|
JP6261500B2
(ja)
|
2011-07-22 |
2018-01-17 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ヌクレアーゼ切断特異性の評価および改善
|
|
CA2909733C
(en)
|
2013-04-18 |
2023-10-17 |
Fondazione Telethon |
Effective delivery of large genes by dual aav vectors
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
EP3322800A4
(en)
|
2015-07-13 |
2019-05-01 |
University of Utah Research Foundation |
PROCESS FOR THE PRODUCTION OF RED BLOOD BODIES AND BLOOD PLATES IN VITRO AND USES THEREOF
|
|
JP7109784B2
(ja)
|
2015-10-23 |
2022-08-01 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
遺伝子編集のための進化したＣａｓ９蛋白質
|
|
ES2949163T3
(es)
*
|
2016-01-29 |
2023-09-26 |
Univ Princeton |
Inteínas divididas con actividad de corte y empalme excepcional
|
|
KR102547316B1
(ko)
|
2016-08-03 |
2023-06-23 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
EP3526320A1
(en)
*
|
2016-10-14 |
2019-08-21 |
President and Fellows of Harvard College |
Aav delivery of nucleobase editors
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
JP2020510038A
(ja)
|
2017-03-09 |
2020-04-02 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
がんワクチン
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
CA3057192A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
|
WO2019023680A1
(en)
|
2017-07-28 |
2019-01-31 |
President And Fellows Of Harvard College |
METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE)
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
KR20250107288A
(ko)
|
2017-10-16 |
2025-07-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
WO2019118949A1
(en)
|
2017-12-15 |
2019-06-20 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
EP3797160A1
(en)
|
2018-05-23 |
2021-03-31 |
The Broad Institute Inc. |
Base editors and uses thereof
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
AU2019316094B2
(en)
|
2018-08-03 |
2026-02-19 |
Beam Therapeutics Inc. |
Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence
|
|
US11530245B2
(en)
*
|
2018-08-31 |
2022-12-20 |
Washington University |
Split intein mediated polymerization and production of mussel foot adhesive protein materials
|
|
KR20210055733A
(ko)
|
2018-09-07 |
2021-05-17 |
빔 테라퓨틱스, 인크. |
핵염기 편집 시스템을 전달하기 위한 조성물 및 방법
|
|
EP3850088A4
(en)
|
2018-09-07 |
2023-07-19 |
Beam Therapeutics, Inc. |
Compositions and methods for improving base editing
|
|
AU2019360372B2
(en)
*
|
2018-10-15 |
2026-02-26 |
Fondazione Telethon |
Intein proteins and uses thereof
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
LU101118B1
(en)
*
|
2019-02-06 |
2020-08-06 |
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) |
Method for detecting a specific splice event of a gene of interest
|
|
WO2020168122A1
(en)
|
2019-02-13 |
2020-08-20 |
Beam Therapeutics Inc. |
Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence
|
|
JP7657726B2
(ja)
|
2019-03-19 |
2025-04-07 |
ザ ブロード インスティテュート，インコーポレーテッド |
編集ヌクレオチド配列を編集するための方法および組成物
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CN110714020B
(zh)
*
|
2019-05-22 |
2021-08-03 |
北京理工大学 |
一种高效简便纯化蛋白的方法
|
|
WO2021016075A1
(en)
|
2019-07-19 |
2021-01-28 |
Flagship Pioneering Innovations Vi, Llc |
Recombinase compositions and methods of use
|
|
CA3152679A1
(en)
*
|
2019-08-28 |
2021-03-04 |
The Trustees Of Princeton University |
Atypical split inteins and uses thereof
|
|
US20220332757A1
(en)
*
|
2019-09-09 |
2022-10-20 |
Wuhan Yzy Biopharma Co., Ltd. |
Split intein and preparation method for recombinant polypeptide using the same
|
|
EP4034138A4
(en)
|
2019-09-27 |
2024-07-31 |
Beam Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
|
|
KR20220070481A
(ko)
*
|
2019-10-01 |
2022-05-31 |
유타대학연구재단 |
순환 종양 세포를 표적화하기 위한 혈소판 조작 방법
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
GB201917046D0
(en)
*
|
2019-11-22 |
2020-01-08 |
Ge Healthcare Bioprocess R&D Ab |
Improved protein production
|
|
IL296024A
(en)
|
2020-03-04 |
2022-10-01 |
Flagship Pioneering Innovations Vi Llc |
Methods and compositions for modulating a genome
|
|
CN111235174A
(zh)
*
|
2020-03-11 |
2020-06-05 |
梦芊科技知识产权有限公司 |
利用枯草芽孢杆菌和核酸内切酶制备人碱性成纤维细胞生长因子
|
|
EP3885440A1
(en)
*
|
2020-03-26 |
2021-09-29 |
Splicebio, S.L. |
Split inteins and their uses
|
|
DE112021002672T5
(de)
|
2020-05-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
|
|
US20230227508A1
(en)
|
2020-06-12 |
2023-07-20 |
Massachusetts Institute Of Technology |
Split intein-based selection for peptide binders
|
|
AU2021347359A1
(en)
|
2020-09-25 |
2023-05-18 |
Beam Therapeutics Inc. |
Fratricide resistant modified immune cells and methods of using the same
|
|
CA3216901A1
(en)
*
|
2021-05-12 |
2022-11-17 |
Cytiva Bioprocess R&D Ab |
Improved protein purification
|
|
CN113735941B
(zh)
*
|
2021-08-13 |
2024-01-30 |
江南大学 |
一种蛋白纯化方法及其应用
|
|
KR102663243B1
(ko)
*
|
2021-08-30 |
2024-05-03 |
국립순천대학교산학협력단 |
트립신 특이적 형광 프로브 및 이의 용도
|
|
JP2024533311A
(ja)
|
2021-09-08 |
2024-09-12 |
フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー |
ゲノムを調節するための方法及び組成物
|
|
WO2023081714A1
(en)
*
|
2021-11-02 |
2023-05-11 |
Cornell University |
Intein systems and uses thereof
|
|
WO2023229029A1
(ja)
*
|
2022-05-26 |
2023-11-30 |
国立大学法人山形大学 |
ヘテロダイマータンパク質の製造方法、ダイマータンパク質、モノマータンパク質、および標的反応性のヘテロダイマータンパク質のスクリーニング方法
|
|
CA3267375A1
(en)
*
|
2022-09-26 |
2024-04-04 |
Beam Therapeutics Inc. |
SYNTHETIC POLYPEPTIDES AND THEIR USES
|
|
EP4612166A1
(en)
*
|
2022-11-01 |
2025-09-10 |
Memorial Sloan-Kettering Cancer Center |
Intein-based sorting system and modular chimeric polypeptides
|
|
WO2024170051A1
(en)
*
|
2023-02-13 |
2024-08-22 |
Kutzner Christoph |
Fusion polypeptides for manufacturing of cyclic peptides
|
|
KR20260040523A
(ko)
|
2023-06-11 |
2026-03-24 |
리제너론 파아마슈티컬스, 인크. |
환형화 항체 분자
|
|
AU2024338787A1
(en)
|
2023-09-04 |
2026-03-19 |
Splicebio, Sl |
Use of split intein for the treatment of scn1a associated disease
|
|
WO2025153705A1
(en)
|
2024-01-18 |
2025-07-24 |
Splicebio, Sl |
Use of split intein for the treatment of myo7a-associated disease
|
|
WO2025194124A1
(en)
|
2024-03-14 |
2025-09-18 |
Tessera Therapeutics, Inc. |
Modified st1cas9 guide nucleic acids
|
|
WO2026013288A1
(en)
|
2024-07-12 |
2026-01-15 |
Splicebio, Sl |
Split intein for use in the treatment of cep290-associated disease
|
|
WO2026057767A1
(en)
|
2024-09-13 |
2026-03-19 |
Splicebio, Sl |
Use of split intein for the treatment of abca3-associated disease
|