutaciones de manera precisa
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
DE202013012824U1 (de) 2012-09-04 2020-03-10 Guardant Health, Inc. Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
KR102160389B1 (ko) 2013-08-05 2020-09-28 트위스트 바이오사이언스 코포레이션 드 노보 합성된 유전자 라이브러리
SG11201604923XA (en) 2013-12-28 2016-07-28 Guardant Health Inc Methods and systems for detecting genetic variants
CN107124888B (zh) * 2014-11-21 2021-08-06 深圳华大智造科技股份有限公司 鼓泡状接头元件和使用其构建测序文库的方法
CA2975852A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
WO2017049231A1 (en) 2015-09-18 2017-03-23 Twist Bioscience Corporation Oligonucleic acid variant libraries and synthesis thereof
CN113604546A (zh) 2015-09-22 2021-11-05 特韦斯特生物科学公司 用于核酸合成的柔性基底
CN115920796A (zh) 2015-12-01 2023-04-07 特韦斯特生物科学公司 功能化表面及其制备
EP4043584A1 (en) 2015-12-08 2022-08-17 Twinstrand Biosciences, Inc. Improved adapters, methods, and compositions for duplex sequencing
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
US11384382B2 (en) 2016-04-14 2022-07-12 Guardant Health, Inc. Methods of attaching adapters to sample nucleic acids
US20190085406A1 (en) 2016-04-14 2019-03-21 Guardant Health, Inc. Methods for early detection of cancer
EP3485033B1 (en) 2016-07-12 2022-09-28 Qiagen Sciences, LLC Single end duplex dna sequencing
CN109312391B (zh) 2016-07-18 2022-06-03 豪夫迈·罗氏有限公司 生成用于单分子测序的单链环状dna文库的方法
WO2018031588A1 (en) * 2016-08-09 2018-02-15 Takara Bio Usa, Inc. Nucleic acid adaptors with molecular identification sequences and use thereof
SG11201901563UA (en) 2016-08-22 2019-03-28 Twist Bioscience Corp De novo synthesized nucleic acid libraries
EP3516528A4 (en) 2016-09-21 2020-06-24 Twist Bioscience Corporation NUCLEIC ACID BASED DATA STORAGE
AU2017378492B2 (en) 2016-12-16 2022-06-16 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
US11414710B2 (en) * 2016-12-28 2022-08-16 Quest Diagnostics Investments Llc Compositions and methods for detecting circulating tumor DNA
RU2022101605A (ru) 2017-01-18 2022-03-25 Иллюмина, Инк. Способы и системы для получения наборов уникальных молекулярных индексов с гетерогенной длиной молекул и коррекции в них ошибок
CN110892485B (zh) 2017-02-22 2024-03-22 特韦斯特生物科学公司 基于核酸的数据存储
WO2018170169A1 (en) 2017-03-15 2018-09-20 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
CA3057867A1 (en) 2017-03-23 2018-09-27 University Of Washington Methods for targeted nucleic acid sequence enrichment with applications to error corrected nucleic acid sequencing
WO2018183942A1 (en) * 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
AU2018261332A1 (en) 2017-05-01 2019-11-07 Illumina, Inc. Optimal index sequences for multiplex massively parallel sequencing
AU2018266377B2 (en) 2017-05-08 2024-06-20 Illumina, Inc. Universal short adapters for indexing of polynucleotide samples
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
EP3638782A4 (en) 2017-06-12 2021-03-17 Twist Bioscience Corporation SEALLESS NUCLEIC ACID ASSEMBLY METHODS
EP3681906A4 (en) 2017-09-11 2021-06-09 Twist Bioscience Corporation GPCR-BINDING PROTEINS AND THEIR SYNTHESIS
US11447818B2 (en) 2017-09-15 2022-09-20 Illumina, Inc. Universal short adapters with variable length non-random unique molecular identifiers
KR20240024357A (ko) 2017-10-20 2024-02-23 트위스트 바이오사이언스 코포레이션 폴리뉴클레오타이드 합성을 위한 가열된 나노웰
CN110800064B (zh) 2017-11-06 2024-03-29 伊鲁米那股份有限公司 核酸索引化技术
EP3707273B1 (en) 2017-11-08 2024-04-10 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
GB2585506A (en) 2018-01-04 2021-01-13 Twist Bioscience Corp DNA-based digital information storage
CN108300716B (zh) * 2018-01-05 2020-06-30 武汉康测科技有限公司 接头元件、其应用和基于不对称多重pcr进行靶向测序文库构建的方法
GB201804641D0 (en) * 2018-03-22 2018-05-09 Inivata Ltd Methods of sequencing nucleic acids and error correction of sequence reads
EP3768853A4 (en) 2018-03-23 2021-04-28 Board Of Regents The University Of Texas System EFFICIENT SEQUENCING OF DSDNA WITH EXTREMELY LOW ERROR RATE
WO2019222560A1 (en) * 2018-05-16 2019-11-21 Twinstrand Biosciences, Inc. Methods and reagents for resolving nucleic acid mixtures and mixed cell populations and associated applications
GB2590196A (en) 2018-05-18 2021-06-23 Twist Bioscience Corp Polynucleotides, reagents, and methods for nucleic acid hybridization
EP3821004A4 (en) * 2018-07-12 2022-04-20 Twinstrand Biosciences, Inc. METHODS AND REAGENTS FOR CHARACTERIZING GENOMIC EDITING AND CLONAL EXPANSION, AND RELATED APPLICATIONS
US20210317517A1 (en) * 2018-08-28 2021-10-14 Sophia Genetics S.A. Methods for asymmetric dna library generation and optionally integrated duplex sequencing
CN112805380A (zh) * 2018-09-21 2021-05-14 豪夫迈·罗氏有限公司 制备用于测序的模块化和组合核酸样品的系统和方法
US11358137B2 (en) 2018-12-26 2022-06-14 Industrial Technology Research Institute Tubular structure for producing droplets and method for producing droplets
CA3131514A1 (en) * 2019-02-25 2020-09-03 Twist Bioscience Corporation Compositions and methods for next generation sequencing
EP3938506A4 (en) 2019-02-26 2022-12-14 Twist Bioscience Corporation VARIANT NUCLEIC ACID LIBRARIES FOR OPTIMIZATION OF ANTIBODIES
WO2020176678A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for glp1 receptor
EP3987019A4 (en) 2019-06-21 2023-04-19 Twist Bioscience Corporation BARCODE-BASED NUCLEIC ACID SEQUENCE ARRANGEMENT
CA3146435A1 (en) * 2019-08-01 2021-02-04 Jesse J. SALK Methods and reagents for nucleic acid sequencing and associated applications
CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
DE112020005433T5 (de) 2019-11-06 2022-10-06 The Board Of Trustees Of The Leland Stanford Junior University Verfahren und Systeme zur Analyse von Nukleinsäuremolekülen
US11783912B2 (en) 2021-05-05 2023-10-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for analyzing nucleic acid molecules
WO2024015869A2 (en) * 2022-07-12 2024-01-18 University Of Washington Systems and methods for variant detection in cells
WO2024022207A1 (en) * 2022-07-25 2024-02-01 Mgi Tech Co., Ltd. Methods of in-solution positional co-barcoding for sequencing long dna molecules

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5308751A (en) 1992-03-23 1994-05-03 General Atomics Method for sequencing double-stranded DNA
EP3034626A1 (en) * 1997-04-01 2016-06-22 Illumina Cambridge Limited Method of nucleic acid sequencing
US6087099A (en) 1997-09-08 2000-07-11 Myriad Genetics, Inc. Method for sequencing both strands of a double stranded DNA in a single sequencing reaction
US6361947B1 (en) 1998-10-27 2002-03-26 Affymetrix, Inc. Complexity management and analysis of genomic DNA
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
US7300751B2 (en) 2000-06-30 2007-11-27 Syngenta Participations Ag Method for identification of genetic markers
US6632611B2 (en) 2001-07-20 2003-10-14 Affymetrix, Inc. Method of target enrichment and amplification
US7297778B2 (en) 2001-07-25 2007-11-20 Affymetrix, Inc. Complexity management of genomic DNA
WO2003034029A2 (en) 2001-10-15 2003-04-24 Bioarray Solutions, Ltd. Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US7406385B2 (en) 2001-10-25 2008-07-29 Applera Corporation System and method for consensus-calling with per-base quality values for sample assemblies
US7459273B2 (en) 2002-10-04 2008-12-02 Affymetrix, Inc. Methods for genotyping selected polymorphism
US7452699B2 (en) 2003-01-15 2008-11-18 Dana-Farber Cancer Institute, Inc. Amplification of DNA in a hairpin structure, and applications
WO2004081183A2 (en) 2003-03-07 2004-09-23 Rubicon Genomics, Inc. In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna
CA2552858A1 (en) 2004-01-23 2005-08-04 Lingvitae As Improving polynucleotide ligation reactions
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US8796441B2 (en) 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
ES2387878T3 (es) 2005-06-23 2012-10-03 Keygene N.V. Estrategias para la identificación de alto rendimiento y la detección de polimorfismos
WO2007037678A2 (en) 2005-09-29 2007-04-05 Keygene N.V. High throughput screening of mutagenized populations
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
US20070172839A1 (en) * 2006-01-24 2007-07-26 Smith Douglas R Asymmetrical adapters and methods of use thereof
JP5389638B2 (ja) 2006-04-04 2014-01-15 キージーン ナムローゼ フェンノートシャップ 制限断片に基づく分子マーカーのハイスループットな検出
EP2121983A2 (en) 2007-02-02 2009-11-25 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
EP2201143B2 (en) 2007-09-21 2016-08-24 Katholieke Universiteit Leuven Tools and methods for genetic tests using next generation sequencing
EP3045542B1 (en) 2008-03-28 2016-11-16 Pacific Biosciences of California, Inc. Methods for nucleic acid sequencing
US8029993B2 (en) 2008-04-30 2011-10-04 Population Genetics Technologies Ltd. Asymmetric adapter library construction
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US20110301042A1 (en) 2008-11-11 2011-12-08 Helicos Biosciences Corporation Methods of sample encoding for multiplex analysis of samples by single molecule sequencing
EP2391732B1 (en) 2009-01-30 2015-05-27 Oxford Nanopore Technologies Limited Methods using adaptors for nucleic acid constructs in transmembrane sequencing
US20100331204A1 (en) 2009-02-13 2010-12-30 Jeff Jeddeloh Methods and systems for enrichment of target genomic sequences
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US20120165202A1 (en) 2009-04-30 2012-06-28 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
EP2248914A1 (en) 2009-05-05 2010-11-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. The use of class IIB restriction endonucleases in 2nd generation sequencing applications
EP3029141A1 (en) 2009-08-20 2016-06-08 Population Genetics Technologies Ltd. Compositions and methods for intramolecular nucleic acid rearrangement
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
EP2580351B1 (en) 2010-06-09 2018-08-29 Keygene N.V. Combinatorial sequence barcodes for high throughput screening
US20120244525A1 (en) * 2010-07-19 2012-09-27 New England Biolabs, Inc. Oligonucleotide Adapters: Compositions and Methods of Use
US20120238738A1 (en) 2010-07-19 2012-09-20 New England Biolabs, Inc. Oligonucleotide Adapters: Compositions and Methods of Use
ES2690753T3 (es) 2010-09-21 2018-11-22 Agilent Technologies, Inc. Aumento de la confianza en las identificaciones de alelos con el recuento molecular
WO2012042374A2 (en) 2010-10-01 2012-04-05 Anssi Jussi Nikolai Taipale Method of determining number or concentration of molecules
EP2635679B1 (en) 2010-11-05 2017-04-19 Illumina, Inc. Linking sequence reads using paired code tags
US9074251B2 (en) * 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
WO2012083225A2 (en) 2010-12-16 2012-06-21 Gigagen, Inc. System and methods for massively parallel analysis of nycleic acids in single cells
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
CN103748236B (zh) 2011-04-15 2018-12-25 约翰·霍普金斯大学 安全测序系统
AU2012281242B2 (en) 2011-07-08 2016-12-22 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays
EP2753712B1 (en) 2011-09-06 2017-03-22 Gen-Probe Incorporated Closed nucleic acid structures
CA2848304A1 (en) * 2011-09-09 2013-03-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for sequencing a polynucleotide
JP5418579B2 (ja) 2011-12-06 2014-02-19 株式会社デンソー 開閉眼検出装置
US20160153039A1 (en) 2012-01-26 2016-06-02 Nugen Technologies, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
WO2013112923A1 (en) 2012-01-26 2013-08-01 Nugen Technologies, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
ES2665071T3 (es) 2012-02-17 2018-04-24 Fred Hutchinson Cancer Research Center Composiciones y métodos para identificar mutaciones de manera precisa
ES2776673T3 (es) 2012-02-27 2020-07-31 Univ North Carolina Chapel Hill Métodos y usos para etiquetas moleculares
US9670529B2 (en) 2012-02-28 2017-06-06 Population Genetics Technologies Ltd. Method for attaching a counter sequence to a nucleic acid sample
NO2694769T3 (pl) * 2012-03-06 2018-03-03
CA2867293C (en) 2012-03-13 2020-09-01 Abhijit Ajit PATEL Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
WO2013142389A1 (en) 2012-03-20 2013-09-26 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
JP6445426B2 (ja) 2012-05-10 2018-12-26 ザ ジェネラル ホスピタル コーポレイション ヌクレオチド配列を決定する方法
EP2855707B1 (en) 2012-05-31 2017-07-12 Board Of Regents, The University Of Texas System Method for accurate sequencing of dna
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
DE202013012824U1 (de) 2012-09-04 2020-03-10 Guardant Health, Inc. Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation
CN102877136B (zh) * 2012-09-24 2014-03-12 上海交通大学 基于基因组简化与二代测序dna文库构建方法及试剂盒
WO2014071070A1 (en) * 2012-11-01 2014-05-08 Pacific Biosciences Of California, Inc. Compositions and methods for selection of nucleic acids
AU2013382098B2 (en) 2013-03-13 2019-02-07 Illumina, Inc. Methods and compositions for nucleic acid sequencing
US10087481B2 (en) 2013-03-19 2018-10-02 New England Biolabs, Inc. Enrichment of target sequences
US11414695B2 (en) 2013-05-29 2022-08-16 Agilent Technologies, Inc. Nucleic acid enrichment using Cas9
SG11201602063UA (en) * 2013-09-24 2016-04-28 Somalogic Inc Multiaptamer target detection
SG11201604923XA (en) 2013-12-28 2016-07-28 Guardant Health Inc Methods and systems for detecting genetic variants
AU2015210705B2 (en) 2014-01-31 2020-11-05 Integrated Dna Technologies, Inc. Improved methods for processing DNA substrates
EP3191628B1 (en) 2014-09-12 2022-05-25 The Board of Trustees of the Leland Stanford Junior University Identification and use of circulating nucleic acids
WO2016118883A1 (en) 2015-01-23 2016-07-28 Washington University Detection of rare sequence variants, methods and compositions therefor
US10686637B2 (en) 2015-02-20 2020-06-16 Nec Corporation Receiving apparatus and receiving method
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
JP6698708B2 (ja) 2015-06-09 2020-05-27 ライフ テクノロジーズ コーポレーション 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体
US10465241B2 (en) 2015-06-15 2019-11-05 The Board Of Trustees Of The Leleand Stanford Junior University High resolution STR analysis using next generation sequencing
GB201515557D0 (en) 2015-09-02 2015-10-14 14M Genomics Ltd Method of sequencing
CN108350491A (zh) 2015-11-18 2018-07-31 加利福尼亚太平洋生物科学股份有限公司 将核酸加载到基材上
EP4043584A1 (en) 2015-12-08 2022-08-17 Twinstrand Biosciences, Inc. Improved adapters, methods, and compositions for duplex sequencing
CN108603234A (zh) 2016-01-22 2018-09-28 格瑞尔公司 基于变体的疾病诊断和追踪
CN108603229A (zh) 2016-01-22 2018-09-28 格瑞尔公司 用于高保真测序的方法和系统
EP3485033B1 (en) 2016-07-12 2022-09-28 Qiagen Sciences, LLC Single end duplex dna sequencing
EP3800461A1 (en) 2016-07-29 2021-04-07 Sysmex Corporation Smear analysis system and method
WO2018031588A1 (en) 2016-08-09 2018-02-15 Takara Bio Usa, Inc. Nucleic acid adaptors with molecular identification sequences and use thereof
WO2018057928A1 (en) 2016-09-23 2018-03-29 Grail, Inc. Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
WO2018119399A1 (en) 2016-12-23 2018-06-28 Grail, Inc. Methods for high efficiency library preparation using double-stranded adapters
CA3057867A1 (en) 2017-03-23 2018-09-27 University Of Washington Methods for targeted nucleic acid sequence enrichment with applications to error corrected nucleic acid sequencing
WO2018183942A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
EP3707273B1 (en) 2017-11-08 2024-04-10 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
SG11202007648WA (en) 2018-02-13 2020-09-29 Twinstrand Biosciences Inc Methods and reagents for detecting and assessing genotoxicity
EP3765063A4 (en) 2018-03-15 2021-12-15 Twinstrand Biosciences, Inc. METHODS AND REAGENTS FOR ENRICHMENT NUCLEIC ACID MATERIAL FOR SEQUENCING APPLICATIONS AND OTHER NUCLEIC ACID MATERIAL INTERROGATIONS
EP3768853A4 (en) 2018-03-23 2021-04-28 Board Of Regents The University Of Texas System EFFICIENT SEQUENCING OF DSDNA WITH EXTREMELY LOW ERROR RATE
WO2019222560A1 (en) 2018-05-16 2019-11-21 Twinstrand Biosciences, Inc. Methods and reagents for resolving nucleic acid mixtures and mixed cell populations and associated applications
EP3821004A4 (en) 2018-07-12 2022-04-20 Twinstrand Biosciences, Inc. METHODS AND REAGENTS FOR CHARACTERIZING GENOMIC EDITING AND CLONAL EXPANSION, AND RELATED APPLICATIONS
KR102662200B1 (ko) 2019-07-15 2024-04-29 엘지디스플레이 주식회사 유기발광표시장치

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PT3387152T (pt) 2022-04-19
IL259788B1 (en) 2023-01-01
EP3387152B1 (en) 2022-01-26
AU2016366231A1 (en) 2018-06-14
AU2016366231B2 (en) 2022-12-15
JP6975507B2 (ja) 2021-12-01
IL259788A (en) 2018-07-31
CN109072294A (zh) 2018-12-21
US20170211140A1 (en) 2017-07-27
CA3006792A1 (en) 2017-06-15
ES2911421T3 (es) 2022-05-19
IL259788B2 (en) 2023-05-01
US20220267841A1 (en) 2022-08-25
US11332784B2 (en) 2022-05-17
JP2019509015A (ja) 2019-04-04
JP2024010122A (ja) 2024-01-23
EP4043584A1 (en) 2022-08-17
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EP3387152A1 (en) 2018-10-17
WO2017100441A1 (en) 2017-06-15

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