JP2019507793A5 - - Google Patents
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- JP2019507793A5 JP2019507793A5 JP2018547964A JP2018547964A JP2019507793A5 JP 2019507793 A5 JP2019507793 A5 JP 2019507793A5 JP 2018547964 A JP2018547964 A JP 2018547964A JP 2018547964 A JP2018547964 A JP 2018547964A JP 2019507793 A5 JP2019507793 A5 JP 2019507793A5
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- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- compound according
- heteroaryl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 CC1C=*C=*C1C Chemical compound CC1C=*C=*C1C 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662307399P | 2016-03-11 | 2016-03-11 | |
| US62/307,399 | 2016-03-11 | ||
| US201662342004P | 2016-05-26 | 2016-05-26 | |
| US62/342,004 | 2016-05-26 | ||
| PCT/US2017/021966 WO2017156495A1 (en) | 2016-03-11 | 2017-03-10 | Compounds and methods for modulating bruton's tyrosine kinase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507793A JP2019507793A (ja) | 2019-03-22 |
| JP2019507793A5 true JP2019507793A5 (https=) | 2020-05-14 |
| JP6972002B2 JP6972002B2 (ja) | 2021-11-24 |
Family
ID=59789888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547964A Active JP6972002B2 (ja) | 2016-03-11 | 2017-03-10 | ブルトン型チロシンキナーゼを調節する化合物及び方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10870652B2 (https=) |
| EP (1) | EP3426637B1 (https=) |
| JP (1) | JP6972002B2 (https=) |
| KR (1) | KR102416971B1 (https=) |
| CN (2) | CN109071455B (https=) |
| AU (1) | AU2017230098B2 (https=) |
| ES (1) | ES2912465T3 (https=) |
| IL (1) | IL261583A (https=) |
| MX (1) | MX388026B (https=) |
| PL (1) | PL3426637T3 (https=) |
| WO (1) | WO2017156495A1 (https=) |
| ZA (1) | ZA201805951B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102416971B1 (ko) * | 2016-03-11 | 2022-07-04 | 엔젤 파마슈티칼 컴퍼니, 리미티드 | 브루톤형 티로신 키나제를 조절하기 위한 화합물 및 방법 |
| JOP20190113A1 (ar) * | 2016-11-18 | 2019-05-15 | Biocad Joint Stock Co | مثبطات بروتون تيروزين كيناز |
| KR102627756B1 (ko) * | 2017-03-22 | 2024-01-23 | 쑤저우 바이지부공 파마수티컬 테크널러지 컴퍼니 리미티드 | 브루톤 타이로신 키나제 억제제 |
| KR102384924B1 (ko) * | 2017-07-12 | 2022-04-08 | 주식회사 대웅제약 | 신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물 |
| CN108191871B (zh) * | 2018-01-02 | 2020-02-18 | 成都倍特药业有限公司 | 新型布鲁顿酪氨酸激酶抑制剂及其制备方法和应用 |
| CN111662232B (zh) * | 2019-03-06 | 2022-08-02 | 中国科学院上海药物研究所 | 具有2h-吲唑结构的小分子化合物及其合成和应用 |
| TWI762939B (zh) | 2019-05-31 | 2022-05-01 | 大陸商海思科醫藥集團股份有限公司 | Btk抑制劑環衍生物及其製備方法和藥學上的應用 |
| WO2020252397A1 (en) * | 2019-06-12 | 2020-12-17 | Baylor College Of Medicine | Small molecule proteolysis-targeting chimeras and methods of use thereof |
| HUE065965T2 (hu) * | 2019-09-26 | 2024-06-28 | Jumbo Drug Bank Co Ltd | 4-fluor-1H-pyrazolo[3,4-C]piridin-származékok mint szelektív bruton-tirozinkináz (BTK) inhibitorok a B-sejtes limfóma és autoimmun betegségek kezelésére |
| CN114437078A (zh) * | 2020-11-03 | 2022-05-06 | 海思科医药集团股份有限公司 | 一种降解btk的氘代物及其在医药上的应用 |
| CN117377675A (zh) * | 2021-06-01 | 2024-01-09 | 正大天晴药业集团股份有限公司 | 含有并环或螺环的布鲁顿酪氨酸激酶降解剂 |
| WO2023009785A1 (en) * | 2021-07-29 | 2023-02-02 | Cedilla Therapeutics, Inc. | Tead inhibitors and uses thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2368631A1 (en) * | 1999-03-26 | 2000-10-05 | Euro-Celtique S.A. | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| SE0301906D0 (sv) | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | New compounds |
| HRP20110892T1 (hr) * | 2005-12-13 | 2011-12-31 | Schering Corporation | Policiklični derivati indazola koji su inhibitori erk |
| US7659283B2 (en) | 2006-02-14 | 2010-02-09 | Vertex Pharmaceuticals Incorporated | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases |
| BRPI0622054B8 (pt) | 2006-09-22 | 2021-05-25 | Oxford Amherst Llc | composto e composição farmacêutica |
| US20120101114A1 (en) * | 2007-03-28 | 2012-04-26 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| EP2283020B8 (en) * | 2008-05-19 | 2012-12-12 | OSI Pharmaceuticals, LLC | Substituted imidazopyr-and imidazotri-azines |
| ES2660418T3 (es) * | 2008-07-16 | 2018-03-22 | Pharmacyclics Llc | Inhibidores de la tirosina quinasa de Bruton para el tratamiento de tumores sólidos |
| US8633318B2 (en) | 2008-09-16 | 2014-01-21 | Proximagen Ltd | Compounds for treatment or prevention of inflammation, an inflammatory disease, or an immune or an autoimmune disorder |
| EP2464647B1 (en) | 2009-08-11 | 2016-09-21 | Bristol-Myers Squibb Company | Azaindazoles as btk kinase modulators and use thereof |
| US7718662B1 (en) | 2009-10-12 | 2010-05-18 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase |
| KR101301533B1 (ko) | 2010-02-09 | 2013-09-04 | 한미사이언스 주식회사 | 암세포 성장 억제 효과를 갖는 신규 피리미딘 유도체 |
| US9138436B2 (en) | 2011-07-13 | 2015-09-22 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| JP5985658B2 (ja) | 2012-01-31 | 2016-09-06 | ナンジン アルゲン ファルマ カンパニー リミテッドＮａｎｊｉｎｇ Ａｌｌｇｅｎ Ｐｈａｒｍａ Ｃｏ． Ｌｔｄ． | ブルトンチロシンキナーゼ阻害薬としての環状分子 |
| WO2014022569A1 (en) | 2012-08-03 | 2014-02-06 | Principia Biopharma Inc. | Treatment of dry eye |
| US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| US9795604B2 (en) | 2013-10-25 | 2017-10-24 | Pharmacyclics Llc | Methods of treating and preventing graft versus host disease |
| WO2015124570A1 (en) | 2014-02-18 | 2015-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of influenza a virus infection |
| EP3414234B1 (en) * | 2015-10-14 | 2022-06-29 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
| US10662187B2 (en) * | 2016-01-21 | 2020-05-26 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
| KR102416971B1 (ko) * | 2016-03-11 | 2022-07-04 | 엔젤 파마슈티칼 컴퍼니, 리미티드 | 브루톤형 티로신 키나제를 조절하기 위한 화합물 및 방법 |
-
2017
- 2017-03-10 KR KR1020187029381A patent/KR102416971B1/ko active Active
- 2017-03-10 CN CN201780028799.7A patent/CN109071455B/zh active Active
- 2017-03-10 EP EP17764260.0A patent/EP3426637B1/en active Active
- 2017-03-10 WO PCT/US2017/021966 patent/WO2017156495A1/en not_active Ceased
- 2017-03-10 AU AU2017230098A patent/AU2017230098B2/en active Active
- 2017-03-10 CN CN202210903642.7A patent/CN115746000A/zh active Pending
- 2017-03-10 US US16/083,409 patent/US10870652B2/en active Active
- 2017-03-10 JP JP2018547964A patent/JP6972002B2/ja active Active
- 2017-03-10 PL PL17764260T patent/PL3426637T3/pl unknown
- 2017-03-10 MX MX2018010971A patent/MX388026B/es unknown
- 2017-03-10 ES ES17764260T patent/ES2912465T3/es active Active
-
2018
- 2018-09-04 IL IL261583A patent/IL261583A/en unknown
- 2018-09-05 ZA ZA2018/05951A patent/ZA201805951B/en unknown
-
2020
- 2020-08-27 US US17/004,943 patent/US11306099B1/en active Active
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