JP2019506159A5 - - Google Patents

Download PDF

Info

Publication number
JP2019506159A5
JP2019506159A5 JP2018538551A JP2018538551A JP2019506159A5 JP 2019506159 A5 JP2019506159 A5 JP 2019506159A5 JP 2018538551 A JP2018538551 A JP 2018538551A JP 2018538551 A JP2018538551 A JP 2018538551A JP 2019506159 A5 JP2019506159 A5 JP 2019506159A5
Authority
JP
Japan
Prior art keywords
aptamer
factor
complement factor
aptamer according
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018538551A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019506159A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/014458 external-priority patent/WO2017127761A1/en
Publication of JP2019506159A publication Critical patent/JP2019506159A/ja
Publication of JP2019506159A5 publication Critical patent/JP2019506159A5/ja
Priority to JP2022039070A priority Critical patent/JP2022078283A/ja
Priority to JP2023220791A priority patent/JP2024029136A/ja
Pending legal-status Critical Current

Links

JP2018538551A 2016-01-20 2017-01-20 D因子を阻害するための組成物および方法 Pending JP2019506159A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022039070A JP2022078283A (ja) 2016-01-20 2022-03-14 D因子を阻害するための組成物および方法
JP2023220791A JP2024029136A (ja) 2016-01-20 2023-12-27 D因子を阻害するための組成物および方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662281092P 2016-01-20 2016-01-20
US62/281,092 2016-01-20
US201662297095P 2016-02-18 2016-02-18
US62/297,095 2016-02-18
PCT/US2017/014458 WO2017127761A1 (en) 2016-01-20 2017-01-20 Compositions and methods for inhibiting factor d

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2022039070A Division JP2022078283A (ja) 2016-01-20 2022-03-14 D因子を阻害するための組成物および方法
JP2023220791A Division JP2024029136A (ja) 2016-01-20 2023-12-27 D因子を阻害するための組成物および方法

Publications (2)

Publication Number Publication Date
JP2019506159A JP2019506159A (ja) 2019-03-07
JP2019506159A5 true JP2019506159A5 (enExample) 2020-02-27

Family

ID=59362699

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018538551A Pending JP2019506159A (ja) 2016-01-20 2017-01-20 D因子を阻害するための組成物および方法
JP2022039070A Pending JP2022078283A (ja) 2016-01-20 2022-03-14 D因子を阻害するための組成物および方法
JP2023220791A Pending JP2024029136A (ja) 2016-01-20 2023-12-27 D因子を阻害するための組成物および方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022039070A Pending JP2022078283A (ja) 2016-01-20 2022-03-14 D因子を阻害するための組成物および方法
JP2023220791A Pending JP2024029136A (ja) 2016-01-20 2023-12-27 D因子を阻害するための組成物および方法

Country Status (8)

Country Link
US (4) US10174325B2 (enExample)
EP (1) EP3405577B8 (enExample)
JP (3) JP2019506159A (enExample)
CN (1) CN108934169A (enExample)
AU (3) AU2017210042B2 (enExample)
CA (1) CA3011819A1 (enExample)
GB (1) GB2553252B (enExample)
WO (1) WO2017127761A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3110419A4 (en) 2014-02-25 2017-07-26 Achillion Pharmaceuticals, Inc. Alkyne compounds for treatment of complement mediated disorders
WO2017035401A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amide compounds for treatment of immune and inflammatory disorders
WO2017035405A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amino compounds for treatment of immune and inflammatory disorders
WO2017035409A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
EP3405577B8 (en) 2016-01-20 2023-02-15 396419 B.C. Ltd. Compositions and methods for inhibiting factor d
WO2018136827A1 (en) 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Stem-loop compositions and methods for inhibiting factor d
WO2018136831A1 (en) * 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Pseudoknot compositions and methods for inhibiting factor d
CA3053818A1 (en) 2017-03-01 2018-09-07 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
WO2018160891A1 (en) 2017-03-01 2018-09-07 Achillion Pharmaceutical, Inc. Pharmaceutical compounds for treatment of medical disorders
WO2019022986A1 (en) * 2017-07-24 2019-01-31 Vitrisa Therapeutics, Inc. NUCLEIC ACID COMPOSITIONS AND METHODS OF INHIBITING D-FACTOR
WO2019028284A1 (en) 2017-08-02 2019-02-07 Achillion Pharmaceuticals, Inc. THERAPEUTIC REGIMES FOR THE TREATMENT OF NOCTURNAL PAROXYSTIC HEMOGLOBINURIA
WO2019210194A1 (en) * 2018-04-26 2019-10-31 Vitrisa Therapeutics, Inc. Pegylated compositions for ocular use, and methods thereof
JP7443375B2 (ja) 2018-09-06 2024-03-05 アキリオン ファーマシューティカルズ, インコーポレーテッド 医学的障害の治療のための大環状化合物
WO2020051538A1 (en) 2018-09-06 2020-03-12 Achillion Pharmaceuticals, Inc. Morphic forms of complement factor d inhibitors
WO2020069024A1 (en) 2018-09-25 2020-04-02 Achillion Pharmaceuticals, Inc. Morphic forms of complement factor d inhibitors
CN113195472A (zh) 2018-12-17 2021-07-30 艾其林医药公司 用于治疗补体介导的病症的靶向给药
WO2020146731A1 (en) * 2019-01-11 2020-07-16 Drive Therapeutics Llc Compositions and methods for inhibiting vascular endothelial growth factor
MX2021011507A (es) 2019-03-22 2021-12-15 Achillion Pharmaceuticals Inc Compuestos farmaceuticos para el tratamiento de trastornos mediados por complemento.
MX2022004939A (es) * 2019-10-23 2022-08-10 Gemini Therapeutics Sub Inc Metodos para tratar pacientes que tienen mutaciones de cfh con proteinas de cfh recombinantes.
CN114686481B (zh) * 2020-12-31 2023-08-15 北京键凯科技股份有限公司 一种抑制cfd表达的干扰rna及其制备方法和应用
JP7829595B2 (ja) * 2021-04-09 2026-03-13 武田薬品工業株式会社 補体因子dを標的とする抗体及びその使用
CN121969751A (zh) * 2023-10-11 2026-05-01 瑞泽恩制药公司 使用补体因子d (cfd)抑制剂治疗黄斑变性

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
ATE318832T1 (de) 1990-06-11 2006-03-15 Gilead Sciences Inc Verfahren zur vervendung von nukleinsäureliganden
US6140490A (en) 1996-02-01 2000-10-31 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of complement system proteins
WO1998055471A1 (en) 1997-06-03 1998-12-10 Biocryst Pharmaceuticals, Inc. Novel compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
AU756490B2 (en) 1997-08-26 2003-01-16 Abgenix, Inc. A process for inhibiting complement activation via the alternative pathway
WO1999027133A1 (en) 1997-11-26 1999-06-03 Medical Research Council Improved selex procedure and an anti-cd4 aptamer
US6956107B2 (en) 1998-02-20 2005-10-18 Tanox, Inc. Inhibitors of complement activation
US7112327B2 (en) 1998-02-20 2006-09-26 Tanox, Inc. Inhibition of complement activation
GB9930659D0 (en) 1999-12-24 2000-02-16 Bio Discovery Ltd Inhibitors of complement activation
US6998468B2 (en) 2000-03-23 2006-02-14 Tanox, Inc. Anti-C2/C2a inhibitors of complement activation
EP1594541A4 (en) 2003-02-21 2007-03-28 Rikshospitalet Radiumhospitale METHOD AND COMPOSITIONS FOR TREATING MECONIUM ASPIRATION SYNDROME
BRPI0506629A (pt) 2004-02-10 2007-05-02 Univ Colorado inibição do fator b, a via alternativa do sistema complemento e métodos relacionados
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
EP1861114B1 (en) 2005-03-11 2011-02-02 Potentia Pharmaceuticals, Inc. Compositions comprising modulators of g-protein-coupled receptor for treatment of macular degeneration
CN103505728A (zh) 2005-05-26 2014-01-15 科罗拉多大学评议会法人机构 用于治疗外伤性脑损伤、脊髓损伤及相关病症的补体旁路抑制
US8168584B2 (en) * 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
KR101126423B1 (ko) 2005-10-21 2012-07-11 카탈리스트 바이오사이언시즈, 인코포레이티드 보체 활성화를 억제하는 변형된 프로테아제
DK2500030T4 (en) 2005-11-04 2018-10-29 Genentech Inc Use of complement pathway inhibitors for the treatment of eye diseases
AU2006337093B2 (en) 2005-12-22 2013-03-14 Opko Pharmaceuticals, Llc. Compositions and methods for regulating complement system
JP2009521506A (ja) 2005-12-22 2009-06-04 アルコン リサーチ, リミテッド 補体因子hの危険である改変体をもつ患者における年齢による斑状変性の予防および処置のためのc3コンバターゼインヒビター
US20070196367A1 (en) 2006-02-22 2007-08-23 Valentin Dinu Methods of preventing and treating Alzheimer's disease, age related macular degeneration and other diseases involving extra-cellular debris through the inhibition of the complement system
DK1991275T3 (en) 2006-03-08 2014-12-08 Archemix Llc Complement aptamers AND ANTI-C5 AGENTS FOR USE IN THE TREATMENT OF EYE DISEASES
LT3028716T (lt) 2006-10-10 2020-12-10 Regenesance B.V. Komplemento slopinimas nervų regeneracijos pagerinimui
US8790924B2 (en) 2006-10-19 2014-07-29 Duke University Reversible platelet inhibition
CN106084055A (zh) 2006-11-02 2016-11-09 健泰科生物技术公司 人源化的抗‑d因子抗体
EP2148691B1 (en) 2007-02-05 2015-05-20 Apellis Pharmaceuticals, Inc. Compstatin analogues for use in the treatment of inflammatory conditions of the respiratory system
RU2009144142A (ru) * 2007-04-30 2011-06-10 Алькон Рисерч, Лтд. (Us) Лечение возрастной дегенерации желтого пятна с применением ингибиторов фактора d комплемента
AR066660A1 (es) * 2007-05-23 2009-09-02 Genentech Inc Prevencion y tratamiento de condiciones del ojo asociadas con su complemento
US20090092980A1 (en) 2007-07-20 2009-04-09 Christoph Arenz miRNA PROCESSING INHIBITOR EFFICACY ASSAYS AND SUBSTANCES
US8981060B2 (en) 2007-08-27 2015-03-17 Novelmed Therapuetics, Inc. Method of inhibiting complement activation with factor Bb specific antibodies
GB0718737D0 (en) 2007-09-25 2007-11-07 Glaxo Group Ltd Antibodies
CA2707859A1 (en) 2007-12-11 2009-06-18 Glaxo Group Limited Antigen binding proteins specific against beta amyloid
CA2718588A1 (en) 2008-02-19 2009-08-27 The Trustees Of The University Of Pennsylvania Complement inhibitors as therapeutic agents for treatment of cancer
US8940299B2 (en) 2008-02-28 2015-01-27 Case Western Reserve University Method of treating cancer
DK2262831T3 (en) 2008-03-03 2015-04-27 Novelmed Therapeutics Inc ANTI-Properdin ANTIBODIES
US8664362B2 (en) 2008-03-03 2014-03-04 NovelMed Therapeutics Humanized and chimeric anti-properdin antibodies
WO2009121065A2 (en) 2008-03-28 2009-10-01 Apellis Ag Modulation and repletion/enhancement of the complement system for treatment of trauma
CR20170001A (es) 2008-04-28 2017-08-10 Genentech Inc Anticuerpos anti factor d humanizados
EP2159286A1 (en) 2008-09-01 2010-03-03 Consiglio Nazionale Delle Ricerche Method for obtaining oligonucleotide aptamers and uses thereof
WO2010030789A1 (en) 2008-09-10 2010-03-18 Novelmed Therapeutics, Inc. Device and method for inhibiting complement activation
GB0904427D0 (en) * 2009-03-13 2009-04-29 Lachmann Peter Treatment of diseases related to hyperactivity of the complement system
US9382544B2 (en) 2009-05-15 2016-07-05 Nec Solution Innovators, Ltd. Aptamer that recognizes peptide
JP5871798B2 (ja) 2009-07-02 2016-03-01 エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント 肝再生を刺激する方法
WO2011007876A1 (ja) 2009-07-16 2011-01-20 Necソフト株式会社 Hmgb1結合核酸分子およびその用途
US20120190578A1 (en) 2009-08-06 2012-07-26 Washington University Plasma Complement Components as Expression Markers for Age-Related Macular Degeneration and Related Phenotypes
US20110165648A1 (en) 2009-11-04 2011-07-07 Menno Van Lookeren Campagne Co-crystal structure of factor D and anti-factor D antibody
KR20130130732A (ko) 2010-11-01 2013-12-02 제넨테크, 인크. 다유전자 스코어를 이용한 진행성 노인성 황반 변성으로의 진행 예측
CN103402996B (zh) 2011-01-04 2015-02-11 诺瓦提斯公司 可用于治疗年龄相关性黄斑变性(amd)的吲哚化合物或其类似物
CA2840270C (en) 2011-06-22 2023-09-26 Apellis Pharmaceuticals, Inc. Methods of treating chronic disorders with complement inhibitors
US10966945B2 (en) 2011-08-01 2021-04-06 Aurin Biotech Inc. Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic synthetic complex
EP2762569B1 (en) 2011-09-28 2018-06-13 RIBOMIC Inc. Ngf aptamer and application thereof
MX355567B (es) 2011-12-30 2018-04-23 Quest Diagnostics Invest Inc Aptameros y metodos de diagnostico para detectar el receptor de egf.
ES2749624T3 (es) 2013-03-14 2020-03-23 Caribou Biosciences Inc Composiciones y métodos de ácidos nucleicos dirigidos a ácido nucleico
MX2016001854A (es) 2013-08-12 2016-09-06 Genentech Inc Composiciones y metodo para tratar condiciones asociadas con el complemento.
US20150104445A1 (en) 2013-10-10 2015-04-16 Viropharma Holdings Limited Methods of inhibiting the alternative pathway of complement immune system activation and compositions used therein
EP3110419A4 (en) 2014-02-25 2017-07-26 Achillion Pharmaceuticals, Inc. Alkyne compounds for treatment of complement mediated disorders
SG11201608868PA (en) * 2014-05-01 2016-11-29 Genentech Inc Anti-factor d antibody variants and uses thereof
TWI623617B (zh) 2014-08-29 2018-05-11 國立清華大學 對卵巢癌具有專一性之適合體及其應用
JP2018535679A (ja) 2015-11-19 2018-12-06 ベース ペア バイオテクノロジーズ,インク. 標的分子の高感度検出のための方法及び材料
WO2017127762A1 (en) 2016-01-20 2017-07-27 Vitrisa Therapeutics, Inc. Methods for improved aptamer selection
EP3405577B8 (en) 2016-01-20 2023-02-15 396419 B.C. Ltd. Compositions and methods for inhibiting factor d
EP3414330A4 (en) 2016-02-08 2019-07-03 Vitrisa Therapeutics, Inc. COMPOSITIONS WITH IMPROVED INTRAVITREAL HALF TIME AND USES THEREOF
WO2018136831A1 (en) 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Pseudoknot compositions and methods for inhibiting factor d
WO2018136827A1 (en) 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Stem-loop compositions and methods for inhibiting factor d
WO2019022986A1 (en) 2017-07-24 2019-01-31 Vitrisa Therapeutics, Inc. NUCLEIC ACID COMPOSITIONS AND METHODS OF INHIBITING D-FACTOR

Similar Documents

Publication Publication Date Title
Motib et al. Modulation of quorum sensing in a gram‐positive pathogen by linear molecularly imprinted polymers with anti‐infective properties
JP2011515073A5 (enExample)
EA200700136A1 (ru) Анти-cd154-антитела
WO2008140653A3 (en) Humaneered anti-factor b antibody
MX2020000435A (es) Anticuerpos anti-cd166 y usos de estos.
UY28641A1 (es) Anticuerpos
BR0211953A (pt) Inibidores de rota complementar ligando-se a cs e csa sem prevenção da formação de csb
AR046682A1 (es) Terapia de combinacion para tratamiento de desordenes neovasculares oculares
NZ600348A (en) Anti-c5a binding moieties with high blocking activity
DK1819830T3 (da) Fremgangsmåder til antistofgenerering
JP2017507657A5 (enExample)
RU2010138612A (ru) ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА ПРОТИВ C5аR
JP2018198596A5 (enExample)
NZ591633A (en) Combination gas vaccines and therapeutics
PL1699826T3 (pl) Syntetyczne domeny immunoglobulinowe o właściwościach wiążących modyfikowane w regionach cząsteczki różnych od regionów determinujących komplementarność
WO2009028880A3 (en) Biomarker composition for detecting diabetic retinopathy and diagnostic kit therefor
CN115666649A (zh) 一种新型冠状病毒抗体的药物组合物及其用途
CN115768476A (zh) 抗il-17a抗体药物组合物及其用途
WO2004075838A3 (en) Method and compositions for the treatment of meconium aspiration syndrome
WO2013177035A3 (en) Humaneered anti-factor b antibody
BR112021021281A2 (pt) Anticorpo monoclonal que se liga especificamente ao gitr
JP2022119899A5 (enExample)
ATE502050T1 (de) Von dd 3b6/22 abgeleitete humanisierte antikörper mit spezifität für das d-dimer fragment von fibrin
WO2006059247A3 (en) VACCINES, COMPOSITIONS AND METHODS BASED ON STAPHYLOCOCCUS AUREUS IRON-REGULATED SURFACE DETERMINANTS IsdA, IsdB, and IsdC
ATE477274T1 (de) Gegen clostridium difficile gerichtete antikörper