JP2019506363A5 - - Google Patents
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- JP2019506363A5 JP2019506363A5 JP2018526763A JP2018526763A JP2019506363A5 JP 2019506363 A5 JP2019506363 A5 JP 2019506363A5 JP 2018526763 A JP2018526763 A JP 2018526763A JP 2018526763 A JP2018526763 A JP 2018526763A JP 2019506363 A5 JP2019506363 A5 JP 2019506363A5
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- Prior art keywords
- amino acid
- acid sequence
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- homology
- monoclonal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 1805
- 125000000539 amino acid group Chemical group 0.000 claims description 879
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 154
- 239000000203 mixture Substances 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 27
- 150000001413 amino acids Chemical class 0.000 claims description 26
- 210000004027 cell Anatomy 0.000 claims description 12
- 230000035772 mutation Effects 0.000 claims description 12
- 230000002093 peripheral effect Effects 0.000 claims description 12
- 210000001519 tissue Anatomy 0.000 claims description 12
- 210000001185 bone marrow Anatomy 0.000 claims description 6
- 210000004400 mucous membrane Anatomy 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 210000002966 serum Anatomy 0.000 claims description 6
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims description 5
- 206010021263 IgA nephropathy Diseases 0.000 claims description 5
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims description 4
- 230000004989 O-glycosylation Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims description 2
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000004602 germ cell Anatomy 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 102000005962 receptors Human genes 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 4
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 101000830600 Homo sapiens Tumor necrosis factor ligand superfamily member 13 Proteins 0.000 description 27
- 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 description 15
- 101000830595 Mus musculus Tumor necrosis factor ligand superfamily member 13 Proteins 0.000 description 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 11
- 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 description 10
- 239000000178 monomer Substances 0.000 description 9
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 description 8
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 description 8
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 208000035475 disorder Diseases 0.000 description 6
- 102000056239 human TNFRSF13B Human genes 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- 206010047115 Vasculitis Diseases 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 description 3
- 101100425947 Mus musculus Tnfrsf13b gene Proteins 0.000 description 3
- 101100425747 Mus musculus Tnfrsf17 gene Proteins 0.000 description 3
- 102000046935 human TNFRSF17 Human genes 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 208000012309 Linear IgA disease Diseases 0.000 description 2
- 229940125364 angiotensin receptor blocker Drugs 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000002489 hematologic effect Effects 0.000 description 2
- 229960003444 immunosuppressant agent Drugs 0.000 description 2
- 230000001861 immunosuppressant effect Effects 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 206010056508 Acquired epidermolysis bullosa Diseases 0.000 description 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 206010009208 Cirrhosis alcoholic Diseases 0.000 description 1
- 208000015943 Coeliac disease Diseases 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
- 208000019758 Hypergammaglobulinemia Diseases 0.000 description 1
- 208000015865 IgA pemphigus Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 101100450563 Mus musculus Serpind1 gene Proteins 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 206010036303 Post streptococcal glomerulonephritis Diseases 0.000 description 1
- 206010038546 Renal vasculitis Diseases 0.000 description 1
- 201000005638 acute proliferative glomerulonephritis Diseases 0.000 description 1
- 208000010002 alcoholic liver cirrhosis Diseases 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 201000000464 cone-rod dystrophy 2 Diseases 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 1
- 208000033679 diabetic kidney disease Diseases 0.000 description 1
- 201000011114 epidermolysis bullosa acquisita Diseases 0.000 description 1
- 229940099472 immunoglobulin a Drugs 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 description 1
- 229960004866 mycophenolate mofetil Drugs 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562259897P | 2015-11-25 | 2015-11-25 | |
| US62/259,897 | 2015-11-25 | ||
| US201662313684P | 2016-03-25 | 2016-03-25 | |
| US62/313,684 | 2016-03-25 | ||
| US201662399087P | 2016-09-23 | 2016-09-23 | |
| US62/399,087 | 2016-09-23 | ||
| US201662422848P | 2016-11-16 | 2016-11-16 | |
| US62/422,848 | 2016-11-16 | ||
| PCT/US2016/063518 WO2017091683A1 (en) | 2015-11-25 | 2016-11-23 | Antibody molecules to april and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132222A Division JP7029018B2 (ja) | 2015-11-25 | 2021-08-16 | Ａｐｒｉｌに対する抗体分子およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019506363A JP2019506363A (ja) | 2019-03-07 |
| JP2019506363A5 true JP2019506363A5 (https=) | 2020-01-09 |
Family
ID=57543212
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526763A Ceased JP2019506363A (ja) | 2015-11-25 | 2016-11-23 | Ａｐｒｉｌに対する抗体分子およびその使用 |
| JP2021132222A Active JP7029018B2 (ja) | 2015-11-25 | 2021-08-16 | Ａｐｒｉｌに対する抗体分子およびその使用 |
| JP2022022801A Withdrawn JP2022068288A (ja) | 2015-11-25 | 2022-02-17 | Ａｐｒｉｌに対する抗体分子およびその使用 |
| JP2024043460A Pending JP2024073611A (ja) | 2015-11-25 | 2024-03-19 | Ａｐｒｉｌに対する抗体分子およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132222A Active JP7029018B2 (ja) | 2015-11-25 | 2021-08-16 | Ａｐｒｉｌに対する抗体分子およびその使用 |
| JP2022022801A Withdrawn JP2022068288A (ja) | 2015-11-25 | 2022-02-17 | Ａｐｒｉｌに対する抗体分子およびその使用 |
| JP2024043460A Pending JP2024073611A (ja) | 2015-11-25 | 2024-03-19 | Ａｐｒｉｌに対する抗体分子およびその使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (9) | US20170145086A1 (https=) |
| EP (2) | EP3380522B1 (https=) |
| JP (4) | JP2019506363A (https=) |
| KR (2) | KR20250008787A (https=) |
| CN (3) | CN109089419B (https=) |
| AU (1) | AU2016361488B2 (https=) |
| CA (1) | CA3006058A1 (https=) |
| CL (2) | CL2018001372A1 (https=) |
| CO (1) | CO2018006461A2 (https=) |
| DK (1) | DK3380522T5 (https=) |
| ES (1) | ES2970864T3 (https=) |
| FI (1) | FI3380522T3 (https=) |
| HK (1) | HK1254337A1 (https=) |
| HR (1) | HRP20231578T1 (https=) |
| HU (1) | HUE064791T2 (https=) |
| IL (2) | IL259585B2 (https=) |
| LT (1) | LT3380522T (https=) |
| MA (1) | MA43308A (https=) |
| MX (2) | MX2018006385A (https=) |
| MY (1) | MY197345A (https=) |
| PL (1) | PL3380522T3 (https=) |
| PT (1) | PT3380522T (https=) |
| SA (1) | SA518391659B1 (https=) |
| SG (1) | SG11201804309PA (https=) |
| SI (1) | SI3380522T1 (https=) |
| WO (1) | WO2017091683A1 (https=) |
| ZA (1) | ZA201803366B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210340266A1 (en) * | 2008-10-09 | 2021-11-04 | Visterra, Inc. | Antibody molecules to april and uses thereof |
| NL2011406C2 (en) | 2013-09-06 | 2015-03-10 | Bionovion Holding B V | Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides. |
| US10793571B2 (en) | 2014-01-31 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| EP3099677A4 (en) | 2014-01-31 | 2017-07-26 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| NL2014108B1 (en) | 2015-01-09 | 2016-09-30 | Aduro Biotech Holdings Europe B V | Altered april binding antibodies. |
| EP3347021A4 (en) | 2015-09-11 | 2019-07-24 | Dana-Farber Cancer Institute, Inc. | CYANOTHIENOTRIAZOLDIAZEPINE AND USES THEREOF |
| RU2018112953A (ru) | 2015-09-11 | 2019-10-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Ацетамидтиенотриазолодиазепины и пути их применения |
| MX2018006499A (es) | 2015-11-25 | 2018-08-01 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos. |
| FI3380522T3 (fi) | 2015-11-25 | 2024-01-16 | Visterra Inc | Vasta-ainemolekyylejä april-proteiinille ja niiden käyttöjä |
| JP7749319B2 (ja) | 2017-10-10 | 2025-10-06 | アルパイン イミューン サイエンシズ インコーポレイテッド | Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用 |
| AU2019417720A1 (en) * | 2018-12-24 | 2021-07-08 | Visterra, Inc. | Methods for identifying epitopes and paratopes |
| CA3131019A1 (en) | 2019-02-22 | 2020-08-27 | Memorial Sloan Kettering Cancer Center | Cd33 antibodies and methods of using the same to treat cancer |
| CN110522902B (zh) * | 2019-09-25 | 2022-10-11 | 南京农业大学 | 一种用于建立慢性肾病模型的组合物及其应用 |
| JP7686000B2 (ja) * | 2019-12-24 | 2025-05-30 | ディザル（ジァンスー）ファーマシューティカル・カンパニー・リミテッド | 新規抗ＦＧＦＲ２ｂ抗体 |
| IL296358A (en) * | 2020-03-13 | 2022-11-01 | Janssen Biotech Inc | Materials and methods for modulating delta chain mediated immunity |
| EP4146684A2 (en) | 2020-05-08 | 2023-03-15 | Alpine Immune Sciences, Inc. | April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof |
| CA3187823A1 (en) * | 2020-06-24 | 2021-12-30 | Visterra, Inc. | Antibody molecules to april and uses thereof |
| WO2022081716A1 (en) * | 2020-10-13 | 2022-04-21 | Accubit LLC - Biotechnology | Methods of treating iga nephropathy with thiol-containing molecules |
| EP4237003A4 (en) | 2020-10-28 | 2025-07-09 | Janssen Biotech Inc | COMPOSITIONS AND METHODS FOR MODULATING GAMMA DELTA CHAIN-MEDIATED IMMUNITY |
| CN112730851B (zh) * | 2021-03-31 | 2021-06-22 | 南京立顶医疗科技有限公司 | 一种高灵敏SARS-CoV-2中和抗体的检测方法、检测试剂盒 |
| AU2022269411A1 (en) * | 2021-05-04 | 2023-12-21 | Immunorizon Ltd. | Anti-nkg2d antibodies and uses thereof |
| US20240279310A1 (en) | 2021-05-07 | 2024-08-22 | Alpine Immune Sciences, Inc. | Methods of dosing and treatment with a taci-fc fusion immunomodulatory protein |
| KR20240021179A (ko) * | 2021-05-14 | 2024-02-16 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 폴리펩티드 및 사용 방법 |
| TW202342548A (zh) | 2022-02-07 | 2023-11-01 | 美商威特拉公司 | 抗獨特型(anti-idiotype)抗體分子及其用途 |
| US20240092921A1 (en) | 2022-04-25 | 2024-03-21 | Visterra, Inc. | Antibody molecules to april and uses thereof |
| KR20250099778A (ko) | 2022-10-04 | 2025-07-02 | 알파인 이뮨 사이언시즈, 인코포레이티드 | 자가항체-매개 질환의 치료에 사용하기 위한 돌연변이된 taci-fc 융합 단백질 |
| CN119930816A (zh) * | 2023-11-02 | 2025-05-06 | 广东菲鹏制药股份有限公司 | 抗cd39人源化抗体或其抗原结合片段及其应用 |
| WO2026067804A1 (zh) * | 2024-09-30 | 2026-04-02 | 信立泰(成都)生物技术有限公司 | 一种抗april抗体或其抗原结合片段及用途 |
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