JP2020534373A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020534373A5 JP2020534373A5 JP2020538750A JP2020538750A JP2020534373A5 JP 2020534373 A5 JP2020534373 A5 JP 2020534373A5 JP 2020538750 A JP2020538750 A JP 2020538750A JP 2020538750 A JP2020538750 A JP 2020538750A JP 2020534373 A5 JP2020534373 A5 JP 2020534373A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- pharmaceutically acceptable
- acceptable salt
- compound
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C1=C(*IC(C=C*C=C2)=CC3=C2N=CN2C3=NC(CC*C#N)C2)CC#CC=C1NS(*)(=O)=O Chemical compound *C1=C(*IC(C=C*C=C2)=CC3=C2N=CN2C3=NC(CC*C#N)C2)CC#CC=C1NS(*)(=O)=O 0.000 description 2
- YIKCYQCGMOAMTK-UHFFFAOYSA-N Ic(cc12)ccc1N=CN1C2=NCCC1 Chemical compound Ic(cc12)ccc1N=CN1C2=NCCC1 YIKCYQCGMOAMTK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762561142P | 2017-09-20 | 2017-09-20 | |
| US62/561,142 | 2017-09-20 | ||
| PCT/US2018/052047 WO2019060611A1 (en) | 2017-09-20 | 2018-09-20 | CYCLIC IMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF KINASES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020534373A JP2020534373A (ja) | 2020-11-26 |
| JP2020534373A5 true JP2020534373A5 (https=) | 2021-11-04 |
| JP7394768B2 JP7394768B2 (ja) | 2023-12-08 |
Family
ID=64457074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538750A Active JP7394768B2 (ja) | 2017-09-20 | 2018-09-20 | キナーゼ阻害剤としての環状イミノピリミジン誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11254680B2 (https=) |
| EP (1) | EP3684772B1 (https=) |
| JP (1) | JP7394768B2 (https=) |
| KR (1) | KR102796209B1 (https=) |
| CN (1) | CN111247152B (https=) |
| AU (1) | AU2018338098B2 (https=) |
| CA (1) | CA3076202A1 (https=) |
| MX (1) | MX2020003126A (https=) |
| WO (1) | WO2019060611A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3684772B1 (en) * | 2017-09-20 | 2023-12-06 | ABM Therapeutics Corporation | Cyclic iminopyrimidine derivatives as kinase inhibitors |
| TWI817018B (zh) * | 2019-06-28 | 2023-10-01 | 美商艾瑞生藥股份有限公司 | 用於治療ｂｒａｆ相關的疾病和失調症之化合物 |
| AU2020403082A1 (en) * | 2019-12-10 | 2022-05-12 | F. Hoffmann-La Roche Ag | New BRAF inhibitors as paradox breakers |
| TW202426436A (zh) | 2020-06-09 | 2024-07-01 | 美商艾瑞生藥股份有限公司 | 用於治療ｂｒａｆ相關的疾病和病症之化合物 |
| KR20230112605A (ko) * | 2020-08-07 | 2023-07-27 | 에이비엠 쎄라퓨틱스 코포레이션 | 키나아제 억제제 및 그의 용도 |
| CN114380697A (zh) * | 2021-11-30 | 2022-04-22 | 上海毕得医药科技股份有限公司 | 一种n-甲基乙基胺盐酸盐的制备工艺 |
| TW202409040A (zh) | 2022-07-19 | 2024-03-01 | 大陸商西藏海思科製藥有限公司 | 作為激酶抑制劑的喹唑啉酮衍生物的製備及其用途 |
| CN117209503B (zh) * | 2023-09-13 | 2025-10-17 | 苏州翔实医药发展有限公司 | 一种5,6-二氢咪唑并[1，2-c]喹唑啉及其衍生物合成的方法 |
| WO2025108405A1 (zh) * | 2023-11-22 | 2025-05-30 | 西藏海思科制药有限公司 | 作为激酶抑制剂的喹唑啉酮衍生物的制备及其用途 |
| TW202545530A (zh) * | 2024-01-17 | 2025-12-01 | 大陸商海思科醫藥集團股份有限公司 | 含ｂｒａｆ抑制劑的藥物組合物及其在醫藥上的應用 |
| WO2025176185A1 (zh) * | 2024-02-23 | 2025-08-28 | 海思科医药集团股份有限公司 | 一种braf抑制剂的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE411996T1 (de) * | 2002-09-30 | 2008-11-15 | Bayer Healthcare Ag | Kondensierte azolpyrimidinderivate |
| PE20121126A1 (es) | 2006-12-21 | 2012-08-24 | Plexxikon Inc | Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa |
| CN101932580B (zh) | 2007-06-01 | 2013-05-22 | 葛兰素史密丝克莱恩有限责任公司 | 咪唑并吡啶激酶抑制剂 |
| WO2009012283A1 (en) | 2007-07-17 | 2009-01-22 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| EP2348020A1 (en) | 2009-12-23 | 2011-07-27 | Esteve Química, S.A. | Preparation process of erlotinib |
| CN103339132B (zh) | 2010-12-02 | 2017-02-15 | 株式会社麦迪帕克特 | 嘌呤基吡啶基氨基‑2,4‑二氟苯基磺酰胺衍生物、其药学上可接受的盐、其制备方法及包含其作为活性成分的对Raf激酶具有抑制活性的药物组合物 |
| US20130023531A1 (en) * | 2011-01-27 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors |
| WO2012118492A1 (en) * | 2011-03-01 | 2012-09-07 | Array Biopharma Inc. | Heterocyclic sulfonamides as raf inhibitors |
| US8889741B2 (en) | 2012-02-09 | 2014-11-18 | Daiichi Sankyo Company, Limited | Cycloalkane derivatives |
| RU2015113597A (ru) * | 2012-09-14 | 2016-11-10 | Итернити Байосайенс Инк. | Производные аминоизохинолина в качестве ингибиторов протеинкиназы |
| US9688635B2 (en) * | 2012-09-24 | 2017-06-27 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| US9321762B2 (en) * | 2013-12-11 | 2016-04-26 | Development Center For Biotechnology | Quinazoline compounds, method for preparing the same and use thereof |
| CN105272970A (zh) * | 2014-07-03 | 2016-01-27 | 中国药科大学 | 基于色原酮结构的Raf激酶抑制剂及其制备方法和用途 |
| CA2954879C (en) | 2014-07-16 | 2022-09-06 | Development Center For Biotechnology | Quinoxaline compounds, method for preparing the same and use thereof |
| EP3684772B1 (en) * | 2017-09-20 | 2023-12-06 | ABM Therapeutics Corporation | Cyclic iminopyrimidine derivatives as kinase inhibitors |
-
2018
- 2018-09-20 EP EP18808139.2A patent/EP3684772B1/en active Active
- 2018-09-20 MX MX2020003126A patent/MX2020003126A/es unknown
- 2018-09-20 KR KR1020207010704A patent/KR102796209B1/ko active Active
- 2018-09-20 CA CA3076202A patent/CA3076202A1/en active Pending
- 2018-09-20 CN CN201880067947.0A patent/CN111247152B/zh active Active
- 2018-09-20 AU AU2018338098A patent/AU2018338098B2/en active Active
- 2018-09-20 US US16/648,908 patent/US11254680B2/en active Active
- 2018-09-20 JP JP2020538750A patent/JP7394768B2/ja active Active
- 2018-09-20 WO PCT/US2018/052047 patent/WO2019060611A1/en not_active Ceased
-
2022
- 2022-01-13 US US17/575,292 patent/US11932647B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020534373A5 (https=) | ||
| KR102796209B1 (ko) | 키나아제 억제제로서의 시클릭 이미노피리미딘 유도체 | |
| KR102008635B1 (ko) | 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 | |
| KR100737090B1 (ko) | 축합 이미다졸륨 유도체 | |
| JP6866967B2 (ja) | サイクリン依存性キナーゼｃｄｋ９の新規阻害剤 | |
| TWI791581B (zh) | 二酮 | |
| JP2019527682A5 (https=) | ||
| CN115605479A (zh) | 吡啶酮并嘧啶类衍生物、其制备方法及其在医药上的应用 | |
| RU2016118753A (ru) | Производные пиридилкетона, способ их получения и их фармацевтическое применение | |
| CA3019450A1 (en) | Indoleamine 2,3-dioxygenase inhibitor, preparation method therefor, and application | |
| JP2010539095A5 (https=) | ||
| RU2012103487A (ru) | Ингибирующие jak соединения на основе пиразолопиримидина и способы | |
| JP2020518672A (ja) | キナーゼ阻害活性を有する化合物、その製造方法及び用途 | |
| RU2003126188A (ru) | Имидазолильные производные как ингибиторы кортикотропин-рилизинг фактора | |
| CN111511745A (zh) | 吡唑并[1,5-a][1,3,5]三嗪-2-胺类衍生物、其制备方法及其在医药上的应用 | |
| JP2022037004A (ja) | 癌の治療に有用なｐａｒｐ１、ｐａｒｐ２、および／またはチューブリンの阻害剤としてのフタラジン誘導体 | |
| JP2017137323A (ja) | 新規抗がん剤 | |
| JP2017502069A (ja) | 有機化合物 | |
| CN106045973B (zh) | 4-酰胺基苯并咪唑吖啶类化合物及其制备方法和用途 | |
| JP2023554391A5 (https=) | ||
| JP2006506319A5 (https=) | ||
| JP2021512894A (ja) | 治療用化合物および組成物 | |
| RU2801302C2 (ru) | Производные циклического иминопиримидина в качестве ингибиторов киназ | |
| BR112020005455B1 (pt) | Compostos derivados de iminopirimidina cíclica, composição farmacêutica que os compreende, seu uso e método in vitro ou ex vivo para inibir atividade de uma cinase b-raf v600e em uma célula | |
| US9321766B1 (en) | Kinase inhibitors |