JP2019506159A - Ｄ因子を阻害するための組成物および方法 - Google Patents

Ｄ因子を阻害するための組成物および方法 Download PDF

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Publication number
JP2019506159A
JP2019506159A JP2018538551A JP2018538551A JP2019506159A JP 2019506159 A JP2019506159 A JP 2019506159A JP 2018538551 A JP2018538551 A JP 2018538551A JP 2018538551 A JP2018538551 A JP 2018538551A JP 2019506159 A JP2019506159 A JP 2019506159A
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aptamer
factor
complement factor
cases
aptamers
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JP2019506159A5 (enExample
Inventor
カール エリクソン，
カール エリクソン，
クリストファー ピー． ルスコーニ，
クリストファー ピー． ルスコーニ，
ケビン ジー． マクルール，
ケビン ジー． マクルール，
Original Assignee
ヴィトリサ セラピューティクス， インコーポレイテッド
ヴィトリサ セラピューティクス， インコーポレイテッド
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Publication of JP2019506159A publication Critical patent/JP2019506159A/ja
Publication of JP2019506159A5 publication Critical patent/JP2019506159A5/ja
Priority to JP2022039070A priority Critical patent/JP2022078283A/ja
Priority to JP2023220791A priority patent/JP2024029136A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
JP2018538551A 2016-01-20 2017-01-20 Ｄ因子を阻害するための組成物および方法 Pending JP2019506159A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022039070A JP2022078283A (ja) 2016-01-20 2022-03-14 Ｄ因子を阻害するための組成物および方法
JP2023220791A JP2024029136A (ja) 2016-01-20 2023-12-27 Ｄ因子を阻害するための組成物および方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662281092P 2016-01-20 2016-01-20
US62/281,092 2016-01-20
US201662297095P 2016-02-18 2016-02-18
US62/297,095 2016-02-18
PCT/US2017/014458 WO2017127761A1 (en) 2016-01-20 2017-01-20 Compositions and methods for inhibiting factor d

Related Child Applications (2)

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JP2022039070A Division JP2022078283A (ja) 2016-01-20 2022-03-14 Ｄ因子を阻害するための組成物および方法
JP2023220791A Division JP2024029136A (ja) 2016-01-20 2023-12-27 Ｄ因子を阻害するための組成物および方法

Publications (2)

Publication Number Publication Date
JP2019506159A true JP2019506159A (ja) 2019-03-07
JP2019506159A5 JP2019506159A5 (enExample) 2020-02-27

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JP2018538551A Pending JP2019506159A (ja) 2016-01-20 2017-01-20 Ｄ因子を阻害するための組成物および方法
JP2022039070A Pending JP2022078283A (ja) 2016-01-20 2022-03-14 Ｄ因子を阻害するための組成物および方法
JP2023220791A Pending JP2024029136A (ja) 2016-01-20 2023-12-27 Ｄ因子を阻害するための組成物および方法

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JP2022039070A Pending JP2022078283A (ja) 2016-01-20 2022-03-14 Ｄ因子を阻害するための組成物および方法
JP2023220791A Pending JP2024029136A (ja) 2016-01-20 2023-12-27 Ｄ因子を阻害するための組成物および方法

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US (4) US10174325B2 (enExample)
EP (1) EP3405577B8 (enExample)
JP (3) JP2019506159A (enExample)
CN (1) CN108934169A (enExample)
AU (3) AU2017210042B2 (enExample)
CA (1) CA3011819A1 (enExample)
GB (1) GB2553252B (enExample)
WO (1) WO2017127761A1 (enExample)

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US20220395557A1 (en) * 2019-10-23 2022-12-15 Gemini Therapeutics Sub, Inc. Methods for treating patients having cfh mutations with recombinant cfh proteins
CN114686481B (zh) * 2020-12-31 2023-08-15 北京键凯科技股份有限公司 一种抑制cfd表达的干扰rna及其制备方法和应用
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AU2021202392A1 (en) 2021-05-20
US11274307B2 (en) 2022-03-15
GB2553252B (en) 2019-07-31
AU2021202392B2 (en) 2023-02-02
EP3405577B8 (en) 2023-02-15
US20200392502A1 (en) 2020-12-17
HK1251610A1 (zh) 2019-02-01
GB2553252A8 (en) 2018-03-14
EP3405577B1 (en) 2022-12-14
AU2023202548A1 (en) 2023-06-01
EP3405577A1 (en) 2018-11-28
CA3011819A1 (en) 2017-07-27
US20250197868A1 (en) 2025-06-19
CN108934169A (zh) 2018-12-04
AU2017210042A1 (en) 2018-07-26
JP2022078283A (ja) 2022-05-24
GB201718801D0 (en) 2017-12-27
US10174325B2 (en) 2019-01-08
WO2017127761A1 (en) 2017-07-27
GB2553252A (en) 2018-02-28
JP2024029136A (ja) 2024-03-05
US20180051287A1 (en) 2018-02-22
US20190161755A1 (en) 2019-05-30
AU2017210042B2 (en) 2021-01-21
EP3405577A4 (en) 2019-09-11

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